Clinical trials: Open Surgery
Shoulder Instability
Operative Treatment of Traumatic Anteroinferior Shoulder Instability in Young Male Patients
Glenohumeral joint is prone to instability, i.e. the humeral head may dislocate off the scapular glenoid plate especially in the anteroinferior direction.
- Trial name
- NCT01998048
- Testing
- Latarjet, Bankart
- Where
- 8 sites in Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Glaucoma, Open-Angle
An Observational Multicenter Clinical Study To Assess The Safety And Effectiveness Of The OMNI® Surgical System In Pseudophakic Eyes With Primary Open Angle Glaucoma (ORION 2.0)
The purpose of this study is to evaluate the safety and effectiveness of the OMNI® Surgical System in subjects who have undergone canaloplasty and trabeculotomy using OMNI® Surgical System without any concomitant surgery in…
- Trial name
- NCT04872348
- Testing
- OMNI® Surgical System
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- Sight Sciences, Inc.
Renal Cancer, Partial Nephrectomy
Complications Associated With Partial Nephrectomy for Renal Cancer
This paper evaluates the initial complications and the complications two years postoperatively necessitating re-hospitalisation for three surgical procedures for renal tumour partial nephrectomy .
- Trial name
- NCT05168761
- Testing
- partial nephrectomy
- Volunteers
- 7,664 people
- Sponsor
- Central Hospital, Nancy, France
Vitreo-Retinal Surgery
DEXTENZA for the Treatment of Postoperative Pain and Inflammation Following Vitreo-retinal Surgery
The purpose of this study is to evaluate efficacy and safety of Dextenza for the treatment of postoperative pain and inflammation following vitreo-retinal surgery
- Trial name
- NCT04462523
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical Prednisolone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Patrick R. Oellers, MD
Open Nephrectomy Surgery
Comparing the Efficacy of Epidural and Quadratus Lumborum Analgesia After Open Nephrectomy Surgery
This study aims to assess if Quadratus Lumborum (QL) blocks are non-inferior to epidural analgesia for pain control and opioid consumption through the third postoperative day in patients having open partial nephrectomy.
- Trial name
- QL Analgesia (NCT03110081)
- Testing
- Quadratus lumborum block, Epidural analgesia
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- The Cleveland Clinic
Hemorrhage
A Study to Compare the Efficacy and Safety of TachoSil and Surgicel Original as an Adjunct to Control Mild to Moderate Soft Tissue Bleeding During Surgery
The purpose of this clinical study is to assess the efficacy and safety of TachoSil compared to the widely known and used for > 60 years local hemostatic product Surgicel Original as an adjunct to control mild to moderate soft…
- Trial name
- NCT06664775
- Testing
- TachoSil, Surgicel Original
- Where
- 9 sites in United States
- Volunteers
- 116 people
- Sponsor
- Corza Medical GmbH
Anesthesia
Trans-incisional Quadratus Lumborum Block Versus Caudal Analgesia in Pediatric Open Renal Surgeries.
There is scare literature about the usage of QLB in pediatric population, particularly the trans-incisional approach. Hence, the purpose of this study is to compare the postoperative analgesic efficacy of ultrasound-guided caudal…
- Trial name
- NCT04790318
- Testing
- Trans-incisional Quadratus lumborum block, Caudal block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Kidney Transplantation
Medical Economic Evaluation and of Quality of Life of the Kidney Living Donors.
The main objective of this multicentre study is to conduct the evaluation of cost-efficiency of various techniques of kidney taking with regard the quality of life of the kidney living donors.
- Trial name
- DOVIREIN (NCT02830568)
- Testing
- open donor nephrectomy, standard and hand-assisted laparoscopic donor nephrectomy, laparoscopic robotic-assisted nephrectomy
- Where
- 24 sites in France
- Volunteers
- 268 people
- Sponsor
- Central Hospital, Nancy, France
Malignant Melanoma
BRIM-P: A Study of Vemurafenib in Pediatric Patients With Stage IIIC or Stage IV Melanoma Harboring BRAFV600 Mutations
This open-label, multicenter. single arm Phase I dose-escalation study with efficacy tail extension will evaluate the maximum tolerated dose/recommended dose, the safety and efficacy of vemurafenib (RO5185426) in pediatric…
- Trial name
- NCT01519323
- Testing
- vemurafenib
- Where
- 26 sites in United States, Australia and 8 more
- Volunteers
- 6 people
- Sponsor
- Hoffmann-La Roche
Disorder of Maxillary Sinus, Maxillary Sinus Floor Augmentation
Comparative Study of Algipore and Decalcified Freeze-dried Bone Allograft in Open Maxillary Sinus Augmentation
The aim of this study was the radiographic and clinical comparison of Algipore with decalcified freeze-dried bone allograft (DFDBA) in the open maxillary sinus lift technique using piezoelectric instruments.
