Clinical trials: Neuronal Plasticity
Schizophrenia
Training-induced Cerebral Reorganization in Schizophrenia
The purpose of this study is to reveal the effects of computer-aided cognitive-auditory training on cerebral reorganization in schizophrenia.
- Trial name
- NCT00695708
- Testing
- Brain Fitness Program, Cogpack
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Stroke, Drop Foot
Pairing Functional Electrical Stimulation (FES) and Volitional Effort Training Promotes Neuroplasticity and Motor Gain
The goal of the study is to explore the effect of combined training involving functional electrical stimulation (FES) of the ankle dorsal flexor with simultaneous maximal-effort voluntary contraction of the same muscle to correct…
- Trial name
- NCT02797886
- Testing
- FES + VOL, FES, VOL
- Volunteers
- 45 people
- Sponsor
- Kessler Foundation
Quadriplegic Cerebral Palsy, Cerebral Palsy (CP)
Intensive Bimanual Therapy Versus Conventional Physical Therapy in Quadriplegic Cerebral Palsy
Quadriplegic cerebral palsy (CP) is a severe neurological condition affecting motor control in all four limbs, often resulting in profound functional limitations in daily activities.
- Trial name
- NCT07134894
- Testing
- Intensive Bimanual Therapy plus Conventional Physical Therapy, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Lahore
Suicide, Attempted, Suicide, Ideation
Teen Brain Training (TBT)
A non invasive treatment study including participants at risk for suicide attempts and undergoing neurofeedback training. Neurofeedback is controlling your brain activity in real time inside the scanner.
- Conditions
- Suicide, Attempted, Suicide, Ideation, Depression
- Trial name
- NCT06183580
- Testing
- neurofeedback training involving dACC, neurofeedback training involving amygdala
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Prematurity, Developmental Delays
HEP® Delivered Via Telerehabilitation for Preterm Infants With Developmental Risks
Preterm infants are at increased risk for developmental delays, making early intervention essential for optimizing developmental outcomes.
- Trial name
- HEP-Preterm (NCT07725367)
- Testing
- Homeostasis-Enrichment-Plasticity (HEP®) Approach, Usual Care Group
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Medipol University
Autism
Early Pharmacotherapy Aimed at Neuroplasticity in Autism : Safety and Efficacy
The purpose of this study is to determine the efficacy, safety, and population pharmacokinetics and determinants of drug responses to buspirone in children with autism using a randomized, double blind, cross over study in…
- Trial name
- NCT00166621
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Chugani, Diane C.
Impaired Synaptic Plasticity, Impaired Cognition
Synaptic Plasticity and Cognitive Function in RASopathies
The project is targeting cognitive impairment, one of the main health problems of patients with RAS pathway disorders. The aim of this study is to translate findings of animal studies to humans.
- Trial name
- SynCoRAS (NCT03504501)
- Testing
- Lovastatin, Lamotrigine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Technical University of Munich
Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD)
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program.
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder)
- Trial name
- GEN-HOPE (NCT07493096)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healing Hope International
Cerebral Palsy
Effect of HABIT-ILE on the Body Function and Structures of Children With Cerebral Palsy
There is strong evidence that recent intensive interventions based on motor skill learning principles are efficient on functional and neuroplastic changes of children with cerebral palsy (CP).
- Trial name
- NCT04403490
- Testing
- HABIT-ILE, Conventional intervention
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Université Catholique de Louvain
Blindness
Neuroplasticity in Blind Subjects After Repetitive Tactile Stimulation
Brain plasticity of cortical activity caused by repetitive tactile stimulation could have a progressive development that was from primary parietal areas, passing over parieto-occipital areas and came secondary to primary…
- Trial name
- NCT01754103
- Testing
- Tactile Training
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Universidad Complutense de Madrid
Cerebral Palsy (CP), Spastic Diplegia Cerebral Palsy
Comparison of Synchronous and Asynchronous Action Observation Therapy in Children With Cerebral Palsy
The aim of this study is to compare the effects of synchronous and asynchronous action observation therapy (AOT) on balance, gait, and functional capacity in children with cerebral palsy (CP).
