Clinical trials: Obesity, Severe
Obese Children and Adolescents
Topiramate and Severe Obesity
The purpose of this study is to evaluate the efficacy of Topiramate on the decrease of Body Mass Index compared to placebo at 9 months.
- Trial name
- TOBI (NCT02273804)
- Testing
- Topiramate
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Morbid Obesity, Diabetes
Factors Influencing the Positive Outcome of Bariatric Surgery for Morbidly Obese Patients
The purpose of this study is to report data with patients after bariatric surgery.
- Conditions
- Morbid Obesity, Diabetes, Hypertension
- Trial name
- NCT01583790
- Where
- Israel
- Volunteers
- 2,000 people
- Sponsor
- Assuta Hospital Systems
Morbid Obesity
Follow-up of Adolescent Bariatric Surgery
Very little information is available about extremely obese (body mass index [BMI] > 40 kg/m2) adolescents. The purpose of the Follow up of Adolescent Bariatric Surgery (FABS) study is to collect information obtained during the…
- Trial name
- FABS (NCT00776776)
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Morbid Obesity
Effect of Liraglutide on Weight Loss in Patients Who Have Undergone Revisional Bariatric Surgeries.
Our primary objective is to assess the effect of Liraglutide on weight loss in patients who have undergone secondary bariatric surgeries.
- Trial name
- NCT05285397
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Behavior
KidQuest Family-Based Weight Control
The purpose of this study is to determine if a family based diet and exercise program is helpful for extremely overweight children aged 8-12, and to compare this approach to standard medical management of severe pediatric obesity.
- Trial name
- NCT00177229
- Testing
- Family-based treatment
- Volunteers
- 192 people
- Sponsor
- University of Pittsburgh
Severe Obesity
Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass
The purpose of this study is to examine the effects of bile acid and bile acids sequestrants on GLP-1 Secretion, during a meal, in patients after Roux-en-Y gastric bypass.
- Trial name
- NCT02876484
- Testing
- Colesevelam, Chenodeoxycholic Acid, Water
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Hvidovre University Hospital
Morbid Obesity
Efficacy and Mechanism Study of Bariatric Surgery to Treat Moderate to Severe Obesity in Han Chinese Population
This is a long-term follow-up and interventional study in individuals who have been diagnosed with moderate to severe obesity with or without diabetes.
- Trial name
- NCT02653430
- Testing
- Sleeve gastrectomy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Obesity, Childhood
A Protein-sparing Modified Fast for Children and Adolescents With Severe Obesity (PSMF)
This is a 12 month prospective observational cohort study of the outpatient protein-sparing modified fast diet for children with severe obesity and serious comorbid condition(s).
- Trial name
- PSMF (NCT03899311)
- Testing
- protein-sparing modified fast diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ihuoma Eneli
Overweight
GRIB Forsoeget-2004
The difficulties in loosing weight may not stem from lack og knowledge about nutrition, as implied by the standard treatment but from difficulties in following the advice.
- Trial name
- GRIB-2004 (NCT00554645)
- Testing
- multi-disciplinary group intervention, traditional information
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Forskningspuljen
Obesity, Morbid, Back Pain
THE EFFECT OF FAST WEIGHT EFFICIENCY AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY ON THE COBB ANGLE IN MORBID OBESE PATIENTS
Obesity has become an increasingly common health problem today. In this context, although many anatomical, physiological and metabolic problems arising from obesity in morbid obese patients are tried to be solved in daily…
- Conditions
- Obesity, Morbid, Back Pain, Scoliosis
- Trial name
- NCT04844320
- Testing
- Cobb angle measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome
Real-World Effects of MC4R Agonist Therapy in BBS and Severe Genetic Obesity
Bardet-Biedl syndrome (BBS) and other rare disorders associated with impairment of the melanocortin-4 receptor (MC4R) pathway are characterized by severe early-onset obesity, hyperphagia, and substantial morbidity.
