Clinical trials: Neuroplasticity
Stroke, Drop Foot
Pairing Functional Electrical Stimulation (FES) and Volitional Effort Training Promotes Neuroplasticity and Motor Gain
The goal of the study is to explore the effect of combined training involving functional electrical stimulation (FES) of the ankle dorsal flexor with simultaneous maximal-effort voluntary contraction of the same muscle to correct…
- Trial name
- NCT02797886
- Testing
- FES + VOL, FES, VOL
- Volunteers
- 45 people
- Sponsor
- Kessler Foundation
Cerebral Palsy
Brain Change After Fun, Athletic, Sports-skill Training (BeFAST)
The purpose of this study is to determine the associations between changes in neural activity and structure, advanced gross motor skills, gait characteristics, and physical activity participation following a gait-related…
- Trial name
- BeFAST (NCT02584491)
- Testing
- Functional gait-related training
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Spinal Cord Injury
Effects of System Suspended Robotic Lokomat Gait in Patients With Incomplete Spinal Cord Injury
Patients with incomplete spinal cord injury
- Trial name
- NCT02342080
- Testing
- Training sessions, Lokomat system (Hocoma AG Switzerland)
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo General Hospital
Amblyopia
Vision Therapy Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills
The primary objective of this study is to evaluate the effects of a personalized vision therapy programme tailored to baseline visual-cognitive abilities in treatment-resistant amblyopia.
- Trial name
- NCT07437807
- Testing
- Motor Free Perception Vision Test
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Okan University
TMJ Disorder
FMRI Study on DC/TMD Patients
Temporomandibular disorders (TMD) are among the most common causes of chronic pain worldwide. It is estimated that about 5-12% of the global population is affected, and some conditions, such as arthritis, may be causative…
- Trial name
- NCT07259902
- Testing
- fMRI
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Milan
Academic Anxiety, Test Anxiety
AVE-Neurofeedback for Academic Anxiety and Divergent Thinking
Academic anxiety is one of the most prevalent psychological challenges among adolescents and has been associated with impaired executive functioning, attentional control, autonomic dysregulation, and reduced creative performance.
- Conditions
- Academic Anxiety, Test Anxiety, Divergent Thinking
- Trial name
- AVE-NFB (NCT07745335)
- Testing
- Audiovisual Entrainment Neurofeedback (AVE-NFB), Neurofeedback Only, Audiovisual Entrainment
- Where
- 3 sites in Indonesia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Daniswara Raditya Suprapto
Attention Deficit Hyperactivity Disorder
Neuroplasticity Technology for Attention-deficit/Hyperactivity Disorder (ADHD)
This study evaluates the impact of computerized inhibitory control training on attention-deficit hyperactivity disorder (ADHD) symptoms and ADHD-linked neural signatures in children with ADHD.
- Trial name
- NCT03363568
- Testing
- Adaptive Inhibitory Control Training, Non-adaptive Inhibitory Control Training
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Boston Children's Hospital
Spinal Cord Injury (SCI)
Restoring Walking in Non-ambulatory Children With Severe Chronic Spinal Cord Injury (SCI) (Kids STEP Study)
The Kids STEP Study aims to 1. Determine if walking can be restored in children with incomplete SCI and little to no leg movement 2. Identify the neural pathways that permit recovery of walking
- Trial name
- NCT00488280
- Testing
- Locomotor Training
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Florida
Down Syndrome
Non-Invasive Brain Stimulation to Improve Language in Down Syndrome.
Down syndrome (DS) is associated with cognitive deficits, caused by alterations in neuroplasticity and synaptic transmission. Non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), can…
- Trial name
- NCT07044804
- Testing
- Active Group (Active Anodal tDCS to the left IFG or Cathodal tDCS to the left IFG)
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Floriana Costanzo
Perinatal Brain Injury
Neuro-MoD: Neuroplasticity With Motor Development
This study is for infants and toddlers between 8 and 24 months old who use one arm and/or hand differently following a perinatal brain injury.
- Trial name
- NCT07738432
- Testing
- Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Wisconsin, Madison
Anterior Cruciate Ligament Reconstruction, Anterior Cruciate Ligament Reconstruction Rehabilitation
Fractal vs Isochronous Cueing in Athletes After ACL Reconstruction
Anterior cruciate ligament (ACL) injuries are among the most prevalent and functionally limiting knee injuries in sports, particularly those that involve pivoting movements.
- Conditions
- Anterior Cruciate Ligament Reconstruction, Anterior Cruciate Ligament Reconstruction Rehabilitation, Athlete
- Trial name
- SyncGait (NCT07243535)
- Testing
- Fractal Cueing, Isochronous Cueing
- Where
- Portugal
- Volunteers
- 36 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Parkinson´s Disease
The Effect of High-Volume Walking With Visual Cues (VC) in Parkinson´s Disease (PD)
People with disease (PD) tend to walk with short steps, decreased velocity, and increased stride time variability. Short steps and increased variability are related to greater fall risk.
- Trial name
- NCT01391741
- Testing
- Visual Cues, Walking without visual cues
- Where
- Iceland
- Volunteers
- 26 people
- Sponsor
- University of Iceland
Dyslexia, Aging Problems
Neuroplasticity of Multisensory Cortical Areas Induced by Musical Training: a Translational Approach (MusicPlast)
Exploiting recent methodological advancements, several neuroimaging studies suggested that multisensory integration emerges from a dynamic interplay of distributed regions operating in large-scale networks.
- Trial name
- MusicPlast (NCT03786185)
- Testing
- MusicPlast, MusicPlast Control
- Where
- Greece
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Spinal Cord Injuries
Spinal Cord Stimulation and Training
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of…
- Trial name
- NCT05472584
- Testing
- Electrophysiology assessment - corticospinal tract, Electrophysiology assessment - reticulospinal tract, Electrophysiology assessment - spinal motoneuron
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Childhood Apraxia of Speech
Childhood Apraxia of Speech: Experience Dependent Changes Induced by Treatment
Childhood Apraxia of Speech (CAS) is a severe speech-language disorder whose aetiological, neuroanatomical correlates are largely unknown.
- Trial name
- CAS (NCT04832503)
- Testing
- PROMPT- treatment, LNSOM-treatment
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Fondazione Stella Maris
Cerebral Palsy
Effect of HABIT-ILE on the Body Function and Structures of Children With Cerebral Palsy
There is strong evidence that recent intensive interventions based on motor skill learning principles are efficient on functional and neuroplastic changes of children with cerebral palsy (CP).
- Trial name
- NCT04403490
- Testing
- HABIT-ILE, Conventional intervention
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Université Catholique de Louvain
Cerebral Palsy
BeFAST or BeSTRONG: Brain Change After Fun Athletic Sports-skill Training or Brain Change After Strength TRaining Focusing ON Gait
The purpose of this study is to compare a motor learning (ML)-based gait-related training intervention to a functional lower limb strength training intervention, with a concurrent evaluation of functional, neural and…
- Trial name
- NCT02754128
- Testing
- BeFAST, BeSTRONG
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
PARKINSON DISEASE (Disorder), Parkinson Disease (PD), Postural Balance
Telerehabilitation Versus Face-to-Face LSVT BIG in Individuals With Parkinson Disease
This prospective, randomized controlled trial will enroll 40 individuals with idiopathic PD (Hoehn \& Yahr stages 1-3, MoCA ≥21).
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson Disease (PD), Postural Balance, Parkinson Disease
- Trial name
- NCT07630792
- Testing
- Face-to-Face LSVT BIG, Telerehabilitation LSVT BIG
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Attention Deficit Hyperactivity Disorder
Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children
This randomized controlled trial will evaluate the effectiveness of neuroplasticity-targeted supplements on neuroinflammatory markers and ADHD symptoms in children aged 6 to 12 years diagnosed with Attention Deficit Hyperactivity…
- Trial name
- NCT07665658
- Testing
- Inulin, Probiotic, Omega-3 Fatty Acids
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Khyber Medical University Peshawar
Internet Gaming Disorder
Effect of Computer-Based Game and HIIT Towards Symptoms, Executive Function and Neuroplasticity in Teens with IGD
The goal of this clinical trial is to learn how effective a combined therapy of computer-based game and also high-intensity interval training (HIIT) physical exercise to improve the clinical symptoms, executive function and…
- Trial name
- NCT06582979
- Testing
- Computer-Based Game Therapy, High-Intensity Interval Training
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Universitas Indonesia