Clinical trials: Obstructive Pulmonary Disease
Asthma
Study of Safety of QAW039 in Patients With Asthma Inadequately Controlled on Standard-of-care Asthma Treatment
This study was a 2-treatment period, randomized, multicenter parallel-group study. The overall purpose of this study was to provide long- term safety data for fevipiprant (QAW039) (Dose 1 and Dose 2), compared with placebo, when…
- Trial name
- NCT03052517
- Testing
- QAW039 150 mg, QAW039 450 mg
- Where
- 347 sites in United States, Argentina and 40 more
- Volunteers
- 2,538 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS)
This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care
- Trial name
- KALOS (NCT04609878)
- Testing
- BGF MDI 320/28.8/9.6 μg, BGF MDI 320/14.4/9.6 μg, BFF MDI 320/9.6 μg
- Where
- 360 sites in United States, Argentina and 19 more
- Volunteers
- 2,274 people
- Sponsor
- AstraZeneca
Osteo Arthritis, Osteoporosis
Determining the Feasibility of Implementing a Combined Cognitive and Exercise Training Program for Older Adults in a Community Setting.
The overarching aim of this project is to implement and evaluate a proven cognitive training regimen in combination with a community exercise program among older adults who attend wellness exercise programs at the YMCA.
- Conditions
- Osteo Arthritis, Osteoporosis, Joint Replacement, Fibromyalgia
- Trial name
- NCT04515758
- Testing
- Exercise and Cognitive Training, Exercise Training Only
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of Waterloo
Respiratory Infection (for Example, Pneumonia, Bronchitis)
Modulation of Gut Microbiota by Probiotic in Children With Respiratory Symptoms
This project aims to study the benefits of probiotics namely Bifidobacterium infantis YLGB-1496 in modulating gut microbiota of children with respiratory symptoms, among pre-school children in Malaysia aged >12 months old, <7…
- Trial name
- NCT05794815
- Testing
- Probiotic
- Where
- Malaysia
- Volunteers
- 120 people
- Sponsor
- Min-Tze LIONG
Immunity, Respiratory Infection
Childhood Infection and Immunity Longitudinal Cohort
This prospective observational study will enroll approximately 1,200 children from birth through 7 years of age in Zhejiang Province, China.
- Conditions
- Immunity, Respiratory Infection, Asthma
- Trial name
- NCT07815925
- Where
- 2 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial Center for Disease Control and Prevention
Viral Bronchiolitis
Evaluation of Chest Physiotherapy for Acute Bronchiolitis in Toddlers (BRONKINOU)
The purpose of this study is to determine whether chest physiotherapy with forced expiratory technique reduces delay of healing in acute bronchiolitis of children between 15 days and 24 months of age.
- Trial name
- BRONKINOU (NCT00125450)
- Testing
- Chest Physiotherapy with Forced Expiratory Technique, Nasopharyngeal Aspiration
- Where
- 7 sites in France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Airway Inflammation in Swimmers
Studies have shown that the prevalence of respiratory symptoms, airway hyperresponsiveness (AHR) and asthma is high and increasing in elite athletes.
- Trial name
- NCT00207038
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Asthma
Computer-Based Decision Support in Managing Asthma in Primary Care
Asthma is a health problem that afflicts many Canadians. Better methods are needed to provide primary care physicians with ways of implementing current guidelines into regular practice for optimal disease management.
- Trial name
- NCT00170248
- Testing
- computer-based decision support for asthma management
- Where
- Canada
- Volunteers
- 4,447 people
- Sponsor
- McGill University
Chronic Obstructive Pulmonary Disease
Racial Inequality in Inhaler Fills for COPD - A Trial of Reduced Cost-Sharing
In partnership with a large Medicare Advantage (MA) insurer (Humana, Inc.) and as part of a Center for Medicare and Medicaid Innovation demonstration program of Value-Based Insurance Design (VBID), the investigators propose to…
- Trial name
- NCT05497999
- Testing
- Proactive Outreach, No Proactive Outreach
- Where
- 3 sites in United States
- Volunteers
- 19,113 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Asthma
Prevention of Asthma With Levocetirizine (36 Month Treatment) in Young Children Suffering From Eczema (Atopic Dermatitis) and Sensitized to Grass Pollen and House Dust Mite and Having Completed the Previous EPAAC Trial (NCT00152464)
Prolongation of the EPAAC™ trial - NCT00152464 (The Early Prevention of Asthma in Atopic Children). 36 months study to evaluate the efficacy and safety of levocetirizine (LCTZ) in preventing the onset of asthma in young atopic…
- Trial name
- NCT00160563
- Testing
- LEVOCETIRIZINE
- Where
- 51 sites in Australia, Belgium and 8 more
- Volunteers
- 207 people
- Sponsor
- UCB Pharma
Asthma
Cessation Versus Continuation of Long-term Mepolizumab in Severe Eosinophilic Asthma Patients
Primary objective of the study is to evaluate whether patients with severe eosinophilic asthma who have received long-term treatment with mepolizumab (at least 3 years) need to maintain treatment with mepolizumab to continue to…
- Trial name
- NCT02555371
- Testing
- Mepolizumab 100mg
- Where
- 73 sites in United States, Argentina and 12 more
- Volunteers
- 306 people
- Sponsor
- GlaxoSmithKline
Primary Immunodeficiency, Secondary Immune Deficiency
Facilitated Immunoglobulin Administration Registry and Outcomes Study (FIGARO)
Long-term observational study on the utilisation and outcomes of HyQvia (a product consisting of recombinant human hyaluronidase and a human normal immunoglobulin 10% solution) under everyday clinical practice conditions.
