Clinical trials: Perioperative
Congenital Cystic Adenomatoid Malformation
Effects of Additional Fentanyl to Epidural Bupivacaine for Post-Thoracotomy Pain in Neonates
The study exams whether adding an opioid to the epidural infusion of a local anesthetic in neonates will significantly improve the quality of the postoperative analgesia.
- Trial name
- NCT00286143
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Children's Hospital of Philadelphia
Burn, Reconstructive Surgical Procedure
Evaluation Perioperative Nutrition on Donor Site Healing in Patients Undergoing Reconstructive Burn Surg
The investigators hope to learn if taking a nutrition drink for a short time after surgery for an elective reconstructive burn injury improves donor site healing, muscle mass and scar maturation time (the point at which the…
- Trial name
- NCT00539097
- Testing
- Juven (Ross Products) protein supplement
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Kidney Transplant; Complications
Effects of Graft Vascular Dimensions on Surgical and Functional Outcomes of Living Donor Kidney Transplantation
1. Correlate the radiological and intraoperative measuring of the vascular dimensions, 2. Assess the effect of the vascular dimensions on the short-term surgical complications and 3.
- Trial name
- NCT05797389
- Volunteers
- 30 people
- Sponsor
- Assiut University
Cleft Palate, Cleft Lip
Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring
Cleft lip and palate surgeries present unique anesthetic challenges due to shared airway access with the surgical field, frequent anatomical abnormalities, and a predominantly infant and toddler population.
- Conditions
- Cleft Palate, Cleft Lip, Laryngospasm, Bronchospasm
- Trial name
- NCT07651904
- Testing
- Standard General Anesthesia per Institutional Protocol
- Volunteers
- 150 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Obstructive Sleep Apnea of Child
Diaphragm Ultrasound İn Children With OSAS
This is a prospective observational study evaluating perioperative diaphragmatic function by ultrasonography in children aged 1-12 years undergoing elective surgery under general anesthesia.
- Trial name
- NCT07380321
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Pain, Postoperative, Adverse Reaction to Epidural Anesthesia
Pediatric Caudal Anesthesia Block. And Pain Control
Caudal epidural block CEB is the most commonly performed neuraxial block to provide effective pain relief and analgesia in patients undergoing infra-umbilical pediatric surgery.
- Conditions
- Pain, Postoperative, Adverse Reaction to Epidural Anesthesia, Anesthesia, Caudal
- Trial name
- CEB (NCT05581940)
- Testing
- Group A Caudal Epidural Anesthesia with bupivacaine 0.25% and group B with opioid intervenors
- Where
- Bahrain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Salmaniya Medical Complex
Progressive Infantile Idiopathic Scoliosis
Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery
Comparison of the Efficacy of ketamine measuring the total consumption of morphine in pediatric patients with idiopathic scoliosis
- Trial name
- NCT02571491
- Testing
- Ketamine Hydrochloride, Remifentanil, Morphine hydrochloride
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Fundació Sant Joan de Déu
Adolescence Idiopathic Scoliosis, Preoperative Anxiety
the Effect of the Preoperative Information Method on Intraoperative Anxiety and Postoperative Outcomes in AIS Patients: a Randomized Clinical Trial
Due to the increasing use of smartphones and social media in contemporary times, adolescents experience a rapid loss of attention while reading or listening.
- Conditions
- Adolescence Idiopathic Scoliosis, Preoperative Anxiety, Postoperative Pain After Spinal Surgery
- Trial name
- NCT07902674
- Testing
- İntervention 1: Video-Based Preoperative Education, İntervention 2: Brochure-Based Preoperative Education, Routine Verbal Preoperative Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Gazi University
Anesthesia, Sedation
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful.
- Conditions
- Anesthesia, Sedation, Monitored Anesthesia Care, Procedure
- Trial name
- MACS (NCT07022951)
- Testing
- Preoperative fasting
- Where
- United States
- Volunteers
- 1,200,000 people
- Sponsor
- Massachusetts General Hospital
Heart Rate Monitoring, Vagal Bradycardia
Heart Rate Variability and Early Cytokine Profile in Pediatric Adenotonsillectomy
This prospective observational cohort study will assess whether perioperative short-term heart rate variability (HRV) indices and early inflammatory cytokine levels are associated with respiratory and cardiac adverse events in…
- Conditions
- Heart Rate Monitoring, Vagal Bradycardia, Adenotonsillar Hypertrophy, Tonsillitis; Hypertrophic
- Trial name
- NCT07719439
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Duzce University
Allergy Drug, Allergic Reaction
Preoperative Survey to Evaluate Patient Allergy
The study will only involve identification of the listed allergies from the electronic medical record and investigation into the symptoms that prompted this allergy listing.
