Clinical trials: Nitrous Oxide
Labor Pain
Comparing Sedara to Butorphanol in Early Labor
Nitrous oxide (N2O) has been used for the treatment of labor pains for over 150 years. The longevity of its use in clinical practice can be attributed to its excellent safety profile, ease of administration, and familiarity of…
- Trial name
- NCT01636999
- Testing
- 50% Nitrous Oxide/50% Oxygen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- West Penn Allegheny Health System
Anesthesia, Pain
Nitrous Oxide Neuroimaging
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide.
- Conditions
- Anesthesia, Pain, Amnesia
- Trial name
- NONI (NCT06702631)
- Testing
- Nitrous oxide, Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Sedation
Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation
This is a clinical trial of propofol and alfentanil as agents for moderated procedural sedation in patients undergoing sedation in the emergency department (ED).
- Trial name
- NCT00997126
- Testing
- Propofol, Alfentanil
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Hennepin Healthcare Research Institute
Bipolar Disorder
Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder
This study is a 7-day randomized, double-blind proof-of-concept pilot study of nitrous oxide vs. midazolam in 40 adults (20-60 years) with bipolar disorder (BD) (type I or II).
- Trial name
- NCT02351869
- Testing
- Nitrous Oxide, Midazolam
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sunnybrook Health Sciences Centre
Opioid-Related Disorders, Substance-Related Disorders
Effects of Behavioral Contingencies on Effects of Nitrous Oxide - 12
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000260
- Testing
- Nitrous oxide
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Pain
Nitrous Oxide for Analgesia During Colonoscopy
The purpose of the study is to determine the analgetic effect of nitrous oxide during colonoscopy, compared to no sedation and intravenous (IV) sedation.
- Trial name
- NCT00318825
- Testing
- Nitrous oxide
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Rikshospitalet University Hospital
Labor Pain
Virtual Reality Compared to Nitrous Oxide for Labor Analgesia
The purpose of this study is to determine if non-invasive distracting devices (Virtual Reality headsets) are non-inferior to conventional therapy (nitrous oxide) for addressing maternal needs during labor who desire non-epidural…
- Trial name
- NCT04749043
- Testing
- Oculus Quest 2 Virtual Reality Device, Nitrous oxide
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brendan Carvalho
Coronary Disease, Myocardial Ischemia
Nitric Oxide Inhalation Therapy to Relieve Chest Pain in Patients With Coronary Artery Disease
This study will test whether inhaling nitric oxide gas can improve blood flow to the heart, ventricular function, exercise tolerance in patients with coronary artery disease and chest pain that has not improved with medical or…
- Trial name
- NCT00014040
- Testing
- Nitric Oxide and INOpulse Delivery System
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obsessive-Compulsive Disorder
Efficacy of Nitrous Oxide in OCD: Pilot Study
This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.
- Trial name
- NCT03826693
- Testing
- Nitrous Oxide, Nitrogen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Dental Anxiety
Modification of Blood Pressure Levels and Oxygen Saturation in Patients Undergoing Conscious Sedation
The objective is to compare the changes produced in cardiological and respiratory parameters in three groups of patients undergoing oral surgery.
- Trial name
- NCT03789942
- Testing
- Oral surgery
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Clinica Luis Ortiz
Dental Anxiety
The Impact of Nitrous Oxide Sedation on Dental Fear and Anxiety Scores in Children Aged 6-10 Years
Dental anxiety (DA) is highly prevalent among children undergoing dental procedures, with 50-80% experiencing fear that disrupts treatment and exacerbates oral health outcomes.
- Trial name
- N₂O (NCT07384988)
- Testing
- Nitrous Oxide Sedation, psychological support
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shaoxing Maternity and Child Health Care Hospital
Emergence Reaction, Procedural Sedation
Inhaled Nitrous Oxide for the Prevention of Emergence Reaction During Ketamine Administration in Adults, a Pilot Study
To describe the safety and efficacy of nitrous oxide during ketamine administration for the prevention of emergence reaction during Emergency Department procedural sedation and analgesia in adults.
- Trial name
- NCT02145169
- Testing
- Inhaled Nitrous Oxide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Albert Einstein Healthcare Network
Contraception
Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion
The purpose of this study is to determine whether Nitrous Oxide is effective in achieving pain control and satisfaction among nulliparous women getting the intrauterine device (IUD).
- Trial name
- NIUD (NCT02391714)
- Testing
- IUD insertion, Povidone-Iodine, Chlorhexidine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Opioid-Related Disorders, Substance-Related Disorders
Subjective/Psychomotor/ Effects of Combined Alcohol & Nitrous Oxide - 16
The purpose of this study is to examine the subjective, psychomotor, and reinforcing effects of combined alcohol and nitrous oxide intake in healthy volunteers.
- Trial name
- NCT00000264
- Testing
- 30% Nitrous oxide, 0.35 g/Kg ethanol, 0.7 g/Kg ethanol
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Barrett Esophagus, Intestinal Metaplasia
Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE)
A multicenter, prospective, single arm, non randomized clinical trial to evaluate the safety and efficacy of the C2 CryoBalloon Focal Ablation System (CbFAS) for the treatment of persistent dysplasia or intestinal metaplasia (IM)…
- Conditions
- Barrett Esophagus, Intestinal Metaplasia, Esophageal Dysplasia
- Trial name
- NO FEAR-BE (NCT03554356)
- Testing
- CryoBalloon Focal Ablation System
- Where
- 11 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Pain
Efficacy of Premixed Nitrous Oxide and Oxygen in Patient With Out-of-hospital Moderate Acute Pain
Less than 10% of patients with a traumatic pain have been managed by a physician before to be admitted in an emergency service. 50 % of those patients have been carried by paramedics.
- Trial name
- MEOPA (NCT01356745)
- Testing
- Premixed 50% nitrous oxide and oxygen (Kalinox), medical air
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Fibromyalgia, Central Neuropathic Pain
Nitrous Oxide as Treatment for Fibromyalgia
The purpose of this study is to explore a potential role of nitrous oxide in treating pain associated with fibromyalgia.
- Trial name
- NCT05357066
- Testing
- Nitrous oxide gas for inhalation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Behavior, Child, Anxiety, Dental
Virtual Reality in Pediatric Dentistry
Dental Fear and Anxiety is an emotional experiences affecting many children and adolescents which can lead to behavioral problems in the dental setting.
- Trial name
- NCT05585905
- Testing
- Virtual Reality, Basic Behavior Guidance Techniques
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Acute Pain, Anxiety
The 50:50 Nitrous Oxide vs 2% Lidocaine Challenge
The main goal of the project is to assess pain levels and patient comfort during the administration of a 50:50 Nitrous Oxide/Oxygen gas mixture, in comparison to the same parameters under the standard method used at our…
- Conditions
- Acute Pain, Anxiety, Central Venous Catheter
- Trial name
- NCT07618676
- Testing
- Nitrous Oxide-Oxygen, Lidocaine 2% Injectable Solution
- Where
- Serbia
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Institute for Oncology and Radiology of Serbia
Anesthesia
Hand Held Nitrous Oxide Delivery Device
To study the safety and efficacy of Hand Held Nitrous. A device that delivers 120 seconds of up to 72% nitrous oxide and ambient air.
- Trial name
- HHN (NCT02119403)
- Testing
- There are no other inteventions.
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Strata Medical Innovations