Clinical trials: Neglected Diseases
Hookworm Infection, Hookworm Disease
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults
Na-GST-1 is a protein expressed during the adult stage of the Necator americanus hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT03373214
- Testing
- Na-GST-1, CPG 10104
- Where
- Gabon
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Cerebrovascular Disorders, Cerebral Stroke
Using Repetitive Transcranial Magnetic Stimulation (rTMS) in the Rehabilitation of Chronic Spatial Neglect After Stroke
Visuospatial neglect is a common neurological symptom which appears following strokes on regions of the right hemisphere of the brain.
- Conditions
- Cerebrovascular Disorders, Cerebral Stroke, VISIO-spatial Neglect, VISUO-spatial Extinction
- Trial name
- NEGLECT (NCT01000103)
- Testing
- Real rTMS
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatic Diseases, Abuse Neglect
Prevalence of Abuse Among Patients With Rheumatic Diseases
Patients with rheumatic diseases (RD) have a relevant representation in the adult population in Mexico. RD are characterized by their chronic and progressive nature, which can impact functionality during the disease and can…
- Conditions
- Rheumatic Diseases, Abuse Neglect, Abuse
- Trial name
- NCT06233760
- Testing
- Rheumatic diseases Mistreatment Scale (RDMS), Health Assessment Questionnaire (HAQ), Depression, Anxiety and Stress Scale (DASS-21)
- Where
- Mexico
- Volunteers
- 244 people
- Sponsor
- National Institute of Medical Sciences and Nutrition, Salvador Zubiran
Platelet Levels and Mean Platelet Volume in Patients With CF
Platelets in Cystic Fibrosis Lung Inflammation
Cystic fibrosis (CF) is a chronic multiorgan disorder caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene.
- Trial name
- NCT05339724
- Testing
- platelet count and mean platelet volume are obtained from whole blood count
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Mersin Training and Research Hospital
Dental Caries, Child Neglect
Improving Family's Adherence to Dental Care After DGA (HECC-CAN-study)
Early childhood caries (ECC) is a common disease. Its prevalence is highest in poor, socially disadvantaged, and minority groups. Dental treatment under General Anaesthesia (DGA) is common, especially among the youngest patients.
- Trial name
- HECC-CAN (NCT04898465)
- Testing
- Social Paediatric Intervention
- Where
- Finland
- Volunteers
- 89 people
- Sponsor
- Helsinki University Central Hospital
Stroke, Spatial Neglect
Evaluation of an Adaptive Computerized Training for Rehabilitation of Spatial Neglect in Stroke Survivors
The aim of this study is to investigate the effect of training with an adaptive computer game, in comparison to standard training, in the rehabilitation of stroke survivors suffering from spatial neglect.
- Conditions
- Stroke, Spatial Neglect, Neglect, Hemispatial, Attention Impaired
- Trial name
- MULTITASK (NCT04227132)
- Testing
- Adaptive computer game training, Standard computerized training
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Hookworm Stool Burden, Anemia
Does Treating Hookworm Improve Productivity of Small Subsistence Farmers
Treatment of hookworm infected groups with albendazole has been shown to result in an increase in hemoglobin levels and a related decrease in the prevalence of anemia.
- Conditions
- Hookworm Stool Burden, Anemia, Exercise Tolerance
- Trial name
- NCT02102321
- Testing
- albendazole
- Where
- Republic of the Congo
- Volunteers
- 300 people
- Sponsor
- Salmon, Margaret, M.D.
Visceral Leishmaniasis
Clinical Prognostic Score to Predict Relapse in VL
This prospective cohort study has the aim to develop a prognostic tool to predict relapse in patients suffering from visceral leishmaniasis (VL) from VL endemic regions in Ethiopia.
- Trial name
- CPS (NCT05602610)
- Testing
- No intervention
- Where
- Ethiopia
- Volunteers
- 741 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Substance Use Disorders, Pregnancy Related
Substance Use Treatment and Access to Resources (STARS) Project
This study is evaluating a randomized clinical trial and a quasi-experimental observational study combined. Pregnant women with substance abuse issues are referred to the Substance Use Treatment and Recovery (STAR) prenatal…
- Conditions
- Substance Use Disorders, Pregnancy Related, Child Neglect
- Trial name
- NCT04459000
- Testing
- STARS + maternal Attachment Biobehavioral Catchup home visiting model, STARs Only
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- University of Oklahoma
Stroke
Prism Adaptation Training for Treatment of Spatial Neglect During Inpatient Rehabilitation
Left sided spatial neglect is a common yet potentially debilitating phenomena associated with right hemisphere stroke. Heilman defines neglect as "the failure to report, respond, or orient to novel or meaningful stimuli presented…
- Trial name
- NCT04977219
- Testing
- Prism Adaptation Training
- Volunteers
- 74 people
- Sponsor
- Sunnyview Rehabilitation Hospital
Stroke, Acquired Brain Injury
Remediation of Spatial Neglect Trial
Problems with attention are a common and debilitating consequence of brain injury. Studies show that poor attention is the number one predictor of poor cognitive functioning one year post-injury.
