Clinical trials: Nitric Oxide
Fontan Operation
Pulmonary Functions Test in Patients After Fontan Operation
Developed in the early 1970s, Fontan Operation has provided palliative care for patients with single ventricle physiology. Single ventricle is a rare subclass of the atrioventricular (AV) alignment abnormalities double inlet and…
- Trial name
- NCT01413308
- Volunteers
- 15 people
- Sponsor
- Rambam Health Care Campus
Anemia, Sickle Cell
Effectiveness of Arginine as a Treatment for Sickle Cell Anemia
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited genetic disease that can cause intense pain episodes.
- Trial name
- Arginine (NCT00513617)
- Testing
- Arginine
- Where
- 17 sites in United States
- Volunteers
- 128 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Asthma
Measuring Exhaled Nitric Oxide (eNO) Using the Apieron INSIGHT System and the Aerocrine NIOX System
Collection of quantitative data to demonstrate the accuracy (bias) and precision (repeatability) of the Apieron INSIGHT(tm) eNO Breath System as compared to the FDA cleared NIOX eNO Breath System when testing is performed by…
- Trial name
- NCT00739531
- Testing
- Exhaled nitric oxide (eNO)
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Apieron
Asthma in Children
Pulmonary Rehabilitation Combined With Speleotherapy in Children With Bronchial Asthma
The goal of this retrospective study is to learn about the effects of rehabilitation and treatment stays combined with speleotherapy in children with asthma.
- Trial name
- NCT06557824
- Testing
- speleotherapeutic intervention
- Where
- Poland
- Volunteers
- 415 people
- Sponsor
- University School of Physical Education, Krakow, Poland
Prematurity, Anemia
Transfusions and Nitric Oxide Level in Preterm Infants
The purpose of this study is to better understand S-nitrosohemeglobin (SNO-Hb) in transfused blood of extremely preterm infants.
- Conditions
- Prematurity, Anemia, Necrotizing Enterocolitis
- Trial name
- NCT00787124
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Pulmonary Arterial Hypertension
Long-Term Extension Study of Inhaled Nitric Oxide (iNO) for PAH
An Open-Label Long-Term Safety Study of Inhaled Nitric Oxide (iNO) for Pulmonary Arterial Hypertension (PAH)
- Trial name
- NCT02652429
- Testing
- Inhaled Nitric Oxide
- Where
- 17 sites in United States, Canada
- Volunteers
- 22 people
- Sponsor
- Bellerophon Pulse Technologies
Asthma, Allergic Rhinitis
Fractional Exhaled Nitric Oxide (FeNO) Result Prediction Factors in Children With Allergic Diseases
In about 800 children with allergic diseases (asthma, allergic rhinitis, atopic dermatitis) the investigators will retrospectively and cross-sectionally analyze the influence/correlation of diagnosis, treatment methods, allergy…
- Conditions
- Asthma, Allergic Rhinitis, Atopic Dermatitis
- Trial name
- NCT00815984
- Testing
- measurements of lung function tests
- Where
- Poland
- Volunteers
- 800 people
- Sponsor
- Medical University of Lodz
Asthma, Chest Syndrome
Clinical Characteristics, Treatment and Prognosis of Chest Tightness Variant Asthma
Asthma, abbreviation for bronchial asthma, is one of the common chronic airways disease that threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually…
- Conditions
- Asthma, Chest Syndrome, Clinical Anxiety, Clinical Depression
- Trial name
- NCT03237221
- Testing
- Treat patient according to Global Initiative for Asthma (GINA) guideline
- Where
- 34 sites in China
- Volunteers
- 76 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Asthma, Allergic Rhinitis
PF and FeNO and Clinical Characteristics in Children Being Diagnosed Due to Suspicion of Allergic Diseases
The aim of this study is to assess the influence of kind of allergic disease, allergic profile, allergen exposure, treatment method on lung function parameters, fractional exhaled nitric oxide level in children suspected and…
- Conditions
- Asthma, Allergic Rhinitis, Atopic Dermatitis, Urticaria
- Trial name
- NCT01805635
- Testing
- No intervention
- Where
- Poland
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Adipose Tissue, Brown, Glucose Intolerance
L-arginine and Brown Adipose Tissue
The South Asian population is facing an epidemic of type 2 diabetes, of which the underlying cause is still unknown. It is currently hypothesized that an ethnic susceptibility towards a disturbed energy metabolism may underlie…
- Conditions
- Adipose Tissue, Brown, Glucose Intolerance, Nitric Oxide
