Clinical trials: Neurodevelopmental Disorder
Autism Spectrum Disorder, Autism
A Proof-of-Concept Study of Minocycline in Autism
The purpose of the study is to determine if Minocycline shows initial evidence of efficacy, safety, and tolerability in youth with Autism Spectrum Disorder ages 12 to 22 years.
- Trial name
- NCT04031755
- Testing
- Minocycline
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autism Spectrum Disorder, Child
AI Toothbrush and Visual Pedagogy to Improve Oral Hygiene in Children With Autism Spectrum Disorder
This randomized clinical trial evaluates the effectiveness of an AI-enabled electric toothbrush and visual pedagogy materials in improving oral hygiene among children with autism spectrum disorder (ASD).
- Conditions
- Autism Spectrum Disorder, Child, Oral Health, Artificial Intelligence
- Trial name
- NCT07160517
- Testing
- Visual Pedagogy and Manual Toothbrushing
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Attention Deficit Hyperactivity Disorder, ADHD
Omega-3 Polyunsaturated Fatty Acids in Youth With ADHD
N-3 polyunsaturated fatty acids(N-3 PUFAs) is important in balancing the immune function and crucial for the developing brain. Deficiency in n-3 PUFAs might be linked to the poor cognitive performances resulting in inattention…
- Trial name
- NCT03542643
- Testing
- n-3 Polyunsaturated fatty acid
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- China Medical University Hospital
Conduct Disorder, Oppositional Defiant Disorder
Genetic and Clinical Correlates of Disruptive Behavior Disorder With and Without Callous-Unemotional Traits
Disruptive Behavior Disorders (DBD), such as Conduct Disorder (CD) and Oppositional Defiant Disorder (ODD), affect children and adolescents in different ways.
- Conditions
- Conduct Disorder, Oppositional Defiant Disorder, Callous Unemotional Traits
- Trial name
- GENCU 2025 (NCT07322055)
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Fondazione Stella Maris
Attention Deficit Hyperactivity Disorder
ERP Based Single-dose Predictions of Stimulants
The purpose of this study was to see if the clinical outcome of stimulant medication (methylphenidate) in pediatric Attention Deficit Hyperactivity Disorder can be predicted on the bases of changes in Event Related Potentials…
- Trial name
- NCT02695355
- Testing
- Methylphenidate (MPH)
- Where
- Norway
- Volunteers
- 87 people
- Sponsor
- Ostfold Hospital Trust
Attention Deficit Hyperactivity Disorder
New Technologies to Help Manage ADHD
Cluster randomized controlled trial to evaluate the general effectiveness of intervention compared to control on medication continuity as measured by prescriptions written and other more proximal outcomes during the first six…
- Trial name
- NCT02390791
- Testing
- enhanced myADHDportal.com, treatment as usual standard portal
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autism Spectrum Disorder
Vitamin/Mineral Supplement for Children With Autism
This is an open-label 3 month clinical trial of a vitamin/mineral supplement designed for children with autism.
- Trial name
- NCT04845776
- Testing
- ANRC Essentials Plus
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Disruptive Behavior Disorder, Childhood Onset, Attention Deficit Hyperactivity Disorder
Enhanced Support for Behavioral Barriers to Learning: An Evaluation of the SCHOOL STARS Program
This small pilot study will enroll children ages 5-12 years of age with disruptive behavior problems at school. These children and their families will be offered an enhanced model of primary care, which includes pre-visit record…
- Conditions
- Disruptive Behavior Disorder, Childhood Onset, Attention Deficit Hyperactivity Disorder, Oppositional Defiant Disorder in Children, Disruptive Mood Dysregulation Disorder
- Trial name
- NCT03669289
- Testing
- enhanced model of primary care
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
ADHD
Neurofeedback Intervention on the Development of ADHD in Children at Risk
Forty children considered at risk for ADHD (subclinical ADHD) will be randomized to either a neurofeedback intervention or waiting list.
- Trial name
- NCT01692548
- Testing
- Neurofeedback
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Autism Spectrum Disorder, Autism
Effectiveness of a Developmental Reciprocity Treatment Program in Autism
This is a research study examining the effectiveness of a Developmental Reciprocity Treatment Program (DRT-P) in treating social deficits in children with Autism Spectrum Disorders (ASD).
- Trial name
- DRTP (NCT03131635)
- Testing
- Developmental Reciprocity Treatment Program (DRT-P)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Stanford University
Apneas of Prematurity
The Effect of Stimulating Substances on Brain Activity of Preterm Infants
Introduction: Methylxanthines and doxapram have been widely used for the treatment of apneas of prematurity. Both substances have effects on the central nervous system.
- Trial name
- NCT01344317
- Where
- 2 sites in Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Intellectual Disability, Mild to Moderate
Adaptive Mixed Reality for Students With Intellectual Disabilities
This study design investigates the empirical efficacy of an Adaptive Mixed Reality Learning Environment (AMRLE) tailored for educable adolescents and young adults (aged 10-20) diagnosed with mild-to-moderate intellectual…
- Trial name
- AMRLE (NCT07647926)
- Testing
- Adaptive Mixed Reality Learning Environment (AMRLE)
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- King Salman Center for Disability Research
Oppositional Defiant, Conduct Disorder
Mobile Health Solutions for Behavioral Skill Implementation Through Homework
The primary purpose of this study is to develop a mobile health (mHealth) application that will both advance theory in and clinical practice of homework (HW) implementation.
- Trial name
- NCT02662140
- Testing
- Mobile Health Applictaion
- Where
- United States
- Sponsor
- NYU Langone Health
Oppositional Defiant Disorder, Conduct Disorder
Evaluating the Feasibility of Internet-delivered PCIT
The present study is leveraging a randomized-controlled design to evaluate an Internet-based format for the delivery of Parent-Child Interaction Therapy (I-PCIT).
- Conditions
- Oppositional Defiant Disorder, Conduct Disorder, Disruptive Behavior Disorder Nos
- Trial name
- NCT03260725
- Testing
- Parent-Child Interaction Therapy (PCIT), Internet-delivered PCIT (I-PCIT)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Florida International University
Intellectual Disability
A Computerized Testing System for Measuring Motor and Sensory Integrative Functions in Children
Assessment of the motor and sensory integrative functions (MSI) is a key component of an overall health and functional evaluation for school-aged children with intellectual disabilities (ID).
- Trial name
- NCT05451238
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Acquired Brain Injury, Pragmatic Communication Disorder
Pragmatic Abilities in Children With Acquired Brain Injury
Although neuroplasticity of the brain is high in childhood, some neuropsychological sequelae could persist over the long term in children with Acquired Brain Injury (ABI).
- Trial name
- ABIabc (NCT04280978)
- Testing
- ABI ABC
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Assessment of Depression, Anxiety and ADHD Among Children and Adolescents With Congenital Heart Disease
Assessment of Depression, Anxiety and ADHD Among Children and Adolescents With Congenital Heart Disease.
Congenital heart disease (CHD) is the most common birth defect, affecting ∼1% of all live births.The spectrum of CHD is wide, ranging from simple (not requiring immediate or possibly any surgical intervention) to severe or…
- Trial name
- Psychiatricy (NCT06836076)
- Volunteers
- 50 people
- Sponsor
- Assiut University
Congenital Hypothyroidism
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.
Congenital hypothyroidism (CH) is a rare disease that affects 1 in 3500 newborn. This condition is detected consistently since the late 1970s in France, which has led to early care and a significant improvement in prognosis and…
- Trial name
- HYPOTYGEN (NCT01916018)
- Testing
- Clinical and radiologic exams and blood samples
- Where
- France
- Volunteers
- 558 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mental Retardation, Body Composition, Beneficial
Resistance Training Program, Labor Inclusion, Intellectual Disability
Resistance exercise (RE) has been proposed as a possible strategy for prevention and rehabilitation of diseases. The increase in both muscle strength and the ability to perform tasks of day-to-day work environment and are…
- Conditions
- Mental Retardation, Body Composition, Beneficial, Muscle Weakness
- Trial name
- NCT01456910
- Testing
- Resistance Training Program
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- University of Brasilia
Autism Spectrum Disorder
An Exploratory Open Label Study of EPI-743 (Vincerinone TM) in Children With Autism Spectrum Disorder
The investigators hypothesize that EPI-743 may provide clinical benefit to children with Autism Spectrum Disorder.
- Trial name
- Autism (NCT02226458)
- Testing
- EPI-743
- Sponsor
- Edison Pharmaceuticals Inc
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