Clinical trials: Osteogenesis
Osteogenesis Imperfecta
An Efficacy and Safety Trial of Intravenous Zoledronic Acid in Infants Less Than One Year of Age, With Severe Osteogenesis Imperfecta
The investigators have currently finished conducting an international multi-center trial that compares the efficacy and safety of pamidronate and zoledronate in the treatment of moderate to severe forms of Osteogenesis Imperfecta…
- Trial name
- INFOI (NCT00982124)
- Testing
- Zoledronic Acid
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Shriners Hospitals for Children
Anorexia Nervosa
Safety Profile of Insulin Like Growth Factor-1 (IGF-I) Administration in Adolescents
The purpose of this study was to determine whether giving insulin like growth factor-I (IGF-I) to adolescent low weight girls is safe and whether this increases levels of bone formation markers.
- Trial name
- NCT00516386
- Testing
- RhIGF-1
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
Osteogenesis Imperfecta (OI)
A Dose REgimen-Finding Study of AGA2115 in Chinese Patients With Osteogenesis ImpeRfecta (EIR)
This study is to evaluate the safety and efficacy of AGA2115 at three different dose regimens in Chinese adults and adolescents with Type I, III, or IV Osteogenesis imperfecta (OI).
- Trial name
- EIR (NCT07557446)
- Testing
- AGA2115
- Where
- 5 sites in China
- Volunteers
- 48 people
- Sponsor
- Angitia Biopharmaceuticals Guangzhou Limited
Micrognathia of Lower Jaw, Retrognathism
Comparison Between Internal and External Distractors in Osteogenesis
Distraction osteogenesis is a powerful technique for creating new bone during significant lengthening of the mandible without the need for bone grafting and associated donor site morbidity.
- Conditions
- Micrognathia of Lower Jaw, Retrognathism, Facial Asymmetry
- Trial name
- NCT03540329
- Testing
- Internal Osteogenesis distractor, External Osteogenesis distractor
- Volunteers
- 30 people
- Sponsor
- Assiut University
Osteogenesis Imperfecta
Mesenchymal Stem Cell Based Therapy for the Treatment of Osteogenesis Imperfecta
The purpose of this study is to determine the safety and effectiveness of five infusions of characterized HLA-identical MSC in non immunosuppressed children with Osteogenesis Imperfecta (OI).
- Trial name
- TERCELOI (NCT02172885)
- Testing
- Mesenchymal Stem Cells
- Where
- 2 sites in Spain
- Volunteers
- 2 people
- Sponsor
- Hospital de Cruces
Indications and Effectiveness for Extended Posterior Circumferential Decompression
Safety and Effectiveness of Extended Circumferential Decompression for Thoracic Ossification of Posterior Longitudinal Ligament
The study was to evaluate the indications, efficiency and safety of the extended posterior circumferential decompression technique for the treatment of thoracic ossification of posterior longitudinal ligament (TOPLL) with dura…
- Trial name
- NCT04910737
- Testing
- extended posterior circumferential decompressive surgery
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Fibrodysplasia Ossificans Progressiva
A Study of Andecaliximab in Participants With Fibrodysplasia Ossificans Progressiva (FOP)
This study is researching an experimental drug called andecaliximab. The study will include pediatric and adult patients with fibrodysplasia ossificans progressiva (FOP).
- Trial name
- ANDECAL (NCT06508021)
- Testing
- Andecaliximab
- Where
- 3 sites in United States
- Volunteers
- 92 people
- Sponsor
- Ashibio Inc
Osteoarthritis, Osteoporosis
Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy
In this study spatially offset Raman spectroscopy (SORS), which allows the collection of Raman spectra through turbid media, is being applied to collect Raman spectra of bone.
- Conditions
- Osteoarthritis, Osteoporosis, Osteogenesis Imperfecta, Rickets / Osteomalacia
- Trial name
- NCT02814591
- Testing
- spatially offset Raman spectrometer (SORS)
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University College, London
Blood Loss, Hemoglobin Change
Prospective Investigation of Intra-Articular Tranexamic Acid Use in Elective Hip Arthroplasty
Tranexamic acid (trans-4-aminomethyl cyclohexane carboxylic acid) is an antifibrinolytic substance that chemically belongs to the group of e-carboxylic acids.
- Conditions
- Blood Loss, Hemoglobin Change, Blood Transfusion, Heterotopic Ossification
- Trial name
- NCT06903299
- Testing
- Intra-articular Tranexamic acid application
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Osteogenesis Imperfecta
High Resolution Thermal Imaging to Identify Vertebral Fractures in Children and Young People With Osteogenesis Imperfecta
Brittle bone disease also known as osteogenesis imperfecta (OI) is characterised by a defect in the bone tissue that leads to recurrent fractures and significant bone deformities in children.
