Clinical trials: Nitrous Oxide
Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction
Combination of Nitrous Oxide 70% With Fentanyl Intranasal for Procedural Analgosedation in Children
This study analyzes the analgesic efficacy and adverse events of nitrous oxide 70% combined with basic analgetics compared to nitrous oxide 70% with fentanyl intranasal for analgosedation for short and painful procedures in…
- Conditions
- Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction, Pain
- Trial name
- NCT02533908
- Testing
- Fentanyl intranasal, NaCl 0.9% intranasal
- Where
- Switzerland
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Conscious Sedation
Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children
The purpose of this study is to compare the safety and efficacy of sedation using orally administered midazolam and promethazine with nitrous oxide/oxygen in uncooperative children receiving dental treatments.
- Trial name
- NCT01118884
- Testing
- Promethazine
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Anxiety
High-Concentration Nitrous Oxide for Dental Procedural Sedation in Children
The use of nitrous oxide as a sedative agent is very common in pediatric dentistry. In concentrations up to 50% it is considered as mild sedation and it is very safe.
- Trial name
- NCT02886351
- Testing
- Nitrous Oxide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Local Anesthetic Efficacy
Effectiveness of Nitrous Oxide 50% for Reducing Pain and Distress Associated with Needle-stick in Children
Venipuncture (puncturing of a vein) through the skin in order to insert a vein catheter (also know as cannula) is one of the most common needle-related medical procedures performed in children.
- Trial name
- NCT03342079
- Testing
- Local Anesthetics,(lidocaine 70 mg/tetracaine 70 mg topical patch; Synera)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Opioid-Related Disorders, Substance-Related Disorders
Effects of Combined Alcohol and Nitrous Oxide Intake - 15
The purpose of this study is to determine the effects of combined alcohol and nitrous oxide intake on mood, psychomotor performance, and the pain response in healthy volunteers.
- Trial name
- NCT00000263
- Testing
- 30% Nitrous oxide, 0.25 g/Kg ethanol, 0.5 g/KG ethanol
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Behavior, Child, Anxiety, Dental
Virtual Reality in Pediatric Dentistry
Dental Fear and Anxiety is an emotional experiences affecting many children and adolescents which can lead to behavioral problems in the dental setting.
- Trial name
- NCT05585905
- Testing
- Virtual Reality, Basic Behavior Guidance Techniques
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Labor Pain
Inhaled Nitrous Oxide and Labor Analgesia
Hypothesis: The administration of nitrous oxide for labor analgesia will decrease the labor epidural anesthesia rate by 15%. Specific Aim: To determine if nitrous oxide can be an effective alternative technique for the provision…
- Trial name
- NCT01738672
- Testing
- Inhaled nitrous oxide
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ya'aqov Abrams
Dental Anxiety
Effectiveness of Children Experiencing Nitrous Oxide/Oxygen Inhalation Sedation at an Assessment Visit Before Having Treatment.
The purpose of this study is to find out the effect of experience of dental sedation at assessment on children's anxiety before the actual treatment session.
- Trial name
- NCT06056492
- Testing
- Experience of nitrous oxide sedation at assessment
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr Richard Balmer
Anesthesia
Mixture Nitrous Oxide - Oxygen 50-50% in Transrectal Prostate Biopsy Guided by Ultrasound
Introduction: Transrectal ultrasound-guided prostate biopsy (TUPB) is the gold standard diagnostic tool for prostate cancer and, though may be well tolerated for some patients, about 65 to 90% of then still complain of…
- Trial name
- NCT02899182
- Testing
- Nitrous Oxide NO, O2
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Clinical Anxiety, Clinical Cooperation
Comparison of Effect of Nitrous Oxide-Oxygen Conscious Sedation and Cognitive-behavioral Therapy on Children's Anxiety in Dentistry
Visiting anxious and fearful children is an inevitable prospect of the daily work of every dentist who treats pediatric patients.
