Clinical trials: Neural Tube Defects
Twin to Twin Transfusion Syndrome, Congenital Diaphragmatic Hernia
Automated Myocardial Performance Index Using Samsung HERA W10
Researchers are using Myocardial performance index (MPI) to assess fetal cardiac function before, during, and after fetal surgery in order to gain more knowledge about fetal cardiac function in high risk pregnancies and the…
- Conditions
- Twin to Twin Transfusion Syndrome, Congenital Diaphragmatic Hernia, Neural Tube Defects, Lower Urinary Tract Infection
- Trial name
- NCT04140669
- Testing
- Automated Myocardial Performance Index (MPI)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Spina Bifida
Fecal Microbium Change in Pediatric Patients With Spina Bifida: Prospective Case-control Study
Purpose: In order to verify the hypothesis that the composition of intestinal microbiota in children with spina bifida is different from that of normal control, prospective comparative analysis would be performed.
- Trial name
- NCT04186130
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Neurogenic Bladder, Bladder Dysfunction
Urinary Artificial Sphincter in Children
Retrospective monocentric study of the outcomes of patients with neurogenic bladder, who had a urinary artificial sphincter before the age of 18 years old.
- Conditions
- Neurogenic Bladder, Bladder Dysfunction, Spina Bifida, Child, Only
- Trial name
- SUA (NCT05858840)
- Testing
- Urinary Artificial Sphincter (UAS) in Children
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University of Lorraine
Spinal Cord Injuries, Spina Bifida
Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.
The goal of this clinical trial is to learn about how a participation-based intervention builds capacity of youth with physical disabilities to pursue activities of their choice in the community.
- Conditions
- Spinal Cord Injuries, Spina Bifida, Musculoskeletal Disorder, Juvenile Arthritis
- Trial name
- NCT06007885
- Testing
- Pathways and Resources to Engagement and Participation (PREP)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McGill University
Spina Bifida
Autologous Human Umbilical Cord Tissue Patch for Postnatal Closure of Open Neural Tube Defects
The purpose of this study is to determine the impact of an autologous umbilical cord patch for dural closure on the repair of open neural tube defect.
- Trial name
- NCT06929572
- Testing
- Autologous umbilical cord patch
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Neural Tube Defects
Genetics of Neural Tube Defects
The Genetics of Neural Tube Defects Study at the University of Miami: The University of Miami John P. Hussman Institute for Human Genomics is looking for families to participate in research to identify the genetic and…
- Trial name
- NTD (NCT01253746)
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- John P. Hussman Institute for Human Genomics
Cerebral Palsy, Brain Injuries
The LETS Study: A Longitudinal Evaluation of Transition Services
This project will describe and evaluate the impact of a unique partnership model designed to coordinate transfer of care by formally linking pediatric and adult heath care services.
- Conditions
- Cerebral Palsy, Brain Injuries, Spinal Dysraphism
- Trial name
- LETS (NCT00975338)
- Testing
- LIFEspan, Non-LIFEspan
- Where
- 2 sites in Canada
- Volunteers
- 149 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Postoperative Neurogenic Lower Urinary Tract Dysfunction Secondary to Tethered Cord Syndrome
Effectiveness of Electrical Pudendal Nerve Stimulation for Neurogenic Lower Urinary Tract Dysfunction in Pediatric Tethered Cord Syndrome Post-Surgery
The goal of this prospective observational study is to evaluate whether the addition of electrical pudendal nerve stimulation (EPNS) to standard conservative treatment can improve bladder function in pediatric patients with…
- Trial name
- NCT07062133
- Testing
- Electrical pudendal nerve stimulation, Conventional conservative treatment
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Spina Bifida
Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up
The aim of the study is to investigate known urinary biomarkers in order to determine whether they can be predictive of a risk of damage to the upper urinary tract and therefore the kidneys in patients with spina bifida.
