Clinical trials: Negative Pressure Wound Therapy
Leg Ulcer
A Randomised Controlled Trial Comparing Vacuum Assisted Closure (V.A.C.®) With Modern Wound Dressings
Current treatment modalities for chronic leg ulcers are time consuming, expensive, and only moderately successful. Recent data suggest that creating a sub-atmospheric pressure by Vacuum Assisted Closure (V.A.C.®) therapy supports…
- Trial name
- NCT00243620
- Testing
- Vacuum therapy (device)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Breast Reconstruction
Negative Pressure in PAP Donor Sites
A retrospective chart review will be conducted to identify patients who received breast reconstruction using free profunda artery perforator (PAP) flap by the investigators from January 2015 to August 2021.
- Trial name
- NCT05491473
- Testing
- Closed incisional negative pressure wound therapy (iNPWT) system
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Chang Gung Memorial Hospital
Wounds and Injuries
Addition of Negative Pressure Wound Therapy to Standard Gauze Dressings for Acute Wounds in a Limited-Resource Setting
The worldwide prevalence of open wounds is estimated to be approximately 200 million per year. Negative Pressure Wound Therapy (NPWT), the application of a controlled vacuum to an open wound cavity, has been clinically…
- Trial name
- NCT02479542
- Testing
- Standard Gauze Dressing, WiCare NPWT dressing
- Sponsor
- Stanford University
Pressure Ulcer, Diabetic Foot Ulcer
The Study of Wound Dressings for Portable NPWT
Introduction Negative pressure wound therapy (NPWT), also known as topical negative pressure, has become a popular therapy for the treatment of many acute and chronic wounds.
- Trial name
- NPWT (NCT03135964)
- Testing
- filler dressing of NPWT
- Where
- Taiwan
- Volunteers
- 57 people
- Sponsor
- Tainan Municipal Hospital
Wounds
Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an Evaluation
Negative pressure wound therapy (NPWT) has become a powerful tool in wound bed preparation of complex wounds and is routinely used in various disciplines, including general surgery and plastic surgery.
- Trial name
- NCT01107821
- Testing
- Engenex™ pump and Bio-Dome™ Wound Dressing
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University Hospital, Ghent
Wound Infections
Prophylactic Incisional Care in Obese Women at Cesarean
Surgical site infections (SSIs) complicate 5 - 12% of cesareans. Negative pressure wound therapy (NPWT) - a closed, sealed system that applies negative pressure to the wound surface - has been used to treat open wounds since the…
- Trial name
- PICO-C (NCT02578745)
- Testing
- Prophylactic NPWT (PICO system), Standard Dressing
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Postoperative Wound Complications
Negative Pressure Wound Therapy in Cesarean Section
The investigators propose a prospective, randomized trial evaluating the use of negative pressure wound therapy (NPWT) with high risk obstetrical patients.
- Trial name
- NPWTCS (NCT02289157)
- Testing
- Negative pressure wound therapy
- Where
- United States
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Sarcoma, Wound Infection
Negative Pressure Dressing Therapy in Soft Tissue Sarcoma Surgery
This randomised controlled trial aims to evaluate the difference in surgical site infection following excision of soft tissue sarcomas.
- Trial name
- NCT02901405
- Testing
- Negative Pressure Wound Therapy (ActivVAC, KCI), Standard dressings
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- NHS Greater Glasgow and Clyde
Wound Infection, Wound Surgical
Efficacy of Negative Pressure Wound Closure Therapy by PICO System in Prevention of Complications of Femoral Artery Exposure
Evaluate negative pressure wound closure therapy by PICO system in Prevention of complications of femoral artery exposure.
- Trial name
- NCT04453319
- Testing
- Femoral Wound Closure and dressing
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Open Abdomen, Temporary Abdominal Closure Mechanisms
Open Abdomen: Vacuum Pack Versus Sylo Bag and Mesh Protocol
The open abdomen is a valid and accepted surgical tactic for the trauma and acute care patient. There have been many mechanisms described for its management, but the most accepted strategy is the vacuum pack.
- Trial name
- NCT01864590
- Testing
- Vacuum Pack, Double Sylo Bag - Mesh Protocol
- Where
- Colombia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Split-thickness Skin Graft Donor Sites, Wound Healing
Effectiveness of Negative Pressure Wound Therapy Dressing on Split-Thickness Skin Graft Donor Site Wound Healing
Split-thickness skin grafting (STSG) is a cornerstone of reconstructive surgery, but donor sites often experience significant morbidity due to partial-thickness wounds created.
