Clinical trials: Neuromodulation
Obsessive Compulsive Behavior
TMS + Exposure Therapy for Pediatric OCD: Second Phase
The goal of this clinical trial is to test transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive Disorder (OCD).
- Trial name
- NExT (NCT07859683)
- Testing
- Transcranial Magnetic Stimulation: continuous theta burst to pre supplementary motor area, Exposure with Response Prevention
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Bradley Hospital
HTN-Hypertension, Blood Pressure Management
Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects
Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies.
- Trial name
- NCT06969846
- Testing
- CSN electrode was implanted around tissue including CSN branches
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Louis Stokes VA Medical Center
Seizures
Boosting The Intervention Effect of Negative Memory Through tACS Stimulation
The objectives of this study include: 1) investigating the impact of negative memory substitution on an individual's other intellectual memories (i.e., neutral memories) and the underlying neurocognitive mechanisms; 2)…
- Trial name
- NCT06375395
- Testing
- Active tACS Device
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Anorexia Nervosa
Theta Burst Stimulation in Anorexia Nervosa: A Case Series
Anorexia Nervosa (AN) is a life-threatening eating disorder characterised by an intense fear of weight gain and disturbed body image, which motivates severe dietary restriction or other weight loss behaviours (e.g. purging).
- Trial name
- ANTS (NCT03979404)
- Testing
- Intermittent Theta Burst Stimulation
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- King's College London
Attention Deficit Hyperactivity Disorder (ADHD)
12 Month Open Extension of TNS for ADHD.
Participants who exhibit sufficient ADHD symptom improvement in a prior study of active TNS will be invited to continue in a 12-month extension study, designed to collect additional data on long-term response and tolerability and…
- Trial name
- NCT03888391
- Testing
- Active TNS
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- James McGough
Chronic Migraine Headache, Radiofrequency Ablation
The Effect of Interventional Procedures on Serum CGRP and PACAP-38 Levels in Chronic Migraine
The study included 100 patients diagnosed with chronic migraine (CM) who received a diagnosis from the headache clinics of the Neurology Department of Adnan Menderes University Hospitals between May 2025 and May 2026.
- Conditions
- Chronic Migraine Headache, Radiofrequency Ablation, Greater Occipital Nerve Block, Calcitonin Gene-related Peptide
- Trial name
- NCT07395908
- Testing
- Greater occipital nerve Pulse radiofrequency, Greater occipital nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Efficacy, Self, Fatigue; Muscle, Heart
Neuromodulation of the Autonomic Nervous System in Athletes
There are few studies in the literature that have evaluated the effects of using percutaneous stimulation of the auricular branch of the vagus nerve for sports purposes (to accelerate recovery after physical exertion).
- Conditions
- Efficacy, Self, Fatigue; Muscle, Heart, Fatigue, Mental, Fatigue; Combat
- Trial name
- NANSA (NCT06281795)
- Testing
- tVNS
- Where
- Russia
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Bedwetting
Foot Neuromodulation for Nocturnal Enuresis
To determine the effects of electrical stimulation of the nerves in the foot on the incidence of nocturnal enuresis (bedwetting) in children
- Trial name
- NCT02315560
- Testing
- TRANSCUTANEOUS ELECTRICAL NERVE STIMULATOR (TENS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Heidi Stephany
Autism Spectrum Disorder, ADHD
Therapeutic Use of rTMS in Pediatric ASD and ADHD Cohorts
In this interventional, pilot clinical trial investigators will stimulate the dorsolateral prefrontal cortex (DLPFC) in patients with Autism and ADHD.
