Clinical trials: Peripheral Nervous System Disorders
Complex Regional Pain Syndromes
Evoked Fields After Median and Ulnar Stimulation
In order to be able to study the effects of evoked fields with magnetoencephalography (MEG) in two groups of patients, comparison is made with a group of healthy volunteers.
- Trial name
- NCT00217243
- Testing
- Evoked fields before and after a local block (Xylocaine)
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Neurofibromatosis 1
iCanCope With NF: Innovating an Efficacious Digital Self-management and Transitional Care Program for Adolescents With Neurofibromatosis
Neurofibromatosis Type 1 (NF1) often significantly impairs the mental health, social life, self-esteem, and quality of life of adolescent patients. These impacts can be made worse with the experience of NF1-related pain.
- Trial name
- NCT07077408
- Testing
- iCanCope-NF Youth app, iCanCope-NF Youth app + CM
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Nerve Sheath Tumors
Neoadjuvant Nivolumab Plus Ipilimumab for Newly Diagnosed Malignant Peripheral Nerve Sheath Tumor
The purpose of the study is to evaluate safety and feasibility of neoadjuvant nivolumab plus ipilimumab prior to standard therapy (surgery, chemotherapy or radiation therapy) in patients with Neurofibromatosis Type 1 (NF1) and…
- Trial name
- NCT04465643
- Testing
- Nivolumab, Ipilimumab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hemianopia, Homonymous, Tunnel Vision
Feasibility Tests for Various Prism Configurations for Visual Field Loss
The investigators will develop and test different configurations of high-power prisms to expand the field of vision of patients with visual field loss to assist them with obstacle detection when walking.
- Conditions
- Hemianopia, Homonymous, Tunnel Vision, Visual Field Defect, Peripheral, Visual Field Constriction Bilateral
- Trial name
- NCT04424979
- Testing
- High power prisms
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Neurofibromatosis 1, Scoliosis
Genetic Evaluation of NF1 and Scoliosis Patients
Neurofibromatosis (NF) is a common genetic disorder that cause tumors to grow along various types of nerves and, in addition, can affect the development of bones and skin. It occurs in 1:4000 persons.
- Trial name
- NCT01776125
- Testing
- Cheek swab
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Minnesota
Carpal Tunnel Syndrome
Continuous And Pulsed Ultrasound Treatments On Carpal Tunnel Syndrome
The aim of this placebo-controlled study was to evaluate the effects of pulsed and continuous ultrasound treatments combined with splint therapy on patients with mild and moderate idiopathic carpal tunnel syndrome
- Trial name
- NCT02054247
- Testing
- ultrasound, pulsed ultrasound
- Volunteers
- 46 people
- Sponsor
- Eskisehir Osmangazi University
Cerebral Palsy (CP), Stroke
High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction
The Hawks in Motion (HIM) High Intensity Exercise program is designed to implement the American Physical Therapy Clinical Practice Guidelines and American College of Sports Medicine recommendations for exercise for people with…
- Conditions
- Cerebral Palsy (CP), Stroke, Spinal Cord Injury, Traumatic Brain Injury
- Trial name
- NCT06945835
- Testing
- Participate in high intensity exercise of at least 20 minutes in 60 minutes session of RPE greater than 6.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Hartford
Neurofibromatosis 1, NF1
Developing Biomarkers of Plexiform Tumor Burden in Patients With Neurofibromatosis-Type 1
The purpose of this study is to identify tumor biomarkers in individuals with Neurofibromatosis type 1 (NF1). Biomarkers are signals that the investigator can measure that tell us about a process such as progress of a disease or…
- Conditions
- Neurofibromatosis 1, NF1, Neurofibromatosis Type 1
- Trial name
- NCT05238909
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Brain and Central Nervous System Tumors, Neuroblastoma
Docetaxel in Treating Children With Recurrent Solid Tumors
Phase II trial to study the effectiveness of docetaxel in treating children with recurrent solid tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Brain and Central Nervous System Tumors, Neuroblastoma, Sarcoma
- Trial name
- NCT00002825
- Testing
- filgrastim, docetaxel
- Where
- 36 sites in United States, Australia and 1 more
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Alström Syndrome (ALMS)
Clinical Study of a Single Ciliopathy: Alström Syndrome
The aim of the study is to characterize the clinical manifestations of ALMS within the ciliopathies to prevent complications and determine preventive and therapeutic targets.
- Trial name
- NCT02890550
- Where
- 14 sites in France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Migraine in Children, Complex Regional Pain Syndromes
Supraspinal Processing of Sensory Aspects of Pain
The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients.
