Clinical trials: PCD
Arthritis, Psoriatic, Psoriasis
A Controlled Trial of Intermittent Fludarabine for Psoriatic Arthritis
This is a placebo controlled study evaluating the role of fludarabine (a nucleoside analog targeting both resting and proliferating lymphocytes) in the treatment of moderate to severe psoriotic arthritis.
- Trial name
- NCT00001422
- Testing
- fludarabine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Primary Ciliary Dyskinesia (PCD)
Malnutrition and Sarcopenia Among Primary Ciliary Dyskinesia
The prevalence and causes of malnutrition and sarcopenia in children and adolescents with Primary ciliary dyskinesia (PCD) have not been sufficiently elucidated.
- Trial name
- Malnutrition (NCT07740538)
- Testing
- Physical assessments of individuals
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Izmir Democracy University
Ciliary Motility Disorders, Primary Ciliary Dyskinesia
Nasal Nitric Oxide Across Mutations in Primary Ciliary Dyskinesia
Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by dysfunction of motile cilia associated with recurrent infections of the airways, laterality defects (Situs inversus totalis in about 50% of cases) and…
- Trial name
- nNO_PCD (NCT04949308)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Muenster
Kartagener Syndrome
Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease
Primary ciliary dyskinesia (PCD), also known as Kartagener syndrome, is a genetic disorder of the cilia, which are microscopic hair-like cells.
- Trial name
- NCT00722878
- Where
- 6 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Endometrial Carcinoma Cellular Diagnosis
Expression Analysis of the COPB 2 and Bcl-2 in Early Stages of Endometrial Carcinoma
COPB2 is a subunit of the intracellular transport system between cell organelles that participates in the regulation of cell division and differentiation.
- Trial name
- NCT05951426
- Testing
- 1.hysterectomy with bilateral oophorectomy and pelvic lymphonodectomy. 2 explorative curettage
- Volunteers
- 60 people
- Sponsor
- Clinical Center Kragujevac
Primary Ciliary Dyskinesia
Registry Study on Primary Ciliary Dyskinesia in Chinese Children
This study is a multicenter, prospective cohort study of patients diagnosed with primary ciliary dyskinesia, the clinical information of recruited patients, including clinical manifestations, lung function, chest imaging, quality…
- Trial name
- NCT02704455
- Volunteers
- 100 people
- Sponsor
- Beijing Children's Hospital
Tonsillitis, Tonsillar Hypertrophy
Relationship of Endoplasmic Reticulum Stress and Tonsillar Tissue Diseases
Tonsillar tissue is a significant organ for the performing of immune systems in children. The Endoplasmic Reticulum (ER), is an organelle needed for the care of a stable function of the cells.
- Conditions
- Tonsillitis, Tonsillar Hypertrophy, Immune System Diseases
- Trial name
- NCT04653376
- Testing
- Tonsillectomy surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Selcuk University
Primary Ciliary Dyskinesia
Chest Physiotherapy and Lung Function in Primary Ciliary Dyskinesia
Primary ciliary dyskinesia (PCD) is a rare disease, caused by impairment of the motile cilia. Patients present with chronic upper and lower respiratory tract infections.
- Trial name
- NCT01929356
- Testing
- Chest physiotherapy
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystic Fibrosis, Primary Ciliary Dyskinesia
Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia
Cytobacteriological examination of sputum and bacteriological sampling in the middle meatus.
- Trial name
- BAVASI (NCT03494894)
- Testing
- Middle meatus aspirations and sputum
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Crohn's Disease
Monoclonal Antibody Treatment of Crohn's Disease
This study will examine the safety and effectiveness of an experimental drug called J695 for treating patients with Crohn's disease-a long-term recurring inflammation of the small and large intestine.
- Trial name
- NCT00007163
- Testing
- J695
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Primary Ciliary Dyskinesia, Kartagener Syndrome
Swiss Primary Ciliary Dyskinesia Registry
The Swiss Primary Ciliary Dyskinesia (PCD) Registry is a national patient registry that collects information on diagnosis, symptoms, treatment and follow-up of patients with PCD in Switzerland and provides data for national and…
- Trial name
- CH-PCD (NCT03606200)
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- University of Bern
Primary Ciliary Dyskinesia, Kartagener Syndrome
International Primary Ciliary Dyskinesia Cohort
The iPCD Cohort is an international cohort that assembles available retrospective datasets and prospectively newly collected clinical and diagnostic data from patients suffering from primary ciliary dyskinesia (PCD) worldwide, to…
- Trial name
- iPCD (NCT03517865)
- Where
- Switzerland
- Volunteers
- 3,400 people
- Sponsor
- University of Bern
Familial Adenomatous Polyposis
Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal Cancers
Primary Objective: To determine whether celecoxib downregulates GATA-6 expression to upregulate 15-LOX-1 expression and induce apoptosis in human rectal tumors, researchers will measure GATA-6 and 15-LOX-1 expression, 13-S-HODE…
- Trial name
- NCT00503035
- Testing
- Celecoxib, Colonoscopy Biopsy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- M.D. Anderson Cancer Center
Psoriasis, Psoriatic Arthritis
Study of Psoriatic Arthritis
This study will examine the genetic and immune factors involved in the cause and development of psoriatic arthritis-a disease of both the skin and joints.
- Trial name
- NCT00001420
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Primary Ciliary Dyskinesia
Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide
Background: Primary ciliary dyskinesia (PCD) is a rare genetic disease characterised by recurrent respiratory infections and subfertility due to dysfunction of cilia (brushes) of the lining cells.
- Trial name
- NCT00739817
- Where
- Israel
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Cancer
Demographics, Clinical Outcomes, and Physician Attitudes in Patients Who Have Received The MiCK Assay (CorrectChemo)
Recently an automated test for measuring cancer cell death in the presence of chemotherapy has been developed. This test has been called the MiCK assay during the ten year development phase and is now called Correct Chemo.
- Trial name
- NCT02137811
- Testing
- MICK Assay
- Where
- 2 sites in United States, Canada
- Sponsor
- Pierian Biosciences
Primary Ciliary Dyskinesia
Muscle Function, Exercise Capacity and Physical Activity Level in Primary Ciliary Dyskinesia and Kartagener Syndrome
Studies evaluating respiratory and peripheral muscle functions in PCD patients and comparing them with healthy children are limited in the literature.
- Trial name
- NCT05816876
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Gazi University
Primary Ciliary Dyskinesia, Kartagener Syndrome
The Ear-Nose-Throat (ENT) Prospective International Cohort of PCD Patients (EPIC-PCD)
The Ear-Nose-Throat (ENT) Prospective International Cohort of patients with Primary Ciliary Dyskinesia (EPIC-PCD) is a prospective observational clinical cohort study, set up as a multinational multi-centre study.
- Trial name
- EPIC-PCD (NCT04611516)
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University of Bern
Ciliary Motility Disorders, Primary Ciliary Dyskinesia
Genotype/Phenotype Correlation With Focus on Lung Function in Primary Ciliary Dyskinesia (PCD)
Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by dysfunction of motile cilia associated with recurrent infections of the airways, laterality defects (Situs inversus totalis in about 50% of cases) and…
- Trial name
- LuFu_PCD (NCT04717115)
- Testing
- Genetic diagnosis
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Muenster
Kidney Failure
Sirolimus and Thymoglobulin to Prevent Kidney Transplant Rejection
This study will test the safety and effectiveness of two drugs, Sirolimus and Thymoglobulin, for preventing rejection of transplanted kidneys.
- Trial name
- NCT00006178
- Testing
- Sirolimus, Thymoglobulin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)