Clinical trials: Naltrexone
Fibromyalgia, Persian Gulf Syndrome
Effects of Low Dose Naltrexone in Fibromyalgia
Low Dose Naltrexone (LDN) has been reported anecdotally to reduce the symptoms of Fibromyalgia, a Chronic Multisystem Illness. The drug may work by regulating natural pain-reducing systems.
- Trial name
- NCT00568555
- Testing
- Low Dose Naltrexone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Stanford University
Opioid-use Disorder
Extended Release Naltrexone Versus Extended Release Buprenorphine With Individuals Leaving Jail
The proposed study is a Type 1 hybrid effectiveness-implementation trial. Individuals with opioid use disorder in county jails throughout the state of Maryland will be randomly assigned within gender within jail to one of two…
- Trial name
- NCT04408313
- Testing
- XR-B, XR-NTX
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Friends Research Institute, Inc.
Alcohol Dependence
Extended-release Naltrexone for Alcohol Dependence in Primary Care
Naltrexone is an opioid antagonist with a high affinity for the mu opioid receptor. The efficacy of extended-release naltrexone (Vivitrol) as a treatment for alcohol dependence has been demonstrated in clinical trials, raising…
- Trial name
- NCT00620750
- Testing
- Extended release injectable naltrexone (Vivitrol)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- NYU Langone Health
Gulf War Illness
Trial of Naltrexone and Dextromethorphan for Gulf War Illness
Veterans of the 1991 Gulf War who developed Gulf War Illness are being studied. Treatments with FDA approved generic drugs are being administered to see if they help with the symptoms of Gulf War Illness, such as chronic fatigue…
- Trial name
- GWI Treatment (NCT02206490)
- Testing
- naltrexone, Dextromethorphan
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- East Carolina University
Alcoholism, Smoking
Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch)
This study will develop a behavioral and drug relapse prevention program for individuals who are dependent on both alcohol and tobacco.
- Trial name
- NCT00000447
- Testing
- naltrexone (Revia), nicotine replacement patch
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center, Houston
Back Pain, Lower Back Pain
Naltrexone and Clonidine Combination (ATNC05) in the Treatment of Chronic Back Pain
The study includes back pain of the cervical, thoracic, and the lumbar regions.
- Conditions
- Back Pain, Lower Back Pain, Cervical Pain
- Trial name
- NCT01415895
- Testing
- Naltrexone and Clonidine Combination
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Annette C. Toledano MD
HIV Infection, Heavy Alcoholic Consumption
Pharmacotherapy for HIV Infected Patients With Alcohol Problems
This is a randomized double blind clinical trial to test the effect of Naltrexone on HIV infected heavy drinkers. The study will select 40 HIV positive patients who meet criteria for heavy drinking.
- Conditions
- HIV Infection, Heavy Alcoholic Consumption, HIV Infections
- Trial name
- NCT00854230
- Testing
- Naltrexone
- Sponsor
- VA Connecticut Healthcare System
Alcoholism
Naltrexone Maintenance Treatment of Alcoholism
The purpose of this study is to determine the long-term effectiveness of naltrexone treatment in alcohol-dependent patients who respond to short-term treatment.
- Trial name
- NCT00000450
- Testing
- Naltrexone Tablet
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- The Scripps Research Institute
Alcoholism
ALK21-003: Study of Medisorb® Naltrexone (VIVITROL®) in Alcohol-Dependent Adults
This was a Phase 3, multicenter, randomized, double-blind, placebo-controlled study conducted in subjects diagnosed with alcohol dependence as defined by the Diagnostic and Statistical Manual of Mental Disorders, 4th Ed.
- Trial name
- NCT01218958
- Testing
- Medisorb naltrexone 190 mg, Medisorb naltrexone 380 mg
- Volunteers
- 624 people
- Sponsor
- Alkermes, Inc.
Opioid-use Disorder, Neonatal Abstinence Syndrome
MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study
This is a multi-center prospective comparative cohort study examining the safety, efficacy, pharmacokinetics, and pharmacogenomics of naltrexone for pregnant women with opioid use disorder.
