Clinical trials: Neonatology
Breastfeeding
Use of Domperidone to Increase Milk Production in Mothers With Newborns in Neonatology
It is a double-blind randomized clinical trial placebo-controlled, which aims to assess whether Domperidone medication helps to increase milk production.
- Trial name
- NCT03221855
- Testing
- Domperidone
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Adverse Reaction to Systemic Agents
Clinical Variations and Pain Assessment in Newborns Submitted to Intratracheal Aspiration With Open and Closed System
To compare clinical effects identified in infants undergoing intratracheal aspiration with open and closed systems and verify the presence and intensity of pain in newborns during intratracheal suction, according to the system…
- Trial name
- NCT01276873
- Testing
- Tracheal aspiration close system
- Where
- 2 sites in Brazil
- Volunteers
- 13 people
- Sponsor
- Federal University of São Paulo
Neonates and Preterm Infants, Neonates or Premature Babies
Prospective Study of the Feasibility of Brain Connectivity Imaging by Functional Ultrasound Imaging (fUS) in Newborn Infant
Neurodevelopmental disorders (NDD) affect how the brain develops and can lead to lifelong difficulties with movement, learning, behavior, and thinking.
- Trial name
- CONEXUS (NCT06940713)
- Testing
- Imaging Time
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Respiratory Distress Syndrome, Newborn
LISA vs Endotracheal Surfactant in Preterm Neonates: A Lung Ultrasound Distribution Study
This prospective, non-randomized, unblinded pilot study evaluates and compares the intrapulmonary distribution of exogenous surfactant in preterm neonates when administered via Less Invasive Surfactant Administration (LISA)…
- Trial name
- LISA-Ven-LUS (NCT07514481)
- Testing
- surfactant administration by ETT, surfactant administration by thin catheter
- Where
- Qatar
- Volunteers
- 22 people
- Sponsor
- Hamad General Hospital
Neonatal Hypoglycemia
Comparing Heel Stick Glucoses in Neonates
Newborn babies can develop low blood sugar (glucose) which can lead to brain injury and poor developmental outcomes. Therefore, it is important to accurately measure the blood glucose in babies.
- Trial name
- CHECK IN (NCT04811612)
- Testing
- Warmed heel stick
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Premature Birth
Developmental Care Program in Neonatal Intensive Care Unit
This project is a Randomised Clinical Trial that includes a family centred education intervention and/or non-directive active listening counselling intervention with families of preterm infants at risk for sensori-motor disorders.
- Trial name
- CIN (NCT05573945)
- Testing
- Family Education and Active Listening, Family Education
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Pisa
Premature Infant, Oxygen Therapy
Servo Controlled Oxygen Targeting Study
Most premature babies require oxygen therapy. There is uncertainty about what oxygen levels are the best. The oxygen levels in the blood are measured using a monitor called a saturation monitor and the oxygen the baby breathes is…
- Conditions
- Premature Infant, Oxygen Therapy, Hypoxia, Hyperoxia
- Trial name
- SCO2T (NCT04177992)
- Testing
- Servo control
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
EEG, Neonatology
An Observational Study of the NeuroBell EEG Monitor
An observational clinical investigation of the NeuroBell EEG Monitor (a portable and wireless EEG monitor).
- Conditions
- EEG, Neonatology, Seizure, Neurology
- Trial name
- NCT07508670
- Testing
- NeuroBell EEG Monitor
- Where
- Ireland
- Volunteers
- 17 people
- Sponsor
- University College Cork
Infant, Newborn, Disease
Benefit of Scarf Support on Skin-to-skin Time and Portage in Neonatology and at Home
Carrying (or kangaroo carrying) is known to reduce neonatal and child morbidity and mortality and improves the quality of survival of premature and term children during the most fragile growth period, the first thousand days of…
- Trial name
- PAPSE (NCT04034719)
- Testing
- portage scarf, usual practice
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pre-Term
Modelling Weight Reference Centiles for Preterm Infants
The aim of this study is to model longitudinal data at NICU of Assuit University Children Hospital to create predictive growth charts for weight in preterm infants from birth till discharge, that take into account the differing…
- Trial name
- NCT04333121
- Testing
- weight
- Volunteers
- 100 people
- Sponsor
- Assiut University
Partial Mineralocorticoid Deficiency
Impact of the Administration of Fludrocortisone in Very Premature Infants
Water and electrolytic homeostasis is remarkably controlled by the mineralocorticoid pathway (renin-angiotensin-aldosterone system acting on the renal tubule).
- Trial name
- MINIPREM (NCT03001089)
- Testing
- Oral Fludrocortisone (enteral)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neonatology
EXTERNAL NEGATIVE PRESSURE DURING LISA
The goal of this clinical trial is to evaluate the feasibility, safety, and preliminary effectiveness of applying external continuous negative pressure (ECNP) during less invasive surfactant administration (LISA) in preterm…
- Trial name
- ENCP LISA (NCT07271368)
- Testing
- ENCP
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- Charles University, Czech Republic
Neonates
Body Composition Assessment in Healthy Full-term Neonates by Anthropometry, Air Displacement Plethysmography and Multiple-frequency Bio-impedance Analysis
Low birth weight and prematurity are associated with adverse metabolic outcome in adult life. Yet it remains to be determined whether this outcome is the consequence of the low birth weight per se, or of the catch up growth…
- Trial name
- NCT00890344
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Paediatric Antimicrobial Pharmacokinetics
Neonatal and Paediatric Pharmacokinetics of Antimicrobials Study
The aim of NAPPA is to develop new models to improve our understanding of how children process ('metabolise') penicillins, to help us discover if we can improve the dosing regimens used for children in the future.
- Trial name
- NAPPA (NCT01975493)
- Where
- 9 sites in United Kingdom
- Volunteers
- 428 people
- Sponsor
- St George's, University of London
Neonatal Intensive Care
Neonatal Mask Seal; a Two-handed Versus One-handed Approach: The NeoSeal Study
When babies can't breathe effectively, we can use a facemask to give them breaths and oxygen. The mask can be held with one or two hands, depending on the preference of the doctor.
- Trial name
- NeoSeal (NCT06740344)
- Testing
- Two-handed facemask hold, Control: One-handed facemask hold
- Where
- Ireland
- Volunteers
- 110 people
- Sponsor
- University College Dublin
Neonatal Infection
Experience of Mutaflor Suspension Use in Preterm Infants for Immunity Improvement
EcN has been registered as a medical drug under the brand name Mutaflor® SUSPENSION in Ukraine in 2010. Indications for its clinical use are acute diarrhea in infants and toddlers including those on tube feeding tube, diarrhea in…
- Trial name
- EMSUP (NCT01540162)
- Where
- Ukraine
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Odessa National Medical University
Hemodynamic Instability
An Optical Neuro-monitor of Cerebral Oxygen Metabolism and Blood Flow for Neonatology
Feasibility trial on the use of a hybrid optical device integrating time-resolved near-infrared spectroscopy (TRS) and diffuse correlation spectroscopy (DCS) for measurement of cerebral oxygen metabolism and blood flow in…
- Trial name
- BabyLux (NCT02815618)
- Testing
- BabyLux Neuro-monitor
- Where
- 2 sites in Denmark, Italy
- Volunteers
- 48 people
- Sponsor
- Gorm Greisen
Neonatology
Parental Real-life Experience During the Neonatal Transfer
The transfer of newborn child from Intensive Care Unit to maternity is very stressfull for parents.This anxiety could have repercussion on parents adaptation on their new environment, on parent's role and also on their relaional…
- Trial name
- NCT03046602
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Premature Birth
Assessment of the Impact of the Return Home of Premature Newborns Less Than 2 Kilos Morbidity/Mortality
The aim of this study is to evaluate the impact of discharge from hospital with a weight of less than 2 kilos. To do this, the investigator will look at the short-term and long-term outcome of newborns weighing less than 2 kilos…
- Trial name
- Petit-Poids (NCT06224764)
- Testing
- Mother and Father questionnaires
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hôpital NOVO
Premature Lungs
Clinical Trial for the Evaluation of Customized 3D Printed NIV Nasal Masks in Premature Infants
Clinical trial with crossed groups, open, masked for the evaluation of the main outcome. Inclusion of all premature infants with a birth weight less than 1500 g requiring Non-invasive Ventilation (NIV).
- Trial name
- M3DPREMAT (NCT06224816)
- Testing
- Custom 3D mask (3DM) application in neonate, Traditional mask (TM) application in neonate
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario 12 de Octubre