- Conditions
- Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome, Bardet-Biedl Syndrome (BBS), Alstrom Syndrome
- Trial name
- REAL-MC4 (NCT07674290)
- Testing
- Setmelanotide
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Tom Hühne
Morbid Obesity
Single-Anastomosis Plication Ileal Bypass for Morbid Obesity
The present study aims to explore the impact of combining laparoscopic greater curvature plication with a single gastro-ileal anastomosis in the same manner of single anastomosis sleeve ileal bypass on weight loss and…
- Trial name
- NCT03428386
- Testing
- Gastric plication ileal bypass
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Morbid Obesity, Obstructive Sleep Apnea Syndrome
LAGB as a Treatment for Morbid Obesity in Adolescents
Laparoscopic adjustable gastric banding (LAGB) has been used worldwide to help selected morbidly obese adults to lose weight. The FDA has approved LAGB only for patients 18 years or older.
- Conditions
- Morbid Obesity, Obstructive Sleep Apnea Syndrome, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01045499
- Testing
- Laparoscopic adjustable gastric banding (Allergan Lap Band)
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Jeffrey L Zitsman, MD
Obesity, Morbid, Pain, Postoperative
Efficacy of CPPLAI in Laparoscopic Sleeve Gastrectomy Patients
The high demand for bariatric surgery due to the increasing prevalence of obesity worldwide necessitate evidence-based clinical pathway such as Enhanced Recovery After Bariatric Surgery (ERABS).
- Trial name
- CPPLAI (NCT04680923)
- Testing
- CPPLAI, Bupivacaine 0.25%
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- King Khalid University Hospital
Childhood Obesity
Genetic Determinants and Clinical Consequences of Early-onset Severe Obesity
The aim of the present study is to identify new obesity-related genetic defects and determine their association with clinical manifestations in families with childhood-onset severe obesity.
- Trial name
- PeLi (NCT02645422)
- Volunteers
- 400 people
- Sponsor
- Helsinki University Central Hospital
Pediatric Obesity
Childhood Obesity, Lifestyle Interventions and Weight Development
Childhood obesity has been associated with increased risk of both continued excess body weight, development of non-communicable lifestyle diseases and impaired mental health.
- Trial name
- NCT05345353
- Testing
- Fat For Fight (FFF), The Aarhus Protocol, The Children's Obesity Clinic Treatment (TCOCT), The Randers Protocol
- Where
- Denmark
- Volunteers
- 2,898 people
- Sponsor
- University of Aarhus
Obstructive Sleep Apnea, Obesity
Impact of Smoking, Benzodiazepine (BZD) Use and Obesity on Severe Obstructive Sleep Apnea (sOSA)
In this study the investigators will analyze the influence of smoking, benzodizepine use, and obesity among patients with severe Obstructive Sleep Apnea (sOSA).
- Conditions
- Obstructive Sleep Apnea, Obesity, Smoking
- Trial name
- NCT02539264
- Testing
- Smoking, Obesity, Benzodiazepine use
- Volunteers
- 920 people
- Sponsor
- Astes
Adolescent Obesity
SMART Use of Medication for the Treatment of Adolescent Severe Obesity
This study will examine the timing and sequence of using adjunct obesity pharmacotherapy for adolescents with severe obesity who do not respond to lifestyle modification therapy alone.
- Trial name
- SMART (NCT04007393)
- Testing
- Lifestyle Modification Therapy (LSMT), Phentermine Pill, Topiramate Pill
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Obesity, Diabetes
Randomized Clinical Trial; Medical vs Bariatric Surgery for Adolescents (13-16 y) With Severe Obesity
Severe childhood obesity is associated with both immediate and chronic health problems and a severe impact on psychosocial development.
- Conditions
- Obesity, Diabetes, Hypertension, Steatohepatitis
- Trial name
- AMOS2 (NCT02378259)
- Testing
- Laparoscopic Roux-en-Y gastric bypass, Intense conservative treatment
- Where
- 3 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Göteborg University
Morbid Obesity
Bariatric Surgery Outcomes
The UCLA Metabolic and Bariatric Surgery Program (adult program) and the UCLA Fit for Healthy Weight Program (adolescent program) are committed to the care of morbidly obese patients. This study is observational.
- Trial name
- NCT01057784
- Testing
- Bariatric surgery.
- Where
- 2 sites in United States
- Sponsor
- University of California, Los Angeles