Clinical trials: Pain Reduction
Postoperative Pain
Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion
Blinded study using oral gabapentin in load pre-operative (15mg/kg) and maintenance 5mg/kg three times a day (TID) for 5 days or discharge, Patient Controlled Analgesia (PCA) morphine and placebo group with similar pills, also…
- Trial name
- NCT00726999
- Testing
- Gabapentin, Morphine
- Volunteers
- 63 people
- Sponsor
- Medical College of Wisconsin
Pain, Postoperative
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
This is a prospective, randomized, double-blinded, placebo controlled trial Potential subjects will be identified from the Pre-Surgical Anesthesia Clinic visit.
- Trial name
- IV APAP SF (NCT01394718)
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Children's Hospital of Philadelphia
Pain
Reducing Operative and Post-operative Morbidity in Living Kidney Donors With the Airseal System
The purpose of this study is to determine if the Airseal System will reduce post-operative pain and reduce the need for narcotics in laparoscopic living kidney donor surgeries.
- Trial name
- NCT02262039
- Testing
- Valveless recirculating insufflation (VTI), Conventional pressure
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Yale University
Dental Anxiety
Augmented Reality Distraction for Reducing Pain in Pediatric Dental Procedures
This randomized controlled trial evaluates the effectiveness of augmented reality (AR) as a distraction technique to reduce procedural pain and anxiety in children aged 6-10 undergoing primary tooth extraction.
- Trial name
- AR (NCT06954883)
- Testing
- Augmented Reality Distraction, Standard Care (Tell-Show-Do Technique)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Post-tonsillectomy Pain, Post-tonsillectomy Activity
The Effects of Reducing Stomach Acid on Post-tonsillectomy Pain
This study was designed to determine whether post-operative pain following a tonsillectomy can be reduced by adding an antacid-like medication to the medications taken after surgery.
- Conditions
- Post-tonsillectomy Pain, Post-tonsillectomy Activity, Post-tonsillectomy Hydration
- Trial name
- NCT00472186
- Testing
- Lansoprazole
- Where
- 2 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Postoperative Pain
Pediatric Tonsillectomy Pain Reduction Study
Tonsillectomy is associated with a significant decrease quality of life in children secondary to pain, which is worsened with swallowing.
- Trial name
- NCT00678379
- Testing
- lidocaine (1%) + bupivacaine (0.5%), Normal saline, Lidocaine (1%) + Bupivacaine (0.5%) + Clonidine (25mcg)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Pain, Traumatic Limb Injury
Pain Reduction With Intranasal Medications for Extremity Injuries
This study compares the analgesic effect of intranasal sub-dissociative dosing of ketamine and intranasal fentanyl in children presenting to the Emergency Department with acute extremity injuries.
- Trial name
- PRIME (NCT02778880)
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Inflammation, Chronic Pain
Gulf War Illness Inflammation Reduction Trial
The primary objective of this clinical trial is to determine if treatment with an anti-inflammatory drug (delayed-release prednisone) improves the health-related quality of life (HRQOL) of veterans with Gulf War Illness (GWI).
- Conditions
- Chronic Inflammation, Chronic Pain, Fatigue, Cognitive Impairment
- Trial name
- GWIIRT (NCT02506192)
- Testing
- Modified-Release Prednisone
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Pain
Buffered Lidocaine in Paracervical Blocks
For pain relief during a first trimester surgical aspiration, most providers use the paracervical block, either alone or in combination with other pain control techniques.
- Trial name
- NCT03107754
- Testing
- Lidocaine, Lidocaine-Sodium Bicarbonate
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy
Preoperative Gabapentin for Post-tonsillectomy Pain in Children
The typical post-operative course for children following surgical removal of their tonsils and adenoids can be challenging, especially for pain control.
- Trial name
- NCT01707420
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Urologic Diseases, Hypospadias
Opioid Reduction Initiative During Outpatient Pediatric Urologic Procedures Using Exparel
This study aims to evaluate the utility of long-acting liposomal bupivacaine (Exparel®) in improving pain scores and reducing narcotic pain requirements in pediatric patients following minor urologic procedures.
- Conditions
- Urologic Diseases, Hypospadias, Undescended Testes, Chordee
- Trial name
- Baby ORIOLES (NCT04826484)
- Testing
- Exparel 133 miligrams per 10 milliliter injection, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Johns Hopkins University
Pain, Nausea
Optimal Dose of Prophylactic Naloxone in Reducing Opioid-Induced Side Effects in Children/Adolescents
This is an investigator initiated dose finding study designed to determine the optimal dose of naloxone to prevent or minimize the most common side effects induced by opioids, namely itching, nausea, and vomiting.
- Conditions
- Pain, Nausea, Pruritus
- Trial name
- NCT00330343
- Testing
- naloxone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Abscess, Fracture
Study to Find the Dose of Rapidly Administered Ketamine for Brief Painful Procedures in Children
The purpose of the study is to find the dose of rapidly administered ketamine in 3 different pediatric age groups (2-5, 6-11 and 12-17) for abscess drainage and fracture reduction.
- Trial name
- NCT01669642
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Washington University School of Medicine
Injection Site Irritation
Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial
This study is a randomized, single-site clinical trial that will take place at Children's Healthcare of Atlanta at Egleston. The investigators want to see if in pediatric patients, giving Zofran prior to propofol, reduces the…
- Trial name
- NCT05378113
- Testing
- Ondansetron, Lidocaine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Emory University
Laryngopharyngeal Reflux, Throat Pain
Anti-reflux Control to Decrease Post Tonsillectomy Pain
The study aims to determine if treating pediatric patients (age 7-17) for four weeks with omeprazole prior to tonsillectomy will decrease post tonsillectomy pain.
- Trial name
- NCT01777854
- Testing
- Omeprazole
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Ascension Health
Neuroblastoma
Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients
The purpose of this study is to identify whether or not the addition of a numbing medicine that is injected directly into the site of the bone marrow procedure can reduce pain and the use of opioid pain medication after bone…
- Trial name
- NCT02924324
- Testing
- propofol, ropivacaine, Wong-Baker FACES® Pain Rating Scale
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pain
Tetracaine Compared to Placebo for Reducing Pain With Palivizumab - A Pilot Study
This is a small study known as a pilot study. This pilot study is being done to see if a difference in pain from intramuscular palivizumab injection can be detected if tetracaine a topical numbing gel is used compared to no…
- Trial name
- NCT00484393
- Testing
- tetracaine 4% gel
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Fraser Health
Pain, Postoperative, Medication Adherence
Scenario Tailored Opioid Messaging Program (STOMP) to Improve Risk Understanding in Young Adults
Legitimate prescription opioid use during adolescence has been associated with later prescription opioid misuse and substance use disorder symptoms during adulthood.
- Conditions
- Pain, Postoperative, Medication Adherence, Opioid Use, Knowledge, Attitudes, Practice
- Trial name
- STOMPYA (NCT03863353)
- Testing
- Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 503 people
- Sponsor
- University of Michigan
Pain, Fever
Safety and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients
The primary objective of this study is to evaluate the pharmacokinetic profile of a single dose of intravenous ibuprofen administered over approximately ten (10) minutes.
- Trial name
- NCT02583399
- Testing
- Ibuprofen
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Cumberland Pharmaceuticals
Pain on IV Injection of Propofol.
Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection
The main objective is to evaluate if combining placing the Synera patch and using Propofol /Lidocaine mixture will further decrease the pain associated with the IV injection of Propofol.
- Trial name
- NCT02240628
- Testing
- Lidocaine/tetracaine transdermal patch, Saline, Lidocaine
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston