Clinical trials: Organization and Administration
Spinal Cord Injuries, Cerebral Palsy
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries
- Trial name
- NCT02592291
- Testing
- MHealth
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Graft-versus-Host-Disease, Leukemia
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults…
- Conditions
- Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer
- Trial name
- NCT04372524
- Where
- 16 sites in United States, Canada
- Volunteers
- 350 people
- Sponsor
- University of British Columbia
Graft Versus Host Disease, Acute Graft Versus Host Disease
BMT Autologous MSCs for GvHD
Subjects in this study have had an allogeneic (blood or marrow cells from another person) blood or marrow transplant to treat leukemia, lymphoma or other cancer of the blood, and have now developed Graft Versus Host Disease…
- Conditions
- Graft Versus Host Disease, Acute Graft Versus Host Disease, Chronic Graft Versus Host Disease
- Trial name
- NCT02359929
- Testing
- Autologous mesenchymal stromal cells (MSCs)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Emory University
Graft vs Host Disease
Pentostatin for High Risk and Refractory Chronic Graft Versus Host Disease in Children
This is a multicenter trial through the Pediatric Blood and Marrow Transplant Consortium. The Primary hypothesis of this study is that because of its effect as a potent immunosuppressive agent targeting lymphocytes, pentostatin…
- Trial name
- NCT00144430
- Testing
- Pentostatin
- Where
- 25 sites in United States
- Volunteers
- 60 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Wounds and Injuries, Burns
Treatment of Wounds With a New Adhesive Foam Dressing
This study will look at whether ELECT, a new adhesive foam dressing, can offer an alternative to traditional wound care methods. Patients will be treated with ELECT for 14 days.
- Trial name
- NCT02807584
- Testing
- ELECT
- Where
- South Africa
- Volunteers
- 25 people
- Sponsor
- Smith & Nephew, Inc.
Bronchiolitis Obliterans Syndrome
Early Detection and Management of Bronchiolitis Obliterans Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation
This study aims to determine whether or not early spirometric detection and management of obstructive lung disease with combined fluticasone/azithromycin/montelukast therapy (FAM) can attenuate declining lung function, prevent…
- Trial name
- NCT03072849
- Testing
- Pulmonary function testing, FAM Therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Breast Cancer
Randomized Boost Versus no Boost Irradiation of Early Breast Cancer
Radiation therapy may kill any tumor cells remaining after surgery. This randomized phase III trial is studying the effect of an extra dose of radiation therapy (Boost dose) after breast conserving surgery and 50 Gy adjuvant…
- Trial name
- NCT02295033
- Testing
- Boost irradiation
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Chronic Graft Versus Host Disease
Upfront Ruxolitinib for Chronic Graft-vs-host Disease
While hematopoietic stem cell transplant (HSCT) is an effective therapy, graft versus host disease (GVHD) is the most significant complication after HSCT.
- Trial name
- NCT06695507
- Testing
- Ruxolitinib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Surgery
Medical Management Survey : Organization of Perioperative Practices in Anesthesia and Ambulatory Surgery
In France, there are no precise data regarding perioperative organization of medical structure and care management of ambulatory surgical patients.
- Trial name
- OPERA (NCT02380430)
- Testing
- ambulatory surgery description
- Where
- 233 sites in France
- Volunteers
- 2,174 people
- Sponsor
- University Hospital, Grenoble
Cesarean Section Rates
Reducing Cesarean Section Rates and Enhancing Vaginal Delivery in Greece: a Stepped-Wedge Randomized Controlled Trial
It is becoming increasingly apparent that there is an urgent need to systematically investigate the rising cesarean section (CS) rates in Greece and develop interventions to substantially reduce these rates.