- Trial name
- SPINLESS (NCT06041334)
- Testing
- Collection of a urine sample, Magnetic Resonance Imaging of the bladder
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Foetus With Myelomeningocele
Prenatal Surgical Repair of Fetal Myelomeningocele
The open surgical repair of myelomeningoceles before 26 weeks gestational age provides a correction of the anomaly of Chiarri, reduces the incidence of ventriculomegaly (defined as a measure of the ventricles at the crossroads ≥…
- Trial name
- PRIUM (NCT01983345)
- Testing
- prenatal surgical repair of fetal myelomeningocele
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spina Bifida, Cerebral Palsy
Medication Management Among Individuals With Neurodevelopmental Disabilities
This is a pilot study to develop a reinforcement learning (RL)-adaptive visual and interactive support application (hereafter RL-adaptive support) to help young adults with spina bifida or cerebral palsy become more independent…
- Trial name
- M-MIND (NCT03121651)
- Testing
- RL-adaptive application
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Michigan
Chiari I Malformation, Pediatric
Postual Control in Pediatric Chiari I Malformation
BACKGROUND: Chiari I malformation is a rare disease characterized by cerebellar amygdalae descent under the level of the foramen magnum.
- Trial name
- NCT04679792
- Testing
- Dynamic posturography
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France
Fetal Anomaly, Spinal Dysraphism
An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience
Brain stem and posterior fossa measurements in spina bifida aperta fetuses to compare them with normal population. Additionally, Describe the difference between pre- and postoperative findings.
- Conditions
- Fetal Anomaly, Spinal Dysraphism, Chiari Malformation Type 2
- Trial name
- NCT03544970
- Where
- Belgium
- Volunteers
- 316 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pituitary Tumor, Meningioma
Long-Term Longitudinal QoL in Patients Undergoing EEA
This is a prospective longitudinal study to access postoperative 2-year quality of life in patients who undergo endonasal endoscopic approach surgeries of the skull base.
- Conditions
- Pituitary Tumor, Meningioma, Rathke Cleft Cysts, Chordoma
- Trial name
- NCT04087902
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Ohio State University
Myelomeningocele, Extubation Time
Operating Room Extubation and Postoperative Outcomes in Neonates With Meningomyelocele
Meningomyelocele is one of the most common neural tube defects requiring surgical repair in the neonatal period. Postoperative respiratory complications and the need for prolonged mechanical ventilation are important causes of…
- Conditions
- Myelomeningocele, Extubation Time, Neonatal
- Trial name
- MEROX (NCT07465055)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziantep City Hospital
Chiari Malformation Type I, Tonsillectomy
PFDD Versus PFDRT in Chiari Decompression Surgery
The purpose of this study is to determine whether a posterior fossa decompression and duraplasty with or without tonsil manipulation results in better patient outcomes with fewer complications and improved quality of life in…
- Trial name
- NCT06079125
- Testing
- Posterior fossa decompression with duraplasty, PFDD with tonsillar resection/reduction
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Xuanwu Hospital, Beijing
Chiari Malformation
Duragen Versus Duraguard in Chiari Surgery
The study evaluates two materials used for duraplasty of the posterior cranial fossa in treatment of Chiari malformation. One material (DuraGen) is a non-suturable collagen matrix that is applied over the defect if brain…
- Trial name
- NCT00741858
- Testing
- Duragen duraplasty, Duraguard duraplasty
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Illinois at Chicago
Spina Bifida
Effectiveness of Biofeedback Training in Children with Neurogenic Bladder and Bowel Disorder Wıth Spina Bifida
The aim of this study is to examine and compare the bladder and bowel functions, activation of pelvic floor and abdominal muscle groups and quality of life of children diagnosed with spina bifida who did not receive any treatment…
- Trial name
- NCT06618378
- Testing
- Biofeedback exercise combined with breathing exercise, urotherapy educational group
- Volunteers
- 24 people
- Sponsor
- Hasan Kalyoncu University
Urologic Diseases
Outcomes of Proactive Management of Children With Myelomeningocele
Spina bifida birth prevalence in Africa is 0.13%. Myelomeningocele (MMC) represents the most frequent and most severe cause of NB in children. Treatment of neuropathic bladder secondary to spina bifida is an ongoing challenge.
- Trial name
- NCT06301802
- Testing
- CIC, Anticholinergic
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spinal Cord Injuries, Spina Bifida
Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disabilities
Participation in community-based activities is essential to the health and well-being of youth with physical disabilities; yet, it is extremely restricted.
- Conditions
- Spinal Cord Injuries, Spina Bifida, Musculoskeletal Disorder, Juvenile Arthritis
- Trial name
- NCT05784285
- Testing
- Engagement in a 8-week community-based activity program
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- McGill University