Clinical trials: Orthodontic Aligner
Tooth Crowding, Malocclusion
Predictability of Orthodontic Tooth Movement With Invisalign Aligners
Together with the increased adult patient demand for orthodontic treatment and the push toward increasingly personalized treatment, technology developments have resulted in a growing worldwide demand for clear aligners, to the…
- Conditions
- Tooth Crowding, Malocclusion, Malocclusion, Angle Class II, Malocclusion, Class I/II
- Trial name
- NCT05356780
- Testing
- Aligner
- Where
- Italy
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Periodontal Diseases, Malocclusion
Influence of Finishing Clear Aligner Marginal Termination Design on Subgingival Periodontal Microbiota During Orthodontic Treatment: A Split-Mouth Study.
The goal of this clinical trial is to learn whether the edge design of a finishing orthodontic clear aligner at the gumline affects the bacteria living in the groove between the tooth and the gum (the gingival sulcus) in patients…
- Conditions
- Periodontal Diseases, Malocclusion, Oral Health
- Trial name
- PATHO-ALIGN (NCT07533058)
- Testing
- CA Pro tri-layer finishing clear aligner (SCHEU-DENTAL GmbH)
- Where
- Romania
- Volunteers
- 36 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Clear Aligner Appliance
Evaluation of the Efficacy of Injectable Platelet-rich Plasma in Tooth Movement Acceleration With Clear Aligner
Aim of the study is evaluation of the efficacy of injectable platelet-rich plasma in orthodontic tooth movement acceleration with clear aligner
- Trial name
- NCT07103551
- Testing
- Platelet-rich plasma
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Patient Comfort, Malocclusion
Comparison of Patient-Reported Comfort Between Two Clear Aligner Trimming-Line Designs: A Split-Mouth Study
The trimming-line design of clear aligners (supragingival versus juxtagingival) is a routine clinical decision whose influence on patient-reported comfort has not been established; available evidence on aligner comfort derives…
- Conditions
- Patient Comfort, Malocclusion, Oral Health
- Trial name
- COMFORT-ALIGN (NCT07660809)
- Testing
- Supragingival trimming-line design, Juxtagingival festooned trimming-line design
- Where
- Romania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Root Resorption, Pain
Side Effects of Different Treatment Methods
this study aimed to compare the effects of fixed orthodontic treatment and clear aligner therapy on root resorption, periodontal status, pain experience and chewing performance.
- Conditions
- Root Resorption, Pain, Chewing Function
- Trial name
- NCT06709287
- Testing
- clear aligners, orthodontic metal bracket
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Bimaxillary Protrusion, Class II Div 1 Malocclusion
Discision as Acceleration Method in Canine Retraction in Orthodontics With Aligner and Fixed Appliances in Young Adults a Split Mouth Study
The effectiveness of discision in accelerating orthodontic canine retraction will be evaluated during clear aligner therapy and during conventional fixed orthodontic appliances.
- Trial name
- NCT07920276
- Testing
- Discision
- Where
- 2 sites in Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Endocrine Disruptors
A Comparison of Direct 3D Printed Clear Aligner System and Indirect Clear Aligner Systems With Fixed Orthodontic Treatment in Terms of Endocrine Disrupting Monomer Release, Treatment Effectiveness and Efficiency
The aim of this study is to evaluate the release of endocrine disrupting monomers from clear aligners as a result of exposure to intraoral factors by measuring their concentration in saliva and to evaluate their reliability of…
- Trial name
- NCT06685029
- Testing
- Clear aligner treatment, Fixed Orthodontic Appliance Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ahmet Yağcı
Clear Aligner Therapy, Aligner Attachment Wear
Clinical Evaluation of Customized Attachment Composites in Clear Aligner Therapy
This prospective observational clinical study aims to evaluate the three-dimensional surface wear and clinical survival of orthodontic attachments fabricated with customized composite materials used in clear aligner therapy.
- Trial name
- NCT07261735
- Testing
- GC G-ænial A'Chord Universal Composite, Spectra ST HV (High Viscosity), Spectra ST LV (Low Viscosity)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Orthodontic Aligner Material, Enamel Demineralization
Development of Biofunctional 3D-Printed Orthodontic Aligners With Antimicrobial and Remineralizing Properties
Clear orthodontic aligners are widely used due to their esthetics and patient comfort; however, prolonged wear may promote biofilm accumulation and enamel demineralization.
- Conditions
- Orthodontic Aligner Material, Enamel Demineralization, Dental Biofilm Formation, Clear Aligner Material Properties
- Trial name
- 3D-BIOALIGN (NCT07603427)
- Testing
- Modified 3D-Printed Orthodontic Aligner Resin
- Where
- Iraq
- Volunteers
- 400 people
- Sponsor
- University of Baghdad
Microplastic Exposure
Microplastic Exposure From Clear Aligner Wear (MPE)
An observational longitudinal study measuring microplastic exposure and physiologic uptake in orthodontic patients receiving clear aligner treatment.
- Trial name
- MPE (NCT06934603)
- Testing
- Clear Aligner Treatment
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of North Carolina, Chapel Hill
Malocclusion
Orthodontic Treatment With a Part-Time Wearing Esthetic Removable Appliance
The trial is aimed to investigate an orthodontic treatment with a new removable-part-time-wearing appliance, based on "High-Tech" technology.
- Trial name
- NCT00485602
- Testing
- orthodontic treatment with "Rafenalign" appliance
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Malocclusion, Esthetics, Dental
Effect of Finishing Clear Aligner Marginal Termination Design (Supragingival vs Juxtagingival) on Aligner Color Stability After 14 Days of Wear: A Split-Mouth Study
The goal of this clinical study is to learn whether the gumline edge design of a finishing orthodontic clear aligner affects how much the aligner's color changes after 14 days of wear.
- Trial name
- SPECTRO-ALIGN (NCT07628491)
- Testing
- Tri-layer thermoplastic finishing clear aligner
- Where
- Romania
- Volunteers
- 50 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Mixed Dentition Using Sequential Dental Aligners
This Study Will Examine Shortened Treatment Wear Time for Patients With Mixed Dentition Using AirFlex Aligner, Sequential Dental Aligners.
This study will examine shortened treatment wear time for patients with mixed dentition using sequential dental aligners. Using the existing AirFlex aligner design that patients with permanent dentition use, it may be possible to…
- Trial name
- NCT07220317
- Testing
- Sequential Aligners
- Volunteers
- 45 people
- Sponsor
- OrthoFX
Mild Intellectual Disability
Comparison of Orthodontic Aligner Treatment Protocols Managed Through Remote Monitoring Versus In-Person Care
This study aims to assess patient adherence to orthodontic treatment with dental aligners delivered through remote monitoring compared with in-person care.
- Trial name
- NCT07413003
- Testing
- Remotely monitored orthodontic aligner treatment, In-person monitored orthodontic aligner treatment
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Oasi Research Institute-IRCCS
The Present Study Aimed to Evaluate Root Parallelism in Cases of Anterior Teeth Spacing Treated With Clear Aligner Versus Fixed Orthodontic Appliances, Spacing Between Anterior Teeth
Evaluation of Root Parallelism in Cases of Anterior Teeth Spacing Clear Aligner Versus Fixed Appliances
evaluate root parallelism in cases of anterior teeth spacing treated with clear aligner versus fixed orthodontic appliances
- Trial name
- NCT06803940
- Testing
- clear aligner, orthodontic treatment
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Faculty of Dental Medicine for Girls