- Trial name
- ENGAGE (NCT04504500)
- Testing
- HSOG guidelines application, Interactive workshops and courses, Feedback through follow-up meetings
- Where
- Greece
- Volunteers
- 6,029 people, healthy volunteers welcome
- Sponsor
- Hellenic Society of Obstetrics and Gynecology
Diffuse Midline Glioma (DMG), Glioblastoma
ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
This phase I trial studies the effects and best dose of ONC206 alone or in combination with radiation therapy in treating patients with diffuse midline gliomas that is newly diagnosed or has come back (recurrent) or other…
- Conditions
- Diffuse Midline Glioma (DMG), Glioblastoma, Recurrent Ependymoma, Recurrent Malignant Central Nervous System Neoplasm
- Trial name
- PNOC023 (NCT04732065)
- Testing
- ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS)
- Where
- 7 sites in United States, Netherlands and 1 more
- Volunteers
- 208 people
- Sponsor
- Sabine Mueller, MD, PhD
Heart Failure, Congestive
Organized Program To Initiate Lifesaving Treatment In Hospitalized Patients With Heart Failure (OPTIMIZE-HF)
This program is designed to improve medical care and education of hospitalized patients with heart failure and accelerate the initiation of evidence-based heart failure guideline recommended therapies by administering them before…
- Trial name
- NCT00344513
- Testing
- Beta-blockers including Carvedilol, ACE inhibitors
- Volunteers
- 50,000 people
- Sponsor
- GlaxoSmithKline
Sarcoma
Economic Evaluation of Sarcoma Patients Management in France
The aim of this project is to (1) evaluate the efficiency of early management of sarcoma patients by the sarcoma referral network (NETSARC) vs.
- Trial name
- OPTISARC (NCT05272358)
- Testing
- NETSARC network
- Where
- 25 sites in France
- Volunteers
- 2,431 people
- Sponsor
- Centre Leon Berard
Caries Experience
Evaluation of Dental Caries Using Caries Assessment Spectrum and Treatment Need (CAST) Index, International Caries Detection and Assessment System (ICDAS) Index and World Health Organization (WHO) Index
This study goals is to compare the three indices in Egyptian children aged 4 to 6 years in caries detection and time needed for the assessments which will contribute to valuable data for pediatric oral health assessments both…
- Trial name
- CAST/ICDAS/WHO (NCT06858462)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cairo University
Glioblastoma
Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas
This study was conducted to evaluate the efficacy and safety of depatuxizumab mafodotin (ABT-414) alone or with temozolomide versus temozolomide or lomustine alone in adult participants with recurrent glioblastoma.
- Trial name
- INTELLANCE-2 (NCT02343406)
- Testing
- Depatuxizumab mafodotin, Temozolomide, Lomustine
- Where
- 102 sites in United States, Australia and 19 more
- Volunteers
- 266 people
- Sponsor
- AbbVie
Bronchiolitis Obliterans Syndrome (BOS)
Mechanisms and Targeted Therapy of Airway Basal Cell Dysfunction in Bronchiolitis Obliterans Syndrome
This experimental study aims to investigate the pathogenesis of bronchiolitis obliterans syndrome (BOS) and provide a basis for clinical diagnosis and treatment.
- Trial name
- NCT07018804
- Testing
- Bronchoscopic brushing, Single - cell cloning, Cell function identification
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Haikou Affiliated Hospital of Central South University Xiangya School of Medicine
Attention Deficit Hyperactivity Disorder (ADHD)
Organizational Skill Training (OST) in Schools
The primary aim of this project is to address the need for an effective school-based intervention for elementary school-aged students with Organization, Time Management, and Planning (OTMP) deficits by adapting an…
- Trial name
- NCT02663986
- Testing
- Organizational Skills Training (OST) Intervention
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- NYU Langone Health
Child Development, Schools
Kettlebell-classroom Training
Physical fitness is a crucial health marker, predicting both cardiovascular and all-cause mortality. Muscular strength, an essential component of physical fitness, underpins physical and psychological well-being, particularly…
- Conditions
- Child Development, Schools, Primary Health Care, Resistance Training
- Trial name
- kettleclass (NCT06910085)
- Testing
- kettlebell-training
- Where
- Switzerland
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Recurrent World Health Organization (WHO) Grade II Glioma, Low-grade Glioma
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)
This phase I trial studies the side effects and best dose of trametinib and everolimus in treating pediatric and young adult patients with gliomas that have come back (recurrent).
- Conditions
- Recurrent World Health Organization (WHO) Grade II Glioma, Low-grade Glioma, High-Grade Glioma (HGG)
- Trial name
- NCT04485559
- Testing
- Everolimus, Trametinib
- Where
- 17 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco