Clinical trials: Open-angle Glaucoma
Iris Diseases
Electron Microscopic Examination of Iris Tissue in Buphthalmos
To revise the etiology of the primary congenital glaucoma in some infants.
- Trial name
- NCT07034651
- Testing
- Combined trabeculotomy trabeculectomy with mitomycin C
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Open Angle Glaucoma and Cataract
RCT to Investigate if Prostaglandin Analogue Drops Increase the Risk of Cystoid Macular Oedema After Cataract Surgery.
Post-operative cystoid macular oedema (CMO) is a common complication causing visual loss following routine cataract surgery. This complication is more prevalent in eyes with excessive inflammation as they heal from surgery.
- Trial name
- CMO (NCT03292796)
- Testing
- Prostaglandins
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Julie Dawson
Open Angle Glaucoma, Intraocular Pressure
An Extension Trial for Patients With Open-Angle Glaucoma Who Participated in the DF6-CL-20-01 Protocol.
The purpose of this study is to evaluate long term safety and effectiveness of the STREAMLINE® SURGICAL SYSTEM
- Trial name
- NCT06230393
- Testing
- STREAMLINE® SURGICAL SYSTEM
- Where
- Costa Rica
- Volunteers
- 17 people
- Sponsor
- New World Medical, Inc.
Glaucoma, Open-Angle
Retrospective Review of Xen Gel Stent Implantation With Open vs. Closed Conjunctiva Approach
To measure surgical success of open vs closed conjunctiva with Xen implantation.
- Trial name
- NCT04406467
- Testing
- Xen Gel Stent
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Johns Hopkins University
Primary Open Angle Glaucoma, Ocular Hypertension
The Efficacy of Selective Laser Trabeculoplasty
Selective laser trabeculoplasty (SLT) is a new method to reduce intraocular pressure in eyes with open angle glaucoma or ocular hypertension. SLT may also be effective for cases with previously failed ALT procedures.
- Conditions
- Primary Open Angle Glaucoma, Ocular Hypertension, Pseudo-Exfoliative Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- NCT00347893
- Testing
- Selective laser trabeculoplasty
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Glaucoma Research & Education Group
Primary Open Angle Glaucoma, Acupressure
Regulation of Intraocular Pressure in Glaucoma Patients by Acupressure
The purpose of this clinical trial is to implement acupressure twice daily and monitor the changes in intraocular pressure (IOP) in patients with different levels of glaucoma.
- Trial name
- NCT05898997
- Testing
- Acupressure
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Open-Angle Glaucoma, Ocular Hypertension
A Phase III Study of Brimonidine Tartrate Ophthalmic Solution, 0.15% in Patients With Open-Angle Glaucoma or Ocular Hypertension
The primary objective of this study is to compare the safety and efficacy of Brimonidine Tartrate Ophthalmic Solution, 0.15% in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00061529
- Testing
- Brimonidine Tartrate Ophthalmic Solution
- Where
- United States
- Sponsor
- Alcon Research
Glaucoma, Open-Angle
Micropulsed Laser Trabeculoplasty Using Different Parameters
This randomized, double blinded, clinical trial compares two different parameters setting of micropulsed laser trabeculoplasty for open angle glaucoma. Group one is treated with 1500 mW of Power, Group two with 1000 mW.
- Trial name
- NCT04900142
- Testing
- Micropulsed laser trabeculoplasty
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Modena and Reggio Emilia
Congenital Glaucoma
Study Aim to Compare the Effect of Different Technique of Airway Managment During Anaesthesia on the Haemodynamics and Intraocular Pressure. Patients Were Divided Into Three Groups of 25 Patients Each. (Group A); Patients Who Were Subjected to LMA Insertion (Group B ).
this study aim to compare the effect of different technique of airway managment during anaesthesia on the haemodynamics and intraocular pressure in pediatric patient undergoing congenital glaucoma surgery.
- Trial name
- Airway and IOP (NCT07504315)
- Testing
- laryngeal mask insertion, I gel mask insertion, Endotracheal tube insertion
- Volunteers
- 75 people
- Sponsor
- Sohag University
Ocular Hypertension, Primary Open Angle Glaucoma
A Study of Ganfort Versus Duotrav in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
This is a single-center, cross-over comparison parallel group randomized trial designed to evaluate the efficacy and safety of Ganfort compared to Duotrav for a treatment period of 8 weeks each.
- Trial name
- NCT01168414
- Testing
- Ganfort, Duotrav
- Where
- Malaysia
- Volunteers
- 42 people
- Sponsor
- Ministry of Health, Malaysia
Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma in Both Eyes
Real World Evidence of Xen45 Gel Implant in Pseudoexfoliation Glaucoma
The Xen implant is an ab interno device that has been shown to be effective in reducing intraocular pressure in several types of glaucoma, although the evidence in pseudoexfoliative glaucoma is limited.
