Clinical trials: Neuromodulation
Spinal Cord Injuries
Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury
The goal of this study is to identify the effect of different types of noninvasive spinal stimulation on spasticity (involuntary muscle activity), muscle strength, and pain in people with spinal cord injury.
- Trial name
- NCT06214208
- Testing
- Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shepherd Center, Atlanta GA
Epilepsy, Drug Resistant
Piriform Cortex Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Piriform cortex as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy…
- Trial name
- NCT07128563
- Testing
- piriform cortex-DBS
- Volunteers
- 5 people
- Sponsor
- Xuanwu Hospital, Beijing
Complications; Neurostimulator, Satisfaction
Investigation of the Use of Remote Presence Robots in Delivery of Neuromodulation
In recent years, robotic devices are becoming more and more common in medical practice. Such devices provide an effective way to communicate within a clinical setting, but recent studies have shown far more diverse uses for these…
- Trial name
- NCT01283633
- Testing
- Neuromodulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Migraine
Acute Treatment of Migraine in Pre-Adolescents: Real-World Analysis of Remote Electrical Neuromodulation (REN)
Migraine is a prevalent neurological disorder that severely impacts both children and adolescents, causing significant disability.
- Trial name
- NCT06138756
- Testing
- Nerivio
- Where
- 2 sites in United States, Israel
- Volunteers
- 293 people
- Sponsor
- Theranica
Autism Spectrum Disorder
pBFS Guided Precision Neuromodulation Treatment for ASD
This study aims to evaluate the neuromodulation (i.e., iTBS) effectiveness for treating autism spectrum disorder (ASD) by targeting at the pBFS-guided executive function brain network or social brain network.
- Trial name
- NCT05735262
- Testing
- active iTBS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changping Laboratory
Binge-Eating Disorder
Theta Burst Stimulation in Binge Eating Disorder: A Case Series
Binge eating disorder (BED) is a common and disabling eating disorder (ED) which presents a substantial disease burden. Individuals seeking treatment for binge eating difficulties typically receive talking therapy treatment…
- Trial name
- BITE (NCT04129970)
- Testing
- Intermittent Theta Burst Stimulation
- Where
- United Kingdom
- Sponsor
- King's College London
Writer's Cramp, Dystonias
VTS Sensorimotor Neuromodulation in WC
Writer's cramps (WC) is a focal task-specific upper limb dystonia that significantly impairs handwriting and other manual skills, affecting functionality.
- Trial name
- VTS in WC (NCT07894198)
- Testing
- Vibro-tactile stimulation
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Ataxia, Cerebellar
Neuromodulation of Social Skills in Childhood Ataxia
The present study aims to define a protocol of electrical stimulation of the cerebellum via transcranial direct current stimulation (tDCS) combined with a virtual reality protocol to assist the rehabilitation of social skills in…
- Trial name
- NCT04297540
- Testing
- Active-tDCS group
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Refractory Chronic Headache Disorders
French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders
The purpose of this non interventional research is to set up a French database, initially for 3 years, of patients suffering from refractory chronic headache disorders (chronic migraine, cluster headache, chronic paroxysmal…
- Trial name
- NGO (NCT01842763)
- Where
- 16 sites in France
- Volunteers
- 246 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Parkinson Disease, Freezing of Gait Symptoms in Parkinson's Disease
Brain-Machine Interface for Freezing of Gait
Gait problems in Parkinson's disease (PD), especially freezing of gait (FOG), greatly affect quality of life. While deep brain stimulation (DBS) is a highly effective treatment for many motor symptoms of PD, it is less effective…
- Trial name
- NCT06642519
- Testing
- Brain Stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Toronto
Rechargeable Sacral Neuromodulation Device, Neurogenic Lower Urinary Tract Dysfunction
Cost Profile and Budget Implications of Rechargeable Versus Non-rechargeable Sacral Neuromodulation Devices for Neurogenic Lower Urinary Tract Dysfunction
Traditional sacral neuromodulation devices are not rechargeable. In recent years, new rechargeable sacral neuromodulation devices have been developed and put into the market.
