Clinical trials: Pathophysiology
Thyroid Disease, Pregnancy
Thyroid Disease in Pregnancy: Case Finding Versus Universal Screening
The purpose of this study is to determine whether treatment of thyroid disease during pregnancy decrease the incidence of adverse outcome, and to compare the impact of Universal Screening versus case Finding strategy in detecting…
- Trial name
- NCT00846755
- Testing
- Levothyroxine, Propylthiouracile
- Where
- Italy
- Volunteers
- 4,657 people, healthy volunteers welcome
- Sponsor
- Ospedale V. Fazzi
Graft Dysfunction, Lung Transplantation
Prediction of Lung Transplant Outcome
Plain Language Summary of the PLUTO Study Prediction of Lung Transplant Outcomes (PLUTO) What is this study about? This study aims to improve how doctors predict the health of lung transplant recipients over time.
- Conditions
- Graft Dysfunction, Lung Transplantation, Chronic Lung Allograft Dysfunction (CLAD), Chronic Rejection of Lung Transplant
- Trial name
- PLUTO (NCT07356752)
- Testing
- Research Blood Sampling and Biocollection
- Where
- 9 sites in France
- Volunteers
- 4,200 people
- Sponsor
- Hopital Foch
Hydrocephalus
Diagnosing Malfunctioning Hydrocephalic Shunt Valves With a Flow Sensor
The study hypothesis is that a transit-time ultrasonic sensor can help doctors diagnose a malfunctioning shunt valve. The study will simulate an implanted shunt flow monitoring system by placing the flow sensor and a programmable…
- Trial name
- NCT00652249
- Where
- United States
- Sponsor
- Transonic Systems Inc.
Primary Graft Dysfunction, Lung Transplantation
Identifying Genetic Characteristics That Increase Risk of Primary Graft Dysfunction Following Lung Transplantation
Primary graft dysfunction (PGD) is a severe lung injury that can occur in the days following lung transplant surgery. The purpose of this study is to identify genetic factors that may put someone at risk for developing PGD.
- Trial name
- NCT00457847
- Where
- United States
- Volunteers
- 1,150 people
- Sponsor
- University of Pennsylvania
Chronic Thrombocytopenia
Cerebral Dysfunction in Chronic ITPwith High Risk of Serious Bleeding Excluding Intracranial Hemorrhage.
Intracranial hemorrhage despite being rare, several chronic ITP patients experience moderate to severe behavioral problems including learning difficulties, memory affection .These changes could be due to the presence of minute…
- Trial name
- NCT01764971
- Testing
- IQ assessment and visual- motor assessment, EEG,brain imaging
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Autism Spectrum Disorder, Asthma
Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)
FACT 4 Child is a follow up study of mothers who participated in the Folic Acid Clinical Trial (NCT01355159) and their children at 4-6 years of age to determine the effect of high dose folic acid supplementation on social…
- Conditions
- Autism Spectrum Disorder, Asthma, Executive Dysfunction, Emotional Problem
- Trial name
- NCT03269110
- Testing
- SRS 2, CBCL, BRIEF-P
- Where
- 58 sites in Australia, Canada and 2 more
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Depression, Bipolar Disorder
Mitochondrial Dysfunction, Inflammation, and White Matter Integrity in Youth With Mood Disorders
This study consists of three separate appointments including a clinical assessment (interview and questionnaires), a blood draw, a social stress test, and a brain MRI.
- Conditions
- Depression, Bipolar Disorder, Bipolar Disorder Not Otherwise Specified, Unspecified Mood Disorder
- Trial name
- NCT02596698
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Postoperative; Dysfunction Following Cardiac Surgery
Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia
Infants and children undergoing cardiac surgery require mechanical support for circulation called cardiopulmonary bypass. The artificial pump ensures that blood flow to the body is maintained during surgical procedure on the…
- Trial name
- I-TRICC (NCT02222532)
- Testing
- Tetronine
- Where
- Indonesia
- Volunteers
- 224 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Relapsing-Remitting Multiple Sclerosis
GER-009-06-AVX Early Therapy in Multiple Sclerosis
This study is being done to increase awareness for early therapy with Avonex for Multiple Sclerosis (MS) and the cognitive dysfunction that accompanies MS, and to record safety data for Avonex.
