Clinical trials: Obstetrical Complications
Preterm Delivery, Obstetrical Complications
Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial
This is a phase-III multi-center double-blind randomized clinical trial of 1,800 individuals with a history of prior preterm birth at less than 35 weeks gestation who are randomized to either 162 mg aspirin or 81 mg aspirin…
- Trial name
- ADEPT (NCT06980025)
- Testing
- 162mg Aspirin, 81mg Aspirin
- Where
- 14 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Obstetrical Complications, Labor and Delivery Complication
Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial
This is a phase-III multi-center double-blind randomized controlled trial of 8,000 individuals undergoing a scheduled or prelabor cesarean delivery who are randomized to either adjunctive azithromycin prophylaxis or to placebo.
- Conditions
- Obstetrical Complications, Labor and Delivery Complication, Cesarean Delivery
- Trial name
- PRECEDE (NCT06605118)
- Testing
- Azithromycin Injection, Standard of Care Preoperative antibiotics
- Where
- 14 sites in United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Preeclampsia
China Obstetrics Alliance Cohort Study
Preeclampsia (PE) is one of a common type of hypertensive disorder complicating pregnancy (HDCP). It is a class of clinical syndromes which shows relevant symptoms, hypertension and proteinuria after 20 weeks pregnant as main…
- Trial name
- COACS (NCT03038555)
- Where
- 5 sites in China
- Volunteers
- 900 people
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Prelabor Rupture of Membranes, Labor (Obstetrics)--Complications
Early V/S Delayed Induction of Labour in Patients With Prelabour Rupture of Membranes
To compare the effects of early V/s delayed induction of labour and its outcomes in patients presenting with PROM without labour.
- Conditions
- Prelabor Rupture of Membranes, Labor (Obstetrics)--Complications, Induction of Labor
- Trial name
- PROM (NCT07261332)
- Testing
- 0.5mg PGE2 gel
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- Laiba Qamar
Obstetrical Complication of Anesthesia
Effects of Intraoperative Oxygen Therapy on Oxygenation of Newborns Born Via Elective Cesarian Section
In this study the investigators examine the effects of intraoperative oxygen administration to the mother on certain enzyme functions of the newborn.
- Trial name
- NCT02804555
- Testing
- Oxygen
- Where
- Hungary
- Volunteers
- 107 people
- Sponsor
- Szeged University
Sudden Unexplained Infant Death, Apnea of Newborn
Advanced Wireless Sensors for Neonatal Care in the Delivery Room
The goals of this observational study is to assess whether a new advanced wireless skin sensor vital sign monitoring system can effectively monitor the vital signs of healthy newborn infants (≥ 35 weeks gestational age).
- Conditions
- Sudden Unexplained Infant Death, Apnea of Newborn, Newborn Morbidity, Newborn Asphyxia
- Trial name
- AWARD (NCT06693817)
- Testing
- Wireless skin sensors vital sign monitoring system, Wired vital sign monitoring system
- Where
- 5 sites in Brazil, Canada and 2 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guilherme Sant'Anna, MD
Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia
Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial Cancer
To construct a prediction model of progesterone sensitivity in patients with endometrial cancer treated with fertility preservation
- Trial name
- NCT05647109
- Testing
- No intervention
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Peking University People's Hospital
Obstetric Labor Complications, Stillbirth
The PartoMa Project: For Improving Monitoring, Action and Triage During Labour
OVERALL OBJECTIVE In an East African referral hospital, to develop and analyze the effect of locally agreed and achievable guidelines and a continual in-house training program for strengthening partogram-based…
- Conditions
- Obstetric Labor Complications, Stillbirth, Maternal Death
- Trial name
- PartoMa (NCT02318420)
- Testing
- The PartoMa intervention
- Where
- Tanzania
- Volunteers
- 3,087 people
- Sponsor
- Ib Christian Bygbjerg
Pregnancy Related, Delivery of Health Care
Evaluating the Saving Babies Lives Care Bundle Version 2
The purpose of this study is to learn about the implementation of NHS England's Saving Babies Lives Care Bundle Version 2 to reduce perinatal mortality.
- Trial name
- eVOLVE (NCT06453954)
- Where
- United Kingdom
- Volunteers
- 1,773 people
- Sponsor
- University of Manchester
Fetal Distress, Stillbirth
Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.
This study is a pilot study taking place in Moshi, Tanzania at the Kilimanjaro Christian Medical Centre (KCMC). The study aims to introduce fetal scalp stimulation into the intermittent auscultation protocols at KCMC, and to…
- Conditions
- Fetal Distress, Stillbirth, Birth Asphyxia, Acidosis
- Trial name
- NCT02862925
- Testing
- Fetal Scalp Stimulation
- Where
- Tanzania
- Volunteers
- 550 people
- Sponsor
- Duke University
Obstetric Complication, Vaginal Bleeding
Reliability of Simple Sonographic Findings Acquired With Hand-held Apparatuses to Inform Obstetric Diagnosis
the study aims to assess the reliability of ultrasound findings measured by hand held ultrasound probes used by operators with variable experience in a low resource hospital.
