Clinical trials: Nitrous Oxide
Dental Anxiety
Effectiveness of Children Experiencing Nitrous Oxide/Oxygen Inhalation Sedation at an Assessment Visit Before Having Treatment.
The purpose of this study is to find out the effect of experience of dental sedation at assessment on children's anxiety before the actual treatment session.
- Trial name
- NCT06056492
- Testing
- Experience of nitrous oxide sedation at assessment
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr Richard Balmer
Pediatric Dentistry
Virtual Reality and Anxiety in Pediatric Dentistry
Two groups of pediatric patients between the ages of 4 to 12 years old will be examined in this study. The treatment group will receive dental treatment while wearing Virtual reality Headset.
- Trial name
- NCT04886141
- Testing
- Virtual Reality Headset
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Geisinger Clinic
Nitrous Oxide Abuse
Biological Diagnosis and Monitoring of Chronic Nitrous Oxide Abuse
There is a toxicity linked to the chronic use of nitrous oxide, leading to neurological disorders such as combined sclerosis of the spinal cord.
- Trial name
- BALON (NCT05540561)
- Testing
- blood collection
- Where
- 8 sites in France
- Volunteers
- 356 people
- Sponsor
- University Hospital, Lille
Nitrous Oxide Abuse, Subacute Combined Cord Degeneration
Neurological Recovery Following NOS-SACD
Nitrous oxide has become an increasingly popular recreational drug amongst young people, particularly at festivals, nightclubs and parties.
- Conditions
- Nitrous Oxide Abuse, Subacute Combined Cord Degeneration, Neurologic Symptoms, Paresthesia
- Trial name
- NCT05714917
- Testing
- Observational study with no interventions
- Where
- 3 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Exposure to Environmental Pollution, Adverse Effect of Unspecified General Anesthetic
Anesthetic Gas Leakage in Children During Tonsillectomy: a Comparison of Cuffed and Uncuffed Tracheal Tubes
Fires and operating room pollution may occur when anesthesia gases leak into the oropharynx during airway surgery. Investigators sought to measure the concentrations of anesthetic gases that leak into the mouth of children…
- Trial name
- NCT02725164
- Testing
- oxygen concentration, nitrous oxide concentration, carbon dioxide concentration
- Volunteers
- 31 people
- Sponsor
- State University of New York at Buffalo
Migraine, Pain
Nitrous Oxide for Acute Migraine Pain in the Emergency Room (ED)
BACKGROUND Migraine headaches account for 8-18% of all headaches seen in pediatric emergency rooms. Standard treatment includes IV pain medications, anti-emetics, and IV fluids.
- Trial name
- NCT01287052
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Periodontal Disease
Study Aimed at Detecting Potential Abuse of Nitrous Oxide in Children During Dental Care
The aim of this study is to evaluate the potential risk of abusive behavior for children in care using nitrous oxide for dental care.
- Trial name
- MEOPAeDent (NCT02894463)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Nantes University Hospital
Pain, Acute, Child, Only
Use of the Equimolar Mixture of Oxide Nitrous and Oxygen (EMONO) Associated With Audiovisuals in Children
Children experience numerous painful experiences from nursing procedures: peripheral venous access placement is the main cause of procedural pain.
- Conditions
- Pain, Acute, Child, Only, Nurse's Role, Nitrous Oxide
- Trial name
- EMONO (NCT05435118)
- Testing
- EMONO + audiovisuals tool
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lodi
Neuropathy
Neurological Impairment in a Young Population Exposed to Recreational Nitrous Oxide
Nitrous oxide (N2O) is a colorless, flammable, analgesic gas used in surgery and dentistry. The consumption of N2O has increased among young French people aiming to relax because of its short-lived neuropsychological effect…
- Trial name
- N2O (NCT05469321)
- Testing
- None, pure observationnal study
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Adult Disease
Time - Related Cuff Pressure and Volume of the Laryngeal Tube With the Use of Nitrous Oxide
The purpose of this study is to investigate the time-related intracuff pressure and volume change (which reflects the pharyngeal pressure) of the LT during anesthesia with N2O.
- Trial name
- NCT01346384
- Testing
- laryngeal tube (VBM Medizintechnik)
- Where
- Thailand
- Volunteers
- 75 people
- Sponsor
- Prince of Songkla University
Cornea, Anesthesia; Reaction
The Effects of Nitrogen Protoxide and Oxygen on Corneal Endothelial in Pediatric Patients
To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.
