Clinical trials: Oral Contraceptive
Endometriosis Ovary
Comparing the Safety and Efficacy in the Use of Hormonal Therapy on Endometriosis Patients After Conservative Surgery
The goal of this clinical trial is to compare safety and efficacy in endometriosis patient after conservative surgery. The main question[s] it aims to answer are: 1. Health-related quality of life (HRQoL) 2. VAS score 3.
- Trial name
- ENDOSafe (NCT06145438)
- Testing
- Dienogest, Depo Medroxyprogesterone acetate, Leuprolide (as Leuprolide Acetate)
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Diponegoro
Reproductive Health
RH and Adolescents
This study will create a model of reproductive health services for HIV-positive female adolescents in Asia.
- Trial name
- NCT02713750
- Testing
- reversible contraceptive methods
- Where
- 4 sites in Thailand
- Volunteers
- 77 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Contraceptive Usage, Diffuse Noxious Inhibitory Control
Effects of Oral Contraceptives on DNIC in Non-painful Healthy Women
The purpose of this study is tu assess the influence of oral contraceptives (OC) on diffuse noxious inhibitory control (DNIC) in healthy women, tested during high, low endogenous estrogens sessions and ovulatory period.
- Trial name
- NCT04365426
- Testing
- Mechanical stimulus, Thermal (cold) stimulus, Oral contraceptive (OC)
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Vina del Mar
Human Immunodeficiency Virus (HIV)
ComBaCaL HIV Prevention TwiCs
This cluster-randomized intervention is embedded in the ComBaCaL (Community-Based Chronic disease care Lesotho) cohort study (EKNZ ID AO_2022-00058, clinicaltrials.gov ID NCT05596773, Lesotho NH-REC ID 210-2022), a platform for…
- Trial name
- CoPrev (NCT07581600)
- Testing
- CoPrev model, Referral to the nearest responsible health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hyperandrogenism
Phase II Randomized Study of Leuprolide Vs Oral Contraceptive Therapy Vs Leuprolide and Oral Contraceptive Therapy for Ovarian Hyperandrogenism
OBJECTIVES: I. Evaluate the beneficial effects of leuprolide depot, oral contraceptive therapy, and leuprolide/oral contraceptive therapy in the management of patients with ovarian hyperandrogenism.
- Trial name
- NCT00004763
- Testing
- leuprolide, Ethinyl estradiol/norethindrone
- Volunteers
- 45 people
- Sponsor
- National Center for Research Resources (NCRR)
Polycystic Ovary Syndrome
71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women
An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has been suggested in previous studies.
- Trial name
- 17b-ACO (NCT01372293)
- Testing
- oral contraceptive pill
- Volunteers
- 49 people
- Sponsor
- Federal University of Rio Grande do Sul
Acne Vulgaris
Evaluate Safety and Efficacy of an Oral Contraceptive (OC) Preparation Versus Placebo for 6 Treatment Cycles in Women With Moderate Acne
The objectives of this study were to evaluate the efficacy and safety of drospirenone 3 mg/ethinyl estradiol 0.02 mg (DRSP/EE) in comparison with placebo in female subjects with moderate acne vulgaris during 6 treatment cycles
- Trial name
- NCT00656981
- Testing
- YAZ (DRSP 3 mg/EE 0.02 mg, BAY86-5300)
- Where
- 22 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Bayer
Dysmenorrhea
Efficacy and Safety Study of Low Dose Oral Contraceptive Pill to Treat Primary Dysmenorrhea
The purpose of this study is to determine whether combination oral contraceptive pill of norethindrone and ethinyl estradiol is effective in the treatment of primary dysmenorrhea.
- Trial name
- NCT00746096
- Testing
- IKH-01
- Volunteers
- 115 people
- Sponsor
- Nobelpharma
Oral Contraception
The Impact of Pack Supply on Birth Control Pill Continuation
The purpose of this study is to determine whether getting more packs of birth control pills leads to improved continuation, when compared with getting the traditional supply.
- Trial name
- SixPack (NCT00677742)
- Testing
- enhanced initial supply of oral contraception, conventional initial supply of oral contraception
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Columbia University
Acne Vulgaris
Study on Safety and Efficacy of an Oral Contraceptive in Treating Acne Papulopustulosa
The purpose of the study is to determine safety and efficacy of an oral contraceptive in treating acne papulopustulosa.