- Trial name
- FIGARO (NCT03054181)
- Testing
- HyQvia
- Where
- 4 sites in France, Germany and 1 more
- Volunteers
- 156 people
- Sponsor
- GWT-TUD GmbH
Asthma, Lung Diseases
Leukotriene Polymorphisms and Montelukast Response - Ancillary to LoDo Trial
To elucidate the mechanisms underlying inter-patient variation in response to montelukast, a drug for asthma.
- Trial name
- NCT00046644
- Sponsor
- Nemours Children's Clinic
Asthma
Outcomes in Patients Taking Fluticasone Propionate/Salmeterol Combination or Other Inhaled Corticosteroids
The objective of this study is to compare healthcare utilization and costs in asthma patients who receive fluticasone propionate/salmeterol combination 100mcg/50mcg ("FSC 100/50") or inhaled corticosteriods in typical clinical…
- Trial name
- NCT01332344
- Testing
- Fluticasone propionate/salmeterol combination, Inhaled corticosteroids
- Volunteers
- 5,180 people
- Sponsor
- GlaxoSmithKline
Asthma (Diagnosis), Adolescent - Emotional Problem
Research on Disease Control and Mental Health Status of Adolescent Asthma Patients
Background: Currently in China, adolescent asthma care is characterized by both undertreatment and overtreatment. Patients in this age group may exhibit negative emotions toward disease treatment and long-term control.
- Trial name
- NCT07412119
- Testing
- Eligible participants will complete a battery of assessment questionnaires
- Volunteers
- 460 people
- Sponsor
- Beijing Children's Hospital
Asthma
Radon Asthma Intervention Trial
To determine if radon mitigation can improve asthma
- Trial name
- ROME (NCT06706336)
- Testing
- radon mitigation system
- Volunteers
- 180 people
- Sponsor
- Boston Children's Hospital
Asthma
Efficacy and Safety of Ciclesonide Administered With or Without Different Spacers in Patients With Asthma (12 to 75 y) (BY9010/M1-145)
The aim of the present study is to investigate the efficacy and safety of ciclesonide on lung function and safety. Ciclesonide will be inhaled at one dose level once daily, using an inhaler device with or without spacer.
- Trial name
- NCT00163436
- Testing
- Ciclesonide
- Where
- 66 sites in Canada, France and 4 more
- Volunteers
- 450 people
- Sponsor
- AstraZeneca
Asthma
A Study on the Diagnostic Value of the Methacholine Choline Provocation Test in the Asthmatic Population
This study was a multicenter, open, observational study and was divided into two stages; Stage I study includes patients with suspected asthma to observe the diagnostic value and safety of Methacholine Choline Provocation Test.
- Trial name
- NCT05870436
- Testing
- Methacholine Choline Provocation Test
- Where
- 6 sites in China
- Volunteers
- 1,100 people
- Sponsor
- jingping Zheng
Asthma
Effect of Inhaled Fluticasone Furoate on Short-term Growth in Paediatric Subjects With Asthma
This study will be conducted to evaluate the effect of once daily treatment with fluticasone furoate (FF) on lower leg growth in pediatric subjects with persistent asthma by using knemometry.
- Trial name
- NCT02502734
- Testing
- Fluticasone furoate, Salbutamol
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- GlaxoSmithKline
Graft vs Host Disease
Pentostatin for High Risk and Refractory Chronic Graft Versus Host Disease in Children
This is a multicenter trial through the Pediatric Blood and Marrow Transplant Consortium. The Primary hypothesis of this study is that because of its effect as a potent immunosuppressive agent targeting lymphocytes, pentostatin…
- Trial name
- NCT00144430
- Testing
- Pentostatin
- Where
- 25 sites in United States
- Volunteers
- 60 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago