Clinical trials: Periapical Disease
Apical Periodontitis, Atherosclerotic Cardiovascular Disease
Association Between Apical Periodontitis and Atherosclerotic Cardiovascular Diseases
The aim of the study is to evaluate the association between apical periodontitis (AP) and atherosclerotic cardiovascular disease (ASCVD) by assessing the multiplicative effect of AP on secondary outcomes of ASCVD.
- Trial name
- NCT05792787
- Testing
- Echo-color-doppler
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- University of Siena
Pulpitis, Periapical Lesions
Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements
The present study aims to compare the radiographic success of endodontic treatment using Orstavik's criteria between two sealers: AH Plus (Dentsply DeTrey, Konstanz, Germany) and Neosealer Flo (Avalon Biomed, Bradenton, Florida…
- Conditions
- Pulpitis, Periapical Lesions, Periapical Periodontitis, Periapical Pathology
- Trial name
- NCT07019298
- Testing
- AH Plus (Dentsply Sirona, Charlotte, NC, USA), NeoSealer Flo, Continuous Wave Condensation
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- University of Siena
Rheumatoid Arthritis AND Apical Periodontitis
Effect of Endodontic Treatment on Inflammatory Markers, Disease Activity and Periapical Healing in Rheumatoid Arthritis Patients With Apical Periodontitis : A Prospective Interventional Study
SUMMARY TITLE: "Effect of endodontic treatment on inflammatory markers, disease activity and periapical healing in rheumatoid arthritis patients with apical periodontitis" RATIONALE: Chronic inflammation plays a pivotal role in…
- Trial name
- NCT06433232
- Testing
- ROOT CANAL TREATMENT
- Where
- India
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Endodontically Treated Teeth, Endodontic Underfill
No Code Artificial Intelligence to Detect Radiographic Features Associated With Unsatisfactory Endodontic Treatment
Developing neural network-based models for image analysis can be time-consuming, requiring dataset design and model training. No-code AI platforms allow users to annotate object features without coding.
- Conditions
- Endodontically Treated Teeth, Endodontic Underfill, Endodontic Overfill, Apical Periodontitis
- Trial name
- NCT06450938
- Testing
- AI guidance for finding radiographic features
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Periodontitis, Gingivitis
Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control
The goal of this study is to learn if dental infection control treatment delivered to older adult nursing home residents at their place of residence will result in : improved dental health reduced risk of pneumonia better glucose…
- Conditions
- Periodontitis, Gingivitis, Periodontal Disease, Periodontal Infections
- Trial name
- NHOralHealth (NCT06890676)
- Testing
- Comprehensive Oral Evaluation, Intraoral Complete Radiographic Series, • Teledentistry-synchronous and asynchronous
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Missouri Department of Health and Senior Services
Apical Periodontitis, Anxiety
Apical Periodontitis and Mental Health
This study is investigating the relationship between anxiety, depression and apical periodontitis (AP), a common oral inflammatory condition.
- Conditions
- Apical Periodontitis, Anxiety, Depression
- Trial name
- NCT06589076
- Testing
- Clinical and Radiographic assessment + Questionnaires
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Siena
Root Canal Infection, Bisphosphonate-Associated Osteonecrosis
Root Canal Treatment Outcome in Patients Under Bisphosphonate Therapy
The aim of this study was to evaluate the survival rate and healing time of compromised teeth and seriously compromised teeth that were endodontically treated in patients which received bisphosphonate therapy .
- Conditions
- Root Canal Infection, Bisphosphonate-Associated Osteonecrosis, Periapical Abscess, Endodontically Treated Teeth
- Trial name
- NCT04399720
- Testing
- Root canal treatment
- Volunteers
- 111 people
- Sponsor
- University of Bologna
Apical Periodontitis
Retreatment and Diabetes
ABSTRACT This prospective, controlled, single-center clinical study aims to compare postoperative pain levels and analgesic consumption after nonsurgical endodontic retreatment in individuals with diabetes mellitus and…
- Trial name
- NCT07679880
- Testing
- root canal retreatment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Symptomatic Apical Periodontitis
Comparison of Postoperative Pain After Double Antibiotic Paste vs Calcium Hydroxide in Teeth With Symptomatic Apical Periodontitis
This randomized controlled trial aims to compare the mean postoperative pain after using double antibiotic paste (DAP) versus calcium hydroxide (CH) as an intracanal medicament in teeth with symptomatic apical periodontitis.