- Trial name
- NCT02024594
- Testing
- Nitrous Oxide-Oxygen conscious sedation, cognitive-behavioral therapy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Behavior, Child
Oral Sedation With and Without Nitrous Oxide
Aims: The objective of the current study was to evaluate the effectiveness of oral midazolam-hydroxyzine with/without nitrous oxide. Design: This was a randomized split mouth, cross over and triple-blinded clinical study.
- Trial name
- NCT03728894
- Testing
- Midazolam-hydroxyzine with 100% O2, Midazolam-hydroxyzine with 50% N2O/O2
- Where
- Syria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Latakia University
Pain Alleviation, Dilatation and Evacuation
Use of Nitrous Oxide for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Dilatation and Evacuation
A randomised control study aiming to examine whether inhaled N2O/O2 during cervical preparation for second trimester dilatation and evacuation with osmotic dilators (laminaria) alleviates pain and is superior to placebo.
- Conditions
- Pain Alleviation, Dilatation and Evacuation, Laminaria Placement, Nitrous Oxide
- Trial name
- NCT05579288
- Testing
- Nitrous oxide (N2O/O2), Oxygen (O2)
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Dental Anxiety in Children, Child Behaviour
Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide Monotherapy
The rationale of this trial is to evaluate whether combining intranasal atomized midazolam with nitrous oxide offers better behavior management leading to successful treatment completion in comparison with using nitrous oxide…
- Trial name
- NCT07876024
- Testing
- Midazolam (Intranasal), Nitrous oxide/oxygen inhalation sedation alone
- Where
- Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Cannulation, Sevoflurane Induction
Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication
Inhalational induction with sevoflurane, nitrous oxide, and oxygen is accepted as a safe technique to avoid any movement during intravenous cannulation in children.
- Conditions
- Cannulation, Sevoflurane Induction, Dexmedetomidine
- Trial name
- NCT05139212
- Testing
- Optimum time for intravenous cannulation in children premedicated with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Pneumoperitoneum
CO2 Absorption During Laparoscopy
CO2 absorption from the pneumoperitoneum increases over time during laparoscopic procedures. Adding 4% of oxygen to the carbon dioxide was shown in rabbits to decrease CO2 resorbtion through prevention of mesothelial hypoxia.
- Trial name
- NCT01340989
- Testing
- alteration of the insufflation gas, full conditioning, standard pneumoperitoneum
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Contraception
Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion
The purpose of this study is to determine whether Nitrous Oxide is effective in achieving pain control and satisfaction among nulliparous women getting the intrauterine device (IUD).
- Trial name
- NIUD (NCT02391714)
- Testing
- IUD insertion, Povidone-Iodine, Chlorhexidine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Glaucoma, Intraocular Pressure
The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops
Pediatric glaucoma is a rare but potentially blinding condition where the pressure in the eye is too high. Diagnosis is based on intraocular pressure (IOP) and assessment of the optic nerve, cornea and other structures.
- Conditions
- Glaucoma, Intraocular Pressure, Anesthesia
- Trial name
- IOP (NCT01925391)
- Testing
- Tono-pen XL Applanation tonometer + Ocu-film +
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Miami
Contraceptive Devices, Long-Acting Reversible Contraception
Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women
This pilot study aims to assess the feasibility, acceptability, and effectiveness of using nitrous oxide (N2O) sedation for intrauterine device (IUD) insertions for nulliparous adolescent and young adult women in a primary care…
- Conditions
- Contraceptive Devices, Long-Acting Reversible Contraception, Analgesia, Adolescent Health
- Trial name
- NCT04089852
- Testing
- Nitrous oxide gas for inhalation, Oxygen Gas for Inhalation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Dental Carie; Orthodontics
Adverse Event Risk Assessment in the Use of Nitrous Oxide for Pediatric Dental Patients
The objective was to assess adverse event risk in the use of Nitrous Oxide for Pediatric Dental Patients. The investigators performed a multicenter observational study.
- Trial name
- NCT02909816
- Where
- France
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Laceration, Abscess
Nitrous Oxide Use in Minor Procedures
Title: High-concentration continuous flow nitrous oxide use for procedural-induced pain or anxiety during pediatric minor procedures.
- Trial name
- NCT01911351
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation