Clinical trials: PERIODONTAL DISEASE
Transgender Individuals
Effects of Gender-Affirming Hormone Therapy on Cardiovascular, Metabolic, and Mental Health Outcomes in Transgender Adults.
The objective of this observational study is to examine the impact of gender-affirming hormone therapy (GAHT) on mood in transgender individuals and to explore its potential association with early atherosclerotic processes.
- Trial name
- NCT07394400
- Where
- Spain
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Periodontitis, Periodontal Diseases
Histatin-1 Levels in Smokers and Non-smokers With Periodontitis Patients: A Comparative Study Before and After Nonsurgical Periodontal Therapy
This study evaluated the impact of smoking on salivary histatin-1 levels and clinical healing in 50 patients with unstable periodontitis (25 smokers and 25 non-smokers) undergoing non-surgical periodontal therapy (NSPT).
- Trial name
- NSPT (NCT07367737)
- Testing
- Non Surgical Periodontal Treatment
- Where
- Iraq
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Periodontal Disease, Periodontitis
Effectiveness of Scaling and Root Planing in Deeper Pockets
This study will retrospectively evaluate the outcomes of scaling and root planing over a two year time period. The study will focus specifically on the effectiveness of SRP in pockets with an initial pre-treatment pocket probing…
- Trial name
- NCT06890689
- Testing
- Scaling and root planing
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Texas A&M University
Periodontal Disease, Periodontal Diseases
Assessment of Pentraxin Levels in the Gingival Fluid of Abutment Teeth in the Context of the Use of Fixed Dentures
The use of fixed dentures in prosthetic treatment requires a thorough analysis of clinical factors such as: the condition of the abutments subject to grinding procedures, the degree of their loosening, the extent of missing…
- Conditions
- Periodontal Disease, Periodontal Diseases, Prosthodontics
- Trial name
- NCT07271563
- Testing
- Diagnostic Pentraxine test
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Periodontal Bone Loss, Periodontitis
The Role of Granulation Tissue in Periodontal Regeneration
The goal of this observational study is to distinguish the infectious, healing, and regeneration-related characteristics of two types of gingival granulation tissues, namely infra-osseous and supra-osseous granulation tissues, in…
- Conditions
- Periodontal Bone Loss, Periodontitis, Periodontal Disease, Periodontal Diseases
- Trial name
- NCT07254117
- Where
- Latvia
- Volunteers
- 46 people
- Sponsor
- Riga Stradins University
Orthodontics, Dental Hygiene
Evaluation of the Effect of a Probiotic in Patients Undergoing Orthodontic Therapy
Orthodontic patients need supplementary oral hygiene tools in addition to professional oral hygiene. The aim of this study is to evaluate the effects of Bifidobacterium animalis subs.
- Conditions
- Orthodontics, Dental Hygiene, Gingivitis and Periodontal Diseases
- Trial name
- NCT06752330
- Testing
- Use of probiotics during oral hygiene at home
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Bacteremia, Periodontal Diseases
Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis
Approximately 40,000 Swedes suffer from sepsiseach year, about 20% die. Biomarkers that are sensitive to current or previous bacteremia are needed in the treatment of sepsis.
- Conditions
- Bacteremia, Periodontal Diseases, Sepsis, Heart Diseases
- Trial name
- NCT04565691
- Testing
- Non-surgical periodontal treatment
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Malmö University
Periodontal Diseases
Effect of Intracanal Medicaments on Post-Operative Pain in Symptomatic Apical Periodontitis: An RCT
Comparison of different intracanal medicaments during root canal treatment to assess their effect on post-operative pain in teeth with Symptomatic Apical Periodontitis
- Trial name
- NCT07123792
- Testing
- Calcium Hydroxide (20%), Chlorhexidine Gel (2%), Modified Triple Antibiotic Paste
- Where
- Pakistan
- Volunteers
- 480 people
- Sponsor
- HITEC-Institute of Medical Sciences
Pediatric Obesity, Periodontal Disease
Dental and Periodontal Health in Obese Adolescents: Clinical, Biochemical, and Microbiological Evaluation
This study aims to investigate whether obesity affects oral and gum health in children and adolescents. A total of 75 children aged 8 to 13 years participated, including both obese and non-obese individuals.
- Conditions
- Pediatric Obesity, Periodontal Disease, Inflammation Biomarkers, Dental Plaque
- Trial name
- PERIOBESITY (NCT07086027)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontal Diseases, Tooth Loss
Internalized Stigma and Tooth Loss Due to Periodontitis
Internalized stigma refers to the adoption of negative judgments, beliefs, stereotypes and stigmatizing views imposed by society.