- Conditions
- Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma in Both Eyes, Open Angle Glaucoma
- Trial name
- NCT06993311
- Testing
- Xen Gel Stent implantation
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Xerencia de Xestión Integrada de Ferrol
Glaucoma, Open-Angle, Ocular Hypertension
A Study of 0.15% Brimonidine Tartrate in Patients With Primary Open Angle Glaucoma and Ocular Hypertension
This study will evaluate 0.15% brimonidine tartrate in patients with primary open angle glaucoma and ocular hypertension.
- Trial name
- APOTUS (NCT02003534)
- Testing
- 0.15% Brimonidine Tartrate
- Where
- China
- Volunteers
- 376 people
- Sponsor
- Allergan
Glaucoma, Open-Angle, Ocular Hypertension
Safety and Efficacy of Combigan® Ophthalmic Solution in Korea
This study is a Post-Marketing Surveillance study in Korea to evaluate the safety and efficacy of Combigan® (brimonidine tartrate/timolol maleate) Ophthalmic Solution in patients with Open Angle Glaucoma or Ocular hypertension…
- Trial name
- NCT01987752
- Testing
- brimonidine tartrate/timolol maleate Ophthalmic Solution
- Where
- South Korea
- Volunteers
- 732 people
- Sponsor
- Allergan
Glaucoma, Glaucoma, Open-Angle
Pigment Dispersion Syndrome With and Without Glaucoma
To compare patients having PDS without and with OH or GL by documenting and following the clinical features and course of their disease and evaluating the patient's performance on a variety of diagnostic tests.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Ocular Hypertension
- Trial name
- NCT00001152
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- National Eye Institute (NEI)
Glaucoma, Open-Angle
An Observational Multicenter Clinical Study To Assess The Safety And Effectiveness Of The OMNI® Surgical System In Pseudophakic Eyes With Primary Open Angle Glaucoma (ORION 2.0)
The purpose of this study is to evaluate the safety and effectiveness of the OMNI® Surgical System in subjects who have undergone canaloplasty and trabeculotomy using OMNI® Surgical System without any concomitant surgery in…
- Trial name
- NCT04872348
- Testing
- OMNI® Surgical System
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- Sight Sciences, Inc.
Congenital Glaucoma
Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma
The objective of this prospective randomised study is to compare the efficacy and safety of ologen CM (Collagen matrix) as adjunct to combined trabeculotomy-trabecuectomy in congenital glaucoma cases, the efficacy being the…
- Trial name
- NCT02121171
- Testing
- Ologen Collagen Matrix, Combined trabeculotomy-trabeculectomy
- Where
- Azerbaijan
- Volunteers
- 40 people
- Sponsor
- National Centre of Ophthalmology named after academician Zarifa Aliyeva
Primary Open Angle Glaucoma
Transconjunctival Needling Revision Versus Medical Treatment
When the glaucoma filtering surgery failures (intraocular pressure rises again), the options is start to use the hypotensive eye drops again (medical treatment).
- Trial name
- NCT01887223
- Testing
- Transconjunctival needling revision, Medical treatment
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Open Angle Glaucoma, Ocular Hypertension
Evaluation of Safety and Efficacy of PDP-716
The study will be conducted to evaluate the efficacy and safety of topical administration of PDP-716 compared with brimonidine tartrate ophthalmic solution.
- Trial name
- NCT03450629
- Testing
- Brimonidine Tartrate Ophthalmic Suspension, Brimonidine Tartrate Ophthalmic Solution
- Where
- 47 sites in United States
- Volunteers
- 682 people
- Sponsor
- Sun Pharma Advanced Research Company Limited
Open Angle Glaucoma
Ologen® Collagen Matrix Versus Mitomycin-C in Patients With Juvenile-onset Open Angle Glaucoma
To the best of Investigator knowledge, no studies to this date have compared the safety and efficacyof ologen® Collagen Matrix to MMC in exaggerated healing response among JOAG patients.
- Trial name
- NCT03548805
- Testing
- ologen® Collagen Matrix, Trabeculectomy with low dose mitomycin C
- Where
- India
- Volunteers
- 30 people
- Sponsor
- L.V. Prasad Eye Institute
Ocular Dryness, Ocular Irritation
Dry Eye and Irritation Comparison of Latanoprost With the Preservative Versus Travoprost Without Preservative
Although Benzalkonium chloride (BAC) has been used as a preservative for many years, many studies have demonstrated that prolonged use of topical ocular medications preserved with BAC may exacerbate sequelae associated with…
- Conditions
- Ocular Dryness, Ocular Irritation, Open-Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT00803387
- Testing
- Travaprost without BAC (Travatan Z)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Air Force