- Conditions
- Obstetric Complication, Vaginal Bleeding, Eclampsia Preeclampsia, Obstructed Labor
- Trial name
- NCT03856307
- Testing
- point of care ultrasound
- Where
- Sierra Leone
- Volunteers
- 300 people
- Sponsor
- Doctors with Africa - CUAMM
Heavy Metal Toxicity, Spontaneous Abortion
the Association Between Blood's and Urinary Heavy Metal Level in Pregnant Women and the Spontaneous Abortion
The aim of the study was to define the possible association between heavy iron level and the consequence of pregnancy especially spontaneous abortion and missed abortion.
- Trial name
- HMLandSA (NCT03332706)
- Testing
- observation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Periodontitis, Infant, Premature
Obstetrics and Periodontal Therapy (OPT) Study
The purpose of this study is to determine if non-surgical periodontal (gum) treatment can reduce the incidence of preterm birth and low birth weight babies in mothers with periodontitis (gum disease).
- Trial name
- OPT (NCT00066131)
- Testing
- Periodontal scaling and root planing, Scaling and root planing
- Where
- United States
- Volunteers
- 823 people
- Sponsor
- University of Minnesota
Cesarean Section Complications, Postpartum Hemorrhage
Obstetric Comorbidity Index in Postpartum Hemorrhage
The objective of this study is to examine the predictive capability of the Obstetric comorbidity index in the identification of severe maternal morbidity associated with postpartum hemorrhage in patients undergoing cesarean…
- Conditions
- Cesarean Section Complications, Postpartum Hemorrhage, Morbidity;Perinatal
- Trial name
- NCT06431204
- Testing
- Obstetric comorbidity index
- Where
- Thailand
- Volunteers
- 583 people
- Sponsor
- Mahidol University
Obstetric Complication, Ultrasound
The Utility of Customised Growth Charts for Identifying Macrosomia and the Effect of Intervention
Best management of suspected large for gestational age (LGA) fetuses is unclear. In some hospitals women with an LGA fetus by customised growth charts are are offered earlier induction.
- Conditions
- Obstetric Complication, Ultrasound, Induction of Labor Affected Fetus / Newborn, Fetal Growth Complications
- Trial name
- NCT04536753
- Testing
- Induction of labour
- Where
- United Kingdom
- Volunteers
- 845 people
- Sponsor
- Newcastle University
Ovarian Cysts
Transvaginal Ultrasound Training for Obstetrics and Gynecology Residents
Obstetrics and gynecology residents are deemed to be proficient in transvaginal ultrasound (TVUS) upon graduation from an accredited program, although TVUS education in residency is not standardized.
- Trial name
- NCT02890914
- Testing
- Transvaginal Ultrasound Educational DVD
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Other Specified Complications of Labor and Delivery
Vaginal Delivery Debrief Checklist to Improve Team Communication
This study is to determine if using a standardized debrief checklist after vaginal delivery improves communication between the vaginal delivery health care team members and if using the checklist increases a sense of enhanced…
- Trial name
- VDD (NCT01822158)
- Testing
- Vaginal Delivery Debrief Checklist
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Providence Health & Services
High Risk Pregnancy, Multidisciplinary Communication
The Center for Peripartum Optimization
In January 2017 investigators started a Center for Peripartum Optimization (CPO) with the aim of optimizing a patient's clinical status in an outpatient setting to minimize unnecessary laboratory tests and studies, costly…
- Conditions
- High Risk Pregnancy, Multidisciplinary Communication, Communication, Obstetric Complication
- Trial name
- NCT03522909
- Testing
- Seen in clinic
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Postoperative Nausea and Vomiting, Abdominal Pain
Bisacodyl Use in the Post-operative Care of Obstetrical/Gynecological (OB/GYN) Patients
The purpose of this study is to determine whether Bisacodyl, 5 mg usage decreases the incidence of nausea and abdominal pain after surgery, and also decreases the number of hospitalization days.
- Trial name
- NCT01011426
- Testing
- Bisacodyl
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- Cooper Norcross Health
Malnutrition in Pregnancy, Malnutrition; Protein
Value of Early Postoperative Peptide-based Formula in Critically Ill Obstetrics on Recovery Enhancement
This is the first trial to assess the early semi-elemental postoperative formula load to meet the protein requirements in the first and second day postoperative to enhance the recovery of critically ill parturient (value on ERAS…
- Conditions
- Malnutrition in Pregnancy, Malnutrition; Protein, Postpartum Disorder, Patient Satisfaction
- Trial name
- NCT06164301
- Testing
- Elemental amino-acids
- Where
- Egypt
- Volunteers
- 83 people
- Sponsor
- Ain Shams University