- Trial name
- NCT07065019
- Testing
- The Internalized Stigma Scale in Mental Illness (ISS)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periodontal Diseases
Interactive School-Based Oral Health Education Program to Reduce Periodontal Disease in Palestinian Adolescents
The goal of this intervention study was to evaluate the effectiveness of a two-month interactive school-based oral health education program in reducing periodontal disease and improving oral health behaviors among 15-year-old…
- Trial name
- ISBOHE-PD (NCT07055932)
- Testing
- "Interactive Oral Health Education Program"
- Where
- Palestinian Territories
- Volunteers
- 946 people, healthy volunteers welcome
- Sponsor
- Al-Quds University
Peri-implantitis, Dental Implant Complications
Analysis of the Factors Influencing the Occurrence of Peri-implant Inflammation in Patients With Oral Implant Repair and Study on the Maintenance Effect of Subgingival Sandblasting
Abstract Objective The purpose of this study was to analyze the factors affecting the occurrence of peri-implant inflammation in patients with oral implant repair, and to explore the effect of subgingival sandblasting technology…
- Conditions
- Peri-implantitis, Dental Implant Complications, Periodontal Inflammation, Gingival Diseases
- Trial name
- NCT06998160
- Testing
- glycine subgingival sandblasting group and erythritol subgingival sandblasting group, control group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Hui Xie
Periodontal Diseases, Pregnancy Complications
Oral Health and Adverse Pregnancy Complications
Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected.
- Conditions
- Periodontal Diseases, Pregnancy Complications, Pregnancy Preterm, Gestational Diabetes
- Trial name
- NCT06110143
- Testing
- Periodontal treatment
- Where
- 3 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Gingivitis
Efficacy of an Amine and Zinc Lactate - Containing Mouthrinse in the Home-based Treatment of Plaque-induced Gingivitis in Adolescents.
The goal of this clinical trial is to evaluate if the adjunctive use of an amine and zinc lactate - containing mouthrinse may give significant benefits in the home-based treatment of plaque-induced gingivitis in adolescents.
- Trial name
- SPA (NCT06671106)
- Testing
- toothbrushing, flossing, Toothpaste Product
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università degli Studi di Ferrara
Gingival and Periodontal Disease, Space Maintenance
The Effects of Fixed Space Maintainers Luting with Self-Adhesive Resin Cement on the Gingival Crevicular Fluid of Interleukin-18 Level
Background:In pediatric dentistry, fixed space maintainers are crucial for preserving the space in edentulous areas following premature tooth loss and promoting the healthy development of the dental arch, maxilla, and mandibula.
- Conditions
- Gingival and Periodontal Disease, Space Maintenance, Resin Cements, Interleukin
- Trial name
- NCT06811597
- Testing
- Voco Meron Conventional Glass Ionomer, High-Q-Bond Band™ self-adhesive resin cement.
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Afyonkarahisar Health Sciences University
Periodontal Disease
Randomized Controlled Trial of a Novel Laser-aided Orthodontic-periodontal Treatment Strategy
The aim of the study is to assess the effects of low-level laser therapy (LLLT) in patients with periodontitis during orthodontic-periodontal treatment for 12 months on the following aspects: (1) Effects on periodontal status…
- Trial name
- NCT02352038
- Testing
- low-level laser therapy, orthodontic treatment
- Where
- Hong Kong
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Oropharyngeal Cancers, Biomarker in Early Diagnosis
Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer
The goal of this observational study is to evaluate whether the active-matrix metalloproteinase-8 (aMMP-8) mouth-rinse test can help detect oral and oropharyngeal cancers.
- Conditions
- Oropharyngeal Cancers, Biomarker in Early Diagnosis, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Periodontal Diseases
- Trial name
- NCT06701058
- Where
- Finland
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Periodontal Diseases, Periodontitis
Frequency of Periodontal Disease in Head and Neck Cancer Patients After Radiation Therapy
This prospective cross-sectional study evaluates the frequency and risk factors of periodontal disease in head and neck cancer patients who have undergone radiotherapy.
- Trial name
- NCT06667362
- Where
- Egypt
- Volunteers
- 189 people
- Sponsor
- Ain Shams University
Periodontal Diseases
"Effect of CPA/EE Drug on Periodontal Tissue and hsCRP Levels in PCOS Patients With Gingivitis
PCOS is a widely reported condition among young female population and anti-androgen agents are increasingly being used as part of the medical management of such cases.
- Trial name
- NCT05657171
- Testing
- cyproterone Acetate/Ethinyl Estradiol Combination
- Where
- India
- Volunteers
- 47 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Pocket, Periodontitis
Evaluation Of Nonsurgical Treatment Of Deep Periodontal Pockets (7-10mm) Using AIRFLOW® Prophylaxis Master Device With Erythritol Powder vs Conventional Instrumentation
Periodontitis is a chronic condition associated with the inflammatory destruction of the periodontal tissues ultimately leading to tooth loss.
- Conditions
- Periodontal Pocket, Periodontitis, Gingival Diseases, Gingival Bleeding
- Trial name
- NCT06490679
- Testing
- Hand and ultrasonic scalers and curettes, Electro Medical Systems AIRFLOW® Prophylaxis Master Device
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University