Clinical trials: Nitric Oxide
Cervical Spondylosis
Effect of Cupping Therapy on Nitric Oxide Level in Patients With Cervical Spondylosis
this study will be conducted to investigate the effect of cupping therapy on the nitric oxide level in patients with cervical spondylosis
- Trial name
- CT (NCT06271525)
- Testing
- cupping therapy
- Volunteers
- 60 people
- Sponsor
- Shady Abdelsattar Refaat
Peripheral Arterial Disease
Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease
The purpose of this study is to determine the long-term effects of statins, atorvastatin, upon Nitric Oxide, as an endothelial function assessment, and C-Reactive Protein, an inflammatory marker, levels in patients with…
- Trial name
- NCT01041729
- Testing
- Atorvastatin, Standard Medical Treatment
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Getafe
Asthma
Zileuton and Exhaled Nitric Oxide in Asthmatics
Evaluate the additive role of zileuton 600mg qid to clinically stable asthmatics on Advair 250/50 bid. Since asthma is an endogenous inflammatory disease there usually is increased total exhaled, bronchial and alveolar nitric…
- Trial name
- NCT00575861
- Testing
- zileuton
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Gelb, Arthur F., M.D.
Asthma, Asthma in Children
Diagnostic and Translational Values of Point-of-care Blood Eosinophils and Exhaled Nitric Oxide (FeNO) in People Referred by Primary Care for Suspected Asthma
Asthma is characterised by episodic symptoms (attacks) caused by airway inflammation and decreased airflow to the lungs. It affects 10% of the Canadian population and is the most common chronic disease in childhood.
- Conditions
- Asthma, Asthma in Children, Diagnosis, Inflammation
- Trial name
- DIVE (NCT05992519)
- Testing
- ¸FeNO
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- Université de Sherbrooke
Rhinitis, Asthma
Airway Inflammation and Bronchial Hyperresponsiveness in Rhinitic Children With or Without Asthma
This is a prospective observational study , to clarity the characteristics of airway inflammation, airway reactivity and airway resistance in rhinitic children with or without asthma and to explore the possible predictors in the…
- Conditions
- Rhinitis, Asthma, Inflammation, Hypersensitivity
- Trial name
- NCT02360072
- Where
- China
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Metastatic Non-small Cell Lung Cancer
Pilot Study of the Contribution of Fractional Exhaled Nitric Oxide as a Prognostic Marker of Response to Anti-PD-L1 Immunotherapy in Non-small Cell Lung Cancer
Based on the use of the patient's natural defences, immunotherapy mobilizes the immune system to recognize and destroy cancer cells, and it has revolutionized the treatment of lung cancer.
- Trial name
- FENOTYPE (NCT05985330)
- Testing
- Measurement of FeNO
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Congenital Heart Defect
The Effects of Inhaled Nitric Oxide After Fontan Operation
Pleural effusions continue to be a post-operative complication seen after Fontan operation. This study will examine the use inhaled nitric oxide (iNO) given for 54 hours after Fontan operation to improve fluid balance.
- Trial name
- NCT00945529
- Testing
- inhaled nitric oxide (iNO)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Ellen Spurrier
Pulmonary Hypertension
Inhaled Aerosolized Prostacyclin for Pulmonary Hypertension Requiring Inhaled Nitric Oxide
Acute secondary pulmonary hypertension (PH) often leads to dysfunction of the right ventricle (RV) and can be a significant cause of patient morbidity and mortality.
- Trial name
- NCT02170519
- Testing
- Inhaled Iloprost
- Volunteers
- 27 people
- Sponsor
- Duke University
Cognition Disorders in Old Age, Cognitive and Behavioral Impairment
Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients
This study aims to evaluate the effect of L-arginine supplementation on cognitive function in geriatric patients. Eligible participants will receive either L-arginine (6 grams once daily) or placebo, and their cognitive…
- Trial name
- NCT07338682
- Testing
- L-Arginine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- German University in Cairo
Dementia
Use of MEOPA (Equimolar Mixture of Nitrogen Protoxide and Oxygen) for Elderly With Dementia
Acute pain is frequent in elderly especially in geriatrics acute care units where painful procedures are often occurring. MEOPA represents an alternative to opioïd therapy to prevent procedural pain during the treatment of…
- Trial name
- NCT00822224
- Testing
- MEOPA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pain Crisis
Natural History of Sickle Cell Disease
This study is not a treatment protocol and no experimental treatments are involved. Study participants may be seen as needed for clinical, translational and basic research studies, or as medically indicated.
- Trial name
- NCT00081523
- Where
- 3 sites in United States
- Volunteers
- 3,500 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma
Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks
This observational study compares the phenotypic variability (clinical and biological) in treatment response to systemic corticosteroids according to the blood eosinophil count and FeNO in physician-diagnosed ≥12-year-old…
- Trial name
- PRISMA (NCT05870215)
- Testing
- Visit 1: Clinical exam and questionnaires, Visit 1: Respiratory physiology, Visit 1: Inflammometry
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Systemic Sclerosis
Nitric Oxide Lung Diffusing Capacity in Systemic Sclerosis
To date, two devices to measure nitric oxide lung diffusing capacity (DLNO) are commercially available in Europe. Previous research has shown systematic between-device differences in lung diffusing capacity outcomes in healthy…
- Trial name
- NCT05505617
- Testing
- Single-breath nitric oxide lung diffusing capacity measurements according to type of device in random order.
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- Holger Dressel
Asthma
Improvement of FeNO and FEF25-75 After Inhaled Corticosteroid Treatment of Asthma
Abnormal lung function and high exhaled nitric oxide (FeNO) have been reported in asymptomatic patients with asthma. The investigators aimed to assess whether FeNO and FEF25-75 improve concurrently after treatment with inhaled…
- Trial name
- NCT01340118
- Testing
- Budesonide
- Where
- South Korea
- Volunteers
- 93 people
- Sponsor
- Chungbuk National University
Blood Pressure, Endothelial Dysfunction
Effect of Inorganic Nitrate Supplement on Blood Pressure
The primary purpose of this project is to assess the efficacy (effectiveness) of plant-based nitrate tablets to elevate nitric oxide in your system as measured by saliva and effect on lowering blood pressure (BP), supporting…
- Trial name
- NCT03909789
- Testing
- Plant based bioequivalent Nitrate supplementation
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Cystic Fibrosis, Pulmonary Fibrosis
Role of Genetic Factors in the Development of Lung Disease
This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease.
- Conditions
- Cystic Fibrosis, Pulmonary Fibrosis, Tuberous Sclerosis, Asthma
- Trial name
- NCT00001532
- Where
- 2 sites in United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pre-Eclampsia, Pregnacy
Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies
Pre-eclampsia is a serious condition that typically affects pregnant women after the 20th week of pregnancy, characterized by high blood pressure and damage to organs such as the kidneys and liver.
- Trial name
- BEET_PE (NCT06387784)
- Testing
- Beetroot juice
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Hypertension
Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduction in vascular oxidative…
- Trial name
- NCT01501929
- Testing
- Metoprolol succinate, Nebivolol, Non-invasive measurement of Cardiac Output (CO)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Tuberculosis, HIV
Arginine as an Adjuvant Treatment Against Tuberculosis
The purpose of this study was to investigate if adjuvant treatment with arginine (the substrate for nitric oxide production) rich food supplements could improve clinical outcome in patients with smear positive tuberculosis by…
- Trial name
- NCT00857402
- Testing
- Peanuts, Daboqolo
- Where
- Ethiopia
- Volunteers
- 180 people
- Sponsor
- Linkoeping University