- Conditions
- Migraine in Children, Complex Regional Pain Syndromes, Musculoskeletal Pain, Functional Abdominal Pain Syndrome
- Trial name
- SCP (NCT05814497)
- Testing
- Multisensory Task, Graphesthesia, Divided attention
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Child, Only, Inhalation; Vapor
Cerebral and Peripheral Near Infrared Spectroscopy Monitoring in Low and High Flow Anaesthesia in Pediatric
To investigate the effects of non-invasive cerebral and peripheral NIRS monitoring and low and high flow sevoflurane anaesthesia on cerebral and peripheral NIRS in paediatric patients.
- Conditions
- Child, Only, Inhalation; Vapor, Anesthesia, Cerebral Oxygenation
- Trial name
- NCT06320743
- Testing
- NIRS ,Ventilation parameters, Oxygen concentration
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara City Hospital Bilkent
Medulloblastoma, Brain Tumors
High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood
The purpose of this study is to evaluate the efficacy of the combination of surgery, conventional chemotherapy, sequential high-dose chemotherapy with peripheral blood stem cell transplantation and reduced dose radiation therapy…
- Conditions
- Medulloblastoma, Brain Tumors, Neuroectodermal Tumors, Primitive
- Trial name
- NCT00180791
- Testing
- Etoposide, carboplatin, melphalan, cisplatin, thiotepa
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Failed Back Surgery Syndrome, Limb Ischemia
Evaluation of Online Tool (E-TOOL SCS) in Spinal Cord Stimulaion
This observational multicenter study aims to evaluate the reliability and validity of the e-tool for selecting patients eligible for SCS for chronic pain caused by one of the four etiologies listed above in the experience of…
- Conditions
- Failed Back Surgery Syndrome, Limb Ischemia, Neuropathic Pain, Complex Regional Pain Syndromes
- Trial name
- E-TOOLSCS (NCT06229015)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Carpal Tunnel Syndrome
Ultrasonographic Assessment of Carpal Tunnel Syndrome
Mucopolysaccharidosis are lysosomal storage disorders such as Hunter, Hurler, and Sanfilippo syndromes. These patients have a genetic enzyme deficiency that results in the inability to degrade glycosaminoglycans.
- Trial name
- NCT02196220
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Utah
Low Back Pain, Sciatica
Long-Term Course of Korean Medicine Treatment for Lumbar Disc Herniation
This observational study will assess the long-term course and effect of Korean medicine treatment in lumbar intervertebral disc herniation patients who received integrative Korean medicine treatment for 24 weeks as part of a…
- Conditions
- Low Back Pain, Sciatica, Intervertebral Disc Displacement
- Trial name
- NCT03426215
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Jaseng Medical Foundation
Pain Syndrome, Fibromyalgia
Neuro-modulation of Central Pain Pathways in Non Inflammatory Musculoskeletal Pain Syndrome
The aim of this clinical trial is to see if transcranial electrical stimulation (tES) can help reduce pain and improve quality of life in children and adolescents (ages 10-21, both sexes) with juvenile fibromyalgia or other…
- Conditions
- Pain Syndrome, Fibromyalgia, CRPS (Complex Regional Pain Syndromes), Neuromodulation
- Trial name
- NMJFP protocol (NCT07785362)
- Testing
- Neuro-modulation of central pain pathways in non inflammatory musculoskeletal pain syndrome (NMJFP)
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Istituto Giannina Gaslini
Neurofibroma
Phase I Clinical Study of the Safety of Photodynamic Therapy (PDT) Using LS11 in Children With Plexiform Neurofibromas
Plexiform neurofibromas (PN) represent one of the most significant complications of NF1. They are a significant cause of morbidity in neurofibromatosis type 1 (NF1) by causing pain, impaired function, and disfigurement.
- Trial name
- PDT (NCT00716469)
- Testing
- LS11
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Children's Hospital of Philadelphia
Humeral Fractures, Ulnar Nerve Compression
Simple Decompression Versus Anterior Transposition of the Ulnar Nerve
Both simple decompression and anterior transposition of the elbow nerve (ulnar nerve) for acute displaced fractures of the elbow (distal humerus) treated with plate fixation are currently used by surgeons.
- Trial name
- NCT01051869
- Testing
- Simple decompression, anterior subcutaneous transposition
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Unity Health Toronto
Spinal Cord Injuries, Neuropathic Pain
Evaluation of Initiation Time on the Efficacy of Gabapentin in Treating Neuropathic Pain in SCI
Neuropathic pain is a common complaint in those with spinal cord injury (SCI) that has a significant negative effect on quality of life. Efficacy of various treatments, however, remains controversial.
- Trial name
- NCT04256603
- Testing
- Gabapentin, No gabapentin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- MetroHealth Medical Center