- Trial name
- NCT01735721
- Testing
- Open Sinus Lift
- Where
- Iran
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Arteriovenous Fistula
Effects of Heparin on Arteriovenous Fistula Patency
Arteriovenous fistula (AVF) is now the optimal method of obtaining vascular access for dialysis. Measures such as systemic anticoagulation have been proposed as means of increasing patency rates but enough evidence does not exist…
- Trial name
- NCT02493504
- Testing
- Heparin
- Volunteers
- 150 people
- Sponsor
- Fatemeh Hoseinzadegan
End-stage Renal Disease, Critical Limb Ischemia
Open Versus Endovascular Revascularization in Patients With End-stage Renal Disease
Treatment of patients with end-stage renal disease and critical limb ischemia still poses challenges to vascular medicine due to limited survival, comorbidities and infrapopliteal involvement of arteriosclerosis in these…
- Trial name
- OERESRD (NCT03293589)
- Testing
- open revascularization, endovascular revascularization
- Where
- Germany
- Volunteers
- 77 people
- Sponsor
- University Hospital Erlangen
Congenital Heart Disease, Open Heart Surgery
Localized Evidence of Cytokine Adsorption Therapy During Pediatric Cardiac Surgery: A Single Center Randomized Controlled Trial (LEAT)
The Localized Evidence of Cytokine Adsorption Therapy (LEAT) study is a prospective, randomized controlled trial conducted at the Institut Jantung Negara in Malaysia.
- Conditions
- Congenital Heart Disease, Open Heart Surgery, Cardiopulmonary Bypass, Endocarditis Acute and Subacute
- Trial name
- LEAT (NCT07771491)
- Testing
- Hemoadsorption (Jafron HA-60/HA380)
- Volunteers
- 120 people
- Sponsor
- Norfaniza Zabidi
Rectal Cancer, Surgery
Pathology Assessment of Mesorectal Fascia After TME by Laparoscopic, Open, TransAnal and Robotic Approaches (LOTARTME)
TME is the gold standard surgical treatment of rectal cancer. Specimen quality, integrity of mesorectal fascia and lymph nodes harvest are expression of radicality and good surgery.
- Trial name
- LOTARTME (NCT04949672)
- Where
- Italy
- Volunteers
- 153 people
- Sponsor
- San Giovanni Addolorata Hospital
Acute Appendicitis
Laparoscopic Versus Open Appendectomy
Comparison of open and laparoscopic appendectomy
- Trial name
- NCT01967745
- Testing
- laparoscopic appendectomy, open appendectomy
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- Varazdin General Hospital
Pilonidal Disease
Open Wide Excision Versus Minimal Surgery for Pilonidal Disease
In order to compare the early recurrence rates of pilonidal disease and overall patient satisfaction between procedures involving minimal and wide open excisions, we propose to perform a prospective, randomized clinical trial…
- Trial name
- NCT01241136
- Testing
- open wide-excision pilonidal cystectomy, minimal invasive pilonidal cystotomy
- Where
- United States
- Sponsor
- United States Naval Medical Center, Portsmouth
Developmental Dysplasia of the Hip (DDH)
Early Outcomes of Arthroscopic Versus Open Reduction for Developmental Dysplasia of the Hip in Children
This study was designed to determine whether arthroscopic-assisted reduction offers better early surgical outcomes than open reduction for treating developmental dysplasia of the hip in children.
- Trial name
- NCT06747767
- Testing
- Arthroscopy, Open reduction
- Where
- Iraq
- Volunteers
- 43 people
- Sponsor
- Hawler Medical University
Primary Congenital Glaucoma, Goniotomy
Goniotomy in Primary Congenital Glaucoma
Brief Summary This is a multicenter cohort study designed to evaluate and compare the efficacy and safety of different surgical extents of goniotomy (GT) - specifically 120°, 240°, and 360° - in the treatment of Primary…
- Trial name
- NCT07550868
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Pain, Postoperative
Study of Indomethacin Capsules to Treat Pain Following Surgery in Children Ages 6 to <17 Years of Age
The purposes of this study are to evaluate the safety and tolerability and to model the single-dose pharmacokinetic profile of indomethacin capsules low dose and high dose in children ages 6 to <17 years experiencing mild to…
- Trial name
- NCT02633969
- Testing
- Indomethacin Capsules low dose, Indomethacin Capsules high dose
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Hypertension, Pulmonary, Ventricular Dysfunction, Left
Confirmatory Study of IK-3001 in Japanese Subjects With Peri-/Post-op Pulmonary Hypertension Assoc. With Cardiac Surgery
Sixteen Japanese subjects (6 adults/10 children) with peri- and post-operative pulmonary hypertension associated with cardiac surgery will be evaluated at approx. 6 sites for safety and efficacy of IK-3001.
- Trial name
- NCT01959828
- Testing
- IK-3001
- Where
- 7 sites in Japan
- Volunteers
- 18 people
- Sponsor
- Mallinckrodt