Clinical trials: Neural Tube Defects
Spina Bifida, Myelomeningocele
tSCS in Children With Spina Bifida
A single-center, open-label, investigational pilot trial to explore potential effects of transcutaneous spinal cord stimulation on leg muscle strength and walking in children with myelomeningocele.
- Trial name
- NCT07615686
- Testing
- Transcutaneous stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bailey Petersen
Neural Tube Defects (NTDs), Facial Cleft Defect
Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population
In a collaborative effort with the Health Research Board, the national organization for medical research in the Republic of Ireland, individuals with neural tube defects (NTDs) or facial cleft defects and their parents will be…
- Conditions
- Neural Tube Defects (NTDs), Facial Cleft Defect, Hereditary Oral Clefts
- Trial name
- NCT00341068
- Where
- United States
- Volunteers
- 7,451 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Chiari Malformation
Dural Graft Equivalent Comparison Trial
This research study is to find out which types of dural grafts used during surgery for Chiari Malformations are superior. We believe that autologous dural grafts are superior to non-autologous grafts.
- Trial name
- DECOMPRESS (NCT01667770)
- Testing
- decompression of Chiari malformation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Myelomeningocele, Bladder, Neurogenic
Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele
The purpose of this study is to examine how injection of botulinum toxin in the bladder affects bladder function. The trial is carried out in children born with malformation of the spinal cord and subsequent overactive bladders.
- Trial name
- NCT00175123
- Testing
- Botulinum A toxin
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Tethered Cord Syndrome
Efficacy and Safety of Nerve Root Axial Decompression Surgery in The Treatment of Tethered Cord Syndrome
Background: Tethered cord syndrome (TCS) is a progressive clinical condition including a series of neurological dysfunctions and deformities attributable to abnormally increased tension on the spinal cord, which is lacking…
- Trial name
- NCT03262844
- Testing
- Conservative treatment, Capsule surgery
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Changzheng Hospital
Spina Bifida, Myelomeningocele
Incontinence and Quality of Life in Children With Spina Bifida
This study aims to develop an innovative, interactive tool for joint use by spina bifida patients and their urologists to identify patients interested in addressing their urinary and fecal incontinence and establish continence…
- Trial name
- NCT03410667
- Testing
- Phase One: Exploration, Phase Two: Creation, Phase Three: Reflection
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Indiana University
Cerebral Palsy, Spinal Muscular Atrophy
Pediatric Powered Wheelchair Standing Devices: An Exploratory Study
For children who use a power wheelchair, a powered wheelchair standing device (PWSD) may be considered for daily use. A PWSD allows a child to electronically move between sitting and standing and can be driven in either position.
- Conditions
- Cerebral Palsy, Spinal Muscular Atrophy, Spinal Cord Injuries, Spina Bifida
- Trial name
- NCT05117827
- Testing
- Power Wheelchair Standing Device
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Chiari Type I Malformation
The Genetics of Chiari Type I Malformation
Duke University Medical Center is investigating the hereditary basis of Chiari type I malformations with or without syringomyelia (CM1/S).
- Trial name
- NCT01060800
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Duke University
Fetal Anomaly, Spinal Dysraphism
An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience
Brain stem and posterior fossa measurements in spina bifida aperta fetuses to compare them with normal population. Additionally, Describe the difference between pre- and postoperative findings.
- Conditions
- Fetal Anomaly, Spinal Dysraphism, Chiari Malformation Type 2
- Trial name
- NCT03544970
- Where
- Belgium
- Volunteers
- 316 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Neurogenic Detrusor Overactivity
Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC
The purpose of this study is to evaluate the safety, efficacy, and PK of Vibegron in pediatric participants with NDO who are regularly using CIC
- Trial name
- KANGUROO (NCT05491525)
- Testing
- Vibegron
- Where
- 38 sites in United States, Belgium and 14 more
- Volunteers
- 71 people
- Sponsor
- Urovant Sciences GmbH
Sleep-disordered Breathing, Myelomeningocele
Sleep-disordered Breathing in Infants With Myelomeningocele
This study aims to determine whether the risk for sleep-disordered breathing in infants with myelomeningocele (a severe form of spina bifida) differs among those who underwent fetal vs.
- Trial name
- NCT04251806
- Testing
- neonatal polysomnography, 2-year Bayley Exam, 2-year polysomnography
- Where
- 9 sites in United States
- Volunteers
- 173 people
- Sponsor
- University of Michigan
Neural Tube Defects, Congenital Abnormalities
Birth Outcomes In Eswatini After Transition To Dolutegravir-Based Treatment
The goal of this observational study is to assess the birth outcomes of HIV-positive women delivering in hospitals in Eswatini who are receiving dolutegravir (DTG) or other anti-retroviral (ARV) drug regimens.
- Conditions
- Neural Tube Defects, Congenital Abnormalities, Teratogens
- Trial name
- NCT05883761
- Where
- 5 sites in Eswatini
- Volunteers
- 50,075 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Cerebral Palsy, Muscle Disorder
A New Training to Enhance Physical Activity in Adolescents With Cerebral Palsy
The purpose of this research study is to test the feasibility and response of a new exercise protocol on improving physical activity in adolescents with cerebral palsy.
- Conditions
- Cerebral Palsy, Muscle Disorder, Physical Disability, Posture Disorders in Children
- Trial name
- FOLIC (NCT05865418)
- Testing
- Loaded high intensity training, High intensity circuit training (HICT)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Alabama at Birmingham
Spina Bifida, Cerebral Palsy
The Impact of Community-based Wellness Programs on The Triple Aim
People with disabilities experience a staggering incidence of secondary conditions that can result in death or negatively impact their health, participation in the community, and quality of life.
- Conditions
- Spina Bifida, Cerebral Palsy, Spinal Cord Injury, Traumatic Brain Injury
- Trial name
- NCT02938130
- Testing
- Wellness Programs
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Pittsburgh
Cerebral Palsy, Spina Bifida
The Effects of a Powered Knee Orthosis on Gait Kinematics of Children With Knee Extension Deficiency
Crouch gait/walking, characterized by an 'over-flexed' knee when the leg is supporting body weight, is common in children with diagnoses of cerebral palsy, spina bifida and other incomplete spinal cord injuries.
- Conditions
- Cerebral Palsy, Spina Bifida, Spinal Cord Injuries
- Trial name
- NCT05330052
- Testing
- Agilik
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of British Columbia
Intraventricular Hemorrhage, Spina Bifida
Micro Ribonucleic Acid (miRNA) Markers of Hydrocephalus in Intraventricular Hemorrhage (IVH)
A collection of biological samples (cerebrospinal fluid [CSF] and blood) from patients under 6 years of age who are diagnosed with intraventricular hemorrhage or spina bifida.
- Trial name
- NCT02386228
- Testing
- collection of CSF and blood
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Spinal Dysraphism
Assessment of Functional Independence and Quality of Life in Adolescents With Spina Bifid
The purpose of this study is to investigate the level of functional independence and the quality of life of adolescents and young adults with spina bifid in an Italian population.
- Trial name
- NCT00966927
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Spina Bifida
Physical Capacity of Spina Bifida and Factors Affecting
Objective: It was aimed to evaluate the physical characteristics of the cases with spina bifida and to review the factors that may affect the etiology of the disease.
- Trial name
- NCT06541366
- Testing
- case-control study
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Chiari Malformation, Type 1
Modalities of Surgical Treatment of Chiari Malformation Disease : Clinical Study and Outcomes
Evaluation of postoperative outcomes of Chiari type I Malformation Patients at Department of Neurosurgery Assiut University Hospital .
- Trial name
- NCT06029101
- Testing
- posterior fossa craniectomy with or without duraplasty
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Assiut University
Spina Bifida, Neuromuscular Diseases
Metformin in Children With Motor Deficit
Obesity with insulin resistance in the paediatric population provides an increasing challenge. Children with neurological or neuromuscular diseases are even more prone to obesity: their locomotor impairment leads to an…
- Trial name
- NCT00720161
- Testing
- Metformin
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven