Clinical trials: Osteomyelitis
Infection
Regional and Seasonal Variations in the Incidence and Causative Organisms for Post-traumatic Wound Infections and Osteomyelitis After Open Fractures
To determine if there is a relationship between people with open fractures and the season and location of where the injury occurred and the infections they develop
- Trial name
- NCT03064009
- Testing
- Infection
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Washington
Osteomyelitis Tibia, Surgical Site Infection
Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures and Biomarkers
The present trial was aimed to identify which biomarkers could be associated in perioperative period after surgical treatment of tibial fracture to the development of POM.
- Trial name
- POMTIBIAL (NCT03459261)
- Testing
- blood sample on admission (ADD), first postoperative day (POD1) and fourth postoperative day (POD4)
- Volunteers
- 86 people
- Sponsor
- University Medical Centre Ljubljana
Fracture, Osteomyelitis
Treatment of Fracture Related Infection in Latin America.
Postoperative bone infection is a severe complication in the treatment of fractures and is more frequent than in elective joint replacement surgeries.
- Conditions
- Fracture, Osteomyelitis, Soft Tissue Injuries, Bone Loss
- Trial name
- NCT05467644
- Testing
- Treatment of Fracture Related Infection
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Manoel Victorino Hospital
Musculoskeletal Infection, Acute Hematogenous Osteomyelitis
Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections
The purpose of this study is to evaluate the use of a blood test: Karius® plasma-based next-generation sequencing test (Karius Test), to see if we can detect and measure the infection causing agent in children with…
- Conditions
- Musculoskeletal Infection, Acute Hematogenous Osteomyelitis, Septic Arthritis, Osteomyelitis
- Trial name
- KDG-002 (NCT03846804)
- Testing
- Karius Test
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Indiana University
Suppurative Osteomyelitis of Jaw, Potential Abnormality of Glucose Tolerance
Risk Factors Associated With Recurrence and Life-threatening Complications for CSOJ
Clinically, recurrence and life-threatening complications are challenging problems for chronic suppurative osteomyelitis of the jaw.
- Trial name
- NCT01670422
- Where
- China
- Volunteers
- 322 people
- Sponsor
- West China College of Stomatology
Osteomyelitis, Pneumonia
Comparative Effectiveness of Intravenous v. Oral Antibiotic Therapy for Serious Bacterial Infections
Some children get serious bacterial infections that require hospitalization and then a long course of antibiotics to completely treat the infection.
- Conditions
- Osteomyelitis, Pneumonia, Appendicitis
- Trial name
- PIVVOT (NCT02311452)
- Testing
- Peripherally Inserted Central Catheter (PICC)
- Volunteers
- 15,000 people
- Sponsor
- Children's Hospital of Philadelphia
Bacterial Infections, Bacteremia
Procalcitonin Level and Kinetics in Children With Bacterial Infections
The purposes of this study are: 1. To determine whether procalcitonin level at admission of pediatric patients with bacterial infections can be used as a marker for prediction of defervescence and hospitalization length 2.
- Conditions
- Bacterial Infections, Bacteremia, Meningitis, Urinary Tract Infection
- Trial name
- NCT00714402
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Osteomyelitis Acute, Septic Arthritis
Initial Oral Antibiotics for Bone and Joint Infections in Children
Initial oral antibiotic treatment for children and adolescents with uncomplicated bone and joint infections (BJI) has been found non-inferior to initial IV antibiotics in one randomized controlled trial (RCT).
- Conditions
- Osteomyelitis Acute, Septic Arthritis, Bone Infection, Joint Infection
- Trial name
- NCT06827496
- Testing
- Oral antibiotic treatment
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute
Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections
The goal of this clinical trial is to learn if trimethoprim-sulfamethoxazole (TMP-SMX) works to treat invasive infections due to methicillin-resistant Staphylococcus aureus (MRSA) in children.
- Conditions
- Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute, Septic Arthritis, Orbital Cellulitis
- Trial name
- NCT06982105
- Testing
- Trimethoprim Sulfamethoxazole
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Osteomyelitis, Septic Arthritis
Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections
The goal of this study is to figure out the best doses for two antibiotics (called cefadroxil and cephalexin) when they are used to treat bone, joint, or muscle infections in children.