- Trial name
- NCT00280657
- Testing
- Valette, Diane
- Where
- 62 sites in Czechia, Poland and 3 more
- Volunteers
- 1,326 people
- Sponsor
- Bayer
Polycystic Ovary Syndrome (PCOS)
Steroid Profiles in PCOS and Effect of OCP Treatment
This prospective observational study investigates the changes in serum steroid intermediates assessed by liquid chromatography-mass spectrometry (LC-MS/MS) in adolescents and young women with polycystic ovary syndrome (PCOS)…
- Trial name
- PCOSLCMS (NCT07161440)
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Istanbul University
Contraception
Prospective Controlled Cohort Study on the Safety of a Monophasic Oral Contraceptive Containing Nomegestrol Acetate (2.5mg) and 17ß-estradiol (1.5mg)
This study compares the risks of short- and long-term use of NOMAC-E2 (containing a fixed dose of nomegestrol acetate and estradiol) compared with levonorgestrel-containing combined oral contraceptives (COC-LNG) in a study…
- Trial name
- PRO-E2 (NCT01650168)
- Where
- Germany
- Volunteers
- 101,498 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Cardiovascular Diseases, Coronary Disease
Myocardial Infarction and Current Oral Contraceptive Use
To assess whether current oral contraceptive (OC) use (within the previous month) increased the risk of myocardial infarction. Also, to assess the combined effects of cigarette smoking and oral contraceptive use.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005241
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Contraception, Change in Bone Mineral Density
Efficacy, Safety, and Tolerability of LPRI-CF113 as an Oral Contraceptive in Females
This study will be in two parts, Part A and Part B. The primary objective of Part A is to evaluate the contraceptive efficacy of LPRI-CF113.
- Trial name
- NCT05461573
- Testing
- Drospirenone
- Where
- 47 sites in United States, Canada
- Volunteers
- 1,542 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Contraceptives, Oral, Combined
Observational Trial With Leios/Alesse
A prospective, observational study (Anwendungsbeobachtung [AWB]) of the prescribing and administration practices of German gynecologists with Leios® Dragées.
- Trial name
- NCT00481650
- Testing
- Leios/Alesse
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Menorrhagia
Tranexamic Acid (TA) vs Combined Oral Contraceptive (COCP) Pilot Study
Menorrhagia, considered a public health challenge and reported by 5 to 10% of adult women, is encountered even more frequently in adolescents.
- Trial name
- NCT01428713
- Testing
- Oral tranexamic acid, Oral Contraceptive Pills
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Contraception
Nexplanon and Combined Oral Contraceptive (COC) Combined Use Study
Women currently using or starting a combined oral contraceptive will be offered study enrollment. Study subjects will have a Nexplanon placed and followed for 6 months to evaluate if they continue the COC, continue the implant…
- Trial name
- NexTOC (NCT02852265)
- Testing
- Etonogestrel contraceptive implant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Contraception
International Active Surveillance Study of Women Taking Oral Contraceptives (INAS-OC)
The study compares the short- and long-term risks of a 24-day regimen of a drospirenone-containing oral contraceptive with the risks of established oral contraceptives in a study population that is representative for the actual…
- Trial name
- NCT00335257
- Where
- Germany
- Volunteers
- 85,109 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Venous Thromboembolism
RIVET - Retrospective Cohort Study on the Risk of Venous Thromboembolism
The risk of venous thromboembolism (VTE) associated with the use of chlormadinone acetate (CMA) compared to the gold-standard progestin levonorgestrel (LNG) as component of combined oral contraceptives (COC) is currently unknown.
- Trial name
- RIVET-RCS (NCT02828904)
- Where
- Germany
- Volunteers
- 124,000 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
HIV Infections, Contraception
A Crossover Acceptability Study Assessing a DPP Capsule for HIV and Pregnancy Prevention
The study design is a single-site, two-arm, randomized, open-label crossover trial in 30 AGYW aged 16-24 in Chitungwiza (Harare), Zimbabwe.
- Trial name
- 952 (NCT04778514)
- Testing
- Dual Prevention Pill, PrEP and combined oral contraceptive (COC) as two separate tablets
- Where
- Zimbabwe
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Population Council