- Conditions
- Allergy Drug, Allergic Reaction, Pediatric, Surgery
- Trial name
- NCT05670756
- Testing
- Survey
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Nationwide Children's Hospital
Analgesia After Coronary Artery Bypass Graft Surgery
Regional Blocks for CABG Artery Bypass Graft Surgery
Pain control after CABG is an essential step to guard against postoperative complications such as lung atelectasis. This major step can be achieved by opioids or regional blocks.
- Trial name
- NCT05691920
- Testing
- Pectointercostal plane block and external oblique intercostal plane block, Fentanyl infusion
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Hemorrhage, Hypocalcemia
The No-Tie Technique Using the Harmonic Scalpel in Total Thyroidectomy With Central Neck Dissection: A Prospective Randomized Study
To investigate the safety and efficacy of the no-tie technique using the harmonic scalpel (HS) in terms of the operating time and complications in total thyroidectomy with central neck dissection (CND).
- Conditions
- Hemorrhage, Hypocalcemia, Vocal Cord Palsy
- Trial name
- NCT00506103
- Where
- South Korea
- Sponsor
- Soonchunhyang University Hospital
Congenital Heart Disease, Neurodevelopmental Disorders
Predictive Value of Neurovascular Coupling in Infants With COngenital Heart Disease
Infants with congenital heart disease (CHD) are at increased risk for delayed neurodevelopment. Multiple etiological explanations have been proposed, as there seems to be a multifactorial interplay of both prenatal and…
- Conditions
- Congenital Heart Disease, Neurodevelopmental Disorders, Electroencephalography, Near-Infrared Spectroscopy
- Trial name
- NICO (NCT06190210)
- Testing
- electroencephalography, Near-Infrared Spectroscopy, neuronal cell-free DNA
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Congenital Heart Disease, Perioperative/Postoperative Complications
Central Venous to Arterial CO2 Difference and Low Cardiac Output Syndrome Related Outcomes in Children After Cardiac Surgery
The goal of this clinical trial is to compare the capability of 3 different bedside surrogates in children who underwent cardiac surgery and were admitted in intensive care unit.
- Conditions
- Congenital Heart Disease, Perioperative/Postoperative Complications, Lactate Blood Increase
- Trial name
- VACO2 (NCT06292910)
- Testing
- arterial and central venous blood gas analysis, lactate
- Where
- Thailand
- Volunteers
- 136 people
- Sponsor
- Prince of Songkla University
Lower Limb Arthroplasty Under Chloroprocaine Spinal Anesthesia
Intrathecal Chloroprocaine for Lower Limb Arthroplasty
This study evaluates the perioperative course in adult patients undergoing total or partial knee arthroplasty, or total hip arthroplasty under chloroprocaine spinal anesthesia.
- Trial name
- NCT05365074
- Testing
- Chloroprocaine Injection
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Hôpital de la Croix-Rousse
Cleft Palate, Pain
Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.
- Conditions
- Cleft Palate, Pain, Postoperative Care, Perioperative Care
- Trial name
- OPAL-Cleft (NCT06962306)
- Testing
- Methadone hydrochloride, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Hemophilia A
A Study of TAK-660 in Surgical Procedures for People With Hemophilia A.
This study is about a factor VIII medicine called Adynovate (TAK-660) used during surgery for people with hemophilia A who have low blood levels of factor VIII.
- Trial name
- NCT04941898
- Testing
- PEGylated Recombinant Factor VIII
- Where
- Japan
- Volunteers
- 16 people
- Sponsor
- Takeda
Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary)
Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy
This study will evaluate whether quantitative pupillometry measurements can be used to identify children at risk for postoperative opioid-induced respiratory depression (OIRD) following tonsillectomy.
- Conditions
- Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary), Respiratory Complications Due to Anesthesia
- Trial name
- NCT07573150
- Testing
- Infrared Pupillometry
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- NeurOptics Inc
Pain
Pharmacogenetic Morphine Spine Study
The purpose of this research study is to identify factors and genes (the DNA material that determines the makeup of the human body) that may be associated with how children cope with pain and respond to pain medication.
- Trial name
- NCT01839461
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati