Clinical trials: Neonatal Pain
Postoperative Pain
Dexmedetomidine Versus Fentanyl for Sedation of Postoperative Mechanically Ventilated Neonates
Newborn infants experience pain after surgical procedures,prevention and management of pain in neonates is important due to its deleterious consequences.
- Trial name
- NCT05324891
- Testing
- Dexmedetomidine, Fentanyl
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Pain and Anxiety in Children With MIH
Preemptive Analgesia for Pain and Anxiety Control in Children With MIH
This randomized, triple-blinded clinical trial aims to evaluate the effect of preemptive analgesia using ibuprofen on pain perception and anxiety during restorative treatment of first permanent molars in children diagnosed with…
- Trial name
- NCT07374354
- Testing
- ibuprofen 100mg/ml oral suspension syrup
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- October University for Modern Sciences and Arts
Post Operative Pain
Does the Newborn Infant Parasympathetic Evaluation (NIPE) Index Predict Postsurgical Pain in Children
An investigation to find out if Newborn Infant Parasympathetic Evaluation (NIPE) index predicts postsurgical pain in children, since NIPE is thought to may be of guide to the appropriate therapy in a timely and objective manner…
- Trial name
- NIPE (NCT04909060)
- Testing
- noninvasive blood pressure, 3 lead ECG, peripheral oxygen saturation
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Analgesic Affect
A Study to Test the Pain-relieving Effect of Laughing Gas in Infants
Our proposal is to study infants in the Neonatal Intensive Care Unit (NICU) who are undergoing a heel stick for blood sampling, a standard procedure in patient care.
- Trial name
- NCT00250692
- Testing
- Nitrous Oxide
- Where
- United States
- Sponsor
- University of California, Los Angeles
Infant Development, Pain, Procedural
Parental Touch Trial (Petal)
This is a two centre two-arm randomised controlled interventional trial. We aim to determine whether parental touch prior to a painful clinical procedure provides effective analgesia in neonates.
- Conditions
- Infant Development, Pain, Procedural, Parents
- Trial name
- Petal (NCT04901611)
- Testing
- Parental touch
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Paediatric Neuroimaging Research Group
Neonatal Pain, Retinopathy of Prematurity (ROP)
Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants
The goal of this clinical trial is to learn whether intranasal fentanyl (a pain medicine given as a nasal spray) can reduce pain and is safe to use during routine eye examinations for retinopathy of prematurity (ROP) in preterm…
- Conditions
- Neonatal Pain, Retinopathy of Prematurity (ROP), Pain Management, Infant, Premature
- Trial name
- FIREFLY (NCT07112430)
- Testing
- Fentanyl Citrate (Intranasal)
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Marsha Campbell-Yeo
NEWBORN, Pain, Acute
Peripheral Central Catheter (PICC) Care
Peripheral Central Catheter (PICC) is one of the painful interventions that are routinely performed repeatedly to establish a safe venous access in preterm babies.Nurses should reduce the pain of babies and ensure their comfort…
- Trial name
- PICC (NCT06352918)
- Testing
- Palmar grasp reflex stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ataturk University
Pain
Caring for Babies During the Newborn Screening Blood Test
Newborn infants have blood work procedures in their first days of life that cause pain, distress and physiological changes. Breastfeeding (BF), skin to skin care (SSC), or giving sweet solutions (sucrose or glucose) has been…
- Trial name
- NCT02608892
- Testing
- BSweet2Babies video
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Developmental Dysplasia of the Hip (DDH)
Truncal Blocks for Pediatric With Developmental Dysplasia of the Hip Undergoing Open Reduction
The aim of the study is to evaluate the effectiveness of ultrasound-guided transversalis fascia plane block (TFPB) and quadratus lumborum block (QLB) on post-operative analgesia in pediatric patients with Developmental Dysplasia…
- Trial name
- NCT03189966
- Testing
- transversalis fascia plane block, quadratus lumborum block
- Where
- 2 sites in China
- Volunteers
- 110 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Lymphatic Malformation, Lymphangioma
Clinical Characteristics of Lymphatic Malformations
The primary purpose of this study is to retrospectively identify the clinical characteristics of abdominal lymphatic malformations (ALMs) in our single center in China.
- Trial name
- NCT06257719
- Testing
- Compare the epidemiological characteristics, clinical presentations, surgical treatments and risk factors for preoperative complications of ALMs between paediatric and adult participants.
- Where
- China
- Volunteers
- 320 people
- Sponsor
- West China Hospital
Sensitive Dentin, Hypomineralization Molar Incisor
BIOSILITACE AS A DESENSITIZING AGENTIN HMI
Molar-Incisor Hypomineralization (MIH) is a qualitative enamel defect caused by systemic hypomineralization that affects one to four first permanent molars, and may or may not involve incisors.
- Conditions
- Sensitive Dentin, Hypomineralization Molar Incisor, Pain
- Trial name
- BDAHMI (NCT07080645)
- Testing
- Pain Relieving, topical application
- Where
- 2 sites in Brazil
- Volunteers
- 42 people
- Sponsor
- University of Sao Paulo
Sickle Cell Crisis, Acute Pain
Low-dose Ketamine vs Morphine for Vaso-occlusive Crisis in Sicklers
This clinical trial will inform of the role of Low dose ketamine in the acute treatment of severe painful sickle cell crisis in children in a day-case sickle cell centre.
- Trial name
- KEM-VOC (NCT02434939)
- Testing
- Low dose ketamine, Morphine
- Where
- Uganda
- Volunteers
- 240 people
- Sponsor
- Makerere University
Preterm Neonates, Venipuncture
Effects of Fetal Positioning During Venipuncture
The study was aimed to examine the effects of fetal positioning during venipuncture on the neonates' pain score and physiological parameters (heart rate, blood-oxygen saturation, body temperature, crying duration) in neonatal…
- Trial name
- NCT06173622
- Testing
- Fetal Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
Pain
Effectiveness of Oral Sucrose During Lung Ultrasound
Background: control of pain in neonates has an important role in preventing long- term effects on neurodevelopment and pain reactivity.
- Trial name
- NCT05717088
- Testing
- 24% Sucrose solution
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Mount Sinai Hospital, Canada
Procedural Pain, Heel Prick
ShotBlocker and Warm Gel Pack During Neonatal Heel Prick (HEAL)
This study evaluated the effects of ShotBlocker and a warm gel pack on pain, comfort, and physiological parameters during heel prick testing in healthy term newborns.
- Conditions
- Procedural Pain, Heel Prick, Newborn
- Trial name
- HEAL (NCT07686627)
- Testing
- ShotBlocker, Warm Gel Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Marmara University
Procedural Pain
Skin Blood Flow Changes Using Laser Doppler Imager for Assessment of Pain and Analgesia in Newborn Infants
The purpose of this study is to assess whether an instrument, the Laser Doppler Imager, is able to measure the effect of pain related changes in skin blood flow in newborn infants.
- Trial name
- NCT00694174
- Testing
- sucrose 24% oral solution, sterile water
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Children's Hospital of Michigan
Pain
Analgesic Effect of Oral 25% Glucose Versus Oral 24% Sucrose for Pain Relief During Heel Lance in Preterm Neonates
RESEARCH HYPOTHESIS-In preterm neonates during heel lance oral 25% glucose is more efficacious in reducing pain as compared to oral 24% sucrose when assessed by PIPP(Premature infant pain profile)
- Trial name
- NCT01931020
- Testing
- Sucrose, Glucose
- Where
- India
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Lady Hardinge Medical College
Preterm Neonates Pain Managment, PreTerm Neonate
Pain Managment in Preterm Neonates
To compare the effect of Intranasal versus Intravenous Fentanyl on oxidative stress by measuring MDA level just before and after 30 minutes from painful procedure and comparing the results.
- Trial name
- NCT07148882
- Testing
- fentanyl
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain Measurement, Newborn
Interest of Using the Sevoflurane in the Prevention of Newborns Pain
The objective of this randomized and controlled study is to compare the sedation with sevoflurane inhalation versus non-nutritive sucking and sucrose administration to facilitate peripheral inserted central catheter insertion in…
- Trial name
- NCT00420693
- Testing
- sevoflurane
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pain, Infant, Newborn, Disease
Effect of Maternal Heart Sound on Crying Time and Pain Level in Newborns During Heel Blood Collection
This study was carried out to determine the effect of maternal heart sound listened to by newborns during heel blood collection on pain level and crying time.
- Trial name
- NCT05520164
- Testing
- Listening the maternal heart sound during the invasive interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi