Clinical trials: Peripheral Neuropathies
Rheumatoid Arthritis (RA, Osteoporosis
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases.
- Conditions
- Rheumatoid Arthritis (RA, Osteoporosis, Osteoarthritis, Interstitial Lung Disease
- Trial name
- NCT07301892
- Testing
- Generative AI prediction report for RA complications
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Peripheral Neuropathy, Trigeminal Neuralgia
Safety of Cultured Allogeneic Adult Umbilical Cordor Placental Derived Stem Cells Exosomes for Trigeminal Neuralgia
This trial will study the safety and efficacy of instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Trigeminal Neuralgia.
- Trial name
- NCT05152368
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth
Natural History Study for Charcot Marie Tooth Disease
The goal of this Natural History Study for Charcot-Marie-Tooth is to acquire, record, and analyze patient-reported data and associated genetic reports, Electronic Health Records (EHRs) and clinical notes to identify the burden…
- Conditions
- Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth, Charcot-Marie-Tooth Disease, Type IA, Charcot-Marie-Tooth Disease Type 2A
- Trial name
- NCT05902351
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Hereditary Neuropathy Foundation
Peripheral Neuropathy
The Effect of Cold Therapy on Peripheral Neuropathy
This study examines the feasibility, acceptability, and efficacy of cold therapy on vincristine-induced peripheral neuropathy (VIPN) in pediatric patients with cancer.
- Trial name
- NCT06488963
- Testing
- NatraCure Cold Therapy gloves and socks
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Koç University
Charcot-Marie-Tooth Disease, Peripheral Neuropathy
NT-3 Levels and Function in Individuals With CMT
This study will assess the serum NT-3 levels in individuals with the diagnosis of peripheral neuropathy or any type of Charcot-Marie-Tooth Neuropathy (CMT) and correlate this with function.
- Conditions
- Charcot-Marie-Tooth Disease, Peripheral Neuropathy, Chronic Inflammatory Demyelinating Polyneuropathy
- Trial name
- NCT05011006
- Testing
- NT3 blood draw
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Zarife Sahenk
Chemotherapy-induced Peripheral Neuropathy
Physiologic Measure of VIPN
The purpose of this study is the development of a physiologic endpoint using a novel technology that would provide an objective, easy to use and more sensitive assessment of VIPN in children and adolescents.
- Trial name
- NCT04786977
- Testing
- No Intervention, Observational Study
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Peripheral Neuropathy, Neuro-Degenerative Disease
A Prospective Natural History and Outcome Measure Discovery Study of Charcot-Marie-Tooth Disease, Type 4J
This is a multicenter, longitudinal, prospective observational natural history study of subjects with a molecularly confirmed diagnosis of CMT4J.
- Conditions
- Peripheral Neuropathy, Neuro-Degenerative Disease, Neuromuscular Diseases
- Trial name
- CMT4J (NCT06151600)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Elpida Therapeutics SPC
Cancer, Childhood Cancer
Light Therapy for Chemotherapy Induced Peripheral Neuropathy in Childhood Cancer Survivors
The purpose of this study is to determine feasibility and acceptability of a six-week at-home light therapy protocol in childhood cancer survivors, to identify facilitators and barriers to implementing this intervention, and to…
- Conditions
- Cancer, Childhood Cancer, Chemotherapy-induced Peripheral Neuropathy
- Trial name
- NCT07019259
- Testing
- Anodyne Therapy System
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Neuropathy;Peripheral, Limb Ischemia
Feasibility and Clinical Utility of Paired Non-Invasive Hemodynamic and Tissue Oximetry Monitoring to Detect Limb Ischemia in Lithotomy-Positioned Surgeries
The LIMB Study is a prospective, observational pilot study evaluating the feasibility of combined non-invasive hemodynamic and lower-limb tissue oximetry monitoring during prolonged minimally invasive pelvic surgeries performed…
- Trial name
- LIMB (NCT07387653)
- Testing
- Lower-Extremity Perfusion Monitoring
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Chemotherapy Induced Neuropathic Pain, Neuropathy Toxic
Prospective Exploratory Study of a Multiomic Blood Biomarker Panel to Predict Chemotherapy-Induced Peripheral Neuropathy (CIPN)
The goal of this prospective, multicenter, observational cohort study with longitudinal blood sampling and standardized neurological evaluation over 6 months is to identify biomarkers to predict the overall occurrence of chronic…
- Conditions
- Chemotherapy Induced Neuropathic Pain, Neuropathy Toxic, Taxane-induced Peripheral Neuropathy, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients
- Trial name
- PRECISE1 (NCT07511569)
- Testing
- longitudinal blood sampling and standardized neurological evaluation over 6 months
- Volunteers
- 192 people
- Sponsor
- Centre Hospitalier de Bligny
Diabetes Mellitus, Diabetes Complications
New Diagnostic Tool (MinION) for Identifying Microorganisms in Foot Wounds of Patients Living With Diabetic Foot Osteomyelitis
Diabetic foot wound infections are predominantly polymicrobial. However, 'conventional' microbiological culture does not identify all the bacteria potentially involved in these infections and requires time, which can have a…
- Conditions
- Diabetes Mellitus, Diabetes Complications, Diabetic Peripheral Neuropathy
- Trial name
- MINI-OS (NCT07391995)
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Preliminary Effectiveness and Feasibility of Transcutaneous Acupoints Electrical Stimulation on Chemotherapy-induced Peripheral Neuropathy Among Children With Acute Lymphoblastic Leukemia
The first goal of this clinical trial is to assess the feasibility of transcutaneous acupoints electrical stimulation (TAES) on children with acute lymphoblastic leukemia (ALL).
