Clinical trials: Neurodevelopmental Conditions
Dyslexia, Reading Disability
Brain Stimulation Paired With Structured Reading Instruction in Children With Dyslexia
This study investigates whether transcranial electrical stimulation (tES) delivered during structured reading instruction affects reading proficiency in children with developmental dyslexia and related reading disabilities.
- Trial name
- NCT07762365
- Testing
- Active transcranial electrical stimulation (tES)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- General Neuro Inc.
Intellectual Disability, Attention Deficit Hyperactivity Disorder
Evaluation of a Home-based Parenting Support Program: Parenting Young Children
Background: Parents with intellectual and developmental disabilities (IDDs) have a tendency to provide insufficient caregiving and often need parenting support to prevent neglect and child removal.
- Conditions
- Intellectual Disability, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
- Trial name
- PYC (NCT05935722)
- Testing
- Parenting Young Children, Treatment as Usual
- Where
- 5 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Örebro University, Sweden
Problem Behavior, Developmental Delay
Problem Behavior Assessment and Intervention in IDEA Part C Services
The purpose of this study is to evaluate the effect of function-based assessment and intervention to reduce problem behavior in children with developmental disability or delay in the context of IDEA Part C services.
- Conditions
- Problem Behavior, Developmental Delay, Developmental Disability
- Trial name
- NCT06771284
- Testing
- Function-based assessment and intervention
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Hepato-splenomegaly, Dysostosis Multiplex
Biomarker for Gangliosidosis: BioGM1/BioGM2 (BioGM1/GM2)
Development of a new MS-based biomarker for the ear-ly and sensitive diagnosis of GM1/GM2 from blood
- Conditions
- Hepato-splenomegaly, Dysostosis Multiplex, Seizures, Mental Retardation
- Trial name
- BioGM1/BioGM2 (NCT02298647)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Mental Retardation
Correlation BIS Scores Mentally Retarded Patients
The BIS monitor is a tool which assists anesthesiologists in monitoring the depth of anesthesia or level of anesthesia. The study doctors would like to see if it is useful tool for patients who are mentally challenged and require…
- Trial name
- NCT00468338
- Testing
- BIS monitor
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Rutgers, The State University of New Jersey
Childhood Apraxia of Speech, Speech Sound Disorders
Feasibility and Preliminary Effects of a Therapeutic Approach Using Ultrasound Visual Biofeedback in Children With AFI: a Pilot Randomized Clinical Trial.
The aim of this study is to evaluate the feasibility of the Ultrax protocol and estimate preliminary effects on articulatory precision, prosody, and speech motor planning.
- Trial name
- PICOS (NCT07087249)
- Testing
- Ultrasound Visual Feedback, Waitlist
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Aline Mara de Oliveira
Dyslexia, Reading Disorder
Group-based Training for Parents of Children With Dyslexia
Children with dyslexia show a variety of comorbid disorders like behavior and adaptive disorders, hyperkinetic and anxiety disorders. Raising and educating a child with dyslexia is a challenging task for parents.
- Conditions
- Dyslexia, Reading Disorder, Reading Disability, Developmental Reading Disorder
- Trial name
- NCT02107534
- Testing
- parent training (dyslexia)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Heidelberg Medical Center
Developmental Delay, Child Development
Prevalence of Developmental Delays in Preschool Children and the Role of Early Physical Therapy
This study was done to determine the prevalence of developmental delays among preschool children in Damietta and to evaluate the effect of early physical therapy intervention on children diagnosed with developmental delays.
- Conditions
- Developmental Delay, Child Development, Physical Therapy
- Trial name
- NCT07555028
- Testing
- domain-specific physical therapy interventions
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Horus University
Attention Deficit Hyperactivity Disorder, ADHD
Imaging Stimulant and Non Stimulant Treatments for ADHD: A Network Based Approach
The growing number of medications used to treat attention-deficit/hyperactivity disorder (ADHD) raises important questions about whether different medications have similar or different therapeutic mechanisms of action.
- Trial name
- NCT01678209
- Testing
- fMRI scans, Atomoxetine arm, Methylphenidate arm
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Dyslexia
Intervention Efficacy of ALD for Children With Dyslexia
This double-blind, randomized controlled crossover trial aimed to evaluate the efficacy of providing assistive listening devices (ALDs) in improving specific abilities among Chinese children diagnosed with dyslexia.
- Trial name
- NCT07247253
- Testing
- Use of a real assistive listening device (FM system) in class.