- Trial name
- THERMOI (NCT04231916)
- Testing
- Thermal imaging device
- Volunteers
- 11 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Nonunion Fractures
Treatment of Non Union of Long Bone Fractures by Autologous Mesenchymal Stem Cell
Treatment of nonunion, delayed union and malunion fractures of long bones remains problematic. The definition of nonunion is a failure of the fracture to heal in six months in a patient in whom progressive repair had not been…
- Trial name
- NCT01206179
- Testing
- cell injection
- Where
- Iran
- Volunteers
- 6 people
- Sponsor
- Royan Institute
Osteogenesis Imperfecta
Registry of Osteogenesis Imperfecta
ROI is a retrospective and prospective registry, finalized for care and research purposes. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains…
- Trial name
- ROI (NCT04115774)
- Testing
- bisphosphonates
- Where
- Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Luca Sangiorgi
Hypochondroplasia
Open-Label, Long-Term, Extension Study of Infigratinib in Children With Hypochondroplasia
Phase 2, multicenter, OLE study to evaluate the long-term safety, tolerability, and efficacy of infigratinib, an FGFR (fibroblast growth factor receptor) 1-3-selective tyrosine kinase inhibitor, in participants with…
- Trial name
- NCT07393373
- Testing
- Infigratinib
- Where
- 24 sites in United States, Australia and 8 more
- Volunteers
- 135 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Heterotopic Ossification
Defining the Pathophysiology of Heterotopic Ossification: A Prospective Study
Our overarching aim is to define the pathophysiology, epidemiology, and natural history of HO by following patients from date of injury until full wound healing has occurred and the window for HO has passed.
- Trial name
- NCT04867018
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Osteogenesis Imperfecta
Zoledronic Acid in Children (1 -17 Years) With Severe Osteogenesis Imperfecta
This is an extension study to examine the long-term safety and efficacy of zoledronic acid in patients who have completed the core CZOL446H2202 study.
- Trial name
- NCT00131118
- Testing
- Zoledronic Acid
- Where
- 10 sites in United States
- Volunteers
- 127 people
- Sponsor
- Novartis Pharmaceuticals
Osteogenesis Imperfecta
Marrow Mesenchymal Cell Therapy for Osteogenesis Imperfecta: A Pilot Study
Osteogenesis imperfecta (OI) is a genetic disease for which there is currently no known cure. OI causes the osteoblasts (bone-forming cells in the body) to grow poorly, which slows the growth of children with the disease and…
- Trial name
- NCT00187018
- Testing
- Bone marrow transplant
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- St. Jude Children's Research Hospital
OPLL, Medicine, Korean Traditional
Long Term Follow-Up of Post Neck Pain Patients Accompanying Ossification of Posterior Longitudinal Ligament Treated With Integrated Complementary and Alternative Medicine: Observational Study
The purpose of this study is to reveal the effectiveness and safety of integrative Korean medicine for Ossification of Posterior Longitudinal Ligament(OPLL) by observation inpatients treated with integrative Korean medicine.
- Trial name
- NCT04446221
- Testing
- phone survey
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Jaseng Medical Foundation
Osteogenesis Imperfecta
Boost to Brittle Bones - Stem Cell Transplantation for Treatment of Brittle Bones
An exploratory, open label, multiple dose, phase I/II trial (n=15) evaluating safety and efficacy of intravenous and intraosseous infusion of allogeneic expanded fetal mesenchymal stem cells (MSC) for the treatment of severe…
- Trial name
- BOOST2B (NCT04623606)
- Testing
- BOOST cells
- Where
- India
- Volunteers
- 15 people
- Sponsor
- Christian Medical College, Vellore, India
Osteogenesis Imperfecta
Management of Combined Fracture Neck of Femur and Femoral Deformity in Osteogenesis Imperfecta Patient
O.I with NOF fixed by Wagner technique and telescoping nail
- Trial name
- OI (NCT05878548)
- Testing
- corrective osteotomy and intramedullary telescoping nail for deformed femur and Wagner technique to fix NOF fracture
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Assiut University
Fibrodysplasia Ossificans Progressiva (FOP)
The Fibrodysplasia Ossificans Progressiva (FOP) Registry
The Fibrodysplasia Ossificans Progressiva (FOP) Registry is a global, non-interventional, voluntary database that captures demographic and disease data directly from FOP patients and their caregivers via a secure, web-based…
- Trial name
- NCT02745158
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- The International FOP Association