- Conditions
- Stroke, Acquired Brain Injury, Hemispatial Neglect
- Trial name
- RESPONSE (NCT01965951)
- Testing
- Computerized Plasticity-based Adaptive Cognitive Training, Commercially available computerized training
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Posit Science Corporation
Dementia, Abuse Client
Partnership in Safeguarding People With Dementia From Primary and Social Care Perspectives
"Adult safeguarding is everyone's responsibility". The Care Act 2014 makes safeguarding a legal duty. It provides local authorities and other agencies in England with a responsibility to protect adults with care and support needs…
- Conditions
- Dementia, Abuse Client, Neglect; Care, Malnutrition
- Trial name
- NCT05883527
- Testing
- Not applicable as not an intervention - PLwD and family/carers, Not applicable as not an intervention - HCP's
- Where
- 5 sites in United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Spatial Neglect, Stroke
A Biomarker for Personalized Care in Post-Stroke Spatial Neglect
More than 30,000 Veterans are hospitalized for stroke each year, and in the critical first months of recovery, at least half are disabled by abnormal 3-D spatial function (spatial neglect).
- Trial name
- NCT05256563
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Spatial Neglect, Stroke
Virtual Reality for Neglect Diagnostics
Compared to the classical "paper and pencil"-tests, testing patients in our virtual reality setup might have a higher sensitivity and specificity.
- Trial name
- KMS-Neglect (NCT01399073)
- Testing
- virtual reality setup, paper and pencil tests, c-mri
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Stroke
Fluoxetine for Motor, Aphasia, and Neglect Recovery After Ischemic Stroke
This pilot study will recruit 25 subjects to assess the feasibility of replicating the FLAME study (Chollet, et al. Lancet 2011), a randomized controlled trial (RCT) that assessed the effect of fluoxetine vs placebo on motor…
- Trial name
- FLAN (NCT01674868)
- Testing
- fluoxetine
- Where
- United States
- Sponsor
- Spaulding Rehabilitation Hospital
Stroke
Improving Measurement and Treatment of Post-stroke Neglect
This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for…
- Trial name
- NCT03317860
- Testing
- Active direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Onchocerciasis, Ascaris Lumbricoides Infection
Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases
This clinical trial compares two treatments - ivermectin and moxidectin - to learn which is better at reducing the proportion of people with onchocerciasis (river blindness) when given through mass drug administration (MDA) in…
- Conditions
- Onchocerciasis, Ascaris Lumbricoides Infection, Trichuris Trichiura; Infection, Hookworm Infections
- Trial name
- EKAIO (NCT07145736)
- Testing
- Moxidectin, Ivermectin
- Where
- Angola
- Volunteers
- 52,000 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Adhesive Capsulitis, Stretch
Efficacy of Static Progressive Stretch Versus Traditional Stretch in Adhesive Capsulitis
This study will be conducted to compare the effectiveness of static progressive stretching using the joint active system (JAS) shoulder device with cyclic manual stretching and controls on shoulder range of motion (ROM), time to…
- Conditions
- Adhesive Capsulitis, Stretch, Physical Neglect
- Trial name
- NCT05988255
- Testing
- Static progressive stretching, Cyclic manual stretching
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Stroke, Spatial Neglect
Increasing Insight in Spatial Neglect: Unraveling Its Longitudinal Interaction With Motor Function After Stroke
Goal: Various studies suggest a negative association between spatial neglect and motor outcomes after stroke (Barrett \& Muzaffar 2014) (Kwakkel 2014).
- Conditions
- Stroke, Spatial Neglect, Postural Control
- Trial name
- NCT05060458
- Testing
- No intervention
- Where
- 3 sites in Belgium
- Volunteers
- 36 people
- Sponsor
- Universiteit Antwerpen