Clinical trials: Neuromodulation
Perinatal Spinal Cord Injury
Understanding Perinatal Spinal Cord Injury
The purpose of this study is to deepen our understanding of children who have a cervical spinal cord injury obtained in utero or at birth and examine the effects of tailored activity-based recovery training (ABRT) in combination…
- Trial name
- NCT06808035
- Testing
- Activity-Based Recovery Training, Transcutaneous Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Louisville
Anorexia Nervosa
Identifying Networks Underlying Compulsivity in Anorexia Nervosa for Targeting With Neuromodulation
Transcranial Magnetic Stimulation (TMS) is approved by the Food and Drug Administration (FDA) for the treatment of refractory Major Depressive Disorder (MDD) and obsessive-compulsive disorder (OCD).
- Trial name
- NCT06138782
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Complications; Neurostimulator, Satisfaction
Investigation of the Use of Remote Presence Robots in Delivery of Neuromodulation
In recent years, robotic devices are becoming more and more common in medical practice. Such devices provide an effective way to communicate within a clinical setting, but recent studies have shown far more diverse uses for these…
- Trial name
- NCT01283633
- Testing
- Neuromodulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Obsessive Compulsive Behavior
TMS + Exposure Therapy for Pediatric OCD: Second Phase
The goal of this clinical trial is to test transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive Disorder (OCD).
- Trial name
- NExT (NCT07859683)
- Testing
- Transcranial Magnetic Stimulation: continuous theta burst to pre supplementary motor area, Exposure with Response Prevention
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Bradley Hospital
Epilepsy, Lennox-Gastaut Syndrome, Intractable
Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot
The CADET Pilot will investigate the safety and feasibility of deep brain stimulation (DBS) to treat children with Lennox-Gastaut syndrome using a novel DBS device (Picostim DyNeuMo-1).
- Trial name
- CADET Pilot (NCT05437393)
- Testing
- Deep brain stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 4 people
- Sponsor
- University College, London
Cerebral Palsy (CP)
A Novel Home-based Non-invasive Neuromodulation Therapy for Children and Adolescents With Cerebral Palsy
The aim of this study is to evaluate the clinical effectiveness, feasibility and acceptability of a novel home-based noninvasive neuromodulation therapy (AscenZ-IV Stimulator) that utilizes transcranial Pulse Current Stimulation…
- Trial name
- NCT06921538
- Testing
- AscenZ-IV neuromodulation device
- Where
- 2 sites in Singapore
- Volunteers
- 60 people
- Sponsor
- KK Women's and Children's Hospital
Migraine
Real World Data Analysis: Impact of High-Frequency REN Treatments As Migraine Preventive Therapy in Adolescence
This is a post-marketing study investigating the safety and efficacy of the REN device (Nerivio by Theranica, ISRAEL) in adolescents with migraine.
- Trial name
- NCT05769322
- Testing
- Nerivio
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Theranica
Migraine, Acute Treatment of Migraine
Nerivio Long-term Usage in Patients With Migraine
This is a post-marketing real-world evidence study investigates long-term treatment with the Remote Electrical Neuromodulation (REN) wearable Nerivio device over 3 consecutive years in patients with migraine.
- Trial name
- NCT06738056
- Testing
- Nerivio
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- Theranica
Cardiac Disease, Syncope
Second Study on Cardio-neuromodulation in Humans
Different approaches to cardio-neuroablation (CNA) to treat neurally mediated syncope, sinus node dysfunction, and functional atrioventricular block have been published.
- Conditions
- Cardiac Disease, Syncope, Syncope, Vasovagal, Sick Sinus Syndrome
- Trial name
- CardNMH2 (NCT02954666)
- Testing
- radio-frequency ablation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Imelda Hospital, Bonheiden
Autism Spectrum Disorder With Language Delay
pBFS Guided Neuromodulation Over DMPFC for ASD Treatment: Pilot Study
This study will evaluate the feasibility and preliminary efficacy of pBFS-guided TMS treatment at DMPFC in autism spectrum disorder comorbid with language delay.
- Trial name
- NCT07515261
- Testing
- active iTBS
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Changping Laboratory
Fecal Incontinence
Sacral Neuromodulation as Treatment for Fecal Incontinence
The objective of this study is to investigate if low level laser therapy will do more good than harm for patients with severe refractory fecal incontinence. It is a proof of concept study without a placebo arm.