- Trial name
- SNM、NLUTD (NCT07173517)
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Qilu Hospital of Shandong University
Syncope, Neurogenic, Syncope
Efficacy of a Right-sided Ablation of the Anterior Ganglionated Plexus for Neurally Mediated Syncope
The third study on CardNM (CardNMH3 study) is a multicenter, double-blind, randomized trial with a sham control group investigating the efficacy and safety of a computed tomography (CT)-guided, right-sided ablation of the…
- Trial name
- CardNMH3 (NCT04755101)
- Testing
- EPS, electro-anatomical mapping, ARGP ablation, and pharmacological evaluation., EPS, electro-anatomical mapping, and pharmacological evaluation.
- Where
- 3 sites in Belgium
- Volunteers
- 110 people
- Sponsor
- Imelda Hospital, Bonheiden
Constipation, Surgery
Effectiveness and Safety of Sacral Neuromodulation in Patients With Idiopathic Slow-transit Constipation
Rationale: Previous reviews showed that the evidence regarding the effectiveness of sacral neuromodulation (SNM) in patients with therapy-resistant, idiopathic (slow-transit) constipation is of suboptimal quality.
- Trial name
- NCT02961465
- Testing
- Sacral Neuromodulation
- Where
- 2 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Maastricht University Medical Center
Minimally Conscious State
Closed-loop tDCS in Patients in Minimally Conscious State
This research will test a closed-loop system using EEG-arousal measures (spectral entropy) to define the best moment of the day for application of transcranial direct current stimulation (tDCS) in patients in MCS This study aims…
- Trial name
- NCT03810079
- Testing
- Anodal transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University of Liege
Migraine in Adolescence
Real-world Data Analysis of REN Treatment in Adolescence With Migraine
This is a Post-marketing study investigating the safety and efficacy of the REN device (Nerivio by Theranica, Israel) in adolescents with migraine.
- Trial name
- NCT05443659
- Testing
- Nerivio
- Where
- 2 sites in United States, Israel
- Volunteers
- 1,629 people
- Sponsor
- Theranica
Spinal Cord Injury Cervical, Spinal Cord Injury, Acute
Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation
The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury…
- Conditions
- Spinal Cord Injury Cervical, Spinal Cord Injury, Acute, Spinal Cord Injury (Quadraplegia)
- Trial name
- CIME_upperlimb (NCT07361627)
- Testing
- Protocol 2: Combination of activity-based therapy and facilitatory transcutaneous spinal cord stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Constipation, Fecal Incontinence in Children
Posterior Tibial Nerve Stimulation for Children With Pelvic Floor Dyssynergia
The overall objective of this study is to determine the effect of posterior tibial nerve stimulation (PTNS) on children with constipation due to pelvic floor dyssynergia.
- Conditions
- Constipation, Fecal Incontinence in Children, Pelvic Floor Dyssynergia
- Trial name
- NCT06528470
- Testing
- Posterior Tibial Nerve Stimulation (PTNS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Nationwide Children's Hospital
Abdominal Pain (AP), Disorders of Gut-brain Interaction
Transauricular Neurostimulation for Abdominal Pain Due to DGBI
This single-site, open-label pilot study will evaluate transcutaneous auricular neurostimulation using the Sparrow Link device as a treatment for adolescents aged 12 to 18 years with abdominal pain related to disorders of…
- Trial name
- NCT07798180
- Testing
- Transcutaneous auricular neurostimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nationwide Children's Hospital
Epilepsy
Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver…
- Trial name
- NCT06898138
- Testing
- Brain Interchange System
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Autism Spectrum Disorder
pBFS-guided Noninvasive Neuromodulation for Pre-school Children With ASD
This randomized controlled trial aims to evaluate the efficacy and safeness of the pBFS-guided rTMS intervention for core symptom relief in pre-school children with autism spectrum disorder (ASD).
- Trial name
- NCT06031948
- Testing
- active iTBS
- Volunteers
- 50 people
- Sponsor
- Changping Laboratory