Clinical trials: Ophthalmology
Eye Diseases, Obesity Associated Disorder
Ophthalmologic Evaluation of Patients With Obesity and Metabolic Syndrome Before and After Bariatric Surgery
The aim of this study was to investigate the pathogenic role of obesity on blinding eye diseases in a population of severely obese patients with no history of eye diseases, and to verify whether weight loss induced by bariatric…
- Trial name
- NCT04926714
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- XiaoYong Liu
Down Syndrome
An Online Health Tool About Down Syndrome: Down Syndrome Clinic to You
The investigators conducted a national two-arm, randomized controlled trial of caregivers of individuals with DS to assess the efficacy of DSC2U in assuring adherence to evidence-based guidelines.
- Trial name
- DSC2U (NCT04227197)
- Testing
- Down Syndrome Clinic to You (DSC2U)
- Where
- United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Ophthalmology, Large Language Models
A Multimodal AI Agent for Ophthalmic Clinical Decision Support
This study is a multicenter randomized controlled trial evaluating the effectiveness and safety of EyeAgent, a multimodal artificial intelligence (AI) agent designed to assist ophthalmologists in clinical decision-making.
- Conditions
- Ophthalmology, Large Language Models, AI Agent, Eye Disease
- Trial name
- NCT07401459
- Testing
- EyeAgent AI system
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Usher Syndrome, Retinitis Pigmentosa
Study of Dietary N-3 Fatty Acids in Patients With Retinitis Pigmentosa and Usher Syndrome
OBJECTIVES: I. Examine the concentration of docosahexanoic acid (DHA) and other n-3 fatty acids in plasma, erythrocyte, and adipose tissue in patients with various forms of retinitis pigmentosa and Usher syndrome. II.
- Trial name
- NCT00004345
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Anxiety, Strabismus
Does Anxiety in Children on the Day of Surgery Impact Compliance in the Ophthalmology Clinic?
The hypothesis is that pediatric patients with increased levels of anxiety on the day of surgery, in particular at point of anesthetic induction, will demonstrate decreased compliance with assessment in ophthalmology clinic…
- Conditions
- Anxiety, Strabismus, Compliance
- Trial name
- NCT02704442
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Queen's University
Educational Problems
The Flipped Classroom Approach in Ophthalmology Residency
This study aims to evaluate the flipped classroom approach compared to the traditional classroom approach in teaching horizontal strabismus in ophthalmology residency didactics.
- Trial name
- NCT04381676
- Testing
- Flipped Classroom Approach
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Washington
Visual Field Defect, Peripheral
Virtual Reality Visual Field Testing as an Alternative in Childhood Eye Disease
The purpose of this study is to test a new way of measuring the peripheral vision (called a visual field test) using a device which can be worn as goggles rather than being a large instrument the patient must sit at.
- Trial name
- NCT05150197
- Testing
- VisuALL, Humphrey Visual Field
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Adverse Event
Comparison of the Sedation Effect of Esketamine and Sevoflurane for Pediatric Ophthalmological Procedure
Emergence agitation is the most common reason for post-anesthesia care unit delay. Sevoflurane is used frequently inhalational anaesthetic agent to provide pediatric anaesthesia because of the nonirritant nature.
- Trial name
- NCT05321160
- Testing
- Esketamine, Sevoflurane
- Where
- China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Eyelid Diseases
Assessment of Eyelid Topology and Kinetics Based on Deep Learning Method
This study plans to assess eyelid topology (such as margin reflex distance, eyelid contour, and corneal exposure area) and blinking (such as frequency, velocity, and duration), using deep learning method to automatically extract…
- Trial name
- NCT04921020
- Testing
- Photography
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Strabismus, Exotropia
Validation of a Smartphone-based Intelligent Diagnosis and Measurement for Strabismus
The current measurement methods of strabismus include the corneal light reflection method, prism alternate covering, etc., which especially rely on the subjective experience of doctors, and there is a large error between…
- Conditions
- Strabismus, Exotropia, Esotropia, Vertical Strabismus
- Trial name
- NCT05615519
- Testing
- A new technology based on 3D reconstruction and deep learning algorithm to achieve an automatic diagnosis of strabismus based on patient-sourced videos of programmatic cover tests.