- Trial name
- NCT07629076
- Testing
- Negative Pressure Wound therapy, conventional dressing
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Mahmoud Abdalla Hifny Taha
Wound Healing
Comparison of Wound Healing Duration Between Vacuum-Assisted Closure (VAC) and Conventional Dressings
This randomized controlled trial will compare vacuum-assisted closure (VAC) therapy with conventional wound dressings for the treatment of open contaminated and dirty wounds.
- Trial name
- VAC-WOUND (NCT07832162)
- Testing
- Vacuum-Assisted Closure (VAC) Therapy Description:, Conventional Wound Dressing
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Skin Transplantation
Negative Pressure Wound Therapy for Skin Grafts
The repairing of various wounds is always a great challenge in burn surgery and plastic surgery. Skin-grafting is the main therapy.
- Trial name
- NCT02374528
- Testing
- Negative pressure wound therapy, standard pressure bolster dressing
- Volunteers
- 98 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
to See Whether Negative Pressure Wound Therapy Decreases Wound Infections.
Negative Pressure Wound Therapy - A Multi-Centered Randomized Control Trial
Children with neuromuscular disorders such as cerebral palsy, children with kyphosis and post-traumatic scoliosis have higher infection rates after scoliosis surgery than healthy children who undergo scoliosis surgery.
- Trial name
- NPWT (NCT02790385)
- Testing
- Negative Pressure Wound Therapy, Standard Gauze Treatment
- Where
- Canada
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Open Abdomen, Fascial Closure
Vacuum Assisted Wound Closure (VAWC) and Mesh Mediated Fascial Traction
The purpose of this multicenter trial is to prospectively evaluate a novel combination of vacuum assisted wound closure (VAWC) and mesh mediated fascial traction for closure of open abdomens.
- Trial name
- NCT00494793
- Testing
- VAWC and mesh mediated fascial traction
- Where
- 5 sites in Sweden
- Volunteers
- 111 people
- Sponsor
- Skane University Hospital
Pilonidal Sinus, Wound Heal
PILONIDAL SINUS: CONVENTIONAL CARE VERSUS NEGATIVE PRESSURE THERAPY.
Pilonidal Sinus PS is a prevalent disease in young patients. There is currently no consensus on the surgical treatment of choice.
- Trial name
- SINUS-TPN (NCT05474911)
- Testing
- Negative pressure therapy, Conventional wound care
- Where
- Spain
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Sebastiano Biondo
Pressure Sores
Effect of Negative Wound Pressure on P.S
This study will compare the NPWT using the NPD to the conventional wound dressing and specifically evaluating (i) reduction of wound surface area and depth, (ii) removal of slough and formation of granulation tissue
- Trial name
- NCT06243328
- Testing
- negative wound pressure therapy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Sarcoma, Negative Pressure Therapy
Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing
To compare the differences in clinical outcomes and health economics between standard absorbent dressings versus Negative Pressure Wound Therapy dressings following the surgical resection of sarcoma tumours.
- Conditions
- Sarcoma, Negative Pressure Therapy, Wound Complication
- Trial name
- SUNDIAL (NCT07048184)
- Testing
- Negative Pressure Wound Therapy (NPWT) Dressings, Standard Absorbent Dressings
- Where
- United Kingdom
- Volunteers
- 94 people
- Sponsor
- NHS Greater Glasgow and Clyde
Negative Pressure Wound Therapy, Cesarean Section; Infection
The Invia Motion at Cesarean Study
To assess patient centered outcomes of the Medela INVIA Motion prophylactic NPWT system at cesarean delivery.
- Trial name
- NCT04365452
- Testing
- Invia Motion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Diabetic Foot, Pressure Ulcer
A Real-World Registry of Chronic Wounds and Ulcers
WOUNDJOURNEY is a longitudinal, real-world, observational registry designed to capture the full clinical course and patient journey associated with chronic wounds and ulcers.
- Conditions
- Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis
- Trial name
- WOUNDJOURNEY (NCT02280733)
- Testing
- Usual care
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- U.S. Wound Registry