- Trial name
- NCT07867951
- Testing
- Calcium Hydroxide (Ca(OH)2), Double Antibiotic Paste
- Where
- Pakistan
- Volunteers
- 662 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Periapical Periodontitis
Evaluation of Three Irrigants, Sodium Hypochlorite, Chlorhexidine and Combination of CHX+H2O2 in Endodontic Treatment.
This study will evaluate the synergistic effect of CHX + H2O2 when used as an irrigant during biomechanical preparation.in root canal treatment on periapical healing and compared with Chlorhexidine( CHX) and Sodium Hypochlorite…
- Trial name
- NCT04373018
- Testing
- Sodium hypochlorite, Chlorhexidine, Chlorhexidine + Hydrogen peroxide
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Endodontic Disease, Pulp Disease, Dental
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal…
- Conditions
- Endodontic Disease, Pulp Disease, Dental, Intracanal Medication
- Trial name
- NCT06207253
- Testing
- Diclofenac Sodium, Calcium hydroxide
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Apical Periodontitis
Comparative Analysis of Photodynamic Therapy on Periapical Healing
As a result of tooth decay, lesions caused by infection occur at the root tip. These teeth can heal with root canal treatment. In this study, additional applications will be made to increase the success of root canal treatment.
- Trial name
- NCT06553144
- Testing
- control, methylene blue, erythrosine b
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- University of Gaziantep
Periapical Disease
Effect of Piezoelectric Surgery on Quality of Life and Periradicular Healing After Endodontic Surgery
This study will compare the effect of piezo Vs bur on quality of life and healing after endodontic surgery.
- Trial name
- NCT04358887
- Testing
- piezoelectric surgery, conventional bur
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Cyst
Examining the Effect of Different Filling Techniques on Healing in Lesional Teeth
Microorganisms are an important factor in the development of periradicular diseases. The goal of non-surgical endodontic treatment is to eliminate microorganisms and their byproducts from the root canal system and to create an…
- Trial name
- NCT06384014
- Testing
- retrograde and orthograde root canal filling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Intervention Studies, ASA Physical Status I
Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications: 1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite 2. Calcium Silicate 3.
- Conditions
- Intervention Studies, ASA Physical Status I, Intracanal Medication, Periapical Abscess
- Trial name
- RCT (NCT07641933)
- Testing
- Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis, Dental Caries
Immediate Implant Placement in the Molar Regions
The purpose of this study is to look at the bonehealing when a molar has been extracted and immediately replaced by an implant leaving some defects around the implant.
- Conditions
- Periodontitis, Dental Caries, Periapical Periodontitis
- Trial name
- NCT00226148
- Testing
- Use of a membrane to cover bonedefects around implant, Use of bonechips to fill up defects around implant, Use of membrane and bonechips to manage defects
- Where
- Denmark
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Teeth, Endodontically-Treated, Tooth, Nonvital
Comparison Between RCT in Single and Two Visits, With and Without Intracanal Dressing, in Apical Repair
This is a randomized, prospective, double-blind, controlled clinical trial designed to evaluate 3 distinct clinical approaches used during endodontic therapy: Group 1- Root canal treatment in single visit (RCT-SV); Group 2- Root…
- Conditions
- Teeth, Endodontically-Treated, Tooth, Nonvital, Periapical Periodontitis, Chronic Nonsuppurative, Periapical Granuloma
- Trial name
- NCT05256667
- Testing
- RCT-SV, RCT-TVWD, RCT-TVWOD
- Where
- Brazil
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- New York University
Antimicrobial Photodynamic Therapy
The Effect of Antimicrobial Photodynamic Therapy on the Success of Root Canal Treatment
The decontamination of the root canal system from pathological microflora is essential for the success of endodontic treatment. Mechanical instrumentation and irrigation solutions, known as the chemomechanical process, are…
- Trial name
- NCT06634745
- Testing
- Standard Needle Irrigation (SNI), Passive Ultrasonic Irrigation (PUI, EndoActivator (EA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Periapical Periodontitis, Polymerase Chain Reaction
The Effect of Ca(OH)2 in Apical Periodontitis
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Intracanal Medicament, Enterococcus Faecalis Infection
- Trial name
- NCT04978545
- Testing
- calciumhydroxide, intracanal medicament, chlorhexidine, intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Necrotic Pulp With Symptomatic Apical Periodontitis
The Impact of Using Different Final Irrigation Modes on Postoperative Pain Following Root Canal Treatment of Non-vital Mandibular First Molar With Periapical Lesion.
The goal of this clinical trial is to learn which rinsing of root canals method works best to lower pain after a root canal in adults.
- Trial name
- NCT07623629
- Testing
- root canal treatment
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt