Clinical trials: Painful Peripheral Neuropathy
Neurofibromatosis 1, Neurofibromatosis Type 1
AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors
Background: Plexiform neurofibromas are tumors that grow in and around nerves. The only way to treat them is with surgery. Some of these tumors cannot be completely removed.
- Conditions
- Neurofibromatosis 1, Neurofibromatosis Type 1, NF1, Neurofibroma, Plexiform
- Trial name
- NCT01362803
- Testing
- AZD6244
- Where
- 4 sites in United States
- Volunteers
- 99 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
"Electro Acupuncture in the Treatment and Management of Chemotherapy Induced Peripheral Neuropathy"
To evaluate the effectiveness of Electro acupuncture (EA) for treatment of persistent painful CIPN symptoms in patients with stages 1-3 breast cancer treated with docetaxel chemotherapy 6 months prior
- Trial name
- NCT02821442
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Neuropathic Pain Diagnostic Questionnaire (DN4) ≥ 4
Reiki and Reflexology Massage Diyabetik Neuropathy Pain
Diabetes Mellitus is a chronic endocrine and metabolic disease that occurs as a result of insufficiency, absence and/or deficiency of the insulin hormone secreted from the beta cells of the pancreas, and is characterized by…
- Trial name
- NCT06979739
- Testing
- reiki, refleksologia, reiki and refleksologia
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Postoperative Pain, Peripheral Neuropathy
Duration of Blockade of Peripheral Nerves With Bupivacaine Depending of the Adjuvants
The main aim of the investigator's study is to propose combination of local anesthetics and adjuvants that provides both adequate anesthesia during surgery and prolonged post-operative analgesia.
- Conditions
- Postoperative Pain, Peripheral Neuropathy, Fractures of the Upper Limb, Fracture of the Lower Limb (Except Hip), Initial Encounter
- Trial name
- DBBA (NCT04498923)
- Testing
- Bupivacaine, dexamethasone, epinephrine
- Where
- Ukraine
- Volunteers
- 68 people
- Sponsor
- Lviv National Medical University
Leg Pain, Peripheral Nerve Discontinuities
Effect of Nerve Stimulation on Sciatic Nerve Injury Pediatric Patients
Brief Summary The goal of this study is to learn if Faradic Nerve Stimulation (FNS) can help children recover from a condition called Post-Injection Sciatic Nerve Injury (PISNI).
- Conditions
- Leg Pain, Peripheral Nerve Discontinuities, Muscle Weakness, Sciatic Nerve Compression
- Trial name
- PISNI (NCT06781060)
- Testing
- Faradic Nerve Stimulation Therapy+Standard Physiotherapy, Physiotherapy Standard Treatment with TENS machine therapy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Azeem Hospital, Multan
Chemotherapy Induced Neuropathic Pain, Neuropathy Toxic
Prospective Exploratory Study of a Multiomic Blood Biomarker Panel to Predict Chemotherapy-Induced Peripheral Neuropathy (CIPN)
The goal of this prospective, multicenter, observational cohort study with longitudinal blood sampling and standardized neurological evaluation over 6 months is to identify biomarkers to predict the overall occurrence of chronic…
- Conditions
- Chemotherapy Induced Neuropathic Pain, Neuropathy Toxic, Taxane-induced Peripheral Neuropathy, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients
- Trial name
- PRECISE1 (NCT07511569)
- Testing
- longitudinal blood sampling and standardized neurological evaluation over 6 months
- Volunteers
- 192 people
- Sponsor
- Centre Hospitalier de Bligny
Chronic Pain, Complex Regional Pain Syndrome
Complex Regional Pain Syndrome: Analgesic Outcome
This retrospective observational study aims to describe the use and analyze the effectiveness of various analgesic interventions in patients diagnosed with Complex Regional Pain Syndrome (CRPS) at the Pain Management Center of…
- Trial name
- NCT07228949
- Where
- 2 sites in Canada
- Volunteers
- 201 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Neuropathic Pain
Safety And Efficacy In Long Term Use Of Lyrica (Regulatory Post Marketing Commitment Plan)
The objective of this investigation is to evaluate the safety and efficacy of long term use with Lyrica in medical practice. Also, occurrence of unknown and known adverse drug reactions (ADRs) in subjects treated with Lyrica will…
- Trial name
- RAINBOW-L (NCT01279850)
- Testing
- Pregabalin (Lyrica) capsule
- Volunteers
- 891 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Painful Diabetic Peripheral Neuropathy, Diabetes Complication
Safety and Effect of Peripheral Nerve Decompression Combined With Peripheral Nerve Stimulation for Painful Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus and a major cause of lower extremity pain, numbness, sensory loss, balance disturbance, diabetic foot ulcer and amputation.
