Clinical trials: Peri-operative
Gram Positive Bacterial Infection
Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics
This is a research study designed to look at the pharmacokinetics (distribution, breakdown, and removal) and tolerability of a single dose of daptomycin in patients aged 3 months to 24 months who have proven or suspected…
- Trial name
- NCT01019395
- Testing
- Daptomycin
- Where
- 8 sites in United States
- Volunteers
- 23 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Type 1 Diabetes Mellitis
Diathermy On Diabetes Glucose Monitoring Effectiveness
The goal of this observational study is to investigate if diathermy (a surgical tool that uses electrical energy to control bleeding) has any affect on the accuracy and functioning of continuous glucose monitoring systems in…
- Trial name
- DODGE (NCT07583238)
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- University of Nottingham
Appendicitis
Peri-operative Analgesia for Single-incision Laparoscopic Appendectomy
Laparoscopic appendectomy is a very common intervention in pediatric surgery. To improve outcomes, some teams have developed the use of single-site laparoscopic appendectomy (SILAP).
- Trial name
- PAMAL (NCT05773521)
- Testing
- SILAP (single incision laparoscopic appendectomy)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Angers
Orbital Fractures
Intra-operative (IO) Navigation and IO-CBCT for 3D Orbital Reconstruction
Background Correction of post traumatic and post-ablative orbita defects remains a challenge for the maxillofacial surgeon. The purpose of such intervention is the restoration of both function and aesthetics by anatomical…
- Trial name
- NCT03057405
- Volunteers
- 22 people
- Sponsor
- AZ Sint-Jan AV
Postoperative Vomiting and Nausea
Acupuncture and Nausea/Vomiting in Pediatric Patients
The purpose of this study is to investigate the effects of intraoperative P6 acupuncture plus standard therapy on postoperative nausea and vomiting in pediatric patients undergoing tonsillectomy with or without adenoidectomy.
- Trial name
- NCT01417741
- Testing
- Acupuncture Needle
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Oregon Health and Science University
Factor 10 Deficiency
Registry Study of COAGADEX® Patients With Moderate or Severe Hereditary Factor X Deficiency Undergoing Major Surgery
This is a non-interventional, multicenter, post-marketing registry study in three patients with moderate or severe hereditary FX deficiency, to assess Coagadex administered peri-operatively for hemostatic cover in major surgery…
- Trial name
- NCT03161626
- Testing
- Coagadex
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Bio Products Laboratory
Breast Cancer Invasive
Intra-operative Detection of Positive Margins and Lymph Nodes in Breast Surgery
In this project, the investigators will develop novel optical coherence tomography (OCT)-Raman spectroscopy and autofluorescence (AF)-Raman spectroscopy systems based on a selective sampling approach optimised for high-resolution…
- Trial name
- NCT06977698
- Testing
- OCT-Raman, AF-Raman
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Nottingham
Self-regulation, Forethought
Exploring Self-regulatory Processes in Anesthesiologists During Massive Transfusion
The purpose of the project is to investigate the function of self-regulatory processes in anesthesiologists and how application of these processes influence performance in a crisis situation.The investigators intend to explore…
- Conditions
- Self-regulation, Forethought, Performance
- Trial name
- NCT02199210
- Testing
- Prompting forethought
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Hemodynamic Stability, Post Operative Pain
Comparative Efficacy & Safety of Dexmedetomidine vs Tramadol in Paeds Hernioraphy. A Caudal Anaesthesia Approach
Among the postoperative adverse effects, pain has significant importance. Caudal block is a common technique for pediatric analgesia for infraumbilical surgeries.
- Conditions
- Hemodynamic Stability, Post Operative Pain, Inguinal Hernia Repair
- Trial name
- NCT06735443
- Testing
- Bupivacaine with Dexmetedomidine, Bupivacaine with Tramadol
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sahiwal medical college sahiwal
Pierre Robin Syndrome, Cleft Palate
Postoperative Complications After Cleft Palate Closure in Patients With Pierre Robin Sequence: Operative Considerations
In cleft surgery there is no current general agreement on the treatment strategy of patients with the Pierre Robin Sequence. The timing of surgery and the surgical approach depends on the treating physician or the hospital…
- Trial name
- NCT02658318
- Where
- Belgium
- Volunteers
- 92 people
- Sponsor
- AZ Sint-Jan AV
Idiopathic Scoliosis
Anesthesia and Motor Evoked Potential (MEP) Recruitment
Test the hypothesis to recruit larger motor responses to transcranial stimulation.
- Trial name
- NCT02199314
- Testing
- Desflurane
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Otitis Media With Effusion
OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement
The purpose of this study is to confirm the effectiveness, safety and tolerability of OTO-201 in the treatment of pediatric subjects with bilateral middle ear effusion who require tympanostomy tube placement.
- Trial name
- NCT01949155
- Testing
- OTO-201
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Otonomy, Inc.
Anesthesia
CARE--Childhood Awareness and Recall Evaluation
The purpose of this study is to describe the incidence of recall or awareness under anesthesia in children aged 5-15 by collecting anesthetic and post-operative follow-up data relating to intra-operative recall during general…
- Trial name
- NCT00308984
- Where
- 3 sites in United States
- Volunteers
- 1,784 people
- Sponsor
- Medtronic - MITG
Hypoxic Ischemic Encephalopathy, Neonatal Convulsions
Intra-operative Feed Back on Traction Force During Vacuum Extraction: Safe Vacuum Extraction Alliance
The objective of the clinical investigation is to test whether intra-operative traction force feed back during vacuum extraction leads to a significant decrease in incidence of brain damage in neonates.
- Conditions
- Hypoxic Ischemic Encephalopathy, Neonatal Convulsions, Subgaleal Hematoma
- Trial name
- SVEA (NCT03071783)
- Testing
- Vacuum extraction intelligent system
- Where
- Sweden
- Volunteers
- 800 people
- Sponsor
- Karolinska Institutet
Liver Transplant Disorder
Perioperative Analgesia by ESP Catheter on Paediatric Recipient for Liver Transplantation
Pediatric Liver transplantation surgery is associated with moderate to severe postoperative pain that is related to large abdominal incision cutting muscles and fascia and the anterior abdominal wall and drains.
- Trial name
- ESPLIVPAED (NCT04838314)
- Testing
- regional analgesia
- Where
- Vietnam
- Volunteers
- 12 people
- Sponsor
- Vinmec Healthcare System
Bone Tumor
The Epidural Anesthesia on the Intra-operative and Post-operative Amount of Bleeding Post Lower Limb Salvage Surgery
Epidural anesthesia is a very useful tool in lower limb salvage surgery, which helps pain control intra and more importantly post-operative pain.
- Trial name
- NCT01679691
- Testing
- epidural anesthesia
- Where
- Egypt
- Sponsor
- Children's Cancer Hospital Egypt 57357
Anesthesia and Analgesia, Pediatrics
Erector Spinae Plane Block for Peri-operative Pain Management in Pediatric Open Pyeloplasty Cases
Regional anesthesia decreases the need for intravenous analgesia in the peri-operative period. Erector spinae plane (ESP) and transversus abdominus plane (TAP) blocks are two common regional anesthesia techniques shown to be…
- Conditions
- Anesthesia and Analgesia, Pediatrics, Urologic Surgical Procedures
- Trial name
- ESPPOP (NCT03790566)
- Testing
- Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Cerebral Palsy, Hip Dysplasia
Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy
Pain management in pediatric patients presents a difficult challenge. Unlike adults, pediatric patients often cannot communicate their pain management needs clearly.
- Conditions
- Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
- Trial name
- NCT06189781
- Testing
- Ropivacaine injection, Bupivacaine, lidocaine, ropivacaine
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Congenital Heart Disease
Peri-operative Nutrition in Infants With Congenital Heart Disease
The purpose of our multi-center cohort study is to build a large platform to follow up the peri-operative nutrition of children with congenital heart disease.
- Trial name
- NCT03626480
- Testing
- No treatment
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Guangzhou Medical University
Hip Arthrosis
Locally Administered Clodronate in the Prevention of Aseptic Implant Loosening
Periprosthetic bone-loss after total hip arthroplasty (THA), detected as an early migration of the prosthesis, may predict later loosening.
- Trial name
- NCT03803839
- Testing
- Clodronate, Saline
- Volunteers
- 19 people
- Sponsor
- University of Oulu