Clinical trials: Paediatric Trauma
Wound Heal
Music During Paediatric Outpatient Wound Dressing Changes: Impact on Anxiety, Pain and Patient Satisfaction
Background: Wound dressing changes can be painful and distressing for children and the consequences of poorly managed pain and anxiety can be lifelong.
- Trial name
- NCT04170842
- Testing
- Music intervention
- Volunteers
- 48 people
- Sponsor
- KK Women's and Children's Hospital
Venous Thromboembolism, Deep Venous Thrombosis
Prevalence and Risk Factors of Venous Thromboembolism in Hospitalized Pediatric Patients
The issue to be studied is the prevalence of venous thromboembolism (VTE) in hospitalized pediatric patients, and to identify if there are subgroups of patients who may be at higher risk.
- Conditions
- Venous Thromboembolism, Deep Venous Thrombosis, Pediatrics
- Trial name
- pediatric DVT (NCT01140386)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Penn State University
Acute Kidney Injury, Renal Injury
Pediatric Acute Kidney Injury (AKI) Retrospective, Real-Time and Repository Research
This proposal will incorporate statistical models developed by the investigators to predict risk for acute kidney injury into our electronic medical record system, enabling an alert to notify providers of the risk status.
- Conditions
- Acute Kidney Injury, Renal Injury, Kidney Disease
- Trial name
- PAR4 (NCT02660931)
- Testing
- AKI Risk Notification
- Where
- United States
- Volunteers
- 12,108 people
- Sponsor
- Vanderbilt University Medical Center
Pediatric Distal Forearm Fractures
Closed Reduction of Distal Forearm Fractures by Pediatric Emergency Medicine Physicians: A Prospective Study
Distal forearm fractures are amongst the most frequently encountered orthopedic injuries in the pediatric emergency department (ED). Immediate closed manipulation and cast immobilization, is still the mainstay of management.
- Trial name
- NCT01101607
- Testing
- Distal Forearm Fracture Reduction
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- InMotion Orthopaedic Research Center
Acquired Brain Injury, Cerebral Palsy
Movement Improvement After Paediatric Armeo®Spring Rehabilitation
Children with acquired and congenital brain lesions (namely, cerebral palsy, CP, and acquired brain injury, ABI) may exhibit upper limb impairment, with consequent limitations in their daily living activities.
- Trial name
- NCT03552614
- Testing
- Upper limb robot-assisted rehabilitation, physiotherapy
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- IRCCS Eugenio Medea
Pain, Acute
Methoxyflurane Analgesia for Paediatric Injuries
This is a randomised, double-blind, multicentre, placebo controlled study to evaluate the safety and efficacy of methoxyflurane (Penthrox®) for the treatment of acute pain in children and adolescents from 6 to less than 18 years…
- Trial name
- MAGPIE (NCT03215056)
- Testing
- Methoxyflurane, Normal saline
- Where
- 11 sites in Ireland, United Kingdom
- Volunteers
- 192 people
- Sponsor
- Medical Developments International Limited
Children, Lacerations
Pain and Anxiety Management With Oral Narcotic for Pediatric Suture Repair
The purpose of this study is: To determine whether oral narcotic medication versus placebo improves the pain and anxiety scores for pediatric patients requiring laceration repair in the pediatric emergency department and…
- Conditions
- Children, Lacerations, Procedures, Child
- Trial name
- NCT01053637
- Testing
- hydrocodone/acetaminophen, Sugar water
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Baylor College of Medicine
Musculoskeletal Injury, Pediatrics
Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children
The TOP-MAP pilot trial has multiple goals. The first goal of this pilot clinical trial is to find out if it will be possible to carry out a study at multiple pediatric emergency department sites (Peds ED) comparing Non-Steroidal…
- Conditions
- Musculoskeletal Injury, Pediatrics, Sprain and Strain of Ankle, Sprain Knee
- Trial name
- TOP-MAP (NCT07145645)
- Testing
- Voltaren Topical Gel, Ibuprofen Oral Suspension 100 mg/5mL, ORA-Blend Oral Suspension
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Kidney Transplantation
BIOMARGIN European, Ambispective Cohort of Adult and Paediatric Renal Transplant Patients
Biomargin is a European research program aimed at evaluating the diagnostic performance of biomarkers with respect to renal graft injuries, as well as their prognostic performance with respect to 3-year and 5-year graft outcomes.
