Clinical trials: Neglected Diseases
Child Maltreatment, Interpersonal Relations
Beneficial or Fostering Future Struggles (B.F.F.s)? Characterizing the Role of Friends in the Development of 13- to 17-Year-Old Adolescents
The goal of this clinical trial is to investigate how the friendship experiences of maltreated (i.e., abused and/or neglected) and non-maltreated adolescents differentially influence their risk for adverse outcomes.
- Conditions
- Child Maltreatment, Interpersonal Relations, Victimisation, Psychopathology
- Trial name
- BFFs (NCT05893459)
- Testing
- Debrief
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Visceral Leishmaniasis
Clinical Prognostic Score to Predict Relapse in VL
This prospective cohort study has the aim to develop a prognostic tool to predict relapse in patients suffering from visceral leishmaniasis (VL) from VL endemic regions in Ethiopia.
- Trial name
- CPS (NCT05602610)
- Testing
- No intervention
- Where
- Ethiopia
- Volunteers
- 741 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Neurological Disorders, Cerebral Malaria
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC
The impact of neurological disorders is enormous worldwide, and it is increased in poor settings, due to lack of diagnosis and treatment facilities as well as delayed management.
- Conditions
- Neurological Disorders, Cerebral Malaria, Bacterial Meningitis, Central Nervous System Tuberculosis
- Trial name
- Nidiag-Neuro (NCT01589289)
- Testing
- Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics)
- Where
- Democratic Republic of the Congo
- Volunteers
- 352 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Buruli Ulcer
Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy
Buruli ulcer (BU) is a skin Neglected Tropical Disease (NTD) that is caused by Mycobacterium ulcerans. It affects skin, soft tissues and bones causing long-term morbidity, stigma and disability.
- Trial name
- BLMs4BU (NCT05169554)
- Testing
- Standard [RC8]: rifampicin plus clarithromycin (RC) therapy for 8 weeks., Investigational [RCA4]: standard (RC) plus amoxicillin/clavulanate (A) for 4 weeks.
- Where
- 3 sites in Benin
- Volunteers
- 140 people
- Sponsor
- Fundacion Agencia Aragonesa para la Investigacion y Desarrollo (ARAID)
Dental Caries, Child Neglect
Improving Family's Adherence to Dental Care After DGA (HECC-CAN-study)
Early childhood caries (ECC) is a common disease. Its prevalence is highest in poor, socially disadvantaged, and minority groups. Dental treatment under General Anaesthesia (DGA) is common, especially among the youngest patients.
- Trial name
- HECC-CAN (NCT04898465)
- Testing
- Social Paediatric Intervention
- Where
- Finland
- Volunteers
- 89 people
- Sponsor
- Helsinki University Central Hospital
Sensory Neglect, Stroke
Feasibility and Effectiveness Study of Implementing Prism Adaptation as a Treatment for Spatial Neglect After Stroke
Spatial neglect is a common attention disorder after right hemisphere stroke and is associated with decreased independence and quality of life.
- Trial name
- NCT02680171
- Testing
- Prism Goggles, Non-Shifting Goggles
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Nova Scotia Health Authority
Cutaneous Leishmaniases
Spatial Analysis of Host-parasite Interactions in Cutaneous Leishmaniasis in Ethiopia
Cutaneous leishmaniasis manifestations range from self-healing localized skin ulcers/nodules to diffusely spread chronic lesions.
- Trial name
- SpatialCL (NCT05332093)
- Testing
- skin biopsy, venous blood sample (plasma, PBMC, WB), venous blood sample (HLA)
- Where
- Ethiopia
- Volunteers
- 92 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Alcohol Abuse, Alcohol Drinking
TREAT Child Alcohol Use Disorder (C-AUD) in Eastern Uganda
The investigators will investigate the existence of alcohol drinking among children living under adult supervision and care, living within the communities.
- Conditions
- Alcohol Abuse, Alcohol Drinking, Alcoholism, Alcohol Use Disorder
- Trial name
- TREAT C-AUD (NCT04743024)
- Where
- Uganda
- Volunteers
- 7,188 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Agitation, Emergence
Mother's Recorded Voice Versus Dexmedetomidine on Postoperative Agitation
The aim of this study is to compare the efficacy of mother's recorded voice versus dexmedetomidine injection on postoperative agitation in children undergoing elective surgery.
- Trial name
- NCT04941508
- Testing
- the mother's recorded voice, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Soil-transmitted Helminthiasis, Schistosomiasis
Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders
NIDIAG is an international collaboration on integrated diagnosis-treatment platforms, funded by the European Commission (EC). NIDIAG aims to develop an improved, patient-centred system for delivering primary health care in…
- Conditions
- Soil-transmitted Helminthiasis, Schistosomiasis, Strongyloidiasis, Shigellosis
- Trial name
- NIDIAGDigest (NCT02105714)
- Testing
- Stool culturing for pathogenic bacteria, Kato-Katz technique, Baermann technique
- Where
- 7 sites in Côte d’Ivoire, Indonesia and 2 more
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Stroke
Effectiveness of Theta Burst Stimulation (TBS) and Voluntary Trunk Rotation for Neglect
This is a double blinded, randomized control trial with a pretest-posttest control and interventional group design. The assessor is blinded to all assessments and evaluations.