- Conditions
- Cerebral Palsy (CP), Spastic Diplegia Cerebral Palsy, Spastic Hemiplegic Cerebral Palsy, Neurodevelopmental Disorder (Diagnosis)
- Trial name
- NCT07114731
- Testing
- Synchronous Action Observation Therapy, Asynchronous Action Observation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Istanbul University - Cerrahpasa
Attention Deficit Hyperactivity Disorder
Online Neuroplasticity Training for Remediation of ADHD in Adolescent Children (ONTRAC)
This project shall rigorously evaluate the effectiveness of a novel, neuroplasticity-based internet-deliverable cognitive training program, which specifically targets the treatment of core cognitive dysfunctions observed in…
- Trial name
- NCT01772485
- Testing
- Cognitive Training, Active Control
- Where
- India
- Volunteers
- 31 people
- Sponsor
- Posit Science Corporation
Spinal Cord Injuries
Spinal Cord Stimulation and Training
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of…
- Trial name
- NCT05472584
- Testing
- Electrophysiology assessment - corticospinal tract, Electrophysiology assessment - reticulospinal tract, Electrophysiology assessment - spinal motoneuron
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Spinal Cord Injury (SCI)
Restoring Walking in Non-ambulatory Children With Severe Chronic Spinal Cord Injury (SCI) (Kids STEP Study)
The Kids STEP Study aims to 1. Determine if walking can be restored in children with incomplete SCI and little to no leg movement 2. Identify the neural pathways that permit recovery of walking
- Trial name
- NCT00488280
- Testing
- Locomotor Training
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Florida
Cerebral Palsy
Intensive Activities-based Locomotor Training Program in Children With Cerebral Palsy
The goal of the proposed work is to investigate the impact of an intensive 3-week activities-based locomotor training (AB-LT) program on activity capacity, activity performance, and participation in children with cerebral palsy…
- Trial name
- NCT05867628
- Testing
- Activities-based locomotor training (physical therapy)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Baylor University
Neuroplasticity
Reaction Time, Cognitive Function and Physical Fitness of Children and Adolescent Soccer Players
Investigation of the effect of an exercise program with visual stimuli on reaction time, cognitive function and physical fitness of children and adolescent soccer players.
- Trial name
- NCT05587907
- Testing
- FitLight Trainer
- Where
- Greece
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Cancer Childhood, Brain Tumor
Musical Training: Promoting Brain Function in Children Who Have Survived Brain Tumours
This study aims to understand whether learning music can help improve brain function and quality of life in children who have recovered from brain tumours. A total of 236 children will join the study.
- Trial name
- NCT07769099
- Testing
- Musical Training Program
- Where
- Hong Kong
- Volunteers
- 236 people
- Sponsor
- The Hong Kong Polytechnic University
Amblyopia
An Active Approach to Treat Amblyopia: Video Game Play
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT01223716
- Testing
- Perceptual learning, Video Game, Crossover (Occlusion therapy + Video Game)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Neurodevelopmental Disorders
Innovative Methodologies for Neuroplasticity in Developmental Age With the Use of Virtual Reality
Neurodevelopmental disorders, such as Cerebral Palsy (CP), Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), are complex conditions that affect various aspects of children's development.
- Trial name
- NCT07426315
- Testing
- CAREN therapy, Conventional interventions
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Spinal Cord Injuries
Dosing of Overground Robotic Gait Training With Functional Outcomes and Neuroplasticity After Spinal Cord Injury
The DOOR SCI project examines dosing effects of robotic gait training (RGT) and transcranial magnetic stimulation (TMS) initiated during inpatient rehabilitation and continued through early outpatient rehabilitation
- Trial name
- DOORSCI (NCT05218447)
- Testing
- Robotic Gait Training, Usual Care (UC) Gait Training
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Baylor Research Institute