Clinical trials: Periapical Disease
Chronic Apical Periodontitis, Pulp Necrosis
Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.
This randomized clinical trial aims to compare regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) with conventional root canal treatment in mature necrotic anterior teeth with chronic apical…
- Trial name
- REGEN-iPRF (NCT07913399)
- Testing
- Conventional Root Canal Treatment, Regenerative Endodontic Treatment with i-PRF, Injectable Platelet-Rich Fibrin (i-PRF)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Irreversible Pulpitis, Apical Periodontitis
Evaluation of iRoot SP as Root Canal Sealer: A Clinical Study
The purpose of this study was to evaluate the clinical and radiological outcomes of iRoot SP as a root canal sealer in comparison with AH Plus sealer within 1-year follow up.Patients needing root canal treatment were enrolled and…
- Trial name
- NCT02981693
- Testing
- Root canal sealer
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Hui Chen
Apical Periodontitis
Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients.
Periodontal health may jeopardize the success of endodontic treatment.Intraorifice barrier apart from enhancing probability of success of endodontic treatment may also augment periodontal therapy as intra pulpal infection is…
- Trial name
- NCT03711942
- Testing
- Intra orifice barrier, Base, Control
- Volunteers
- 90 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Oral Health, Dental Caries
The Use of Artificial Intelligence in the Dental X-rays Analysis
This cross-sectional study aims to perform a population-based assessment of the incidence of decay, dental fillings, root canal fillings, endodontic lesions, implants, implant and dental abutment crowns, pontic crowns, and…
- Conditions
- Oral Health, Dental Caries, Periapical Diseases, Tooth Loss
- Trial name
- NCT06258798
- Testing
- Taking a dental X-ray
- Where
- Poland
- Volunteers
- 1,025 people
- Sponsor
- Hospital of the Ministry of Interior, Kielce, Poland
Apical Periodontitis
N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as…
- Trial name
- NAC (NCT07262554)
- Testing
- Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Apical Periodontitis
Lesion Healing After Regenerative Endodontic Treatment
Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies.
- Trial name
- NCT06843850
- Testing
- regenerative endodontics
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pulp Necrosis, Apical Periodontitis
CGF-Enhanced Autologous Pulp Transplantation in Mature Necrotic Teeth
This pilot clinical study evaluated the clinical, radiographic, and functional outcomes of autologous pulp transplantation combined with concentrated growth factor (CGF) in mature permanent teeth with pulp necrosis and periapical…
- Trial name
- CGF-PULP (NCT07314866)
- Testing
- Autologous Pulp Transplantation With Concentrated Growth Factor
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Dental Pulp Necroses
Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents
Evalaution of clinical success of secondary treatment for total 40 permanent incisors with failed root canal treatment with apical radiolucency.
- Trial name
- PRF (NCT05517187)
- Testing
- no intervention, Platelet rich fibrin
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nahda University
Pulp and Periapical Tissue Disease
Regenerative Endodontics for Non-vital Primary Molars
Non-vital primary molars will be treated with regenerative endodontic idea using different capping materials aiming to replace the necrotic pulp tissue with biological one and to provide perfect seal over the scaffold
- Trial name
- NCT05098483
- Testing
- Regeneration in primary molars by using MTA, Regeneration in primary molars by using biodentine, Conventional Root canal treatment in primary molars
- Where
- Egypt
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periapical Diseases
Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth
Traumatic tooth injuries are common in children and adolescents, and often result in pulpal necrosis and the development of periapical lesions.
- Trial name
- NCT02625298
- Testing
- ProRoot MTA, MTA+ Cerkamed
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Association of Paediatric and Preventive Dentists of Serbia
Necrotic Pulp, Regenerative Endodontic Procedures
Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial
This study investigates a biological approach that allows infected and necrotic teeth to heal themselves instead of being treated with traditional root canal therapy.
- Conditions
- Necrotic Pulp, Regenerative Endodontic Procedures, Mature Teeth, Apical Periodontitis
- Trial name
- NCT06886438
- Testing
- RVS, L-PRF, i-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi
Apical Periodontitis, Trauma
Revitalization of Traumatized Immature Permanent Teeth
This study aims to assess the hypothesis that revitalization of teeth without (a)symptomatic apical periodontitis have a more favourable outcome in terms of further root development, periapical bone healing, maintaining/regaining…
- Trial name
- NCT06043453
- Testing
- revitalization
- Where
- Belgium
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Apical Periodontitis
Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study)
Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis.
- Trial name
- NCT04158232
- Testing
- Method
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minia University
Endodontic Inflammation
Evaluation of the Effect of Different Irrigation Activation Methods During Endodontic Retreatment
The persistent and secondary intraradicular infections are the primary causes of post-treatment disease following endodontic treatment of any tooth.
- Trial name
- NCT07779148
- Testing
- Xp Finisher R file
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Minia University
Rheumatoid Arthritis AND Apical Periodontitis
Effect of Endodontic Treatment on Inflammatory Markers, Disease Activity and Periapical Healing in Rheumatoid Arthritis Patients With Apical Periodontitis : A Prospective Interventional Study
SUMMARY TITLE: "Effect of endodontic treatment on inflammatory markers, disease activity and periapical healing in rheumatoid arthritis patients with apical periodontitis" RATIONALE: Chronic inflammation plays a pivotal role in…
- Trial name
- NCT06433232
- Testing
- ROOT CANAL TREATMENT
- Where
- India
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Endodontic Infection, Periapical Diseases
The Effect of Different Hemostatic Agents on Hemorrhage Control, Pain and Quality of Life After Endodontic Microsurgery.
Background This randomized clinical trial evaluated the effect of two different hemostatic materials for endodontic microsurgery on bleeding control, postoperative pain and patients' quality of life.
- Trial name
- NCT07311291
- Testing
- Hemostatic Agent 1: Surgical glue (IfaBond, Dipromed, Italy), Hemostatic Agent 2: Ferric sulfate
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Turin, Italy
Periapical Periodontitis
Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients
The main objective of this study is the prevention and repair of apical periodontitis in lower molars with pulp necrosis after the execution of endodontic treatment in one or two visits in adolescent patients.
- Trial name
- PHAP (NCT01312194)
- Testing
- Root canal therapy in one visit, Root Canal Therapy in two-vist
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Odontogenic Cysts, Keratocysts of the Jaw
Decompression of Odontogenic Cysts
The aim of this case-control study is to evaluate the effects of decompression of cystic jaw lesions by means of comparing pre- and post-decompression histologic findings.
- Conditions
- Odontogenic Cysts, Keratocysts of the Jaw, Cysts Dental, Pathology
- Trial name
- NCT06536907
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periapical Periodontitis
Single Versus Multiple Visits Endodontic Treatment
Healing rate after single visit or multiple visit endodontic treatment using triple paste intracanal medicament will be assessed both clinically and radio-graphically for follow-up period up to one year
- Trial name
- NCT02947763
- Testing
- mixture of metronidazole, ciprofloxacin, and minocycline
- Volunteers
- 44 people
- Sponsor
- Cairo University
Pulp Necroses, Apical Periodontitis
Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis
The purpose of the study is to evaluate the effect of Mesenchymal Stromal Cell (MSC) implantation on pulp and periapical regeneration of immature teeth with pulp necrosis and chronic apical periodontitis.
- Trial name
- MSC (NCT04545307)
- Testing
- Allogenic transplant of BM-MSC in a root canal from patients with immature apexes and pulpar necrosis and apical periodontitis
- Where
- Venezuela
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Universidad Central de Venezuela