- Trial name
- BECS (NCT02832661)
- Where
- 6 sites in Belgium, France and 1 more
- Volunteers
- 500 people
- Sponsor
- University Hospital, Limoges
Femur Fracture
Titanium Elastic Nails in the Treatment of Pediatric Femur Fractures
Titanium elastic nails in the pediatric femoral fractures: A prospective randomized clinical trial of eliminating nail protrusion to decrease soft tissue complications
- Trial name
- NCT00175656
- Testing
- Elimination of titanium elastic nail prominence at the insertion site and leaving the nails in situ
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Pediatric Burns
Magnesium Sulfate in Pediatric Burn Dressing Changes
Prospective feasibility trial utilizing adjuvant magnesium sulfate for analgesia/sedation during pediatric sedated burn dressing changes, which is ultimately hypothesized to decrease ketamine and/or sedative requirements.
- Trial name
- NCT07126795
- Testing
- magnesium sulfate, Normal Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hennepin Healthcare Research Institute
Ankle Injury
Implementation of the Low Risk Ankle Rule
Ankle injuries are a very common injury in children. Each year approximately 35000 kids present to Ontario emergency departments (ED) with this problem.
- Trial name
- NCT00785876
- Testing
- LRAR Implementation
- Where
- 4 sites in Canada
- Volunteers
- 3,000 people
- Sponsor
- The Hospital for Sick Children
Epidermolysis Bullosa
The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa
The purpose of this study is to assess the efficacy of trimethoprim in promoting wound healing and decreasing blister formation in patients with Epidermolysis Bullosa.
- Trial name
- NCT00380640
- Testing
- Trimethoprim
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Paediatric Brain Damage, Cerebral Palsy
Transcranial Direct Current Stimulation and Gamified Rehabilitation for Upper Limb Function in Pediatric Brain Damage
The goal of this clinical trial is to acknowledge the effects of transcranial direct current stimulation as an adjuvant with gaming rehabilitation for upper limb function rehabilitation in paediatric population with…
- Conditions
- Paediatric Brain Damage, Cerebral Palsy, Paediatric Stroke, Paediatric Traumatic Brain Injury
- Trial name
- NCT06214364
- Testing
- Active Transcranial Direct Current Stimulation
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Universidad Francisco de Vitoria
Burns, Child
Virtual Reality Distraction for Procedural Pain Management in Children With Burn Injuries: a Randomized Controlled Trial
Procedural pain is the most intense and often undertreated pain associated with burn injuries. The use of analgesics does not always provide optimal relief and is accompanied by several side effects.
- Conditions
- Burns, Child, Pain
- Trial name
- NCT02986464
- Testing
- Virtual Reality Prototype, Standard Pharmacological Treatment
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- St. Justine's Hospital
Traumatic Brain Injury (TBI)
Prognostic Model for Predicting Outcome After Moderate to Severe Paediatric Traumatic Brain Injury
Due to ethical and logistical challenges related to paediatric research, there is limited age-appropriate evidence for managing paediatric traumatic brain injury (pTBI).
- Trial name
- PROMPT (NCT07538440)
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Seizure
OPALS Pediatric Study
The OPALS Pediatric Study will examine the incremental impact of introducing a prehospital full advanced life support in pediatric patients.
- Trial name
- NCT00298532
- Testing
- Advanced Life Support
- Where
- 10 sites in Canada
- Volunteers
- 9,000 people
- Sponsor
- Ottawa Hospital Research Institute
Congenital Heart Disease
Paediatric Brain Injury Following Cardiac Interventions
Children born with congenital heart problems face numerous physical, developmental, and social challenges. Complications in pregnancy have potential to impair brain development, leading a smaller brain volume and less mature…
- Trial name
- BICI2Kids (NCT04992793)
- Testing
- Congenital heart surgery
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University of Leicester
Acute Renal Insufficiency
Incidence of Acute Renal Failure Associated With Iodinated Contrast Agents in Pediatrics
Iodinated contrast media are now frequently used in diagnostic imaging exams, including pediatrics. In adults, the acute renal failure (ARF) associated with contrast agents (CA-AKI) occur in 3-33% of exposed patients, especially…
- Trial name
- CANOPY (NCT02955979)
- Testing
- CT scan with iodinated contrast agents
- Where
- 2 sites in France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fracture, Pain
Ibuprofen Versus Codeine. Is One Better for Post-operative Pain Relief Following Reduction of Paediatric Forearm Fractures?
For simple fractures treated in the emergency department with cast immobilisation only, ibuprofen has been shown to be superior to, or a least or equivalent to codeine with less side effects.
- Trial name
- NCT01605240
- Testing
- Acetaminophen and Ibuprofen, Acetaminophen and Codeine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba