Clinical trials: Neurodevelopmental Disability
Behavior Problem, Developmental Delay
Stamford Group Family Nurture Intervention
The purpose of this current study is to investigate the efficacy of a group model of Family Nurture Intervention in ameliorating behavioral problems in preschool-aged children.
- Conditions
- Behavior Problem, Developmental Delay, Emotional Disturbances, Family Conflict
- Trial name
- NCT03442439
- Testing
- Nutrition and Play Intervention, Family Nurture Intervention
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Columbia University
Developmental Dyscalculia
tRNS Combined to Cognitive Training in Children With Dyscalculia
The present study grounds on the absence of evidence-based treatment in individuals with developmental dyscalculia (DD). At this topic, the present study will explore the potential effect of transcranial random noise stimulation…
- Trial name
- NCT04242680
- Testing
- Brainstim DLPFC, Brainstim PPC, Cognitive Training
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Reading Disability
Neurocognitive Factors in EdTech Intervention Response
The current project will carry out a large-scale, randomized controlled trial (RCT) to examine the effectiveness of a home-administered technology-based treatment for reading disability (GraphoLearn) in a diagnostically diverse…
- Trial name
- NCT04568824
- Testing
- GraphoLearn reading intervention, Math control intervention
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Autism Spectrum Disorder, Neurodevelopmental Disorders
KneuroKnits: Participation and Anxiety in People With Neurological Conditions Participating in a Knitting Group
The reported social benefits of knitting combined with the urgent need for social and activity-based programs in the disability community suggest that a knitting intervention may fill a substantial gap in available programs.
- Conditions
- Autism Spectrum Disorder, Neurodevelopmental Disorders, Acquired Brain Injury, Physical Disability
- Trial name
- NCT04639570
- Testing
- KneuroKnits
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Reading Disability
Rhythm and Music to Rehabilitate Reading Disorders
The purpose of this study is to determine whether music training is an effective treatment of reading disorders
- Trial name
- ReMus (NCT02316873)
- Testing
- Music training, Visual arts
- Volunteers
- 48 people
- Sponsor
- Aix Marseille Université
Neurodevelopmental Outcomes
Single Patient Room Versus Open Bay in NICU
The NICU at the IWK Health Center in Halifax, Nova Scotia is embarking on a redevelopment project that will see its current open bay design converted to a single room care environment.
- Trial name
- NCT03867669
- Testing
- Open Bay Unit, Single patient room
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- IWK Health Centre
Autism Spectrum Disorder (ASD), Intellectual Disability
Emotion Intensity Modulates Intention in ASD
This study used eye-tracking to examine how emotional expression intensity (low/medium/high) influences intention understanding in children with ASD, PDD, and TD during a puzzle-search task.
- Trial name
- NCT07597655
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Smith-Lemli-Opitz Syndrome
Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome
The purpose of this study is to determine whether supplementation with an oil-based cholesterol suspension will correct the biochemical abnormalities in cholesterol and its precursors in individuals with the Smith-Lemli-Opitz…
- Trial name
- NCT00272844
- Testing
- crystalline cholesterol oil-based suspension
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Boston Children's Hospital
Developmental Delay
Effects of Insoles on Children With Developmental Delays
Using double blind, randomized controlled design to investigate the short-term therapeutic effects of function of customized insoles on children with developmental delays
- Trial name
- NCT03191006
- Testing
- MEI BIN insoles
- Where
- Taiwan
- Volunteers
- 52 people
- Sponsor
- Taipei Medical University
Developmental Disabilities
Developing an Interdisciplinary Pharmacogenomic Treatment Approach to Reduce Medication Burden and Improve Outcomes
There is no common rule as to how a drug will affect patients. This is due to the effect specific DNA sequences of genes have on drug response, by the effect they have on how medications are metabolized.
- Trial name
- NCT01274065
- Testing
- Genetic analysis
- Volunteers
- 38 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Preterm Birth, Developmental Dyslexia
Reading-FREE Markers for Early Detection of Developmental Dyslexia
This study aims to identify early signs of developmental dyslexia (DD) and other reading difficulties in children born preterm, using behavioral, cognitive, and brain imaging data collected before reading problems typically…
- Trial name
- FREE-DD (NCT07072104)
- Testing
- Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 2, MRI - Grade 2, Multidomain Neuropsychological and Reading-Free Screening Tool (RSFT) Assessment Battery - Grade 3
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Developmental Delay
Coaching in Early Development Project
Among young children, homelessness is an independent predictor of child developmental delay and disability, and children experiencing homelessness (CEH) are 2-4x more likely to demonstrate developmental delays compared to housed…
- Trial name
- NCT06347666
- Testing
- Caregiver coaching
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Epilepsy, Cerebral Palsy
A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging
This is a pilot study to determine if a standard bolus dose and infusion of dexmedetomidine can significantly decrease the dose of propofol (infusion) required for accomplishing an MRI.
- Conditions
- Epilepsy, Cerebral Palsy, Developmental Delay
- Trial name
- NCT02633241
- Testing
- Dexmedetomidine bolus and high infusion-Propofol, Dexmedetomidine bolus and low infusion-Propofol, Dexmedetomidine bolus only - Propofol
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Joseph Cravero
Severe Intellectual Disability
Gross Motor Skills Predict Adaptive Behavior in Institutionalized Children With Severe Intellectual Disability: A Cross-Sectional Study
This study examines whether gross motor skills are linked to everyday functioning (adaptive behavior) in children with severe intellectual disability (ID) living in social welfare institutions.
- Trial name
- TGMD-ADQ (NCT07358143)
- Testing
- Test of Gross Motor Development-Second Edition (TGMD-2) Assessment, Adaptive Behavior Questionnaire for Children (ADQ) Assessment
- Where
- China
- Volunteers
- 227 people
- Sponsor
- Xili Wen
Development, Infant, Development, Language
Early Neurophysiological Markers of Language Impairments
The present project aims at identifying very early electrophysiological risk markers for language impairments. The long-term goals of the study include the characterization of learning developmental trajectories in children at…
- Conditions
- Development, Infant, Development, Language, Developmental Language Disorder, Learning Disabilities
- Trial name
- NCT05767242
- Testing
- Electrophysiological recording, Behavioral assessment
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Children, Neurologic Disorder
Psychometric Properties of the Turkish Version of the Modified Mini Mental State Examination
One of the most commonly used screening tests for the mental status of adults is the Standardized Mini Mental State Examination (MMSE).
- Conditions
- Children, Neurologic Disorder, Cerebral Palsy, Down Syndrome
- Trial name
- NCT06865248
- Where
- Cyprus
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Dyslexia, Special Education
Multiple Family Narrative Therapy for Chinese Families of Children With Dyslexia
The goal of this randomized controlled trial (RCT) is to develop and to implement a multiple family narrative therapy (MFNT) intervention consisting of parent-child relationships training among Chinese families of children with…
- Conditions
- Dyslexia, Special Education, Special Needs Children
- Trial name
- MFNT-CDYS (NCT05949346)
- Testing
- Multiple Family Narrative Therapy (MFNT), School services for families of children with Dyslexia
- Where
- Hong Kong
- Volunteers
- 123 people
- Sponsor
- Hong Kong Baptist University
CTNNB1 Neurodevelopmental Syndrome
CTNNB1 Neurodevelopmental Syndrome - Natural History Study
The aim of the Dragonfly study is to characterise and monitor the neurodevelopment of children and adults diagnosed with CTNNB1 syndrome through an international collaborative effort.
- Trial name
- Dragonfly (NCT07167732)
- Testing
- A General Medical and Neurological Assessment, World Health Organisation (WHO) Motor Milestones, Burke-Fahn-Marsden Dystonia Rating Scale
- Where
- 2 sites in Australia, Slovenia
- Volunteers
- 250 people
- Sponsor
- University Medical Centre Ljubljana
Learning Disorder, Specific, Learning Disability
Examining the Effect of a Digital MD for Cognitive and Musical Training + Reduced Conventional SOC on the Reading and Writing Skills of Pediatric Participants With a Specific Learning Disability With Reading and/or Written Expression Deficit vs a Control Group Receiving Conventional SOC.
Poppins-02 is a multicentric randomized non-inferiority study examining the effect of the digital medical device Poppins Clinical for cognitive and musical training in addition to bi-monthly speech and reading therapy sessions on…
- Conditions
- Learning Disorder, Specific, Learning Disability, Specific Learning Disorder, With Impairment in Reading, Dyslexia
- Trial name
- POPPINS-02 (NCT06592911)
- Testing
- Poppins Clinical
- Where
- 2 sites in France
- Volunteers
- 306 people
- Sponsor
- Poppins
Asthma in Children, Intellectual Disabilities (F70-F79)
Smart Inhaler and Remote Asthma Management in Adolescents With Intellectual and Developmental Disabilities
Correct use of daily medications containing inhaled corticosteroids is key for asthma control, yet children with intellectual and developmental disabilities (IDD) face additional barriers to proper inhaler use.
- Conditions
- Asthma in Children, Intellectual Disabilities (F70-F79), Developmental Disability, Autism Spectrum Disorder
- Trial name
- IDD (NCT07746921)
- Testing
- Use of active remote smart inhaler in the home setting, Use of passive remote smart inhaler in the home setting
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Children's Hospital Los Angeles