Clinical trials: Oxytocin
Induction of Labour, Labour, Induced
Misoprostol Labour Induction Study
Labour induction is a frequent obstetric intervention (~20%). Prostaglandins (PGs) are effective agents, but gastrointestinal (GI) intolerance has limited use to non-oral routes.
- Trial name
- NCT03489928
- Testing
- Oral Misoprostol, Vaginal Misoprostol, Dinoprostone
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- David Young
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Postpartum Bleeding
When and How to Administer Oxytocin for Active Management of Third Stage of Labour
To compare the efficacy of the route and timing of oxytocin administration for Active management of third stage of labour (AMTSL).
- Trial name
- NCT01954186
- Testing
- intravenous & intramuscular oxytocin, after delivery of the fetus & when anterior shoulder seen
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Etlik Zubeyde Hanim Womens' Health and Teaching Hospital
Induction of Labor
Methods of Labor Induction and Perinatal Outcomes
Since it is a frequent intervention in Obstetrics, labor induction is rarely evaluated from national population-based cohorts. The study aims to assess the frequency of different induction methods used in France from a…
- Trial name
- MEDIP (NCT02477085)
- Testing
- all women with an induced labor
- Where
- France
- Volunteers
- 3,049 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Response
The Effect of Oxytocin (OT) and Oxytocin Plus Human Chorionic Gonadotropin (hCG), in Cycles Induced by Letrozole or Clomiphene Citrate
The specific aims of this study were to assess whether letrozole as an aromatase inhibitor plus hCG or OT alone, or in combination compared with CC, improves ovarian response.Ethical design of this study is based on the ethical…
- Trial name
- NCT00844350
- Testing
- letrozole , oxytocin,hCG,clomiphene citrate
- Volunteers
- 177 people
- Sponsor
- Tabriz University
Oxytocin Group, L-DOPA Group
Oxytocin and Dopamine's Effect on Vicarious Optimism
To investigate the effect of intranasal Oxytocin and L-DOPA's effect on vicarious optimism.
- Conditions
- Oxytocin Group, L-DOPA Group, Placebo Group
- Trial name
- NCT03891095
- Testing
- Oxytocin, L-DOPA
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Beijing Normal University
Postpartum Hemorrhage
Investigating the Effect of Pulsatile Administration of Oxytocin on the Desensitization of Human Myometrium In-vitro
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide and is caused most commonly by poor uterine muscle (myometrium) tone after delivery.
- Trial name
- NCT02338089
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Prader-Willi Syndrome
Intranasal Oxytocin for Infants With Prader-Willi Syndrome
The purpose of this study is to compare the change in suck and swallow competency from baseline to morning of day 6 with intranasal oxytocin spray vs placebo in infants/children with Prader-Willi Syndrome who are in nutritional…
- Trial name
- NCT03245762
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Florida
Autistic Disorder
Oxytocin in Spectrum Autism Disorders
Observe effects of oxytocin on individuals with autism spectrum disorder
- Trial name
- OxytocinASD (NCT03183674)
- Testing
- Oxytocin
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Severe Preeclampsia, Postpartum Hemorrhage
Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia
Postpartum hemorrhage is an important cause of maternal morbidity and mortality. In patients with severe preeclampsia there is an increased risk of postpartum hemorrhage but the hemodynamic changes associated with this pathology…
- Trial name
- NCT01382732
- Testing
- Carbetocin, Oxytocin
- Where
- Panama
- Volunteers
- 636 people
- Sponsor
- Saint Thomas Hospital, Panama
Duration of Labor
Does Oral Propranolol Accelerate Labor Induction/Augmentation With Oxytocin in Nulliparous Women in Abakaliki?
Labour is usually physiologic, spontaneous and progressive, but occasionally, there may be the need for induction or augmentation of labour especially in nulliparous women, who are at increased risk of dysfunctional labour.
- Trial name
- NCT05251610
- Testing
- 20mg oral propranolol and oxytocin, Oxytocin only
- Where
- Nigeria
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Postpartum Haemorrhage
Carbetocin Versus Oxytocin in Caesarean Section for the Control of Postpartum Haemorrhage
Post-partum haemorrhage is one of the life threatening emergencies. It accounts for nearly one-quarter of all maternal death worldwide. Atonic uterus contributes about 80% among the causes.
- Trial name
- NCT02396303
- Testing
- Carbetocin
- Where
- Bangladesh
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Obesity
Intranasal Oxytocin and Food Intake in Obese Adolescents
The purpose of the study is to determine the effect of intranasal OXT caloric intake and eating behaviors in otherwise healthy obese adolescents.
- Trial name
- NCT03497988
- Testing
- Syntocinon
- Sponsor
- Shana McCormack, MD
Autism Spectrum Disorder
Oxytocin in Adolescents With Autism Spectrum Disorders
This study is design to evaluate the influence of oxytocin in some aspects of Autism Spectrum Disorder (ASD), such as, repetitive and stereotyped behavior, social skills, quality of life and disruptive behaviors.
- Trial name
- OXYASD (NCT02007447)
- Testing
- OCYTOCINA - SPRAY NASAL
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Failed Induction of Labor
Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Nulliparas at Term
To compare concurrent oxytocin with membrane sweeping versus dinoprostone pessary in labor induction for nulliparas at term with an unfavorable cervix
- Trial name
- NCT02416583
- Testing
- Oxytocin, Dinoprostone, Membrane sweeping
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul National University Hospital
Autism Spectrum Disorder, Bone Health
Oxytocin Effects on Bone in Children With Autism Spectrum Disorder
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin on bone health in children with autism spectrum disorder, ages 6-18 years old.
- Trial name
- BOX (NCT05754073)
- Testing
- 1. Intranasal oxytocin spray, 3. Intranasal Oxytocin spray
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Elizabeth Austen Lawson
Post Partum Hemorrhage
Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage
Post partum Hemorrhage (PPH) is one of three main causes of death in pregnant women. Oxytocin is widely used for prevention of PPH. Some studies suggested misoprostol as an alternative treatment when Oxytocin isn't available.
- Trial name
- NCT01863706
- Testing
- Misoprostol, Oxytocin
- Where
- Iran
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hormozgan University of Medical Sciences
Autism Spectrum Disorder
Intranasal Oxytocin for the Treatment of Children and Adolescents With Autism Spectrum Disorders (ASD)
We are studying an investigational drug called intranasal oxytocin (Syntocinon®). Syntocinon® has been approved by the U.S. Food and Drug Administration for use in helping women breastfeed, but it has not been approved for use in…
- Trial name
- OXY-R (NCT01908205)
- Testing
- Intranasal Oxytocin
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Postpartum Hemorrhage
Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization: an In-vitro Analysis of Oxytocin Receptor Expression and Signaling
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity worldwide, and is caused most commonly by poor uterine muscle contraction after delivery of the baby and placenta.
- Trial name
- NCT02762669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Second Trimester Abortion
Second Trimester Pregnancy Termination in Women With Previous Caesarean Sections
it is a randomized controlled trial comparing the safety and efficacy of Vaginal Misoprostol versus combined Intracervical Foley's Catheter and Oxytocin Infusion for Second Trimester Pregnancy Termination.
- Trial name
- NCT04501809
- Testing
- compare misoprostol with combined oxytocin and cervical foly catheter
- Where
- 2 sites in Egypt
- Volunteers
- 158 people
- Sponsor
- Zagazig University