Clinical trials: Neonatology
Newborn; Newborn, Transient
Variations of High Sensitivity Troponin T in Neonates
Troponin T-us is a cardiac marker for myocardial infarction. Its use in neonates is increasing, yet normal values are still to be determined for the latest generation of tests, such as High sensitivity cardiac troponin T test.
- Trial name
- TnTc-us (NCT02880098)
- Testing
- Troponin T blood level
- Where
- France
- Volunteers
- 497 people, healthy volunteers welcome
- Sponsor
- Hôpital NOVO
Infant of Diabetic Mother
Infants of Diabetic Mothers in Neonatology Unit at Assiut University Children's Hospital
Determine spectrum of clinical presentations and complications associated with maternal diabetes mellitus in their newborns attending and admitted to Neonatal Intensive Care Unit of Assiut University Children's Hospital.
- Trial name
- NCT06111157
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Neonatology
Optimization and Clinical Study of Early Prediction Model for Neonatal Acute Respiratory Distress Syndrome
The goal of this observational study is to learn about neonatal acute respiratory distress syndrome in describe participant population.
- Trial name
- NCT05647850
- Testing
- No intervention
- Where
- 2 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University-Town Hospital of Chongqing Medical University
Neonatal Intensive Care
Neonatal Mask Seal; a Two-handed Versus One-handed Approach: The NeoSeal Study
When babies can't breathe effectively, we can use a facemask to give them breaths and oxygen. The mask can be held with one or two hands, depending on the preference of the doctor.
- Trial name
- NeoSeal (NCT06740344)
- Testing
- Two-handed facemask hold, Control: One-handed facemask hold
- Where
- Ireland
- Volunteers
- 110 people
- Sponsor
- University College Dublin
Paediatric Antimicrobial Pharmacokinetics
Neonatal and Paediatric Pharmacokinetics of Antimicrobials Study
The aim of NAPPA is to develop new models to improve our understanding of how children process ('metabolise') penicillins, to help us discover if we can improve the dosing regimens used for children in the future.
- Trial name
- NAPPA (NCT01975493)
- Where
- 9 sites in United Kingdom
- Volunteers
- 428 people
- Sponsor
- St George's, University of London
Adverse Reaction to Drug, Neonatal Disorder
Exploratory Propofol Dose Finding Study In Neonates
The aim of the study is to explore the optimal propofol dose in neonates receiving a single intravenous propofol bolus for endotracheal intubation during (semi-)elective INSURE (intubation-surfactant-extubation) procedure…
- Trial name
- NEOPROP (NCT01621373)
- Testing
- propofol administration
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pain Score
Prevention of Pain Caused by the Oro-gastric Tube Laying in Neonatology
Subject of research : Evaluation of a technique of care to reduce the pain caused by the laying of the gastric tube in the newborn
- Trial name
- DOLATSONG (NCT03142230)
- Testing
- the laying of the gastric tube and a group using the holed baby bottle nipple, the feeding tube ideally positioned at the center of the intersection pharyngeal, the laying of the gastric tube and a group with simple non-nutritive suction, the feeding tube passing next to the newborn's personal pacifier
- Where
- 3 sites in France
- Volunteers
- 71 people
- Sponsor
- Centre Hospitalier Sud Francilien
Invasive Ventilation, Infant Pain
Dexmedetomidine for Invasive Ventilation In the NEOnate
Despite the increasing use of non-invasive ventilation, a large majority of premature neonates still receive invasive ventilation during their NICU (neonatal intensive care unit) stay.
- Conditions
- Invasive Ventilation, Infant Pain, Infant Discomfort, Infant Neurodevelopment
- Trial name
- NCT07493785
- Testing
- Dexmedetomidine Injectable Solution, Glucose 5% Injectable Solution
- Where
- 12 sites in France
- Volunteers
- 246 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Preterm Newborn
Radiofrequency Fields in Neonatology: Exposure and Impact on the Nervous System
Previously, the investigators showed that preterm newborns are exposed chronically to very low radiofrequency levels in average while hospitalized in NICUs.
- Trial name
- CHARLINE (NCT06281093)
- Testing
- questionary, Daily continuous recording of radiofrequency exposure levels, Follow-up of daily infants clinical parameters
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
EEG, Neonatology
An Observational Study of the NeuroBell EEG Monitor
An observational clinical investigation of the NeuroBell EEG Monitor (a portable and wireless EEG monitor).