- Trial name
- LLLT-FI (NCT03825575)
- Testing
- Low level laser therapy (LLLT)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Migraine
Migraine Prevention With the Remote Electrical Neuromodulation (REN) Wearable: A Real-world Evidence Study
Preventive pharmacologic therapies for migraine aim to reduce attack frequency and duration and improve quality of life; however, their use, overall benefit and adherence are often limited.
- Trial name
- NCT07487701
- Testing
- Nerivio REN device
- Where
- United States
- Volunteers
- 332 people
- Sponsor
- Theranica
Pain Syndrome, Fibromyalgia
Neuro-modulation of Central Pain Pathways in Non Inflammatory Musculoskeletal Pain Syndrome
The aim of this clinical trial is to see if transcranial electrical stimulation (tES) can help reduce pain and improve quality of life in children and adolescents (ages 10-21, both sexes) with juvenile fibromyalgia or other…
- Conditions
- Pain Syndrome, Fibromyalgia, CRPS (Complex Regional Pain Syndromes), Neuromodulation
- Trial name
- NMJFP protocol (NCT07785362)
- Testing
- Neuro-modulation of central pain pathways in non inflammatory musculoskeletal pain syndrome (NMJFP)
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Istituto Giannina Gaslini
Laryngeal Dystonia, Spasmodic Dysphonia
Transcranial Magnetic Stimulation in Laryngeal Dystonia
This randomized clinical trial with a crossover design aims to investigate the effects of neuromodulation through repetitive transcranial magnetic stimulation (rTMS) applied to patients diagnosed with laryngeal dystonia.
- Trial name
- NCT07683767
- Testing
- Active rTMS, Speech-Language Therapy
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Binge-Eating Disorder
Theta Burst Stimulation in Binge Eating Disorder: A Single Session RCT
Binge eating disorder (BED) is a common and disabling eating disorder (ED) which presents a substantial disease burden. Individuals seeking treatment for binge eating difficulties typically receive talking therapy treatment…
- Trial name
- BITE (NCT04130906)
- Testing
- Intermittent Theta Burst Stimulation
- Where
- United Kingdom
- Sponsor
- King's College London
Refractory Epilepsy, Neuromodulation
Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG
The prospective study aims to characterize the network-specific modulatory effects of piriform cortex stimulation in patients undergoing stereotactic EEG for drug-resistant epilepsy.
- Trial name
- NCT07305311
- Testing
- SEEG recordings and SPES
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Refractory Chronic Headache Disorders
French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders
The purpose of this non interventional research is to set up a French database, initially for 3 years, of patients suffering from refractory chronic headache disorders (chronic migraine, cluster headache, chronic paroxysmal…
- Trial name
- NGO (NCT01842763)
- Where
- 16 sites in France
- Volunteers
- 246 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Nocturnal Enuresis
Treatment of Monosymptomatic Nocturnal Enuresis
A prospective randomized trial to study the effect of spinal magnetic stimulation versus posterior tibial neuromodulation in the treatment of monosymptomatic nocturnal enuresis.
- Trial name
- NCT05306639
- Testing
- Rehabilitation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- University of Alexandria
Chronic Pain Syndromes, CRPS
Neuro-Pain Provides a Dynamic and Interactive Register for the Invasvive Neuromodulatory Therapies for Different Chronic Pain Syndromes. Patients Living in Belgium and Suffering From Persistent Spinal Pain Syndromes Type 2 as Well as Suffering From Complex Regional Pain Syndromes Are Included.
Patients suffereing from chronic pain due to persistent spinal pain syndromes or complex regional pain syndromes and living in Belgium will be included in this register once they are being considered for a treatment with invasive…
- Trial name
- NCT06835868
- Testing
- Spinal cord stimulation
- Where
- Belgium
- Volunteers
- 7,000 people
- Sponsor
- University Hospital, Antwerp
Vocal Performance, Neuromodulation
Safety and Acute Effects of tDCS on Vocal Performance in Adolescent Singers
This randomized, sham-controlled proof-of-concept study aims to investigate the safety, tolerability, and acute effects of transcranial direct current stimulation (tDCS) on vocal performance in adolescent singers aged 12 to 16…
- Trial name
- NCT07861490
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centro Universitário Augusto Motta