Clinical trials: Opioid Use Disorders
Substance-Related Disorders, Alcohol-Related Disorders
Conflict Between Maternal Autonomy and Child Health in Substance-use
Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Amphetamine-Related Disorders, Inhalant Abuse
- Trial name
- NCT02797990
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cholelithiasis, Postoperative Pain, Laparoscopic Cholecystectomy
ESP vs Subcostal TAP Block for Analgesia After Laparoscopic Cholecystectomy
This prospective, randomized, double-blind study compares the analgesic efficacy of ultrasound-guided erector spinae plane (ESP) block and subcostal transversus abdominis plane (TAP) block in patients undergoing laparoscopic…
- Trial name
- ESP TAP (NCT07661693)
- Testing
- Erector Spinae Plane Block, Subcostal Transversus Abdominis Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Gaziantep City Hospital
Opioid Use Disorder, Pain, Chronic
Adolescent Outcomes of Post-operative Opioid EXposure
The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients.
- Trial name
- APEX (NCT06350409)
- Where
- 5 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- Sharon Levy
Opioid Related Disorders, Opiate Addiction
Evaluation of Drug Utilization Patterns for Extended Release/Long Acting Opioids and Comparator Products
A drug utilization study will be performed to describe trends in the number of prescriptions and patients for class REMS ER/LA opioids and comparator products.
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02925806
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 5,575,834 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Opioid Use, Opioid Dependence
Safe Return and Disposal of Unused Opioids
The opioid epidemic in the United States has become a clear health and safety concern for our children and families. Opioids given to our patients for the treatment of pain that go unused after the immediate post operative period…
- Conditions
- Opioid Use, Opioid Dependence, Opioid Abuse, Unspecified
- Trial name
- NCT03352479
- Testing
- Opioid Return
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Opioid Use Disorder, Opioid Dependence
Medication-Assisted Treatment for Youth With Substance Use Disorders
The purpose of this open-label pilot study is to determine the tolerability and applicability of outpatient long-acting injectable naltrexone (Vivitrol) treatment in individuals age 16-25 ("older youth") with opioid use disorder.
- Trial name
- NCT02593474
- Testing
- Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- New York State Psychiatric Institute
Methamphetamine Abuse, Opioid-use Disorder
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
The investigators propose to develop and evaluate optimal combinations of evidence-based interventions to improve HIV outcomes and reduce methamphetamine use (hereafter: meth use) among people with opioid use disorder who are in…
- Conditions
- Methamphetamine Abuse, Opioid-use Disorder, HIV Seropositivity
- Trial name
- STAR-OM (NCT04706624)
- Testing
- Contingency management (12 weeks), Contingency management (6 weeks), SMS reminders
- Where
- 4 sites in Vietnam
- Volunteers
- 667 people
- Sponsor
- Hanoi Medical University
Ureteropelvic Junction Obstruction, Hypospadias
Effect of Oxybutynin on Opioid Use After Urologic Surgery in Children
The goal of this clinical trial is to determine whether giving oxybutynin before urologic reconstruction surgery reduces the amount of opioid pain medication needed in children.
- Trial name
- NCT07911137
- Testing
- Oxybutynin
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
Substance Use Disorders, Recidivism
Preventing OUD in Justice-Involved Youth
The United States is experiencing an opioid epidemic. Sadly, opioid-related fatalities are on the rise, causing profound emotional, financial, and cultural impacts.
- Trial name
- POST (NCT04901312)
- Testing
- Adolescent Community Reinforcement Approach, Assertive Continuing Care, Trauma Affect Regulation Guide for Education and Therapy
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- Seattle Children's Hospital
Opioid Dependence
Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use Disorder
Patients with opioid use disorder seeking medication-assisted treatment will be recruited. Each participant will be allocated to one of the two study groups with the equal chance of receiving either opium tincture (OT) or…
- Trial name
- OT-RCT (NCT02502175)
- Testing
- opium, methadone
- Where
- 4 sites in Iran
- Volunteers
- 204 people
- Sponsor
- University of British Columbia
Adenotonsillectomy, Post-operative Analgesia
Non-opioids for Analgesia After Adenotonsillectomy in Children
The goal of this study is to determine if non-opioid pain control is a safe way to manage pain after adenotonsillectomy surgery in children.
- Conditions
- Adenotonsillectomy, Post-operative Analgesia, Opioid Use
- Trial name
- NCT03618823
- Testing
- Oxycodone, Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- David Chi, MD
Substance Abuse, Opioid Abuse (Disorder)
Youth Overdose & Use Reduction in Rural Systems
The goal of this study is to conduct a clinical trial to understand effects of providing multilevel intervention to young people in the legal system.
- Conditions
- Substance Abuse, Opioid Abuse (Disorder), Overdose Prevention, Substance Use Disorder (SUD)
- Trial name
- YOURS (NCT07846735)
- Testing
- Navigator - Flexible Care Management
- Volunteers
- 550 people
- Sponsor
- Seattle Children's Hospital
Opioid Use Disorder (OUD), Chronic Pain
Addiction Treatment in Primary Care Expansion
The Veterans Health Administration (VA) is a national leader in addressing the twin epidemics of chronic pain and opioid use, misuse, and opioid use disorder (OUD); but important challenges remain.
- Trial name
- APEX (NCT03547882)
- Where
- 2 sites in United States
- Sponsor
- VA Office of Research and Development
Opioid Use Disorder, Neonatal Abstinence Syndrome
RESPECT-PLUS: Services for Infants With Prenatal Opiate Exposure
The impact of parental opioid use disorder and other substance use exposure on child welfare and the healthcare system is undeniable.
- Conditions
- Opioid Use Disorder, Neonatal Abstinence Syndrome, Child Development, Child Abuse
- Trial name
- RESPECT-Plus (NCT02334111)
- Testing
- RESPECT-Plus
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Medical Center
Rheumatoid Arthritis
Changes in the Use of Opioids, Antidepressants, and Benzodiazepines in Rheumatoid Arthritis Patients Treated With Biologic Agents
To compare the proportion of rheumatoid arthritis (RA) patients prescribed opioids, benzodiazepines, and antidepressants before versus after starting each of the following biologics: abatacept, infliximab, etanercept, adalimumab…
- Trial name
- NCT01137838
- Volunteers
- 1,810 people
- Sponsor
- Bristol-Myers Squibb
Opioid Use Disorder (OUD)
HEALing Communities Study
This study will test the impact of implementing the Communities That Helping to End Addiction Long-term (HEAL) intervention on opioid overdose deaths within 67 highly affected communities with the goal of reducing opioid overdose…
- Trial name
- NCT04111939
- Testing
- Communities That HEAL, Wait-list control
- Where
- 4 sites in United States
- Volunteers
- 67 people
- Sponsor
- RTI International
Anterior Cruciate Ligament (ACL) Tear, Sports Injuries in Children
Evaluation of Pain Management After Surgery When Using Nerve Blocks in the Pediatric Population
The goal of this randomized clinical trial is to determine if single-shot ropivacaine peripheral nerve blocks (PNB - perineural injections) for anterior cruciate ligament (ACL) reconstruction procedures in pediatric orthopaedic…
- Conditions
- Anterior Cruciate Ligament (ACL) Tear, Sports Injuries in Children, Analgesia, Pain, Postoperative
- Trial name
- NCT06559137
- Testing
- Ropivacaine 0.2% Injectable Solution
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Texas Scottish Rite Hospital for Children
Opioid Use Disorder
Medications for Opioid Use Disorders (MOUD) Via Telemedicine
Medication Assisted Treatment (MAT) of Veterans with Opioid Use Disorder (OUD) decreases mortality and improves treatment follow-up.
- Trial name
- NCT03566459
- Testing
- CBOC offering Tele-MOUD to Veterans, CBOC not offering Tele-MOUD to Veterans
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Analgesics, Antipyretics and Anti-Inflammatory Drugs Causing Adverse Effects in Therapeutic Use
Developing a Method to Objectively Measure Opioid Analgesia
Inappropriate prescribing is the fundamental upstream driver of the opioid epidemic. Objective measures to determine the appropriateness of an opioid intervention, provide monitoring of the therapy for adequacy of dose and…
- Trial name
- NCT03605966
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Julia Finkel
Opioid Addiction, Opioid Abuse, Continuous Use
Healthy Adult Male Facial Skin Surface Lipid Pheromone p.o. to Treat Opioid Addiction
Healthy adult human male facial skin surface lipid liquid pheromone given by mouth to opioid addicts cures them without any withdrawal symptoms whatsoever 250mg on chewing gum vehicle by mouth.
- Conditions
- Opioid Addiction, Opioid Abuse, Continuous Use, Opioid Use, Opioid-Related Disorders
- Trial name
- NCT03394911
- Testing
- 250mg healthy adult male facial skin surface lipid liquid pheromone
- Volunteers
- 500 people
- Sponsor
- Bubba Nicholson