- Conditions
- Osteomyelitis, Septic Arthritis, Pyomyositis
- Trial name
- NCT03802552
- Testing
- Cefadroxil, Cephalexin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Chronic Recurrent Multifocal Osteomyelitis, Pediatrics
Reliability and Validation of the WB-MRI Radiological Score in CRMO
This study evaluates the inter-observer reliability of a standardized WB-MRI scoring system for CRMO and its consistency with the PedCNO clinical score.
- Trial name
- NCT07483853
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Nasal Neoplasm, Nasal Neoplasm Benign
Prospective Study of Sinonasal and Skull-base Tumours Management
This observational prospective clinical study aims to describe the epidemiology, management and outcome of patients with sinonasal and skull-base pathology (tumours and diseases with malignant clinical characteristics) in a…
- Conditions
- Nasal Neoplasm, Nasal Neoplasm Benign, Skull Base Neoplasms, Skull Base Osteomyelitis
- Trial name
- Sinonasal_Tu (NCT05607888)
- Where
- Slovenia
- Volunteers
- 120 people
- Sponsor
- University Medical Centre Ljubljana
Refractory Bone or Joint Infections
Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections
To evaluate the safety and effectiveness of oral sodium fusidate (CEM-102) as chronic antibiotic for the treatment of bone or joint infections.
- Trial name
- NCT02569541
- Testing
- sodium fusidate
- Where
- 19 sites in United States
- Volunteers
- 30 people
- Sponsor
- Arrevus Inc.
Acute Hematogenous Osteomyelitis
Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)
The purpose of the study is to determine whether daptomycin is effective and safe in the treatment of pediatric participants with AHO when compared to vancomycin (or equivalent) or nafcillin (or β-lactam equivalent).
- Trial name
- NCT01922011
- Testing
- Daptomycin, Vancomycin (or equivalent), Nafcillin (or equivalent)
- Volunteers
- 149 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Osteomyelitis
Acute Non-severe Osteomyelitis in Children - Outpatient Management Strategy With Oral Antibiotic Therapy Compared to a Standard Strategy With Conventional Hospitalization and Intravenous Antibiotic Therapy: a Randomized Open-label Non-inferiority Study With Bayesian and Medical-economic Analyses.
The incidence of bone and joint infections (BJI) in children (osteomyelitis, septic arthritis and spondylodiscitis) is 22 per 100,000 children in France.
- Trial name
- POOMA (NCT04554108)
- Testing
- therapeutic strategy
- Where
- France
- Volunteers
- 189 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Sepsis, Bacteraemia
Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity…
- Conditions
- Sepsis, Bacteraemia, Meningitis, Abscess
- Trial name
- ERNIE2 (NCT02024282)
- Testing
- Use of C-reactive protein (CRP) point of care test, Brief intervention and parent leaflet, Finger Pulse Oximeter
- Where
- 2 sites in Belgium
- Volunteers
- 8,962 people
- Sponsor
- KU Leuven
Vertebral Osteomyelitis
Characterization and Differential Diagnosis of Vertebral Osteomyelitis
Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus.
- Trial name
- NCT01125839
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Osteomyelitis
Drug Delivery Devices for Osteomyelitis
Fifty-one patients suffering from chronic post-traumatic or postoperative osteomyelitis of the lower extremities were included in the retrospective investigation.
- Trial name
- NCT02968693
- Testing
- antibiotic-loaded calcium sulfate, antibiotic-loaded polymethyl methacrylate, Vancomycin
- Where
- 2 sites in China
- Volunteers
- 51 people
- Sponsor
- Yulin Orthopedics Hospital of Chinese and Western Medicine
Immune System Disease, Musculoskeletal Disease
Chronic Non-bacterial Osteomyelitis Treated With Pamidronate
In a randomized double blind placebo controlled trial to investigate the effect of pamidronate in treatment of chronic non bacterial osteomyelitis. Main objective: 1.
- Trial name
- CNOPAM (NCT02594878)
- Testing
- Pamidronatdinatrium, Natrium chloride 9mg/ml
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Aarhus