- Conditions
- Opioid-use Disorder, Neonatal Abstinence Syndrome, Pregnancy, High Risk, Alcohol Use Disorder
- Trial name
- NCT03718104
- Testing
- Pharmacokinetic analysis, Safety and Efficacy, Genetic and epigenetic analysis
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Boston Medical Center
Bipolar Disorders, Schizophrenia
Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI)
The primary aim of this study is to determine the feasibility of long-acting injectable naltrexone administration in a clinical trial in patients with SMI who also have a diagnosis of alcohol dependence.
- Conditions
- Bipolar Disorders, Schizophrenia, Schizoaffective Disorders, Alcohol Dependence
- Trial name
- vivitrol (NCT00453804)
- Testing
- injectable naltrexone, oral naltrexone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- State University of New York - Upstate Medical University
Tobacco Use Disorder
Naltrexone Augmentation of Nicotine Patch Therapy - 1
Naltrexone Augmentation of Nicotine Patch Therapy
- Trial name
- NCT00218153
- Testing
- Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder
Naltrexone for Individuals of East Asian Descent
This study will elucidate the pharmacogenetic effects of the Asn40Asp SNP of the OPRM1 gene on biobehavioral and neural markers of response to naltrexone in individuals of East Asian descent, an ethnic group most likely to…
- Trial name
- NCT02026011
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Los Angeles
Opiate Dependence, Human Immunodeficiency Virus
Opioid Relapse & HIV Risk: 48 Versus 24 Weeks of Injectable Extended Release Naltrexone
To address the question of the comparison of two courses of Vivitrol with differing lengths in 130 HIV negative, consenting, opioid addicted patients who have completed inpatient treatment.
- Trial name
- NCT01882361
- Testing
- injectable naltrexone
- Where
- Russia
- Volunteers
- 77 people
- Sponsor
- University of Pennsylvania
Opioid-use Disorder
Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder
This study will evaluate the effectiveness of a new pharmacological approach to increase efficacy of treatment with extended release naltrexone (XR-naltrexone) for individuals with opioid use disorder by combining it with…
- Trial name
- COMBO (NCT05011266)
- Testing
- Buprenorphine/naloxone
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- New York State Psychiatric Institute
Naltrexone, Placebo
Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences
The study is a randomized, placebo-controlled design with the opioid antagonist, oral naltrexone. Following random assignment, participants will take 50mg of naltrexone or placebo once a day for 7 days.
- Trial name
- NCT05007561
- Testing
- Naltrexone Hydrochloride
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Alcoholism, Alcohol Dependence
Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)
This study will assess the ability of naltrexone (Revia) to reduce the risk of relapse in Alaska natives with alcohol dependence.
- Trial name
- NCT00000451
- Testing
- sertraline, naltrexone
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Yale University
Opioid Dependence, Heroin Dependence
Memantine as a Supplement to Naltrexone in Treating Heroin Dependence
Prospective participants will undergo a screening process at the clinic to determine eligibility. After screening, eligible patients will complete an 8-day inpatient detoxification, followed by a 12-week outpatient phase.
- Trial name
- NAMHS (NCT00476242)
- Testing
- Vivitrol, memantine
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- New York State Psychiatric Institute
Opiate Addiction
Treatment Study Using Depot Naltrexone (1/6) Philadelphia Coord/Data Mgmt Site
The aim of this project is to conduct a multi-site effectiveness study to determine whether the addition of a monthly injection of depot naltrexone to treatment as usual (TAU) will significantly improve outcome in parolees and…
- Trial name
- NCT00781898
- Testing
- Depot naltrexone, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV Seropositivity
Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+
In the vast majority of those infected with HIV virus who are untreated, there is deterioration in immune health over a period of months or years inevitably leading to full-blown AIDS and demise.
- Trial name
- NCT01174914
- Testing
- Naltrexone, Naltrexone + ARV's
- Where
- Mali
- Volunteers
- 171 people
- Sponsor
- The Ojai Foundation