Hemianopia, HomonymousNCT04424979
Feasibility Tests for Various Prism Configurations for Visual Field Loss
A study testing High power prisms in people with Hemianopia, Homonymous and Tunnel Vision, run by Massachusetts Eye and Ear Infirmary at 1 site in United States.
Trial summary
The investigators will develop and test different configurations of high-power prisms to expand the field of vision of patients with visual field loss to assist them with obstacle detection when walking. Read more about this study
- Who is it for?
- Ages 7 to 80 years
- Conditions the study is for
- Hemianopia, Homonymous, Tunnel Vision, Visual Field Defect, Peripheral
- What is being tested?
- High power prisms
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteUnited States
- Study dates
- 6 Nov 2020to 30 Sep 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 7 to 80 years
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Visual field loss, either peripheral field loss or hemianopic field loss
- Visual acuity of at least 20/50 in the better eye
- In sufficiently good health to be able to complete sessions lasting 2-4 hours
- Able to independently walk short distances
- Able to give voluntary, informed consent
- Able to speak English
Who cannot join
- Any physical or mental impairments, including cognitive dysfunction, balance problems or other deficits that could impair the ability to walk or use the prism spectacles
- A history of seizures in the last 6 months
- Hemispatial neglect (subjects with hemianopic field loss only)
Trial locations and contacts
1 site in 1 country.
United States1 site
Schepens Eye Research Institute
Boston, Massachusetts, 02114
About this study
Official title: Visual Field Expansion Through Innovative Multi-Periscopic Prism Design
The investigators will develop and test different configurations of high-power prisms to expand the field of vision of patients with visual field loss to assist them with obstacle detection when walking. The study will involve multiple visits (typically four) to Schepens Eye Research Institute for fitting and testing with the prism glasses. The overall objective is to determine best designs and fitting parameters for implementation in prism devices for future clinical trials.
- Conditions
- Hemianopia, Homonymous, Tunnel Vision, Visual Field Defect, Peripheral, Visual Field Constriction Bilateral, Visual Field Defect Homonymous Bilateral
- Being tested
- High power prisms
- Keywords
- Visual field expansion, Prisms, Hemianopsia, Tunnel vision, Visual field loss
- Medical subject headings
- Hemianopsia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High power prismsDevice
High power prisms designed to shift images from blind areas into portions of the wearer's remaining, seeing, field of vision
| Study group | Role | What they receive |
|---|---|---|
| High power prisms | Experimental | Various configurations of high power prisms will be developed for each individual and custom fit into spectacles lenses. Receives: Device: High power prisms |
What is being measured
The primary outcome is the main question the study is designed to answer.
Field of view expansion
Horizontal and vertical extent of the expansion (in degrees) of the field of view
Measured: Through study completion, an average of four months
Secondary outcomes (1)
Pedestrian detection rate
Proportion of pedestrians detected (in simulated walking or simulated driving)
Measured: Through study completion, an average of four months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2020
- Study start6 Nov 2020
- Primary completion30 Jun 2026
- Study completion30 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Hemianopia, HomonymousStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Device feasibility
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 10 participants (actual)
Sponsor and investigators
- Lead sponsor
- Massachusetts Eye and Ear Infirmary
- Sponsor type
- University, hospital or other
- Collaborators
- National Eye Institute (NEI)
- Responsible party
- Principal investigator, Alexandra Bowers, Massachusetts Eye and Ear Infirmary
- Investigators
- Eliezer Peli, MSc, OD, Study director, Schepens Eye Research Institute of Massachusetts Eye and Ear
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04424979
- Sponsor's protocol ID
- MPP_Feasibility1
- Other IDs
- R01EY023385
- Status last verified
- Oct 2026
- First submitted
- 5 Jun 2020
- Last updated
- 6 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Publications
Bowers AR, Manda S, Shekar S, Hwang AD, Jung JH, Peli E. Pilot study of a pedestrian collision detection test for a multisite trial of field expansion devices for hemianopia. Optom Vis Sci. 2024 Jun 1;101(6):408-416. doi: 10.1097/OPX.0000000000002152.
