Clinical trials: Oral Microbiome
Tooth Decay, Probiotics
Effects of Probiotics on Streptococcus Mutans ve Lactobacillus Spp
To evaluate the change of S. mutans and Lactobacillus spp. counts after all dental treatments were completed under general anesthesia and compare the groups in case of using probiotics and not using probiotics with the time for…
- Conditions
- Tooth Decay, Probiotics, Streptococcus Mutans
- Trial name
- NCT05859646
- Testing
- Probiotic use
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Didem Sakaryali Uyar
Bacterial Infections
Effect of Xylitol on Oral Microbiota in Children
1. The present controlled, randomized, doubleblind study aims to answer the following questions: How will the "normal flora" be affected by the xylitol consumption? Will daily consumption of xylitol change the plaque-saliva…
- Trial name
- NCT01528969
- Testing
- xylitol, sorbitol
- Where
- Kuwait
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Kuwait University
Streptococcus Mutans
Investigation of Oral Microflora of Infants
The placement of cariogenic microorganisms in oral microflora is an important factor in dental caries. The aim of this study is to research from whom, when and how the cariogenic microorganisms are first transmitted to the…
- Trial name
- NCT04228861
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Inonu University
Less Than 3 Months Old, Healthy Infants
An Intervention Study in Healthy Infants Aged 0-6 Months With Probiotics Lacticaseibacillus Rhamnosus LRa05 (LRa05) and Bifidobacterium Animalis Subsp. Lactis BLa80 (BLa80) vs. Placebo, for Promoting Gut Microbiome Development.
The probiotics Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 have potential to enhance infant health and development based on previous research conducted on human infants.
- Trial name
- SMILE (NCT07505329)
- Testing
- Probiotic
- Where
- Ireland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University College Cork
Sleep Deprivation, Gut Microbiota
Microbiota Profiles in Newly Married Couples: Potential Effects on Vision, Sleep and Psychometric Parameters
Oral, fecal and conjunctival samples will be collected from participants and will be stored (at - 20 and - 80 ◦C) until further processing.
- Conditions
- Sleep Deprivation, Gut Microbiota, Optometry Examinations, Oral Microbiota
- Trial name
- NCT06638606
- Testing
- Sleep improvement techniques
- Where
- Iran
- Volunteers
- 1,740 people, healthy volunteers welcome
- Sponsor
- Reza Rastmanesh
Apical Periodontitis
Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment
Post-treatment apical periodontitis is commonly associated with persistent intracanal infection following root canal treatment. Effective disinfection of the complex root canal system during nonsurgical retreatment remains…
- Trial name
- NCT07469150
- Testing
- GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Changes in the Oral Microbiota
Oral Administration of Colostrum to Premature Babies: Impact on the Oral Microbiota
Oropharyngeal administration of mother's colostrum to premature infants has been proposed as a stimulus to the oropharyngeal lymphatic tissues to decrease the incidence of pneumonia and sepsis, particularly in intubated babies.
- Trial name
- NCT02306980
- Testing
- Colostrum
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Davis
Autism Spectrum Disorder, Microbiota
Gut-oral Axis Microbiome in Autism Spectrum Disorders
Autism Spectrum Disorder (ASD) is a neurodevelopment disorder characterized by impairment in social interaction, communication, and behavior, as well as sensory challenges.
- Trial name
- NCT05830591
- Testing
- Characterization of the microbiome in oral and fecal samples
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- IRCCS Burlo Garofolo
Bleeding on Probing, Pocket Depth
This Study Utilized Fermented Lingonberry Juice in a Spray Form, Allowing it to be Applied to the Mouth Four Times a Day.
A human intervention study was performed to examine the antimicrobial effects of fermented lingonberry spray (FLJ spray) treatment, used for a period of 30 days.
- Conditions
- Bleeding on Probing, Pocket Depth, Plaque Control, Saliva Microbiome
- Trial name
- FLJS_TRE (NCT07143344)
- Testing
- Fermented lingonberry juice sprey
- Where
- Finland
- Volunteers
- 11 people
- Sponsor
- Lahanna oy
pH, Microbiome
Oral Changes With Caloric and no Caloric Sweeteners
The objective of this clinical trial is to compare the effect that the intake of beverages without sweeteners, added with non-caloric sweeteners (stevioside) and caloric sweeteners (sucrose) on oral pH and dental biofilm…
- Conditions
- pH, Microbiome, Dental Plaque
- Trial name
- NCT05852145
- Testing
- Stevioside, Sucrose, Natural water
- Where
- Mexico
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Allergy;Food
Biomarkers in Food Allergy Diagnosis
Food allergy is a global burden, affecting patients, society as a whole and the economy. For most common food allergies, patients synthesize specific IgE-antibodies against harmless food proteins.
- Trial name
- APSIS (NCT04604912)
- Where
- 2 sites in Luxembourg
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Milk Allergy
Swedish Study of Immunotherapy for Milk Allergy in Children
This trial is a two-armed open randomized controlled trial in children aged 5-15 years with challenge proven Immunoglobulin E (IgE)-associated milk allergy.The purpose is to determine if oral immunotherapy with milk can induce…
- Trial name
- SWITCH (NCT03819556)
- Testing
- Milk protein in fresh milk
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Health Behavior
Sweet Cheeks: How Early Nutrition Affects Oral Microbiota Populations and Disease Incidence
Dietary and oral hygiene habits are known to affect oral microorganisms and disease incidence, but most research has focused on preschool aged (2-4 yr old) children.
- Trial name
- NCT01836952
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Peanut Allergy
Pinpoint Trial: Prebiotics IN Peanut Oral ImmunoTherapy
The purpose of this research is to gather information on the safety and efficacy of using a prebiotic as an adjunctive therapy to peanut oral immunotherapy.
- Trial name
- NCT05138757
- Testing
- Prebiotic
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Dental Caries, Dental Plaque
Orthodontic Varnish Microbiology Study
Orthodontic treatment is common in teenagers, which typically involve the attachment of metal brackets to the teeth. These brackets often impede proper oral hygiene, leading to plaque accumulation and the development of white…
- Conditions
- Dental Caries, Dental Plaque, Dental White Spot
- Trial name
- NCT04528134
- Testing
- Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Gestational Hypertension
Role of the Oral Microbiome in Blood Pressure Regulation in Pregnancy
High blood pressure in pregnancy is associated with poor outcomes for both mum and baby, increasing the risk of pregnancy complications including pre-eclampsia, fetal growth restriction and preterm birth.
- Trial name
- NCT03930693
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Dental Caries, Oral Bacterial Infection
Ecological Effect of Arginine Dentifrice on Oral Microbiota
caries-free (CF) individuals caries-active (CA) individuals (DMFT ≥ 6) will be recruited. Subjects will be instructed to brush their teeth twice daily for 3 min using Colgate® Sensitive Pro-Relief® toothpaste (containing 8%…
- Conditions
- Dental Caries, Oral Bacterial Infection, Microbiota
- Trial name
- NCT02988349
- Testing
- Colgate® Sensitive Pro-Relief® toothpaste
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sichuan University
Orthodontic Appliance Complication, Lactobacillus Infection
SPACE MAINTAINERS EFFECTS ON ORAL MİCROFLORA
Space maintainers are used to preserve the space after premature loss of teeth but they could effect some factors that play a role in caries formation.
- Conditions
- Orthodontic Appliance Complication, Lactobacillus Infection, Dental Caries in Children, Streptococcus, Other Specified Group
- Trial name
- NCT04749654
- Testing
- The Salivary pH measured, The saliva flow rate was measured, Streptococcus mutans and Lactobacillus counts in saliva were measured
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University