- Trial name
- NCT02526238
- Testing
- TMS and trunk rotation
- Where
- Hong Kong
- Volunteers
- 14 people
- Sponsor
- Kowloon Hospital, Hong Kong
Child Abuse, Child Neglect
Child-Parent Psychotherapy - a Feasibility Study for Children in Foster Care
Children in foster care have an increased risk of exposure to adverse experiences during childhood and across the lifespan. In current studies of interventions children in foster care are often excluded, or they are too few to be…
- Conditions
- Child Abuse, Child Neglect, Post-Traumatic Stress Disorder in Children, Parent-Child Relations
- Trial name
- NCT04519229
- Testing
- Child-Parent Psychotherapy
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Kronoberg County Council
Depressive Symptoms, Conduct Disorder
Intervening Early: Key Adolescent Outcomes
This study follows children into adolescence who were first randomized to intervention condition in infancy.
- Conditions
- Depressive Symptoms, Conduct Disorder, Anxiety Disorders
- Trial name
- SCOH-A (NCT04168684)
- Testing
- Attachment and Biobehavioral Catch-up (ABC), Developmental Education for Families (DEF)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Delaware
Clubfoot
Percutaneous Achilles Tendon Tenotomy vs Tendo-Achilles Lengthening (TAL) in Neglected Clubfoot Children.
Achilles tendon tenotomy is the established worldwide gold standard for correcting idiopathic clubfoot. However, in neglected cases, surgical interventions such as percutaneous Achilles tendon tenotomy (PAT) and open…
- Trial name
- NCT07561697
- Testing
- Tenotomy of Achilles Tendon, Tendo-Achilles Lengthening
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Muhammad Aamir Latif
Behavior, Child, Caries,Dental
Are Dental Neglect and the Siblings Risk Factors in Children
Neglect insidiously affects a child's overall health in all aspects. The aim of this study was to determine whether the presence of siblings caused dental neglect, and whether there was a relationship between dental neglect and…
- Conditions
- Behavior, Child, Caries,Dental, Neglect, Child, Anxiety
- Trial name
- NCT04122508
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Substance Abuse, Substance Use
Enhancing Permanency in Children and Families
The Enhancing Permanency in Children and Families (EPIC) program is a collaborative effort between the Ohio State University College of Social Work, two county offices of the Ohio Department of Job and Family Services, two…
- Conditions
- Substance Abuse, Substance Use, Child Abuse, Neglect, Child
- Trial name
- EPIC (NCT04700696)
- Testing
- Peer Recovery Support, Family Treatment Drug Court with Medications for Opioid Use Disorders (MOUD), Relational Skill Building based on the Nurturing Parenting Program (NPP)
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Ohio State University
Conduct Disorder, ADHD
Intervening Early With Neglected Children
This study will assess early and middle childhood outcomes of an intervention for neglecting parents that was implemented in the children's infancy.
- Conditions
- Conduct Disorder, ADHD, Depression
- Trial name
- NCT02093052
- Testing
- Attachment and Biobehavioral Catch-up, Developmental Education for Families
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Delaware
Platelet Levels and Mean Platelet Volume in Patients With CF
Platelets in Cystic Fibrosis Lung Inflammation
Cystic fibrosis (CF) is a chronic multiorgan disorder caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene.
- Trial name
- NCT05339724
- Testing
- platelet count and mean platelet volume are obtained from whole blood count
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Mersin Training and Research Hospital
Yaws, Treponema Infection
Single-dose Azithromycin for the Treatment of Yaws
Yaws, an endemic treponematosis and as such a neglected tropical disease (NTD), is currently making a comeback in children in rural areas. Injectable long acting penicillin remains the drug of choice for the treatment of yaws.
- Conditions
- Yaws, Treponema Infection, Neglected Tropical Disease
- Trial name
- NCT01382004
- Testing
- Penicillin-G-benzathine, Azithromycin
- Where
- Papua New Guinea
- Volunteers
- 255 people
- Sponsor
- Lihir Medical Centre
Cutaneous Leishmaniasis, Skin Diseases, Parasitic
Accuracy of a Rapid Diagnostic Test for Cutaneous Leishmaniasis in Morocco
The aim of this study is to estimate the accuracy of CL Detect Rapid Test™ compared to a composite reference standard test (Direct examination of skin smears + PCR test) in patients with clinically suspected Cutaneous…
- Conditions
- Cutaneous Leishmaniasis, Skin Diseases, Parasitic, Neglected Diseases
- Trial name
- NCT02979002
- Where
- 9 sites in Morocco
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- National School of Public Health, Morocco