PubMed 38990239
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Visual Field Expansion Through Innovative Multi-Periscopic Prism Design
- ClinicalTrials.gov ID
- NCT04424979
- Acronym / sponsor ID
- MPP_Feasibility1
- Conditions
- Hemianopia, Homonymous, Tunnel Vision, Visual Field Defect, Peripheral, Visual Field Constriction Bilateral, Visual Field Defect Homonymous Bilateral
- Keywords
- Visual field expansion, Prisms, Hemianopsia, Tunnel vision, Visual field loss
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 10 participants (actual)
- Lead sponsor
- Massachusetts Eye and Ear InfirmaryUniversity, hospital or other
- Collaborators
- National Eye Institute (NEI)
- Study start
- 6 Nov 2020 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Sep 2026 (actual)
- First posted
- 11 Jun 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators will develop and test different configurations of high-power prisms to expand the field of vision of patients with visual field loss to assist them with obstacle detection when walking. The study will involve multiple visits (typically four) to Schepens Eye Research Institute for fitting and testing with the prism glasses. The overall objective is to determine best designs and fitting parameters for implementation in prism devices for future clinical trials.
Study design
- Primary purpose
- Device feasibility
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| High power prisms | Experimental | Device: High power prismsVarious configurations of high power prisms will be developed for each individual and custom fit into spectacles lenses. |
Who may qualify
- Ages
- 7 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (6 listed)
- Visual field loss, either peripheral field loss or hemianopic field loss
- Visual acuity of at least 20/50 in the better eye
- In sufficiently good health to be able to complete sessions lasting 2-4 hours
- Able to independently walk short distances
- Able to give voluntary, informed consent
Key exclusion criteria (3 listed)
- Any physical or mental impairments, including cognitive dysfunction, balance problems or other deficits that could impair the ability to walk or use the prism spectacles
- A history of seizures in the last 6 months
- Hemispatial neglect (subjects with hemianopic field loss only)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High power prismsHigh power prisms designed to shift images from blind areas into portions of the wearer's remaining, seeing, field of vision | Device | High power prisms |
Primary outcome
Field of view expansion
Time frame: Through study completion, an average of four months
Horizontal and vertical extent of the expansion (in degrees) of the field of view
1 secondary outcome
Pedestrian detection rate
Time frame: Through study completion, an average of four months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
- Derived from this study: PubMed 38990239Bowers AR, Manda S, Shekar S, Hwang AD, Jung JH, Peli E. Pilot study of a pedestrian collision detection test for a multisite trial of field expansion devices for hemianopia. Optom Vis Sci. 2024 Jun 1;101(6):408-416. doi: 10.1097/OPX.0000000000002152.
- Individual participant dataSharing planned: No
Related trials for Hemianopia, Homonymous
Not yet recruiting
Ameliorating Stroke-induced Hemianopia Via Multisensory Training
Hemianopia, Homonymous, Cortical Blindness, Unspecified Side of Brain
Active, not recruiting
Statistical Learning as a Novel Intervention for Cortical Blindness
Stroke, Ischemic, Hemianopia, Homonymous
Not yet recruitingObservational study
Anatomical and Functional Predictions of Blindsight Capabilities in Patients With Lateral Hemianopsia
Homonymous Hemianopia, Stroke
Not yet recruiting
Effects of Optokinetic Stimulation Without a Reading Task in Patients With Hemianopic Alexia
Hemianopia Homonymous, Stroke
Recruiting
Home-based Vision Rehabilitation Guided by Brain Imaging
Visual Field Defect, Stroke
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Eliezer Peli, MSc, OD study director
Schepens Eye Research Institute of Massachusetts Eye and Ear
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High power prisms in people with Hemianopia, Homonymous and Tunnel Vision, run by Massachusetts Eye and Ear Infirmary at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Field of view expansion (time frame: Through study completion, an average of four months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04424979, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026; AzTrials last refreshed its copy on 26 Oct 2026.