- Trial name
- FIT (NCT00492570)
- Volunteers
- 230 people
- Sponsor
- Biogen
Memory Disorders
AIT-082 Phase 1B Study
AIT-082 is a novel small molecule that crosses the blood-brain barrier to enhance nerve function by increasing levels of neurotrophic growth factors and encouraging nerve sprouting in the brain.
- Trial name
- NCT00000180
- Testing
- AIT-082
- Where
- 4 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Bone Disorder
Clinico-biological Collection of Bone, Calcium and Growth Plate Pathologies
The aim of this project is to set up a biological and clinical collection of patients with progressive bone, calcium and growth plate pathologies.
- Trial name
- OSCAR (NCT06444503)
- Testing
- Biological samples, Biological
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Toulouse
Neurogenic Bladder Disorder, Spina Bifida
Complications of Bladder Augmentation in Children
The goal of this observational study is to describe the complications in participants who underwent enterocystoplasty in childhood.
- Conditions
- Neurogenic Bladder Disorder, Spina Bifida, Complications of Surgical Procedures or Medical Care, Child, Only
- Trial name
- AVPED (NCT06733194)
- Where
- France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Clermont-Ferrand
Native Right Ventricle Outflow Tract(RVOT) Dysfunction
VenusP-Valve™ System Long-term Follow-up 6-10 Years
The goal of this study is to assess the long-term safety, efficacy and performance of VenusP-Valve™ implantation. in all subjects who provided informed consent and received VenusP-Valve™ implantation in the VenusP-Valve™ system…
- Trial name
- NCT07531303
- Volunteers
- 55 people
- Sponsor
- Venus MedTech (HangZhou) Inc.
Diaphragm Dysfunction
Point of Care Ultrasound to Evaluate Diaphragmatic Function in Children Undergoing Thoracic Surgery
In children undergoing pulmonary resection, the diaphragm function is evaluated using ultrasound before and after surgery to evaluate the incidence of diaphragm dysfunction after pulmonary resection.
- Trial name
- NCT04400370
- Testing
- Diaphragm ultrasound
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Seoul National University Hospital
Ataxia Telangiectasia
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis
Study design: Parallel group, placebo-controlled, dose-escalation each 2 months for 12 months. Dose based on percent (%) of calculated caloric intake.
- Trial name
- A-TC7 (NCT04513002)
- Testing
- Triheptanoin
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- The University of Queensland
Sepsis
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
The purpose of this study is to determine whether inhaled nitric oxide is an effective treatment for microcirculatory dysfunction and acute organ system failure in the early stage of sepsis therapy.
- Trial name
- NCT00608322
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
STEMI
Erectile Dysfunction After Percutaneous Coronary Intervention Versus the Thrombolytic Therapy in Acute ST Elevation Myocardial Infarction
Erectile dysfunction is a common sexual problem affecting up to one-third of men throughout their life. It is now well recognized that risk factors for erectile dysfunction (ED) include the same risk factors as coronary artery…
- Trial name
- NCT03328156
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Liver Failure, Acute on Chronic, Liver Dysfunction
A Validation Cohort for ACLF Diagnosis and Prognosis
Acute on chronic liver failure (ACLF) is a distinct entity encompassing the acute deterioration of liver function, culminating in multiple organs failure and high short-term mortality.
- Trial name
- Ch-CANONIC-Val (NCT03641872)
- Testing
- Standary therapy
- Where
- 12 sites in China
- Volunteers
- 1,370 people
- Sponsor
- Hai Li
Primary Graft Dysfunction
Pneumoproteins Expression in the Organ Donor
Primary graft dysfunction, a form of reperfusion pulmonary edema that occurs early after lung transplantation, shares key clinical and pathological features with acute lung injury and its more severe form, the acute respiratory…
- Trial name
- NCT02032069
- Testing
- no intervention
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital of Mont-Godinne
Alzheimer Disease, Mild Cognitive Impairment
Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Alzheimer Disease
The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety…
- Trial name
- NCT04771845
- Testing
- Transcranial Magnetic Stimulation
- Volunteers
- 73 people
- Sponsor
- The New York Memory Services
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