- Conditions
- EEG, Neonatology, Seizure, Neurology
- Trial name
- NCT07508670
- Testing
- NeuroBell EEG Monitor
- Where
- Ireland
- Volunteers
- 17 people
- Sponsor
- University College Cork
Neonatology
A Stylet Use May be Beneficial for Elective and Rescue Intubation of Prematurely Born Infants
Contrary to recent findings suggesting that stylets offer no advantage in general infant intubations, this study focuses on their potential benefits for premature infants undergoing elective or rescue intubation in the delivery…
- Trial name
- NCT06316765
- Testing
- Intubation with stylet
- Volunteers
- 70 people
- Sponsor
- Charles University, Czech Republic
Microbial Colonization, Viral Infection
Follow-up of the Nasal Microbiome and Viral Infections in Newborns Hospitalised in Neonatology.
The goal of this interventional study is to learn about nasal microbiome and viral infections in newborns hospitalised in neonatology.
- Conditions
- Microbial Colonization, Viral Infection, Neonatal Infection
- Trial name
- NEOBIOME (NCT05717283)
- Testing
- Nasal swab
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Caen
Prematurity
Early Exposure to OMT Prevents Long LOS
The application of osteopathic manipulative treatment (OMT) in preterm infants has been demonstrated to be effective in reducing length of stay (LOS).
- Trial name
- NCT01784835
- Testing
- osteopathic manipulative treatment, Usual care
- Where
- Italy
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Partial Mineralocorticoid Deficiency
Impact of the Administration of Fludrocortisone in Very Premature Infants
Water and electrolytic homeostasis is remarkably controlled by the mineralocorticoid pathway (renin-angiotensin-aldosterone system acting on the renal tubule).
- Trial name
- MINIPREM (NCT03001089)
- Testing
- Oral Fludrocortisone (enteral)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Growth, Necrotizing Enterocolitis
Bovine Colostrum as a Fortifier Added to Human Milk for Preterm Infants
Very preterm infants (<32 weeks gestation) with very low birth weight (VLBW, <1500 g) show immaturity of organs and have high nutrient requirements forgrowth and development.
- Conditions
- Growth, Necrotizing Enterocolitis, Late-Onset Sepsis, Feeding Intolerance
- Trial name
- FortiColos (NCT03537365)
- Testing
- Bovine Colostrum (BC) / intervention group, FM85 / control group
- Where
- 7 sites in Denmark
- Volunteers
- 252 people
- Sponsor
- Per Torp Sangild
Sepsis, Neonatal
Comparison Between Split Septum and Mechanical Valve Needleless Connector in Preterm Babies
The goal of this clinical trial study is to compare the effectiveness between split septum and mechanical valve needleless connector in very preterm babies (or under 1500 grams) The main questions it aims to answer are: What is…
- Trial name
- NCT06414174
- Testing
- Split septum needleless connector, Mechanical valve needleless connector
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Feeding; Difficult, Newborn, Pre-Term
Effect of Co-morbidities on the Development of Oral Feeding Ability in Pre-term Infants
The aim of this study is to investigate the effect of co-morbidities on the timing of the achievement of full oral feeding in a cohort of pre-term infants and to evaluate their mode of feeding and feeding status at the time of…
- Trial name
- NCT04812249
- Testing
- Clinical assessment
- Volunteers
- 160 people
- Sponsor
- Assiut University
Neonates and Preterm Infants, Neonates or Premature Babies
Prospective Study of the Feasibility of Brain Connectivity Imaging by Functional Ultrasound Imaging (fUS) in Newborn Infant
Neurodevelopmental disorders (NDD) affect how the brain develops and can lead to lifelong difficulties with movement, learning, behavior, and thinking.
- Trial name
- CONEXUS (NCT06940713)
- Testing
- Imaging Time
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Neonatology
The Impact of Non-Routine Events on Neonatal Safety
The study objective is to decrease neonatal mortality and morbidity by elucidating the etiology of system failures during perioperative care.
- Trial name
- NCT02756195
- Where
- United States
- Volunteers
- 395 people
- Sponsor
- Vanderbilt University
Newborns, Neonatology
Interest of Peripheral Venous Catheter Insertion Using a Micro-guide in Neonatology
Peripheral venous catheterization represents the preferential option for term or preterm infant care in order to start drug treatment or hydration, or perform anesthesia.
- Conditions
- Newborns, Neonatology, Intensive Care
- Trial name
- EASYCATH (NCT04984967)
- Testing
- Insertion of peripheral venous catheter with micro-guide, Classic insertion of peripheral venous catheter, without micro-guide
- Where
- France
- Volunteers
- 116 people
- Sponsor
- University Hospital, Montpellier