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Ophthalmology, Artificial Intelligence
Screening and Identifying Hepatobiliary Diseases Via Deep Learning Using Ocular Images
Artificial Intelligence may provide insight into exploring the potential covert association behind and reveal some early ocular architecture changes in individuals with hepatobiliary disorders.
- Conditions
- Ophthalmology, Artificial Intelligence, Hepatobiliary Disease
- Trial name
- NCT04213183
- Testing
- Hepatobiliary Disorders
- Where
- China
- Volunteers
- 1,789 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Neuro-Ophthalmology
Safety and Normative Data With Neos™
The goal of this clinical study is to collect standard data for the medical device neos™. neos™ is a system that shows images and measures the resulting eye movements and pupil size. Collecting standard data involves three steps.
- Trial name
- neos-SNOW (NCT07258212)
- Where
- 3 sites in Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- machineMD AG
Ophthalmopathy, Artificial Intelligence
Validation of the Utility of Ophthalmology Intelligent Diagnostic System
The prevention and treatment of diseases via artificial intelligence represents an ultimate goal in computational medicine. Application scenarios of the current medical algorithms are too simple to be generally applied to…
- Trial name
- NCT03499145
- Testing
- Ophthalmology diagnostic system.
- Where
- China
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Non-emergency Ocular Diseases
Evaluate the Performance of Large Language Models in Ophthalmologic Patient Consultation
The intelligent image models lack an understanding of diagnostic and treatment logic, and have not considered textual information such as symptoms and signs.
- Trial name
- NCT06824389
- Testing
- Consultation Model of large language model in Ophthalmology Clinics
- Where
- China
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Ophthalmology
The Clinical Application of Artificial Intelligent(AI) Visual Inspection System
In this study, the investigators provide participants from ophthalmic clinic the AI visual inspection system and EDTRS in the purpose of seeking out a better way of visual inspection with high efficiency and accuracy, and report…
- Trial name
- AI (NCT03310216)
- Testing
- Order I of visual inspection, Order II of visual inspection
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Visual Function, Vision
Visual Function Screening System With Special Needs Children and Typical Preschoolers
The early visual screening of children plays a critical role in promoting visual development, especially for those with visual impairments.
- Conditions
- Visual Function, Vision, Special Needs Children
- Trial name
- NCT07081139
- Testing
- observational study, no interventional
- Where
- Taiwan
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mild Traumatic Brain Injury, Concussion, Binocular Visual Function
An Early Prospective Study of the Traq™ Device for Characterization of Binocular Ocular Function in Normal Subjects and Subjects With Recent Traumatic Brain Injury
The early prospective study of Traq™ (an investigational binocular ophthalmic neurodiagnostic device) will measure binocular ocular functions (bilateral foveal fixation, foveal binocularity, and fovea-tracked saccadic latency) in…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Binocular Visual Function, Neuro-Ophthalmology, Saccadic Eye Movements
- Trial name
- REB-001 (NCT07742878)
- Testing
- Binocular ophthalmic neurodiagnostic device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rebiscan, Inc.
Ophthalmology, Macular Degeneration
A Follow-up Physician Survey to Evaluate Physician Knowledge of Safety and Safe Use Information for Aflibercept Administered by Intravitreal Injection in Europe
With this follow up physician survey researcher want to collect the same data from all participants of the study using a highly structured questionnaire.
- Trial name
- NCT04067583
- Testing
- Physician questionnaire
- Where
- Germany
- Volunteers
- 454 people, healthy volunteers welcome
- Sponsor
- Bayer
Ophthalmology
Study on the Effect of Eye-covering Pretreatment on Acute Delirium After General Anesthesia in Pre-school Aged Children
Participants (preschool children), because their cognitive ability and anti pressure ability are obviously weaker than adults, most of the children who have this kind of operation and anesthesia stressors will have perioperative…
- Trial name
- NCT04973150
- Testing
- To explore whether pretreatment with eye covering can reduce the incidence of acute delirium and the score of delirium after general anesthesia in ophthalmology pre-age children.
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Retinopathy of Prematurity
Clinical and Genetic Analysis of ROP
Retinopathy of Prematurity (ROP) is a vascular disease affecting the retinas (back of the eye) of low birth weight infants. Although it can be treated effectively if diagnosed early, it continues to be a leading cause of…
- Trial name
- (ROP) (NCT04420156)
- Testing
- No intervention administered.
- Where
- 5 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University