- Conditions
- Autism Spectrum Disorder, ADHD, Neurodevelopmental Disorders
- Trial name
- NCT06069323
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ospedali Riuniti di Foggia
Separation Anxiety Disorder, Generalized Anxiety Disorder
Acoustic Neuromodulation (ANM) for Youth With Anxiety Disorders
The acoustic neuromodulation trial (ANM-T) is a two-phase, single-site, pilot randomized clinical trial examining the feasibility of completing a larger scale efficacy study of a novel treatment of non-linear modulated acoustic…
- Conditions
- Separation Anxiety Disorder, Generalized Anxiety Disorder, Social Phobia
- Trial name
- ANM (NCT02572973)
- Testing
- Acoustic Neuromodulation (ANM)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Brain Concussion, Mild Traumatic Brain Injury
Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive Impairment
- Trial name
- CI-tDCS (NCT05762796)
- Testing
- tDCS in Youth with mild traumatic brain injury
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Migraine
A Prospective Post-marketing Observational Study Assessing the Safety and Efficacy of Nerivio for Migraine Prevention.
Nerivio is a remote electrical neuromodulation (REN) device that is FDA-cleared for migraine prevention (as well as for acute treatment of migraine), in individuals 12 and older.
- Trial name
- NCT05940870
- Testing
- Nerivio
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Theranica
Dyslexia, Reading Disability
Brain Stimulation Paired With Structured Reading Instruction in Children With Dyslexia
This study investigates whether transcranial electrical stimulation (tES) delivered during structured reading instruction affects reading proficiency in children with developmental dyslexia and related reading disabilities.
- Trial name
- NCT07762365
- Testing
- Active transcranial electrical stimulation (tES)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- General Neuro Inc.
Refractory Overactive Bladder
Clinical Trial of Sacral Neuromodulation for Treatment of Refractory Overactive Bladder (OAB)
Evaluate the long-term clinical effectiveness and safety of the PINS Sacral Neuromodulation to patients with refractory Overactive Bladder.
- Trial name
- NCT02619721
- Testing
- PINS SNS
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Gastrointestinal Motility Disorders in Children, Hirschsprung Disease
Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables
The goal of this study is to learn about the effects of sacral neuromodulation in pediatric patients with gastrointestinal motility disorders.
- Conditions
- Gastrointestinal Motility Disorders in Children, Hirschsprung Disease, Constipation - Functional
- Trial name
- SMART-GUT (NCT07519915)
- Testing
- SNM/MRI/EMG
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Epilepsy
Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver…
- Trial name
- NCT06898138
- Testing
- Brain Interchange System
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Bedwetting
Hand & Foot Nocturnal Enuresis TENS Study
The investigators believe in order to strengthen the evidence in support of transcutaneous foot stimulation in this population the investigators need to move forward with a randomized comparison study using the TENS device on the…
- Trial name
- NCT02747849
- Testing
- TENS
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Rajeev Chaudhry
Tic Disorders
Clinical Study on a Novel Strategy of Individualized Non-Invasive Neuromodulation for the Treatment of Tic Disorders in Children
This study aims to establish a novel personalized closed-loop NiBS/TMS therapeutic strategy and clinical protocol for children with Tic Disorders (TDs) through a series of scientific investigations.
- Trial name
- NCT07351955
- Testing
- Transcranial Magnetic Stimulation, general behavioral therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Children's Medical Center
Attention Deficit Hyperactivity Disorder (ADHD)
Four-week Open-trial Extension TNS for ADHD
The purpose of this study will be to offer children previously randomized to sham treatment in a 5-week double-blind sham controlled study of Trigeminal Nerve Stimulation for ADHD (NCT02155608) an opportunity to receive 4-weeks…
- Trial name
- NCT03870737
- Testing
- Active TNS
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, Los Angeles
Migraine
Real-World Evidence (RWE) Data Analysis of 1-year Consecutive Use of Remote Electrical Neuromodulation (REN)
This is a Post-marketing study investigating the long-term safety, utilization, and efficacy of REN during 12 consecutive months of using Nerivio in migraine patients.
- Trial name
- NCT05760638
- Testing
- Nerivio
- Where
- 2 sites in United States, Israel
- Volunteers
- 409 people
- Sponsor
- Theranica