- Where
- Hong Kong
- Volunteers
- 71 people
- Sponsor
- Education University of Hong Kong
Intellectual Disability
Computerized Testing System for Measuring Motor and Sensory Integrative Functions in Intellectual Disabilities
Assessment of the motor and sensory integrative functions (MSI) is a key component of an overall health and functional evaluation for school-aged children with intellectual disabilities (ID).
- Trial name
- NCT05473377
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Speech and Language Therapy
Parent-based Intervention for Language Delayed 2 to 3 Year Olds
The aim of the study is to evaluate the impact of parent based intervention on the language of 2 to 3 year old children from socially disadvantaged populations with a clinical diagnosis of primary language delay.
- Trial name
- NCT03083236
- Testing
- Standard PBI, Enhanced
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Solent NHS Trust
Mental Health Conditions, Developmental Disability
Evaluation of Telehealth Services on Mental Health Outcomes for People With Intellectual and Developmental Disabilities
Roughly 40% of those with intellectual and developmental disabilities (IDD) have mental health needs, which is twice the national average.
- Trial name
- NCT05336955
- Testing
- Intake and quarterly assessment:, Consultation & coping skills coaching:, 24-hour urgent crisis response and intervention:
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- University of New Hampshire
Self-Injurious Behavior, Problem Behavior
Expanding Interventions for Automatically Maintained SIB
The goal of this clinical trial is to demonstrate feasibility of procedures and compare the outcomes of intervention arrangements to reduce sensory based self-injurious behavior exhibited by individuals with intellectual and…
- Conditions
- Self-Injurious Behavior, Problem Behavior, Intellectual Disability, Autism Spectrum Disorder
- Trial name
- NCT06739616
- Testing
- AUTOSIB across time, AUTOSIB diminished reinforcement
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Georgia
Intellectual Disability, Mild to Moderate
Adaptive Mixed Reality for Students With Intellectual Disabilities
This study design investigates the empirical efficacy of an Adaptive Mixed Reality Learning Environment (AMRLE) tailored for educable adolescents and young adults (aged 10-20) diagnosed with mild-to-moderate intellectual…
- Trial name
- AMRLE (NCT07647926)
- Testing
- Adaptive Mixed Reality Learning Environment (AMRLE)
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- King Salman Center for Disability Research
Developmental Disability
Communication Outcomes for South African Children With Developmental Disabilities
The goal is to remediate speech and language disorders early in the lives of South African children with significant developmental disorders (DD) by enhancing the health care service delivery system to better serve families…
- Trial name
- NCT03409406
- Testing
- Caregiver Intervention, ST Intervention
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- Georgia State University
Dementia, Cognitive Decline
Ammonia Levels and Cognitive Impairment
The purpose and objective of this study is to determine the prevalence of elevated ammonia levels in subjects with cognitive impairment, and to observe if treating the cause of the elevated ammonia level improves mental status.
- Conditions
- Dementia, Cognitive Decline, Cognitive Impairment, Developmental Delay
- Trial name
- NCT02059356
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Cleft Lip and Palate, Cleft Palate Children
Perceptions of High and Low Intensity Speech Intervention in Children With a Cleft Palate
A cleft (lip and) palate is the most common congenital abnormality of the face and skull with a significant social impact, affecting speech, hearing, feeding, oral behavior, dentition and satisfaction with appearance.
- Conditions
- Cleft Lip and Palate, Cleft Palate Children, Speech Therapy, Speech Disorders in Children
- Trial name
- NCT07781566
- Testing
- High-intensity speech therapy for children with cleft palate, Low-intensity speech therapy for children with cleft palate
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- University Ghent
Sleep Disorders, Autism Spectrum Disorder
Verification of the Efficacy of NPC-15 for Sleep Disorders of Children With Autism Spectrum Disorders
The purpose of this study is to verify the efficacy of NPC-15 (melatonin 1 mg/d or 4 mg/d) versus placebo to sleep latency with electronic sleep diaries.
- Trial name
- NPC-15-5 (NCT02757066)
- Testing
- NPC-15 Granules Lower Dose, NPC-15 Granules Higher Dose
- Volunteers
- 196 people
- Sponsor
- Nobelpharma
Selective Mutism, Anxiety Disorder of Childhood
VR Homework Exercises for Selective Mutism Treatment
Selective mustism (SM) is an anxiety disorder that manifests in childhood. Children with Children with SM do not speak in certain social situations where this is expected of them.
- Trial name
- NCT06882629
- Testing
- 'Speaking at school, a matter of doing' combined with VR homework exercises
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Luuk Stapersma
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