- Trial name
- NCT03006211
- Testing
- Nitrogen protoxide, Oxygen
- Volunteers
- 40 people
- Sponsor
- Inonu University
Pediatric Dentistry
Virtual Reality vs Nitrous Oxide in Pediatric Dentistry
Two groups of pediatric patients between the ages of 4 to 12 years old will be examined in this study. Control group will receive the standard of care dental treatment with under nitrous sedation (N2O) and will have a second…
- Trial name
- NCT05890898
- Testing
- Virtual Reality Headset, Nitrous Oxide
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Geisinger Clinic
Pneumoperitoneum
Comparing Nitrous Oxide and Carbon Dioxide for Laparoscopic Cholecystectomy
There is no general agreement about the ideal gas for pneumoperitoneum. CO2, now in common use, has not compared to N2O sufficiently to disclose which one has minimal "physiological" invasiveness characters.
- Trial name
- NCT01512511
- Testing
- nitrous oxide use for pneumoperitoneum creation
- Where
- Iran
- Volunteers
- 64 people
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Anesthesia
Mixture Nitrous Oxide - Oxygen 50-50% in Transrectal Prostate Biopsy Guided by Ultrasound
Introduction: Transrectal ultrasound-guided prostate biopsy (TUPB) is the gold standard diagnostic tool for prostate cancer and, though may be well tolerated for some patients, about 65 to 90% of then still complain of…
- Trial name
- NCT02899182
- Testing
- Nitrous Oxide NO, O2
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Clinical Anxiety, Clinical Cooperation
Comparison of Effect of Nitrous Oxide-Oxygen Conscious Sedation and Cognitive-behavioral Therapy on Children's Anxiety in Dentistry
Visiting anxious and fearful children is an inevitable prospect of the daily work of every dentist who treats pediatric patients.
- Trial name
- NCT02024594
- Testing
- Nitrous Oxide-Oxygen conscious sedation, cognitive-behavioral therapy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Dental Anxiety, Pain
Nitrous Oxide Prior to Intranasal Midazolam for Moderate Dental Sedation in Pediatric Patients
The purpose of this study is to assess the effectiveness of nitrous oxide/oxygen administration in reducing the discomfort of intranasal midazolam administration for moderate sedation for dental procedures.
- Trial name
- NCT04083105
- Testing
- Nitrous Oxide, Midazolam
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Hospital Colorado
Vomiting
Preprocedural Fasting and Nitrous Oxide -Oxygen Inhalation Analgesia for Dental Treatment of Children
Nitrous oxide analgesia is used routinely for the dental treatment of anxious or uncooperative pediatric patients. In many instances it is used alone without any supplemental oral premedication.
- Trial name
- NCT00263289
- Testing
- preprocedural fasting
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Behavior, Child
Oral Sedation With and Without Nitrous Oxide
Aims: The objective of the current study was to evaluate the effectiveness of oral midazolam-hydroxyzine with/without nitrous oxide. Design: This was a randomized split mouth, cross over and triple-blinded clinical study.
- Trial name
- NCT03728894
- Testing
- Midazolam-hydroxyzine with 100% O2, Midazolam-hydroxyzine with 50% N2O/O2
- Where
- Syria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Latakia University
Pain Alleviation, Dilatation and Evacuation
Use of Nitrous Oxide for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Dilatation and Evacuation
A randomised control study aiming to examine whether inhaled N2O/O2 during cervical preparation for second trimester dilatation and evacuation with osmotic dilators (laminaria) alleviates pain and is superior to placebo.
- Conditions
- Pain Alleviation, Dilatation and Evacuation, Laminaria Placement, Nitrous Oxide
- Trial name
- NCT05579288
- Testing
- Nitrous oxide (N2O/O2), Oxygen (O2)
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Dental Anxiety in Children, Child Behaviour
Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide Monotherapy
The rationale of this trial is to evaluate whether combining intranasal atomized midazolam with nitrous oxide offers better behavior management leading to successful treatment completion in comparison with using nitrous oxide…
- Trial name
- NCT07876024
- Testing
- Midazolam (Intranasal), Nitrous oxide/oxygen inhalation sedation alone
- Where
- Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University