- Trial name
- NCT07319481
- Testing
- Transcutaneous Acupoints Electrical Stimulation (TAES)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Cancer, Neuropathy
Nutritional Supplement for Treating Chemotherapy Induced Neuropathy
Administration of a nutritional supplement containing palmitoyethanolamide, alpha lipoic acid, vitamin B12, vitamin B6 , vitamin B1, nicotinamide, magnesium, zinc, vitamin E, and superoxide of dismutase in individuals receiving…
- Conditions
- Cancer, Neuropathy, Chemotherapy Induced Pain Neuropathy, Chemotherapy-Induced Peripheral Neuropathy
- Trial name
- NCT07022938
- Testing
- Epineuron
- Where
- Greece
- Volunteers
- 71 people
- Sponsor
- Aristotle University Of Thessaloniki
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Improving Chemotherapy Induced Peripheral Neuropathy in Children With Leukemia: A Study of Transcutaneous Acupoints Electrical Stimulation and Auricular Acupressure Interventions
The goal of this clinical trial is to compare the effectiveness of Transcutaneous Acupoints Electrical Stimulation (TAES) and Auricular Acupressure (AA) on subject CIPN symptoms, sensory function, motor and physical function…
- Trial name
- NCT07279818
- Testing
- Transcutaneous Acupoints Electrical Stimulation (TAES), Auricular Acupressure (AA), No intervention
- Where
- China
- Volunteers
- 132 people
- Sponsor
- The Hong Kong Polytechnic University
Chemotherapy-induced Peripheral Neuropathy
Diagnostic of Chemotherapy Induced Neuropathy in Children
The purpose of this study is to determine the diagnostic accuracy of a newly developed tool (Electrochemical Skin Conductances (ESC) measurement) easy-to-perform, non-invasive, highly reproductible and not requiring specific…
- Trial name
- SUDOPED (NCT04262778)
- Testing
- electrochemical skin conductance measurement
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Direct Acting Anticoagulant Adverse Reaction, Needle Injury
Ultrasound Evaluation of Hematoma Risk After Needle EMG in Patient on DOAC Therapy
Approximately 30 minutes after needle EMG, patients who are taking direct oral anticoagulants (DOACs) will undergo an ultrasound examination to evaluate for the presence of possible intramuscular hematomas at the muscles where…
- Conditions
- Direct Acting Anticoagulant Adverse Reaction, Needle Injury, EMG, Peripheral Neuropathies
- Trial name
- U-HAND (NCT07166302)
- Where
- 2 sites in Czechia
- Volunteers
- 70 people
- Sponsor
- Masaryk University
Waldenstrom Macroglobulinaemia, Peripheral Neuropathies
This Study Aims to Clarify the Prevalence and Characteristics of Neuropathy, Along With Associated Paraclinical Findings in Patients With Waldenström's Macroglobulinemia (WM) in a Cohort of WM Patients to Optimize the Diagnostic Process
Neuropathy severely reduces patients' quality of life due to sensory loss, chronic neuropathic pain, and loss of mobility of arms and legs.
- Trial name
- NCT07160270
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Adult Patients Developing Optic or Peripheral Neuropathy, While Receiving Tedizolid Therapy Between July 2019 and December 2024
Tedizolid Neuropathies
Tedizolid is a new oxazolidinone, related to linezolid. It has obtained marketing authorization for the treatment of skin and soft tissue infections.
- Trial name
- NCT07143240
- Testing
- Determine patient demographic and clinical characteristics at baseline
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Diabetic Neuropathy Peripheral
Evaluating a Nitric Oxide Generator, Nebivolol as a Disease Modifier in Patients With Diabetic Neuropathy.
The goal of this clinical trial is to test in patients with diabetic neuropathy, Can Nevibolol at a dose of 2.5 mg- 10 mg compared with standard pain modulating treatment conserve the mean nerve action potential amplitude (sural…
- Trial name
- EVANESCENT-DPN (NCT06201611)
- Testing
- Nebivolol+ Standard care arm, Epalrestat + Alpha Lipoic Acid +Standard care, Standard care alone
- Where
- 2 sites in India
- Volunteers
- 120 people
- Sponsor
- St. John's Research Institute