- Trial name
- NCT07911410
- Where
- 4 sites in China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Neuropathy, Phantom Limb Pain
Immersive Virtual Reality for Neuropathic Pain
Investigating how neuropathic limb pain, including phantom limb pain or complex regional pain syndrome, is affected by virtual reality.
- Conditions
- Neuropathy, Phantom Limb Pain, Complex Regional Pain Syndromes, Neuropathic Pain
- Trial name
- NCT03203772
- Testing
- Immersive Virtual Reality
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Loma Linda University
Complex Regional Pain Syndrome I of Upper Limb, Pain
THE EFFECTS OF FUNCTIONAL ELECTRICAL STIMULATION-ASSISTED BICYCLE ERGOMETRY IN PATIENTS DIAGNOSED WITH COMPLEX REGIONAL PAIN SYNDROME.(CRPS)
The goal of this clinical study is to evaluate the effectiveness of functional electrical stimulation (FES)-assisted cycling in patients with post-stroke Complex Regional Pain Syndrome (CRPS) Type 1.
- Trial name
- CRPS (NCT07570199)
- Testing
- Functional Electrical Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Zeynep Nur Köseoğlu
Elbow Injuries and Disorders, Neuritis, Ulnar
Physical Therapy on Non-structural Medial Elbow Pain
This study is investigating the effect of using a regional interdependence approach of managing non-structural elbow pain with physical therapy.
- Conditions
- Elbow Injuries and Disorders, Neuritis, Ulnar, Neuritis, Brachial, Neuritis; Nerve Root
- Trial name
- NCT05537636
- Testing
- Rehabiltiation using exercise and manual therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Timothy Uhl
Lumbosacral Radiculopathy
Procedural Framing and Epidural Steroid Injection Outcomes
Back pain is the leading cause of disability and military medical boards across the globe. Epidural steroid injections (ESI) are the most commonly performed pain procedure in the world.
- Trial name
- PEACE (NCT07498140)
- Testing
- Behavioral manipulation of ESI expectations, No behavioral manipulation of ESI expectations, No behavioral manipulation of pharmacotherapy expectations
- Where
- 4 sites in United States, Thailand and 1 more
- Volunteers
- 210 people
- Sponsor
- Northwestern University
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Neuropathic Pain
Identifying Biomarkers and Changes in Cerebrospinal Fluid Collected Pre and Post Spinal Cord Stimulation in Subjects Suffering From Chronic Refractory Pain Conditions
This is a single center exploratory study in subjects suffering from chronic refractory pain to identify cellular, molecular and protein biomarkers within cerebrospinal fluid (CSF).
- Trial name
- CSF-STIM (NCT03986255)
- Testing
- Lumbar Puncture
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Facial Pain, Comorbidity
Somatosensory Investigation of Orofacial Pain Patients
Orofacial pain, specially neuropathic orofacial pain, is a challenge of diagnosis and treatment in orofacial pain. It is associated with sensory abnormalities.With increasing life expectancy of the population is more and more…
- Conditions
- Facial Pain, Comorbidity, Neuralgia
- Trial name
- QST (NCT02910336)
- Testing
- Quantitative Sensory Testing
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pain, Neuropathic Pain
Efficacy of Gabapentin in Treating Pain in Children With SNI (Gabapentin Trial)
Children born with severe brain-based developmental disabilities frequently experience persistent unexplained periods of pain and irritability, often compounded by a limited capacity to communicate their distress.
- Conditions
- Pain, Neuropathic Pain, Irritability
- Trial name
- NCT04619862
- Testing
- Gabapentin
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of British Columbia
Pain, Irritability
Implementation of the Pain and Irritability of Unknown Origin (PIUO) Pathway in Community Pediatric Practices
The Pain and Irritability of Unknown Origin (PIUO) Pathway is a clinical pathway that was developed to evaluate and manage unexplained pain and irritability for children with severe neurological impairments (SNI) who cannot…
- Conditions
- Pain, Irritability, Neuropathic Pain
- Trial name
- NCT06869928
- Testing
- PIUO Pathway
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Complex Regional Pain Syndrome Type I
Complex Regional Pain Syndrome in Children: Impact of Bergès Relaxation on the Autonomic Balance
Complex regional pain syndrome (CRPS) is a disease provoking chronic pain in the limbs, following a trauma. Patient care is complicated by the variable clinical picture and response to treatment.
- Trial name
- NCT03309774
- Testing
- questionnaires, holter electrocardiogram, blood pressure
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Chronic Pain, Neuralgia
GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain
The broad aim of the study is to implement and evaluate the efficacy of Graded Exposure Treatment (GET Living) to target elevated pain-related fears in children with chronic pain.
- Conditions
- Chronic Pain, Neuralgia, Musculoskeletal Pain, Headache
- Trial name
- GET Living (NCT01974791)
- Testing
- GET Living
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Boston Children's Hospital