- Trial name
- ArgMB (NCT02291458)
- Testing
- L-arginine
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pulmonary Hypertension
NO Need to Ventilate: A Trial of Non-invasive Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn
The primary objective of the trial is to determine the feasibility and clinical safety and efficacy of non-invasive inhaled nitric oxide in infants with PPHN without significant pulmonary +-parenchymal disease who would normally…
- Trial name
- NCT00139217
- Testing
- iNO, Non-invasive nitric oxide
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Emory University
Postural Tachycardia Syndrome
Local Vasoconstriction in Postural Tachycardia Syndrome
The investigators study will determine how often blood flow regulation abnormalities and abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and oxidative stress occur in POTS and the mechanism(s) of…
- Trial name
- NCT01210430
- Testing
- Losartan, Ascorbic Acid (Vitamin C), Normal Saline
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Asthma
The Use of Exhaled Nitric Oxide in Conjunction With the Asthma Control Test to Determine Asthma Control in Pediatric Patients
The purpose of this study is to determine if exhaled nitric oxide (eNO) levels will be increased in pediatric patients with uncontrolled asthma as determined by the Asthma Control Test (ACT).
- Trial name
- NCT00575445
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Akron Children's Hospital
Leukemia, Non Hodgkin Lymphoma
Evaluation of the Analgesy With Emla and/or Nitrous Oxide in Pediatric Patients for Lumbar Puncture
In this randomised controlled study the investigators intended to compare the analgesic effects of EMLA and\or nitrous oxide in children submitted to lumbar puncture.
- Trial name
- NCT00808171
- Testing
- Livopan, EMLA
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Persistent Pulmonary Hypertension of the Newborn, Inhaled Nitric Oxide
Close Loop Smart Weaning for INO With PPHN
In contemporary clinical practice concerning the administration of inhaled nitric oxide (iNO) within neonatal intensive care units (NICUs), a stepwise reduction approach is frequently employed in accordance with established…
- Trial name
- NCT06832163
- Testing
- Nitric Oxide Generation and Delivery System
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Fudan University
Pulmonary Hypertension
Inhaled Aerosolized Prostacyclin for Pulmonary Hypertension Requiring Inhaled Nitric Oxide
Acute secondary pulmonary hypertension (PH) often leads to dysfunction of the right ventricle (RV) and can be a significant cause of patient morbidity and mortality.
- Trial name
- NCT02170519
- Testing
- Inhaled Iloprost
- Volunteers
- 27 people
- Sponsor
- Duke University
Asthma
The Use of Fractional Exhaled Nitric Oxide in the Identification of Non-adherence in Difficult Asthma
Asthma usually responds to standard doses of inhaled steroids with or without additional therapies to control their symptoms. However, approximately 5-10% do not respond to this treatment strategy and are referred to as having…
- Trial name
- NCT01219036
- Testing
- Budesonide (directly observed)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Liam Heaney
Pain Crisis
Natural History of Sickle Cell Disease
This study is not a treatment protocol and no experimental treatments are involved. Study participants may be seen as needed for clinical, translational and basic research studies, or as medically indicated.
- Trial name
- NCT00081523
- Where
- 3 sites in United States
- Volunteers
- 3,500 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma
Use of fenoTRACK Device for Monitoring Changes of Fractional Exhaled Nitric Oxide (FeNO) in Uncontrolled Asthma Subjects and Controlled Asthma Subjects
This study incorporates objectives directed at two subject cohorts: 1. Uncontrolled Adult and Pediatric Asthma Subjects: To demonstrate a statistically significant and clinically meaningful decline in Point Of Care (POC) FeNO as…
- Trial name
- NCT07228026
- Testing
- fenoTRACK Device
- Where
- 13 sites in United States
- Volunteers
- 160 people
- Sponsor
- Biometry Inc
Cornea, Anesthesia; Reaction
The Effects of Nitrogen Protoxide and Oxygen on Corneal Endothelial in Pediatric Patients
To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.
- Trial name
- NCT03006211
- Testing
- Nitrogen protoxide, Oxygen
- Volunteers
- 40 people
- Sponsor
- Inonu University