Clinical trials: Pain Insensitivity, Congenital
Pain and Anxiety in Children With MIH
Preemptive Analgesia for Pain and Anxiety Control in Children With MIH
This randomized, triple-blinded clinical trial aims to evaluate the effect of preemptive analgesia using ibuprofen on pain perception and anxiety during restorative treatment of first permanent molars in children diagnosed with…
- Trial name
- NCT07374354
- Testing
- ibuprofen 100mg/ml oral suspension syrup
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- October University for Modern Sciences and Arts
Neonatal Pain, Retinopathy of Prematurity (ROP)
Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants
The goal of this clinical trial is to learn whether intranasal fentanyl (a pain medicine given as a nasal spray) can reduce pain and is safe to use during routine eye examinations for retinopathy of prematurity (ROP) in preterm…
- Conditions
- Neonatal Pain, Retinopathy of Prematurity (ROP), Pain Management, Infant, Premature
- Trial name
- FIREFLY (NCT07112430)
- Testing
- Fentanyl Citrate (Intranasal)
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Marsha Campbell-Yeo
Developmental Dysplasia of the Hip (DDH)
Truncal Blocks for Pediatric With Developmental Dysplasia of the Hip Undergoing Open Reduction
The aim of the study is to evaluate the effectiveness of ultrasound-guided transversalis fascia plane block (TFPB) and quadratus lumborum block (QLB) on post-operative analgesia in pediatric patients with Developmental Dysplasia…
- Trial name
- NCT03189966
- Testing
- transversalis fascia plane block, quadratus lumborum block
- Where
- 2 sites in China
- Volunteers
- 110 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pectus Excavatum, Chest Deformities
SPSIPB Versus SAPB for Postoperative Analgesia After Minimally Invasive Repair of Pectus Excavatum
This prospective observational cohort study will compare postoperative analgesic outcomes in patients undergoing minimally invasive repair of pectus excavatum.
- Trial name
- NCT07697222
- Testing
- Postoperative Analgesia Protocol, Bispectral Index Monitoring, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Marmara University
Retinopathy of Prematurity, Pain Management
Pain Management During Screening for Retinopathy of Prematurity
Abstract Background: Screening examinations for retinopathy of prematurity (ROP) is critical to reduce ROP-related vision loss, however, the procedure is painful and uncomfortable, and topical anesthetics do not completely…
- Trial name
- NCT04767178
- Testing
- Ibuprofen (Sanofi, Istanbul, Turkey), Paracetamol (GlaxoSmithKline, Istanbul, Turkey)
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Istanbul Medeniyet University
Pain
Analgesic Strategies in Newborns Receiving Prostaglandin Therapy
This is a randomised trial comparing the efficacy of 3 different analgesic strategies in newborns on prostaglandin for ductus dependent congenital heart disease.
- Trial name
- NCT00200590
- Testing
- acetaminophen and nalbuphine, acetaminophen and morphine, acetaminophen and reduced dosage of prostaglandin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Nerve Block, Analgesia
ESPB vs TPVB for Postoperative Analgesia After the Nuss Procedure
This is a prospective randomized double-blind non-inferiority trial designed to test the hypothesis that erector spinae plane block (ESPB) is non-inferior to thoracic paravertebral block (TPVB) in postoperative pain control after…
- Conditions
- Nerve Block, Analgesia, Pectus Excavatum
- Trial name
- NCT05034601
- Testing
- ESPB group, TPVB group
- Where
- China
- Volunteers
- 68 people
- Sponsor
- West China Hospital
Postoperative Pain
Peripheral Nerve Block Techniques During Cleft Palate
Regional blocks are commonly used in pediatric anesthesia to achieve adequate postoperative analgesia. Suprazygomatic Maxillary nerve block (SMN) and Greater Palatine nerve block (GPN) are regional blocks described for use during…
- Trial name
- NCT04467463
- Testing
- peripheral nerve block by 0.25% levobupivacaine
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Ventilator Lung; Newborn
NIPE as an Indicator of Pain in Sedated/Ventilated Patient Under 3 Years-old Hospitalized in Intensive Care Unit
The main objective is to assess correlation between Newborn Infant Parasympathetic Index values and external evaluation by Comfort Behaviour Scale during painful medical cares in sedated intubated children admitted in pediatric…
- Trial name
- NIPE (NCT04195672)
- Testing
- NIPE (MDoloris®) and CBS values
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille
Procedural Pain, Congenital Heart Disease
Procedural Pain Management by Multimodal Sedation Analgesia Combining Hypnosis in Children With Congenital Heart Disease
The aim of this prospective randomized controlled trial is to evaluate therapeutic hypnosis as a co-analgesia in thoracic drain removal in children with congenital heart disease.
- Conditions
- Procedural Pain, Congenital Heart Disease, Heart Surgery, Hypnosis
- Trial name
- PEACE-HYPNO (NCT06373627)
- Testing
- Hypnosis, Conventional medications used for sedation-analgesia, Medications used in addition to hypnosis
- Volunteers
- 104 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Asphyxia Neonatorum
Fentanyl and Clonidine for Analgesia During Hypothermia in Term Asphyxiated Infants
A prospective pharmacokinetic (PK), pharmacodynamic (PD) and pharmacogenetic (PG) observation study, including the PK/PD/PG relationship, in fentanyl and clonidine administered for analgesia and sedation to term newborn…
- Trial name
- SANNI 1 (NCT03177980)
- Testing
- Fentanyl, Fentanyl and clonidine
- Where
- 2 sites in Sweden
- Volunteers
- 49 people
- Sponsor
- Region Skane
Pain
Pudendal Block Versus Caudal Block for Hypospadias
The aim of this prospective randomized study is to assess the analgesic efficacy and duration of Pudendal block compared with Caudal block for pediatric patients undergoing hypospadias surgery concerning intraoperative analgesic…
- Trial name
- NCT02390388
- Testing
- pudendal nerve block, caudal block
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Inguinal Hernia, Cryptorchidism
Caudal Versus Intravenous Dexmedetomidine for Supplementation of Caudal Analgesia in Children
The purpose of this study is to compare the effects of caudal dexmedetomidine with intravenous dexmedetomidine on caudal levobupivacaine analgesia in children undergoing lower abdominal surgeries.
- Trial name
- NCT01701778
- Testing
- Caudal Dexmedetomidine, Intravenous Dexmedetomidine, sevoflurane
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yao Yusheng
Congenital Heart Disease, Postoperative Pain After Cardiac Surgery Via Median Sternotomy
Comparison of Erector Spinae Plane Block and Modified Pectoral Fascial Plane Block for Postoperative Analgesia in Pediatric Cardiac Surgery
Postoperative pain management is an essential component of perioperative care in pediatric congenital cardiac surgery. Regional anesthesia techniques, including the erector spinae plane block (ESPB) and modified pectoral fascial…
- Conditions
- Congenital Heart Disease, Postoperative Pain After Cardiac Surgery Via Median Sternotomy, Anesthesia
- Trial name
- NCT07740915
- Testing
- Ultrasound-Guided Erector Spinae Plane Block, Ultrasound-Guided Modified Pectoral Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Hypospadias, Postoperative Pain
Caudal Epidural Block and DPNB in Hypospadias
Hypospadias, seen in every 200-300 births, is one of the most common congenital anomalies of the penis and is defined as the urethral meatus being located in the ventral part of the penis instead of its normal place.
- Trial name
- NCT04215874
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Cleft Palate, Pain
Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.
- Conditions
- Cleft Palate, Pain, Postoperative Care, Perioperative Care
- Trial name
- OPAL-Cleft (NCT06962306)
- Testing
- Methadone hydrochloride, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Neuropathic Pain, Sickle Cell Disease
Sickle Cell Pain: Intervention With Capsaicin Exposure
This study evaluates the safety and feasibility of using high dose topical capsaicin patches for the treatment of neuropathic pain in pediatric patients with sickle cell disease, as well as the feasibility of using a number of…
- Trial name
- SPICE (NCT03899246)
- Testing
- Eight Percent Topical Capsaicin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Michigan
Pain
Methadone Pharmacokinetics and Cardiac Effects in Newborns
The Primary objectives of this proposal are to determine the population kinetics for methadone and its enantiomers in preterm newborns and infants at 29 weeks to 48 weeks post menstrual age (PMA) who are 1 week old and older and…
- Trial name
- NCT00715988
- Testing
- Methadone HCl Inject 10 mg/ml (will require dilution), Methadone
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Utah
Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease
Intranasal Ketamine for Pain Control in Patients with Sickle Cell Disease and Vaso-occlusive Episode (VOE) in the PED
This will be a descriptive cohort study of intranasal ketamine as the initial analgesic for children with sickle cell disease who present to the pediatric emergency department with vaso-occlusive crisis and are awaiting…
- Conditions
- Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease, Vaso-occlusive Crisis, Ketamine
- Trial name
- NCT04150757
- Testing
- Intranasal ketamine
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Abigail Nixon
Sickle Cell Disease
Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine
The use of oral ibuprofen combined with Opioid (Morphine or Diamorphine) administered through patient controlled analgesia (PCA) will be clinically effective for acute pain crisis in adults with sickle cell disease (SCD).
- Trial name
- SWIM (NCT00880373)
- Testing
- Ibuprofen, Diamorphine or Morphine
- Where
- 2 sites in United Kingdom
- Volunteers
- 320 people
- Sponsor
- London North West Healthcare NHS Trust